SI1656386T1 - Postopek za pripravo spojin, ki so bifosfonske kisline - Google Patents
Postopek za pripravo spojin, ki so bifosfonske kislineInfo
- Publication number
- SI1656386T1 SI1656386T1 SI200431349T SI200431349T SI1656386T1 SI 1656386 T1 SI1656386 T1 SI 1656386T1 SI 200431349 T SI200431349 T SI 200431349T SI 200431349 T SI200431349 T SI 200431349T SI 1656386 T1 SI1656386 T1 SI 1656386T1
- Authority
- SI
- Slovenia
- Prior art keywords
- preparation
- acid compounds
- bisphosphonic acid
- acid
- reacting
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229960004343 alendronic acid Drugs 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Vending Machines For Individual Products (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN837MU2003 | 2003-08-21 | ||
| EP04816640A EP1656386B1 (en) | 2003-08-21 | 2004-08-10 | A process for preparation of bisphosphonic acid compounds |
| PCT/IN2004/000238 WO2005044831A2 (en) | 2003-08-21 | 2004-08-10 | A process for preparation of bisphosphonic acid compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1656386T1 true SI1656386T1 (sl) | 2010-04-30 |
Family
ID=34566872
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200431349T SI1656386T1 (sl) | 2003-08-21 | 2004-08-10 | Postopek za pripravo spojin, ki so bifosfonske kisline |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US7411087B2 (sl) |
| EP (1) | EP1656386B1 (sl) |
| JP (1) | JP4642762B2 (sl) |
| AT (1) | ATE451380T1 (sl) |
| CA (1) | CA2536229C (sl) |
| DE (1) | DE602004024545D1 (sl) |
| DK (1) | DK1656386T3 (sl) |
| ES (1) | ES2337063T3 (sl) |
| PL (1) | PL1656386T3 (sl) |
| PT (1) | PT1656386E (sl) |
| SI (1) | SI1656386T1 (sl) |
| WO (1) | WO2005044831A2 (sl) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003233569A1 (en) * | 2002-05-17 | 2003-12-02 | Teva Pharmaceutical Industries Ltd. | Use of certain diluents for making bisphosphonic acids |
| HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
| WO2006002348A2 (en) | 2004-06-23 | 2006-01-05 | Teva Pharmaceutical Industies Ltd. | Solid and crystalline ibandronic acid |
| WO2006051553A1 (en) * | 2004-11-09 | 2006-05-18 | Jubilant Organosys Limited | Process for preparing a pure polymorphic form of 3-pyridyl-1-hydroxyethylidine-1,1-bisphosphonic acid sodium salt |
| US8071574B2 (en) | 2005-02-22 | 2011-12-06 | John Dennis Bobyn | Implant improving local bone formation |
| US7872144B2 (en) * | 2005-06-13 | 2011-01-18 | Jubilant Organosys Limited | Process for producing biphosphonic acids and forms thereof |
| WO2007010556A1 (en) * | 2005-07-20 | 2007-01-25 | Lupin Limited | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| JP2009507831A (ja) * | 2005-09-12 | 2009-02-26 | ドクター レディズ ラボラトリーズ リミテッド | ゾレドロン酸の結晶性三水和物 |
| US8003820B2 (en) | 2005-10-20 | 2011-08-23 | Dr. Reddy's Laboratories Limited | Process for preparing bisphosphonic acids |
| WO2007083240A2 (en) | 2006-01-20 | 2007-07-26 | Aurobindo Pharma Limited | An improved process for the preparation of bisphosphonic acids |
| US20090137808A1 (en) * | 2006-03-21 | 2009-05-28 | Albemarle Corporation | Process for manufacturing bisphosphonic acids |
| WO2007125521A2 (en) * | 2006-05-02 | 2007-11-08 | Ranbaxy Laboratories Limited | Polymorphic form of zoledronic acid and processes for their preparation |
| JP5354858B2 (ja) * | 2006-05-09 | 2013-11-27 | 株式会社Ａｄｅｋａ | スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物 |
| BRPI0710421A2 (pt) * | 2006-05-11 | 2011-08-09 | Ind Swift Ltd | processo para a preparação de ácido risedrÈnico puro ou sais |
| NZ573137A (en) * | 2006-06-23 | 2011-03-31 | Cipla Ltd | Process for the synthesis of ibandronate sodium |
| AU2007270897A1 (en) * | 2006-07-03 | 2008-01-10 | Generics [Uk] Limited | Novel process for the preparation of bisphosphonic acids |
| PT103600B (pt) * | 2006-11-06 | 2009-01-30 | Hovione Farmaciencia Sa | Processo para a preparação de ácidos biosfónicos e seus sais farmaceuticamente aceitáveis |
| CA2683971C (en) * | 2007-04-11 | 2013-02-26 | F. Hoffmann-La Roche Ag | Multi step systhesis of ibandronate |
| US20100317859A1 (en) * | 2007-05-16 | 2010-12-16 | Actavis Group Ptc Ehf | Process for the Preparation of Risedronate Sodium |
| WO2009050731A2 (en) * | 2007-06-20 | 2009-04-23 | Alkem Laboratories Ltd | Novel process for preparing risedronic acid |
| JP5258370B2 (ja) * | 2008-05-08 | 2013-08-07 | ダイト株式会社 | リセドロン酸の工業的製造方法 |
| PL213599B1 (pl) | 2008-10-31 | 2013-03-29 | Politechnika Gdanska | Sposób otrzymywania kwasu [1-hydroksy-2-(1H-imidazol-1-ilo)-etylideno] bisfosfonowego |
| GB0906068D0 (en) | 2009-04-07 | 2009-05-20 | King S College London | Bisphosphonate Compounds for chelating radionuclides |
| US9169279B2 (en) | 2009-07-31 | 2015-10-27 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US8399023B2 (en) | 2009-07-31 | 2013-03-19 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| US20160016982A1 (en) | 2009-07-31 | 2016-01-21 | Thar Pharmaceuticals, Inc. | Crystallization method and bioavailability |
| WO2011016738A1 (en) | 2009-08-05 | 2011-02-10 | Zaklady Farmaceutyczne Polpharma Sa | A process for the synthesis of 1-hydroxy-3-(n-methylpentylamino) propylidene bisphosphonic acid monosodium salt, monohydrate |
| US8882740B2 (en) * | 2009-12-23 | 2014-11-11 | Stryker Trauma Gmbh | Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone |
| US9340565B2 (en) | 2010-11-24 | 2016-05-17 | Thar Pharmaceuticals, Inc. | Crystalline forms |
| CN102276650A (zh) * | 2011-06-22 | 2011-12-14 | 苏州莱克施德药业有限公司 | 一种唑来膦酸的制备方法 |
| WO2017208070A1 (en) | 2016-05-31 | 2017-12-07 | Grünenthal GmbH | Bisphosphonic acid and coformers with lysin, glycin, nicotinamide for treating psoriatic arthritis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3016289A1 (de) | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| US4304734A (en) * | 1980-10-16 | 1981-12-08 | Vysoka Skola Chemicko-Technologicka | 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof |
| IT1196315B (it) | 1984-10-29 | 1988-11-16 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3822650A1 (de) * | 1988-07-05 | 1990-02-01 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| DE3917153A1 (de) * | 1989-05-26 | 1990-11-29 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4922007A (en) | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) * | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| CA2197267C (en) | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| PE20011065A1 (es) * | 2000-02-01 | 2001-11-21 | Procter & Gamble | Proceso para fabricar bisfosfonatos geminales |
| TR200101250A2 (tr) | 2001-05-10 | 2003-04-21 | E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. | 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses |
| GB0115824D0 (en) | 2001-06-28 | 2001-08-22 | Rhodia Cons Spec Ltd | Improved solvent systems |
| AU2003233569A1 (en) | 2002-05-17 | 2003-12-02 | Teva Pharmaceutical Industries Ltd. | Use of certain diluents for making bisphosphonic acids |
-
2004
- 2004-08-10 EP EP04816640A patent/EP1656386B1/en not_active Not-in-force
- 2004-08-10 AT AT04816640T patent/ATE451380T1/de not_active IP Right Cessation
- 2004-08-10 DE DE602004024545T patent/DE602004024545D1/de active Active
- 2004-08-10 CA CA2536229A patent/CA2536229C/en not_active Expired - Fee Related
- 2004-08-10 JP JP2006523750A patent/JP4642762B2/ja not_active Expired - Fee Related
- 2004-08-10 WO PCT/IN2004/000238 patent/WO2005044831A2/en active Application Filing
- 2004-08-10 DK DK04816640.9T patent/DK1656386T3/da active
- 2004-08-10 PT PT04816640T patent/PT1656386E/pt unknown
- 2004-08-10 PL PL04816640T patent/PL1656386T3/pl unknown
- 2004-08-10 US US10/569,308 patent/US7411087B2/en not_active Expired - Fee Related
- 2004-08-10 ES ES04816640T patent/ES2337063T3/es active Active
- 2004-08-10 SI SI200431349T patent/SI1656386T1/sl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1656386B1 (en) | 2009-12-09 |
| ES2337063T3 (es) | 2010-04-20 |
| PT1656386E (pt) | 2010-03-05 |
| ATE451380T1 (de) | 2009-12-15 |
| US7411087B2 (en) | 2008-08-12 |
| WO2005044831A3 (en) | 2005-07-28 |
| WO2005044831A2 (en) | 2005-05-19 |
| CA2536229C (en) | 2012-09-25 |
| JP4642762B2 (ja) | 2011-03-02 |
| US20060293524A1 (en) | 2006-12-28 |
| EP1656386A2 (en) | 2006-05-17 |
| DK1656386T3 (da) | 2010-04-19 |
| CA2536229A1 (en) | 2005-05-19 |
| JP2007502810A (ja) | 2007-02-15 |
| DE602004024545D1 (de) | 2010-01-21 |
| PL1656386T3 (pl) | 2010-05-31 |
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