ATE420885T1 - Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)- 1,1-bisphosphonsäuren und deren salzen - Google Patents
Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)- 1,1-bisphosphonsäuren und deren salzenInfo
- Publication number
- ATE420885T1 ATE420885T1 AT04705466T AT04705466T ATE420885T1 AT E420885 T1 ATE420885 T1 AT E420885T1 AT 04705466 T AT04705466 T AT 04705466T AT 04705466 T AT04705466 T AT 04705466T AT E420885 T1 ATE420885 T1 AT E420885T1
- Authority
- AT
- Austria
- Prior art keywords
- salts
- synthesis
- substituted
- hydroxyethylidene
- technical process
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 4
- 239000002253 acid Substances 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000007513 acids Chemical class 0.000 title 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 abstract 1
- 229940098779 methanesulfonic acid Drugs 0.000 abstract 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 abstract 1
- ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3839—Polyphosphonic acids
- C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/58—Pyridine rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU0300227A HUP0300227A2 (hu) | 2003-01-28 | 2003-01-28 | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE420885T1 true ATE420885T1 (de) | 2009-01-15 |
Family
ID=89981108
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04705466T ATE420885T1 (de) | 2003-01-28 | 2004-01-27 | Grosstechnisches verfahren zur synthese von hochreinen 2-substituierten 1-(hydroxyethyliden)- 1,1-bisphosphonsäuren und deren salzen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7612229B2 (de) |
| EP (1) | EP1587814B1 (de) |
| AT (1) | ATE420885T1 (de) |
| DE (1) | DE602004019047D1 (de) |
| EA (1) | EA007947B1 (de) |
| HU (1) | HUP0300227A2 (de) |
| PL (1) | PL214441B1 (de) |
| UA (1) | UA80023C2 (de) |
| WO (1) | WO2004067541A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100681282B1 (ko) * | 2002-05-17 | 2007-02-12 | 테바 파마슈티컬 인더스트리즈 리미티드 | 특정 희석제를 사용하는 비스포스폰산 및 그 염의 제조방법 |
| HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
| EP1883644A2 (de) * | 2005-05-06 | 2008-02-06 | Medichem, S.A. | Process of making geminal bisphosphonic acids and pharmaceutically acceptable salts and/or hydrates thereof |
| JP5354858B2 (ja) * | 2006-05-09 | 2013-11-27 | 株式会社Ａｄｅｋａ | スルホンアミド化合物の金属塩を含有するポリエステル樹脂組成物 |
| EP2016084A2 (de) | 2006-05-11 | 2009-01-21 | Ind-Swift Laboratories Limited | Verfahren zur herstellung von reiner risedronsäure oder -salzen |
| WO2008152518A2 (en) * | 2007-05-16 | 2008-12-18 | Actavis Group Ptc Ehf | Process for the preparation of risedronic acid or risedronate sodium |
| WO2009050731A2 (en) * | 2007-06-20 | 2009-04-23 | Alkem Laboratories Ltd | Novel process for preparing risedronic acid |
| CN102639545B (zh) * | 2009-10-02 | 2016-08-03 | 施里特马克控股公司 | 制备氨基羟基二膦酸的方法 |
| WO2012098255A1 (en) * | 2011-01-21 | 2012-07-26 | Straitmark Holding Ag | METHOD FOR THE MANUFACTURE OF COMPOUNDS CONTAINING AN α-OXY PHOSPHORUS GROUP |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2702631A1 (de) | 1977-01-22 | 1978-07-27 | Henkel Kgaa | Verfahren zur herstellung von 1-hydroxy-3-amino-propan-1,1-diphosphonsaeuren |
| DE3016289A1 (de) | 1980-04-28 | 1981-10-29 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren |
| DE3428524A1 (de) | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| US4990503A (en) | 1988-08-12 | 1991-02-05 | Yamanouchi Pharmaceutical Co., Ltd. | Heterocyclic bisphosphonic acid derivatives |
| US4922007A (en) | 1989-06-09 | 1990-05-01 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5019651A (en) | 1990-06-20 | 1991-05-28 | Merck & Co., Inc. | Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof |
| US5159108A (en) * | 1990-09-18 | 1992-10-27 | Merck & Co., Inc. | Process for preparing an antihypercalcemic agent |
| US5039819A (en) * | 1990-09-18 | 1991-08-13 | Merck & Co., Inc. | Diphosphonate intermediate for preparing an antihypercalcemic agent |
| IT1246992B (it) | 1991-01-08 | 1994-12-12 | Gentili Ist Spa | Procedimento per la preparazione di acidi difosfonici e loro sali |
| IT1244698B (it) * | 1991-02-01 | 1994-08-08 | Gentili Ist Spa | Acidi aril-o arilalchil-acil ammino-alchil-idrossidifosfonici, procedimento per la loro preparazione e loro uso in terapia osteo-articolare e dei tessuti connettori in generale |
| CA2197267C (en) * | 1997-02-11 | 2000-02-08 | Yong Tao | Process for the production of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof |
| US5908859A (en) | 1997-08-11 | 1999-06-01 | Eli Lilly And Company | Benzothiophenes for inhibiting hyperlipidemia |
| BR0010112A (pt) * | 1999-02-17 | 2001-12-26 | Teva Pharma | Processo para preparação de ácido alendrÈnico |
| ES2153794B1 (es) | 1999-08-06 | 2001-10-16 | Medichem Sa | Procedimiento para la obtencion del acido 4-amino-1-hidroxibutiliden-1,1-bisfosfonico y de su sal monosodica trihidratada. |
| PE20011061A1 (es) * | 2000-02-01 | 2001-11-20 | Procter & Gamble | Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato |
| TR200101250A2 (tr) * | 2001-05-10 | 2003-04-21 | E�S Eczaciba�I �Zg�N K�Myasal �R�Nler Sanay� A.�. | 4-amino-1-hidroksibutiliden-1,1-bifosfonik asit veya tuzlarının hazırlanmasına ilişkin proses |
| WO2004065397A1 (en) * | 2003-01-17 | 2004-08-05 | Teva Pharmaceutical Industries Ltd. | Risedronate sodium having a very low content of iron |
| HUP0300227A2 (hu) * | 2003-01-28 | 2004-09-28 | Richter Gedeon Vegyészeti Gyár Rt. | Eljárás nagy tisztaságú 2-szubsztituált -1-(hidroxi-etilidén)-1,1-biszfoszfonsavak és sóik előállítására |
| ATE451380T1 (de) * | 2003-08-21 | 2009-12-15 | Sun Pharmaceuticals Ind Ltd | Verfahren zur herstellung von bisphosphonsäureverbindungen |
-
2003
- 2003-01-28 HU HU0300227A patent/HUP0300227A2/hu unknown
-
2004
- 2004-01-27 WO PCT/HU2004/000009 patent/WO2004067541A1/en active Application Filing
- 2004-01-27 AT AT04705466T patent/ATE420885T1/de not_active IP Right Cessation
- 2004-01-27 UA UAA200508269A patent/UA80023C2/uk unknown
- 2004-01-27 EP EP04705466A patent/EP1587814B1/de not_active Expired - Lifetime
- 2004-01-27 EA EA200501188A patent/EA007947B1/ru not_active IP Right Cessation
- 2004-01-27 DE DE602004019047T patent/DE602004019047D1/de not_active Expired - Lifetime
- 2004-01-27 PL PL378438A patent/PL214441B1/pl unknown
- 2004-01-27 US US10/541,866 patent/US7612229B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US7612229B2 (en) | 2009-11-03 |
| HUP0300227A2 (hu) | 2004-09-28 |
| US20060122395A1 (en) | 2006-06-08 |
| EA200501188A1 (ru) | 2005-12-29 |
| EA007947B1 (ru) | 2007-02-27 |
| EP1587814A1 (de) | 2005-10-26 |
| EP1587814B1 (de) | 2009-01-14 |
| UA80023C2 (en) | 2007-08-10 |
| PL214441B1 (pl) | 2013-08-30 |
| DE602004019047D1 (de) | 2009-03-05 |
| PL378438A1 (pl) | 2006-04-03 |
| HU0300227D0 (en) | 2003-03-28 |
| WO2004067541A1 (en) | 2004-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |