EA200501188A1 - Промышленный способ получения 2-замещенных 1-(гидроксиэтилиден)-1,1-бисфосфоновых кислот и их солей высокой чистоты - Google Patents

Промышленный способ получения 2-замещенных 1-(гидроксиэтилиден)-1,1-бисфосфоновых кислот и их солей высокой чистоты

Info

Publication number
EA200501188A1
EA200501188A1 EA200501188A EA200501188A EA200501188A1 EA 200501188 A1 EA200501188 A1 EA 200501188A1 EA 200501188 A EA200501188 A EA 200501188A EA 200501188 A EA200501188 A EA 200501188A EA 200501188 A1 EA200501188 A1 EA 200501188A1
Authority
EA
Eurasian Patent Office
Prior art keywords
substituted
obtaining
bisphosphone
hydroxyethylidene
acids
Prior art date
Application number
EA200501188A
Other languages
English (en)
Other versions
EA007947B1 (ru
Inventor
Йожеф Неу
Янош Фишер
Тамаш Фодор
Йожеф Тёрли
Тибор Гизур
Шандор Левай
Адам Деметер
Ева Переньи
Original Assignee
Рихтер Гедеон Ведьесети Дьяр Рт.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Рихтер Гедеон Ведьесети Дьяр Рт. filed Critical Рихтер Гедеон Ведьесети Дьяр Рт.
Publication of EA200501188A1 publication Critical patent/EA200501188A1/ru
Publication of EA007947B1 publication Critical patent/EA007947B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Способ получения 2-замещенной-1-(гидроксиэтиледен)-1,1-бисфосфоновой кислоты формулы (I) высокой чистоты, ее солей и гидратов, где значение R представляет собой 3'-пиридильную или 2'-аминоэтилиденную группы, из соединений формулы (II), в которых значение R описано выше, или из ее солей и гидратов с фосфористой кислотой в присутствии метансульфоновой кислоты, используя пентоксид фосфора в качестве реактива и в данном случае полученную кислоту переводят в соль с помощью основания.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200501188A 2003-01-28 2004-01-27 Промышленный способ получения 2-замещенных 1-(гидроксиэтилиден)-1,1-бисфосфоновых кислот и их солей высокой чистоты EA007947B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0300227A HUP0300227A2 (hu) 2003-01-28 2003-01-28 Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
PCT/HU2004/000009 WO2004067541A1 (en) 2003-01-28 2004-01-27 Industrial process for the synthesis of 2-substituted 1-(hydroxy-ethylidene)-1,1-bisphosphonic acids of high purity and the salts thereof

Publications (2)

Publication Number Publication Date
EA200501188A1 true EA200501188A1 (ru) 2005-12-29
EA007947B1 EA007947B1 (ru) 2007-02-27

Family

ID=89981108

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501188A EA007947B1 (ru) 2003-01-28 2004-01-27 Промышленный способ получения 2-замещенных 1-(гидроксиэтилиден)-1,1-бисфосфоновых кислот и их солей высокой чистоты

Country Status (9)

Country Link
US (1) US7612229B2 (ru)
EP (1) EP1587814B1 (ru)
AT (1) ATE420885T1 (ru)
DE (1) DE602004019047D1 (ru)
EA (1) EA007947B1 (ru)
HU (1) HUP0300227A2 (ru)
PL (1) PL214441B1 (ru)
UA (1) UA80023C2 (ru)
WO (1) WO2004067541A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2485443C (en) * 2002-05-17 2010-04-06 Teva Pharmaceutical Industries Ltd Use of aromatic hydrocarbons and silicone fluids for making bisphosphonic acids
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
US20080194525A1 (en) * 2005-05-06 2008-08-14 Jordi Puig Serrano Process of Making Geminal Bisphosphonic Acids and Pharmaceutically Acceptable Salts and/or Hydrates Thereof
JP5354858B2 (ja) * 2006-05-09 2013-11-27 株式会社Ａｄｅｋａ スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物
WO2007132478A2 (en) 2006-05-11 2007-11-22 Ind-Swift Laboratories Limited Process for the preparation of pure risedronic acid or salts
WO2008152518A2 (en) * 2007-05-16 2008-12-18 Actavis Group Ptc Ehf Process for the preparation of risedronic acid or risedronate sodium
WO2009050731A2 (en) * 2007-06-20 2009-04-23 Alkem Laboratories Ltd Novel process for preparing risedronic acid
EP2483283B1 (en) * 2009-10-02 2015-01-07 Straitmark Holding AG Method for the manufacture of aminohydroxy diphosphonic acids
PL2665734T3 (pl) * 2011-01-21 2016-12-30 Sposób wytwarzania związków zawierających grupę alfa-oksyfosforową

