ATE128470T1 - Verbessertes verfahren zur herstellung von salzen der 4-amino-1-hydroxybutyliden-1,1- bisphosphonsäure. - Google Patents

Verbessertes verfahren zur herstellung von salzen der 4-amino-1-hydroxybutyliden-1,1- bisphosphonsäure.

Info

Publication number
ATE128470T1
ATE128470T1 AT91201490T AT91201490T ATE128470T1 AT E128470 T1 ATE128470 T1 AT E128470T1 AT 91201490 T AT91201490 T AT 91201490T AT 91201490 T AT91201490 T AT 91201490T AT E128470 T1 ATE128470 T1 AT E128470T1
Authority
AT
Austria
Prior art keywords
hydroxybutylidene
amino
bisphosphonic acid
improved method
acid
Prior art date
Application number
AT91201490T
Other languages
English (en)
Inventor
Gerard R Kieczykowski
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24157769&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE128470(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE128470T1 publication Critical patent/ATE128470T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT91201490T 1990-06-20 1991-06-14 Verbessertes verfahren zur herstellung von salzen der 4-amino-1-hydroxybutyliden-1,1- bisphosphonsäure. ATE128470T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/540,997 US5019651A (en) 1990-06-20 1990-06-20 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof

Publications (1)

Publication Number Publication Date
ATE128470T1 true ATE128470T1 (de) 1995-10-15

Family

ID=24157769

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91201490T ATE128470T1 (de) 1990-06-20 1991-06-14 Verbessertes verfahren zur herstellung von salzen der 4-amino-1-hydroxybutyliden-1,1- bisphosphonsäure.

Country Status (21)

Country Link
US (1) US5019651A (de)
EP (1) EP0462663B1 (de)
JP (1) JPH07119229B2 (de)
KR (1) KR0173467B1 (de)
AT (1) ATE128470T1 (de)
AU (1) AU642264B2 (de)
CA (1) CA2044923C (de)
CY (1) CY1907A (de)
DE (1) DE69113325T2 (de)
DK (1) DK0462663T3 (de)
ES (1) ES2079026T3 (de)
FI (1) FI94347C (de)
GR (1) GR3017544T3 (de)
HK (1) HK64496A (de)
IE (1) IE69171B1 (de)
IL (1) IL98462A (de)
LV (1) LV11471B (de)
NO (1) NO180050C (de)
NZ (1) NZ238493A (de)
PT (1) PT97963B (de)
ZA (1) ZA914708B (de)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1246778B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1246777B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US6399592B1 (en) 1992-12-23 2002-06-04 Merck & Co., Inc. Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
TW257765B (de) * 1993-08-25 1995-09-21 Merck & Co Inc
US5462932A (en) * 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
US5449819A (en) * 1994-06-06 1995-09-12 Merck & Co., Inc. Process for removing waste pox, alendronate and its by products
US5589691A (en) * 1994-06-06 1996-12-31 Merck & Co., Inc. Process for recovery and recycle of methanesulfonic acid and phosphorous acid
US5780455A (en) * 1994-08-24 1998-07-14 Merck & Co., Inc. Intravenous alendronate formulations
CN1181012A (zh) * 1995-02-17 1998-05-06 麦克公司 减小非椎骨骨折危险的方法
TW393488B (en) * 1995-04-20 2000-06-11 Merck & Co Inc Process for making 1-hydrox-ybisphosphonates
EP0824341A4 (de) * 1995-05-12 1999-07-07 Merck & Co Inc Vorbeugung gegen zahnverlust durch verabreichung von alendronat oder dessen salze
WO1996039107A1 (en) 1995-06-06 1996-12-12 Merck & Co., Inc. Bisphosphonate cement composition to prevent aseptic loosening of orthopedic implant devices
DK0833643T3 (da) * 1995-06-06 2005-05-30 Merck & Co Inc Formuleringer af vandfrit mononatriumsalt af alendronat og deres anvendelse til behandling af knoglesygdomme
KR100192215B1 (ko) * 1996-09-03 1999-06-15 강재헌 3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법
TR199900730T2 (xx) * 1996-10-04 1999-07-21 Merck & Co., Inc S�v� alendronat form�lasyonlar�
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US6420568B1 (en) 1998-04-29 2002-07-16 The Procter & Gamble Company Process for making 1,3-disubstituted-4-oxocyclic ureas
US6414151B1 (en) 1998-04-29 2002-07-02 The Procter & Gamble Company Process for making 1,3-disubstituted-4-oxocyclic ureas
US20030078211A1 (en) * 1998-06-24 2003-04-24 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
EP1088333A4 (de) 1998-06-24 2005-08-10 Merck & Co Inc Verfahren und zussamensetzungen zur verbindung von osteoprose
US6008207A (en) * 1998-08-13 1999-12-28 Merck & Co., Inc. Anhydrous alendronate monosodium salt formulations
PL346347A1 (en) 1998-08-27 2002-02-11 Teva Pharma Novel hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
EP1702924A3 (de) * 1998-08-27 2007-07-18 Teva Pharmaceutical Industries Ltd Hydratformen des Natriumsalzes von Alendronat, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
KR100327786B1 (ko) * 1999-03-25 2002-03-14 유승필 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법
US6143919A (en) * 1999-05-18 2000-11-07 3M Innovative Properties Company Polymerizable acidic compounds and methods of preparation
US6315566B1 (en) 1999-05-18 2001-11-13 3M Innovative Properties Company Dental materials
US6963008B2 (en) * 1999-07-19 2005-11-08 Teva Pharmaceutical Industries Ltd. Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
KR100327787B1 (ko) * 2001-02-27 2002-03-15 유승필 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 일나트륨 삼수화물의 제조방법
US6558702B2 (en) 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems
CN100479823C (zh) * 2001-12-21 2009-04-22 宝洁公司 双膦酸盐在制造药物套盒中的用途以及用于增加骨质的套盒
AU2002364051A1 (en) * 2002-01-24 2003-09-02 Children's Medical Center Corporation Anti-cancer combination and use thereof
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
ES2532393T3 (es) * 2002-05-10 2015-03-26 F. Hoffmann-La Roche Ag Acidos bisfosfónicos para tratamiento y prevención de osteoporosis
US7038083B2 (en) 2002-05-17 2006-05-02 Teva Pharmaceutical Industries, Ltd. Process for making bisphosphonic acids using diluents other than halogenated hydrocarbons
EP1513523A1 (de) * 2002-06-06 2005-03-16 Merck Frosst Canada & Co. 1,5-disubstituierte imidazolidin-2-on derivate zur verwendung als ep4 rezeptor agonisten zur behandlung von augen- und knochen-krankheiten
JP4485117B2 (ja) * 2002-06-27 2010-06-16 日東電工株式会社 保護剥離用フィルム
JP2006504679A (ja) * 2002-08-28 2006-02-09 メルク フロスト カナダ アンド カンパニー 緑内障の治療においてｅｐ４受容体作動薬として使用するためのオキサゾリジン−２−オンおよびチアゾリジン−２−オン誘導体
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
NZ536273A (en) * 2002-12-20 2007-08-31 Hoffmann La Roche High dose ibandronate formulation
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
CA2535556C (en) * 2003-08-12 2014-01-07 3M Innovative Properties Company Self-etching dental compositions and methods
DE602004024545D1 (de) 2003-08-21 2010-01-21 Sun Pharmaceuticals Ind Ltd Indungen
CA2535359A1 (en) 2003-08-21 2005-03-03 Merck Frosst Canada Ltd. Cathepsin cysteine protease inhibitors
WO2005027921A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
WO2005035542A1 (en) * 2003-10-14 2005-04-21 Pliva-Istrazivanje I Razvoj D.O.O. Solid-state form of alendronate sodium and preparation thereof
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
ATE475412T1 (de) 2004-05-24 2010-08-15 Warner Chilcott Co Llc Enterische feste orale dosierform eines bisphosphonats mit einem chelate
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
US8465284B2 (en) * 2004-07-08 2013-06-18 3M Innovative Properties Company Dental methods, compositions, and kits including acid-sensitive dyes
WO2006020760A1 (en) * 2004-08-11 2006-02-23 3M Innovative Properties Company Self-adhesive compositions including a plurality of acidic compounds
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
PL1855674T3 (pl) 2005-03-02 2015-01-30 Merck Sharp & Dohme Kompozycja do hamowania katepsyny K
US8158153B2 (en) * 2005-03-17 2012-04-17 Alkermes Pharma Ireland Limited Nanoparticulate bisphosphonate compositions
WO2006134603A1 (en) * 2005-06-13 2006-12-21 Jubilant Organosys Limited Process for producing bisphosphonic acids and forms thereof
AR054673A1 (es) 2005-07-28 2007-07-11 Gador Sa Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
PT1803727E (pt) * 2005-12-27 2009-06-15 Ipca Lab Ltd Processo melhorado para o fabrico de ácido 4-amino-hidroxibutilideno-1,1 bisfosfónico e seus sais
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
EP1987046A1 (de) * 2006-02-20 2008-11-05 Alembic Limited Verbessertes verfahren zur herstellung von biphosphonderivaten
EP2016084A2 (de) * 2006-05-11 2009-01-21 Ind-Swift Laboratories Limited Verfahren zur herstellung von reiner risedronsäure oder -salzen
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
CN101557791B (zh) * 2006-12-13 2013-05-22 3M创新有限公司 使用具有酸性组分和可光漂白染料的牙科用组合物的方法
US20090170815A1 (en) * 2007-12-28 2009-07-02 Roxane Laboratories Incorporated. Alendronate oral liquid formulations
WO2010003704A2 (en) * 2008-07-11 2010-01-14 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
WO2010143193A1 (en) 2009-06-11 2010-12-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
WO2011023280A1 (en) 2009-08-28 2011-03-03 Synthon B.V. Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
WO2011039378A1 (en) 2009-10-02 2011-04-07 Straitmark Holding Ag Method for the manufacture of aminohydroxy diphosphonic acids
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
TR201903835T4 (tr) 2010-12-06 2019-04-22 Effrx Pharmaceuticals Sa Hızlı çözünme özelliklerine sahip stabil efervesan bifosfonat formülasyonları.
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
EP2731591B1 (de) 2011-07-13 2020-06-17 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Liposomen zur gemeinsamen verkapselung eines bisphosphonats und eines amphipatischen stoffes
AU2014332250B2 (en) 2013-10-08 2018-07-19 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
EP3148587B1 (de) 2014-05-30 2021-02-24 Pfizer Inc Carbonitrilderivate als selektive androgenrezeptormodulatoren
WO2016199111A1 (en) 2015-06-12 2016-12-15 Simon Fraser University Amide-linked ep4 agonist-bisphosphonate compounds and uses thereof
EP3827010A4 (de) 2018-07-23 2022-03-16 Brise Pharmaceuticals Co., Ltd. Bisphosphonat-wirkstoff-konjugate
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1387311A (en) * 1972-03-24 1975-03-12 Gullick Dobson Ltd Mine roof supports
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2534390C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1,3-Di-aminoalkan-1,1-diphosphonsäuren
US4163733A (en) * 1977-10-25 1979-08-07 Buckman Laboratories, Inc. Synergistic compositions for corrosion and scale control
US4100167A (en) * 1977-05-09 1978-07-11 Nalco Chemical Company Production of 1-aminoalkane-1, 1-diphosphonic acids using phosphorous acid and nitriles in a non-aqueous system
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2943498C2 (de) * 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
DE3047107A1 (de) * 1980-12-13 1982-07-29 Hoechst Ag, 6000 Frankfurt Verfahren zur hertellung von 1-amino-alkan-1,1-diphosphonsaeuren
IT1194748B (it) * 1981-02-12 1988-09-28 Gentili Ist Spa Composizioni farmaceutiche per il trattamento di osteopatie
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
IT1187828B (it) * 1985-05-24 1987-12-23 Gentili Ist Spa Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Also Published As

Publication number Publication date
US5019651A (en) 1991-05-28
LV11471B (en) 1996-12-20
LV11471A (lv) 1996-08-20
FI94347C (fi) 1995-08-25
JPH07119229B2 (ja) 1995-12-20
DE69113325T2 (de) 1996-05-02
AU642264B2 (en) 1993-10-14
HK64496A (en) 1996-04-19
IL98462A0 (en) 1992-07-15
NO912395L (no) 1991-12-23
GR3017544T3 (en) 1995-12-31
ZA914708B (en) 1992-03-25
PT97963B (pt) 1998-11-30
PT97963A (pt) 1992-03-31
NO912395D0 (no) 1991-06-19
AU7849891A (en) 1992-01-02
FI94347B (fi) 1995-05-15
DE69113325D1 (de) 1995-11-02
CA2044923C (en) 1996-06-18
DK0462663T3 (da) 1996-01-29
KR0173467B1 (en) 1999-04-01
CA2044923A1 (en) 1991-12-21
FI913008A0 (fi) 1991-06-19
NO180050C (no) 1997-02-05
IE69171B1 (en) 1996-08-07
NZ238493A (en) 1992-09-25
IE912112A1 (en) 1992-01-01
EP0462663A1 (de) 1991-12-27
JPH05132492A (ja) 1993-05-28
IL98462A (en) 1995-12-08
CY1907A (en) 1991-06-14
ES2079026T3 (es) 1996-01-01
FI913008A (fi) 1991-12-21
NO180050B (no) 1996-10-28
EP0462663B1 (de) 1995-09-27

Similar Documents

Publication Publication Date Title
ATE128470T1 (de) Verbessertes verfahren zur herstellung von salzen der 4-amino-1-hydroxybutyliden-1,1- bisphosphonsäure.
NO941726L (no) Fremgangsmåte for fremstilling av 4-amino-1-hydroxy-butyliden-1,2-bisfosfonsyre
DE69806470D1 (de) Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure
ATE1242T1 (de) Verfahren zur herstellung von 3-amino-1-hydroxypropan-1,1-diphosphonsaeure.
ATE2532T1 (de) Verfahren zur herstellung von omega-amino-1hydroxyalkyliden-1,1-bisphosphonsaeuren.
ATE213249T1 (de) Verfahren zur herstellung von n- phosphonomethyliminodiessigesäure.
ATE210669T1 (de) Verfahren zur herstellung von n- phosphonomethyliminodiessigsäure
ATE111102T1 (de) Verfahren zur herstellung von n- phosphonomethylglycin.
ATE113587T1 (de) Verfahren zur herstellung von 4,5-dichlor-6- ethylpyrimidin.
ATE121410T1 (de) Verfahren zur herstellung von diphosphonsäuren und salzen davon.
DE3864927D1 (de) Verfahren zur herstellung von aminomethylenphosphonalkylphosphinaten.
ATE155789T1 (de) Verfahren zur herstellung von aminomethanphosphonsäure
ATE147395T1 (de) Verfahren zur herstellung von acylaminomethanphosphonsäuren
ATE21107T1 (de) Verfahren zur herstellung von 3-amino-1hydroxypropan-1,1-diphosphonsaeure.
ATE29501T1 (de) Verfahren zur herstellung von nphosphonomethylglyzin.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time