DE69113325D1 - Verbessertes Verfahren zur Herstellung von Salzen der 4-Amino-1-hydroxybutyliden-1,1-bisphosphonsäure. - Google Patents

Verbessertes Verfahren zur Herstellung von Salzen der 4-Amino-1-hydroxybutyliden-1,1-bisphosphonsäure.

Info

Publication number
DE69113325D1
DE69113325D1 DE69113325T DE69113325T DE69113325D1 DE 69113325 D1 DE69113325 D1 DE 69113325D1 DE 69113325 T DE69113325 T DE 69113325T DE 69113325 T DE69113325 T DE 69113325T DE 69113325 D1 DE69113325 D1 DE 69113325D1
Authority
DE
Germany
Prior art keywords
hydroxybutylidene
salts
amino
preparation
improved process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69113325T
Other languages
English (en)
Other versions
DE69113325T2 (de
Inventor
Gerard R Kieczykowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24157769&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69113325(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE69113325D1 publication Critical patent/DE69113325D1/de
Application granted granted Critical
Publication of DE69113325T2 publication Critical patent/DE69113325T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69113325T 1990-06-20 1991-06-14 Verbessertes Verfahren zur Herstellung von Salzen der 4-Amino-1-hydroxybutyliden-1,1-bisphosphonsäure. Expired - Lifetime DE69113325T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/540,997 US5019651A (en) 1990-06-20 1990-06-20 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof

Publications (2)

Publication Number Publication Date
DE69113325D1 true DE69113325D1 (de) 1995-11-02
DE69113325T2 DE69113325T2 (de) 1996-05-02

Family

ID=24157769

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69113325T Expired - Lifetime DE69113325T2 (de) 1990-06-20 1991-06-14 Verbessertes Verfahren zur Herstellung von Salzen der 4-Amino-1-hydroxybutyliden-1,1-bisphosphonsäure.

Country Status (21)

Country Link
US (1) US5019651A (de)
EP (1) EP0462663B1 (de)
JP (1) JPH07119229B2 (de)
KR (1) KR0173467B1 (de)
AT (1) ATE128470T1 (de)
AU (1) AU642264B2 (de)
CA (1) CA2044923C (de)
CY (1) CY1907A (de)
DE (1) DE69113325T2 (de)
DK (1) DK0462663T3 (de)
ES (1) ES2079026T3 (de)
FI (1) FI94347C (de)
GR (1) GR3017544T3 (de)
HK (1) HK64496A (de)
IE (1) IE69171B1 (de)
IL (1) IL98462A (de)
LV (1) LV11471B (de)
NO (1) NO180050C (de)
NZ (1) NZ238493A (de)
PT (1) PT97963B (de)
ZA (1) ZA914708B (de)

Families Citing this family (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1246777B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Aminoacil derivati di acidi gem-difosfonici,un processo per la loro preparazione e composizioni farmaceutiche che li contengono
IT1246778B (it) * 1991-04-12 1994-11-26 Boehringer Mannheim Italia Nitrosocarbamoil derivati di acidi gem-difosfonici, un processo per la loro preparazione e composizioni farmaceutiche che li contengono
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
US6399592B1 (en) 1992-12-23 2002-06-04 Merck & Co., Inc. Bishphosphonate/estrogen synergistic therapy for treating and preventing bone loss
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids
TW257765B (de) * 1993-08-25 1995-09-21 Merck & Co Inc
US5462932A (en) * 1994-05-17 1995-10-31 Merck & Co., Inc. Oral liquid alendronate formulations
US5449819A (en) * 1994-06-06 1995-09-12 Merck & Co., Inc. Process for removing waste pox, alendronate and its by products
US5589691A (en) * 1994-06-06 1996-12-31 Merck & Co., Inc. Process for recovery and recycle of methanesulfonic acid and phosphorous acid
US5780455A (en) * 1994-08-24 1998-07-14 Merck & Co., Inc. Intravenous alendronate formulations
EP0809502A4 (de) * 1995-02-17 2001-12-05 Merck & Co Inc Verfahren zur verminderung des risikos nicht-vertebraler knochenbrüche
TW393488B (en) * 1995-04-20 2000-06-11 Merck & Co Inc Process for making 1-hydrox-ybisphosphonates
EP0824341A4 (de) * 1995-05-12 1999-07-07 Merck & Co Inc Vorbeugung gegen zahnverlust durch verabreichung von alendronat oder dessen salze
ATE289199T1 (de) * 1995-06-06 2005-03-15 Merck & Co Inc Formulierungen mit dem wasserfreien mononatriumsalz von alendronat und deren verwendung zur behandlung von knochenkrankheiten
EP0831756A1 (de) 1995-06-06 1998-04-01 Merck & Co., Inc. Bisphosphonat-zementzusammensetzung zur verhinderung von aseptischer lockerung orthopädischer prothesen
KR100192215B1 (ko) * 1996-09-03 1999-06-15 강재헌 3-아미노-1-히드록시프로판-1,1-디포스폰산의 제조방법
AU723357B2 (en) * 1996-10-04 2000-08-24 Merck & Co., Inc. Liquid alendronate formulations
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
BR9910074A (pt) 1998-04-29 2000-12-26 Procter & Gamble Processo para fabricação de uréias 1,3-di-substituìdas-4-oxocìclicas
NZ506773A (en) 1998-04-29 2004-03-26 Procter & Gamble Process for making 1, 3-disubstituted-4-oxocyclic ureas
US6432931B1 (en) 1998-06-24 2002-08-13 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US20030078211A1 (en) * 1998-06-24 2003-04-24 Merck & Co., Inc. Compositions and methods for inhibiting bone resorption
US6008207A (en) * 1998-08-13 1999-12-28 Merck & Co., Inc. Anhydrous alendronate monosodium salt formulations
RO122854B1 (ro) * 1998-08-27 2010-03-30 Teva Pharmaceutical Industries Ltd. Alendronat de sodiu hidrat, procedeu de obţinere şi compoziţie farmaceutică
EP1702924A3 (de) * 1998-08-27 2007-07-18 Teva Pharmaceutical Industries Ltd Hydratformen des Natriumsalzes von Alendronat, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
KR100327786B1 (ko) * 1999-03-25 2002-03-14 유승필 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 또는 이의 염의 제조방법
US6143919A (en) * 1999-05-18 2000-11-07 3M Innovative Properties Company Polymerizable acidic compounds and methods of preparation
US6315566B1 (en) 1999-05-18 2001-11-13 3M Innovative Properties Company Dental materials
US6963008B2 (en) * 1999-07-19 2005-11-08 Teva Pharmaceutical Industries Ltd. Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6677320B2 (en) 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US6476006B2 (en) 2000-06-23 2002-11-05 Teva Pharmaceutical Industries, Ltd. Composition and dosage form for delayed gastric release of alendronate and/or other bis-phosphonates
KR100327787B1 (ko) * 2001-02-27 2002-03-15 유승필 4-아미노-1-하이드록시부틸리덴-1,1-비스포스폰산 일나트륨 삼수화물의 제조방법
US20060269602A1 (en) * 2001-04-13 2006-11-30 Dasch James R Method of modifying the release profile of sustained release compositions
US6558702B2 (en) 2001-04-13 2003-05-06 Alkermes Controlled Therapeutics, Inc. Method of modifying the release profile of sustained release compositions
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems
WO2003055496A1 (en) * 2001-12-21 2003-07-10 The Procter & Gamble Company Method for the treatment of bone disorders
CA2472578A1 (en) * 2002-01-24 2003-07-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Anti-cancer combination and use thereof
ITMI20020908A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
KR20120065435A (ko) 2002-05-10 2012-06-20 에프. 호프만-라 로슈 아게 골다공증 치료 및 예방용 비스포스폰산
ATE461205T1 (de) * 2002-05-17 2010-04-15 Teva Pharma Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
JP2005534653A (ja) * 2002-06-06 2005-11-17 メルク フロスト カナダ アンド カンパニー 眼及び骨疾患の治療に於いてｅｐ４受容体作動薬として使用するための１，５−二置換イミダゾリジン−２−オン誘導体
JP4485117B2 (ja) * 2002-06-27 2010-06-16 日東電工株式会社 保護剥離用フィルム
EP1545517A1 (de) * 2002-08-28 2005-06-29 Merck Frosst Canada & Co. Oxazolidin-2-on und thiazolidin-2-on-derivate zur verwendung als ep4-rezeptor-agonisten bei der behandlung von glaukom
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
BR0309691A (pt) * 2002-12-20 2005-08-02 Hoffmann La Roche Formulação de ibandronato em alta dose
US20040206932A1 (en) * 2002-12-30 2004-10-21 Abuelyaman Ahmed S. Compositions including polymerizable bisphosphonic acids and methods
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
WO2005018581A2 (en) * 2003-08-12 2005-03-03 3M Innovative Properties Company Self-etching dental compositions and methods
EP1673336B1 (de) 2003-08-21 2014-06-04 Merck Canada Inc. Cathepsincysteinproteasehemmer
US7411087B2 (en) * 2003-08-21 2008-08-12 Sun Pharmaceutical Industries Limited Process for preparation of bisphosphonic acid compounds
CA2539359A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a bisphosphonate
WO2005035542A1 (en) * 2003-10-14 2005-04-21 Pliva-Istrazivanje I Razvoj D.O.O. Solid-state form of alendronate sodium and preparation thereof
US20050181043A1 (en) * 2004-02-12 2005-08-18 Indranil Nandi Alendronate salt tablet compositions
KR20080083068A (ko) 2004-05-24 2008-09-12 더 프록터 앤드 갬블 캄파니 킬레이팅제를 함유하는 비스포스포네이트의 고형의 장용 경구 투여 형태
UA87854C2 (en) 2004-06-07 2009-08-25 Мерк Энд Ко., Инк. N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
CA2573020A1 (en) * 2004-07-08 2006-02-09 3M Innovative Properties Company Dental methods, compositions, and kits including acid-sensitive dyes
EP1784155B1 (de) * 2004-08-11 2011-09-28 3M Innovative Properties Company Selbstklebende zusammensetzungen mit einer vielzahl von sauren verbindungen
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
EP1855674B1 (de) 2005-03-02 2014-07-16 Merck Sharp & Dohme Corp. Zusammensetzung zur hemmung von cathepsin k
BRPI0606280A2 (pt) * 2005-03-17 2009-06-09 Elan Pharma Int Ltd composições de bisfosfonato nanoparticulado
EP1891081B1 (de) * 2005-06-13 2014-08-20 Jubilant Organosys Limited Verfahren zur herstellung von bisphosphonsäuren und formen davon
AR054673A1 (es) 2005-07-28 2007-07-11 Gador Sa Una forma cristalina del acido zoledronico, un proceso para su obtencion y la composicion farmaceutica que la comprende
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
ES2323728T3 (es) 2005-12-27 2009-07-23 Ipca Laboratories Limited Proceso mejorado para la fabricacion de 4-amino-hidroxibutilideno-1,1-bisfosfonico y sus sales.
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
WO2007096896A1 (en) * 2006-02-20 2007-08-30 Alembic Limited An improved process for the preparation of biphosphonic derivatives
KR20090005206A (ko) * 2006-05-11 2009-01-12 인드-스위프트 래버러토리즈 리미티드 순수한 리세드론산 또는 염의 제조 방법
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
EP2101716A2 (de) * 2006-12-13 2009-09-23 3M Innovative Properties Company Verfahren zur verwendung einer dentalen zusammensetzung mit saurer komponente und lichtbleichbarem farbstoff
US20090170815A1 (en) * 2007-12-28 2009-07-02 Roxane Laboratories Incorporated. Alendronate oral liquid formulations
US8026388B2 (en) * 2008-07-11 2011-09-27 Synthon Bv Process for making 1-hydroxyalkylidene-1,1-biphosphonic acids
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
US20120100206A1 (en) 2009-06-11 2012-04-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
EA201270328A1 (ru) 2009-08-28 2012-09-28 Синтон Б. В. Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
BR112012007554B1 (pt) * 2009-10-02 2018-09-04 Monsanto Technology Llc método para a fabricação de ácidos amino hidróxi disfofônico
CA2738045C (en) 2010-05-28 2019-02-19 Simon Fraser University Conjugate compounds, methods of making same, and uses thereof
BR112013010476B1 (pt) 2010-12-06 2021-07-06 Effrx Pharmaceuticals Sa formulações efervescentes estáveis de bisfosfonato com características de solubilização rápida
EP2675440B1 (de) 2011-02-14 2020-03-25 Merck Sharp & Dohme Corp. Cathepsin-cysteinproteasehemmer
PL2731591T3 (pl) 2011-07-13 2021-05-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomy zawierające bisfosfonian i środek amfipatyczny w wyniku ko-enkapsulacji
WO2015051479A1 (en) 2013-10-08 2015-04-16 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
CN105593230B (zh) 2013-10-08 2018-07-06 默沙东公司 组织蛋白酶半胱氨酸蛋白酶抑制剂
WO2015120580A1 (en) 2014-02-11 2015-08-20 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
PL407922A1 (pl) 2014-04-16 2015-10-26 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Nowe bisfosfoniany i ich zastosowanie
US9650414B1 (en) 2014-05-30 2017-05-16 Simon Fraser University Dual-action EP4 agonist—bisphosphonate conjugates and uses thereof
KR20160147007A (ko) 2014-05-30 2016-12-21 화이자 인코포레이티드 선택적인 안드로겐 수용체 조절제로서의 카보니트릴 유도체
CN107849072B (zh) 2015-06-12 2020-12-15 西蒙弗雷泽大学 酰胺连接的ep4激动剂-二膦酸盐化合物及其用途
EP3827010A4 (de) 2018-07-23 2022-03-16 Brise Pharmaceuticals Co., Ltd. Bisphosphonat-wirkstoff-konjugate
WO2023275715A1 (en) 2021-06-30 2023-01-05 Pfizer Inc. Metabolites of selective androgen receptor modulators

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1387311A (en) * 1972-03-24 1975-03-12 Gullick Dobson Ltd Mine roof supports
DE2534391C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1-Hydroxy-3-aminoalkan-1,1-diphosphonsäuren
DE2534390C2 (de) * 1975-08-01 1983-01-13 Henkel KGaA, 4000 Düsseldorf 1,3-Di-aminoalkan-1,1-diphosphonsäuren
US4163733A (en) * 1977-10-25 1979-08-07 Buckman Laboratories, Inc. Synergistic compositions for corrosion and scale control
US4100167A (en) * 1977-05-09 1978-07-11 Nalco Chemical Company Production of 1-aminoalkane-1, 1-diphosphonic acids using phosphorous acid and nitriles in a non-aqueous system
DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2943498C2 (de) * 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
DE3047107A1 (de) * 1980-12-13 1982-07-29 Hoechst Ag, 6000 Frankfurt Verfahren zur hertellung von 1-amino-alkan-1,1-diphosphonsaeuren
IT1194748B (it) * 1981-02-12 1988-09-28 Gentili Ist Spa Composizioni farmaceutiche per il trattamento di osteopatie
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
DE3434667A1 (de) * 1984-09-21 1986-04-03 Henkel KGaA, 4000 Düsseldorf 4-dimethylamino-1-hydroxybutan-1,1-diphosphonsaeure, deren wasserloesliche salze, verfahren zu ihrer herstellung sowie ihre verwendung
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
IT1187828B (it) * 1985-05-24 1987-12-23 Gentili Ist Spa Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Also Published As

Publication number Publication date
IE69171B1 (en) 1996-08-07
NZ238493A (en) 1992-09-25
CA2044923A1 (en) 1991-12-21
IL98462A (en) 1995-12-08
IE912112A1 (en) 1992-01-01
ZA914708B (en) 1992-03-25
NO180050C (no) 1997-02-05
HK64496A (en) 1996-04-19
IL98462A0 (en) 1992-07-15
NO180050B (no) 1996-10-28
NO912395D0 (no) 1991-06-19
EP0462663B1 (de) 1995-09-27
LV11471A (lv) 1996-08-20
AU7849891A (en) 1992-01-02
US5019651A (en) 1991-05-28
ATE128470T1 (de) 1995-10-15
JPH05132492A (ja) 1993-05-28
DE69113325T2 (de) 1996-05-02
FI94347B (fi) 1995-05-15
KR0173467B1 (en) 1999-04-01
PT97963B (pt) 1998-11-30
FI94347C (fi) 1995-08-25
CA2044923C (en) 1996-06-18
CY1907A (en) 1991-06-14
DK0462663T3 (da) 1996-01-29
ES2079026T3 (es) 1996-01-01
EP0462663A1 (de) 1991-12-27
NO912395L (no) 1991-12-23
FI913008A (fi) 1991-12-21
GR3017544T3 (en) 1995-12-31
PT97963A (pt) 1992-03-31
LV11471B (en) 1996-12-20
AU642264B2 (en) 1993-10-14
FI913008A0 (fi) 1991-06-19
JPH07119229B2 (ja) 1995-12-20

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