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2702631A1 (de) 1977-01-22 1978-07-27 Henkel Kgaa Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
DE3428524A1 (de) * 1984-08-02 1986-02-13 Boehringer Mannheim Gmbh, 6800 Mannheim Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5159108A (en) * 1990-09-18 1992-10-27 Merck & Co., Inc. Process for preparing an antihypercalcemic agent
US5039819A (en) * 1990-09-18 1991-08-13 Merck & Co., Inc. Diphosphonate intermediate for preparing an antihypercalcemic agent
IT1246992B (it) 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
IT1244698B (it) * 1991-02-01 1994-08-08 Gentili Ist Spa Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale
CA2197267C (en) * 1997-02-11 2000-02-08 Yong Tao Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
US5908859A (en) * 1997-08-11 1999-06-01 Eli Lilly And Company Benzothiophenes for inhibiting hyperlipidemia
HUP0200342A3 (en) * 1999-02-17 2005-02-28 Teva Pharma Novel process for preparing alendronic acid
ES2153794B1 (es) * 1999-08-06 2001-10-16 Medichem Sa Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada.
US6410520B2 (en) * 2000-02-01 2002-06-25 The Procter & Gamble Company Selective crystallization of 3-pyridyl-1-hydroxyethylidene-1, 1-bisphosphonic acid sodium as the hemipentahydrate or monohydrate
TR200101250A2 (tr) * 2001-05-10 2003-04-21 E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses
PT1583768E (pt) * 2003-01-17 2008-09-11 Teva Pharma Processo de redução do teor de ferro em risedronato de sódio
HUP0300227A2 (hu) * 2003-01-28 2004-09-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására
PT1656386E (pt) * 2003-08-21 2010-03-05 Sun Pharmaceuticals Ind Ltd Processo para a preparação de compostos de ácido bifosfónico

Also Published As

Publication number Publication date
UA80023C2 (en) 2007-08-10
US7612229B2 (en) 2009-11-03
DE602004019047D1 (de) 2009-03-05
ATE420885T1 (de) 2009-01-15
EP1587814B1 (en) 2009-01-14
WO2004067541A1 (en) 2004-08-12
EP1587814A1 (en) 2005-10-26
PL214441B1 (pl) 2013-08-30
HU0300227D0 (en) 2003-03-28
HUP0300227A2 (hu) 2004-09-28
US20060122395A1 (en) 2006-06-08
EA007947B1 (ru) 2007-02-27
PL378438A1 (pl) 2006-04-03

Similar Documents

Publication Publication Date Title
DK1656386T3 (da) Fremgangsmåde til fremstilling af bisphosphonsyreforbindelser
ES8607969A1 (es) Un procedimiento para preparar un derivado de acido quinoli-no naftiridin- carboxilico
CY1107403T1 (el) Μια μεθοδος δια την παρασκευη υπερινδοπριλης,των αναλογων ενωσεων αυτης και των αλατων αυτων με χρησιμοποιηση ενδιαμεσων ενωσεων 2,5-διοξο-οξαζολιδινης
EA200300211A1 (ru) Азабициклические соединения, способ их получения и их применение в качестве лекарственных средств, в частности в качестве антибактериальных средств
ES8307749A1 (es) Un procedimiento para la preparacion de inhibidores biciclicos de tromboxano sintetasa
DE69106977D1 (de) Verfahren zur Herstellung von Nitrilen.
DE50001411D1 (de) Tris(oxalato)phosphate, verfahren zu deren herstellung und deren verwendung
EA200701470A1 (ru) Способы получения производных 4-(фенокси-5-метилпиримидин-4-илокси)пиперидин-1-карбоновой кислоты и родственных соединений
EA200501188A1 (ru) Промышленный способ получения 2-замещенных 1-(гидроксиэтилиден)-1,1-бисфосфоновых кислот и их солей высокой чистоты
NO20032731L (no) Fremgangsmåte for fremstilling av sulfonamid-substituerte imidazotriazinoner
EA200200807A1 (ru) Аминокислотные соединения и их применение в качестве ингибиторов nep, ace и ece
BR0309775A (pt) Halogenetos de ácido halossulfonilbenzóico, processo para a sua preparação e sua aplicação para a preparação de fenilsulfoniluréias substituìdas
DK1347965T3 (da) Hidtil ukendte desloratidinsalte, fremgangsmåde til syntese deraf samt farmaceutiske præparater deraf
ATE350501T1 (de) Verfahren zur trennung von dreiwertigem americium von dreiwertigem curium
EE200300090A (et) Asendatud imidasopüridiinühendite valmistamise meetod
DE602006005597D1 (de) Verbesserter Herstellungsprozess von 4-Amino-Hydroxybutyliden-1,1-bisphosphonischer Säure und ihrer Salze
DE602004030091D1 (de) Verfahren zur reduktiven deshalogenierung
ATE349545T1 (de) Enzymatisches verfahren zur herstellung von substituierter 2-amino-3-(2-amino-phenylsulfanyl)-propionsäure
ATE401884T1 (de) Arzneizusammensetzungen enthaltend oxapenem-3- carbonsäuren
ATE246693T1 (de) Verfahren zur sulfurierung von phosphor- enthaltenden verbindungen
AR029484A4 (es) Sistema de recaudacion dirigida de ingresos
BRPI0407971A (pt) processo para a preparação de um sal de adição de pelo menos um estabilizador de luz de amina impedida e pelo menos um composto ácido contendo fósforo
DK100788A (da) Fremgangsmaade til fremstilling af indanderivater
WO2002100804A3 (en) Novel use of sulfamic acids as resolving agent.
AR029324A1 (es) Procedimiento de preparacion de compuestos biciclicos y aplicacion de este procedimiento como etapa intermedia para la preparacion de un compuesto inhibidor de la enzima que convierte interleuquina 1-beta (ice)

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM