DE69806470T2 - Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure - Google Patents

Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure

Info

Publication number
DE69806470T2
DE69806470T2 DE69806470T DE69806470T DE69806470T2 DE 69806470 T2 DE69806470 T2 DE 69806470T2 DE 69806470 T DE69806470 T DE 69806470T DE 69806470 T DE69806470 T DE 69806470T DE 69806470 T2 DE69806470 T2 DE 69806470T2
Authority
DE
Germany
Prior art keywords
amino
hydroxybutyliden
producing
acid
biphosphonic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69806470T
Other languages
English (en)
Other versions
DE69806470D1 (de
Inventor
Rudolf Kubela
Yong Tao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apotex Inc
Original Assignee
Apotex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apotex Inc filed Critical Apotex Inc
Publication of DE69806470D1 publication Critical patent/DE69806470D1/de
Application granted granted Critical
Publication of DE69806470T2 publication Critical patent/DE69806470T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69806470T 1997-02-11 1998-02-06 Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure Expired - Fee Related DE69806470T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002197267A CA2197267C (en) 1997-02-11 1997-02-11 Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
PCT/CA1998/000091 WO1998034940A1 (en) 1997-02-11 1998-02-06 Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid

Publications (2)

Publication Number Publication Date
DE69806470D1 DE69806470D1 (de) 2002-08-14
DE69806470T2 true DE69806470T2 (de) 2003-02-20

Family

ID=4159900

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69806470T Expired - Fee Related DE69806470T2 (de) 1997-02-11 1998-02-06 Verfahren zur herstellung von 4-amino-1-hydroxybutyliden-1,1-biphosphonsäure

Country Status (12)

Country Link
US (1) US5908959A (de)
EP (1) EP0971938B1 (de)
AT (1) ATE220404T1 (de)
AU (1) AU728164B2 (de)
BR (1) BR9807568A (de)
CA (1) CA2197267C (de)
DE (1) DE69806470T2 (de)
DK (1) DK0971938T3 (de)
ES (1) ES2180141T3 (de)
PL (1) PL335053A1 (de)
PT (1) PT971938E (de)
WO (1) WO1998034940A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL144941A0 (en) * 1999-02-17 2002-06-30 Teva Pharma Novel process for preparing alendronic acid
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
PE20011065A1 (es) * 2000-02-01 2001-11-21 Procter & Gamble Proceso para fabricar bisfosfonatos geminales
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
GB0115824D0 (en) * 2001-06-28 2001-08-22 Rhodia Cons Spec Ltd Improved solvent systems
EP2172192A1 (de) * 2001-12-24 2010-04-07 Teva Pharmaceutical Industries Ltd. Dosierform mit einer Kerntablette mit einem Wirkstoff, der in einem komprimierten Ringkörper aus Pulver- oder granulärem Material gehüllt ist, und Verfahren und Werkzeuge zu ihrer Herstellung
US20040052843A1 (en) * 2001-12-24 2004-03-18 Lerner E. Itzhak Controlled release dosage forms
ITMI20020908A1 (it) 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione di sodio alendronato
DE60331724D1 (de) * 2002-05-17 2010-04-29 Teva Pharma Verwendung von bestimmten lösungsmitteln zur herstellung von bisphosphonsäuren
US20040138180A1 (en) * 2002-10-03 2004-07-15 Barr Laboratories, Inc. Bisphosphonate composition and process for the preparation thereof
HUP0300227A2 (hu) 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20040213917A1 (en) * 2003-04-23 2004-10-28 Courtney Douglas L. Spray booth and filter system
SI1656386T1 (sl) * 2003-08-21 2010-04-30 Sun Pharmaceuticals Ind Ltd Postopek za pripravo spojin, ki so bifosfonske kisline
US7361761B2 (en) * 2004-09-28 2008-04-22 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of bisphosphonic acid
US7872144B2 (en) * 2005-06-13 2011-01-18 Jubilant Organosys Limited Process for producing biphosphonic acids and forms thereof
US8003820B2 (en) * 2005-10-20 2011-08-23 Dr. Reddy's Laboratories Limited Process for preparing bisphosphonic acids
AR058168A1 (es) * 2005-11-07 2008-01-23 Merck & Co Inc Sintesis del alendronato de sodio trihidratado
DE602006005597D1 (de) 2005-12-27 2009-04-23 Ipca Lab Ltd Verbesserter Herstellungsprozess von 4-Amino-Hydroxybutyliden-1,1-bisphosphonischer Säure und ihrer Salze
WO2007083240A2 (en) 2006-01-20 2007-07-26 Aurobindo Pharma Limited An improved process for the preparation of bisphosphonic acids
EP1996599A2 (de) * 2006-03-21 2008-12-03 Albermarle Corporation Verfahren zur herstellung von bisphosphonsäuren
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Ａｄｅｋａ スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
BRPI0710421A2 (pt) 2006-05-11 2011-08-09 Ind Swift Ltd processo para a preparação de ácido risedrÈnico puro ou sais
CA2656053A1 (en) * 2006-07-03 2008-01-10 Generics [Uk] Limited Novel process for the preparation of bisphosphonic acids
CA2570949A1 (en) * 2006-12-12 2008-06-12 Apotex Pharmachem Inc. Ibandronate sodium propylene glycol solvate and processes for the preparation thereof
CA2689504A1 (en) * 2007-06-19 2008-12-24 Albemarle Corporation Processes for manufacturing bisphosphonic acids
CN102124016A (zh) * 2008-07-11 2011-07-13 斯索恩有限公司 制备1-羟基亚烷基-1，1-双膦酸的方法
EP2192126B1 (de) 2008-11-26 2013-03-27 Synthon B.V. Verfahren zur Herstellung von Zoledronsäure
US20100130746A1 (en) * 2008-11-26 2010-05-27 Martin Kas Process for Making Zoledronic Acid
WO2010060619A1 (en) * 2008-11-26 2010-06-03 Synthon B.V. Process for making zoledronic acid
EA201270328A1 (ru) 2009-08-28 2012-09-28 Синтон Б. В. Способ получения 1-гидроксиалкилиден-1,1-дифосфоновых кислот
US8779135B2 (en) 2009-10-02 2014-07-15 Straitmark Holding Ag Method for the manufacture of aminohydroxy diphosphonic acids

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163733A (en) * 1977-10-25 1979-08-07 Buckman Laboratories, Inc. Synergistic compositions for corrosion and scale control
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
US5510517A (en) * 1993-08-25 1996-04-23 Merck & Co., Inc. Process for producing N-amino-1-hydroxy-alkylidene-1,1-bisphosphonic acids

Also Published As

Publication number Publication date
PL335053A1 (en) 2000-03-27
DE69806470D1 (de) 2002-08-14
EP0971938A1 (de) 2000-01-19
BR9807568A (pt) 2000-03-21
CA2197267A1 (en) 1998-08-11
US5908959A (en) 1999-06-01
ATE220404T1 (de) 2002-07-15
AU728164B2 (en) 2001-01-04
MX9801171A (es) 1998-12-31
CA2197267C (en) 2000-02-08
PT971938E (pt) 2002-11-29
AU5977298A (en) 1998-08-26
ES2180141T3 (es) 2003-02-01
WO1998034940A1 (en) 1998-08-13
EP0971938B1 (de) 2002-07-10
DK0971938T3 (da) 2002-10-14

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee