DE69808093D1 - Verfahren zur herstellung von 2-substituierten 1-(tetrazol-5-yl)benzenverbindungen durch ortho-metallierung - Google Patents

Verfahren zur herstellung von 2-substituierten 1-(tetrazol-5-yl)benzenverbindungen durch ortho-metallierung

Info

Publication number
DE69808093D1
DE69808093D1 DE69808093T DE69808093T DE69808093D1 DE 69808093 D1 DE69808093 D1 DE 69808093D1 DE 69808093 T DE69808093 T DE 69808093T DE 69808093 T DE69808093 T DE 69808093T DE 69808093 D1 DE69808093 D1 DE 69808093D1
Authority
DE
Germany
Prior art keywords
metalization
benzenes
tetrazol
ortho
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69808093T
Other languages
English (en)
Other versions
DE69808093T2 (de
Inventor
Marco Villa
Pietro Allegrini
Katiuscia Arrighi
Maurizio Paiocchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zach System SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Publication of DE69808093D1 publication Critical patent/DE69808093D1/de
Application granted granted Critical
Publication of DE69808093T2 publication Critical patent/DE69808093T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F3/00—Compounds containing elements of Groups 2 or 12 of the Periodic Table
    • C07F3/02—Magnesium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69808093T 1997-06-30 1998-06-29 Verfahren zur herstellung von 2-substituierten 1-(tetrazol-5-yl)benzenverbindungen durch ortho-metallierung Expired - Lifetime DE69808093T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT97MI001544A IT1292437B1 (it) 1997-06-30 1997-06-30 Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
PCT/EP1998/003969 WO1999001459A1 (en) 1997-06-30 1998-06-29 Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes

Publications (2)

Publication Number Publication Date
DE69808093D1 true DE69808093D1 (de) 2002-10-24
DE69808093T2 DE69808093T2 (de) 2003-06-05

Family

ID=11377464

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69808093T Expired - Lifetime DE69808093T2 (de) 1997-06-30 1998-06-29 Verfahren zur herstellung von 2-substituierten 1-(tetrazol-5-yl)benzenverbindungen durch ortho-metallierung

Country Status (12)

Country Link
US (1) US6271375B1 (de)
EP (1) EP0994881B1 (de)
JP (1) JP4128633B2 (de)
AT (1) ATE224395T1 (de)
CA (1) CA2294609C (de)
CZ (1) CZ293277B6 (de)
DE (1) DE69808093T2 (de)
ES (1) ES2182349T3 (de)
HU (1) HU226471B1 (de)
IL (1) IL133249A (de)
IT (1) IT1292437B1 (de)
WO (1) WO1999001459A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU226948B1 (en) * 1999-04-28 2010-03-29 Takeda Pharmaceutical Use of angiotensin ii antagonist for prevention or therapy of progression of simplex retinopathy or preproliferating retinopathy
CA2769703A1 (en) 2002-07-26 2004-02-19 Amo Groningen B.V. Method and device for manipulation of an intraocular lens
EP2039693A3 (de) * 2003-01-16 2009-06-17 Teva Pharmaceutical Industries Limited Neuartige Synthese von Irbesartan
US7199144B2 (en) 2003-04-21 2007-04-03 Teva Pharmaceuticals Industries, Ltd. Process for the preparation of valsartan and intermediates thereof
EP1511739B1 (de) * 2003-03-17 2008-04-30 Teva Pharmaceutical Industries Ltd. Polymorphe formen von valsartan
EP1950204A1 (de) 2003-03-17 2008-07-30 Teva Pharmaceutical Industries Ltd. Amorphe Form von Valsartan
EP1618097A1 (de) * 2003-04-21 2006-01-25 Teva Pharmaceutical Industries Ltd Verfahren zur herstellung von valsartan
EP1556363A2 (de) * 2003-04-21 2005-07-27 Teva Pharmaceutical Industries Limited Verfahren zur herstellung von valsartan und zwischenprodukte davon
EP1660463B1 (de) * 2003-08-08 2007-12-05 Dipharma Francis S.r.l. Verfahren zur herstellung von phenyltetrazolderivaten
WO2005049587A1 (en) * 2003-11-21 2005-06-02 Ranbaxy Laboratories Limited Process for preparation of biphenyl tetrazole
EP1750862B1 (de) 2004-06-04 2011-01-05 Teva Pharmaceutical Industries Ltd. Irbesartan enthaltende pharmazeutische zusammensetzung
WO2006067216A2 (en) * 2004-12-22 2006-06-29 Enantia, S. L. Intermediate compounds for the preparation of an angiotensin ii receptor and process for the preparation of valsartan
DE602005007384D1 (de) * 2004-12-22 2008-07-17 Algry Quimica S L Zwischenprodukte für die herstellung von antagonisten des angiotensin-ii-rezeptors
WO2007005967A2 (en) * 2005-07-05 2007-01-11 Teva Pharmaceutical Industries Ltd. Process for preparing valsartan
EP2043607A2 (de) * 2006-06-23 2009-04-08 Usv Limited Verfahren zur herstellung von mikronisiertem valsartan
EP2090567A3 (de) 2008-02-13 2011-06-01 Ranbaxy Laboratories Limited Verfahren zur Herstellung von Zwischenprodukten von Valsartan
EP2260018A2 (de) * 2008-04-07 2010-12-15 Hetero Research Foundation Verfahren zur herstellung eines valsartan-zwischenprodukts
WO2012056294A1 (en) 2010-10-29 2012-05-03 Jubilant Life Sciences Ltd. An improved process for the preparation of n-pentanoyl-n-[[2'-(1h-tetrazol-5-yi)[1,1'-biphenyl]-4-yi]methyl]-l-valine
WO2018002673A1 (en) 2016-07-01 2018-01-04 N4 Pharma Uk Limited Novel formulations of angiotensin ii receptor antagonists

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes
TW226375B (de) * 1991-10-24 1994-07-11 American Home Prod
US5256654A (en) 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US5149699A (en) 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
EP0550313A1 (de) 1991-12-30 1993-07-07 Synthelabo 2-(Tetranol-5-yl)-(1,1'-Biphenyl)derivate, ihre Herstellung und Anwendung als Zwischenverbindungen
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
FR2696746B1 (fr) * 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
HUP9900871A3 (en) * 1995-06-07 2000-07-28 Wyeth Corp Process for preparation of biphenyl derivatives
US5760220A (en) 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives

Also Published As

Publication number Publication date
ITMI971544A1 (it) 1998-12-30
IL133249A0 (en) 2001-04-30
IT1292437B1 (it) 1999-02-08
EP0994881B1 (de) 2002-09-18
ATE224395T1 (de) 2002-10-15
HUP0004227A3 (en) 2003-03-28
ITMI971544A0 (de) 1997-06-30
CZ477499A3 (cs) 2000-07-12
JP2002510314A (ja) 2002-04-02
US6271375B1 (en) 2001-08-07
WO1999001459A1 (en) 1999-01-14
CA2294609C (en) 2008-08-19
EP0994881A1 (de) 2000-04-26
CA2294609A1 (en) 1999-01-14
ES2182349T3 (es) 2003-03-01
JP4128633B2 (ja) 2008-07-30
CZ293277B6 (cs) 2004-03-17
DE69808093T2 (de) 2003-06-05
IL133249A (en) 2003-12-10
HU226471B1 (en) 2008-12-29
HUP0004227A2 (hu) 2001-06-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ZACH SYSTEM S.P.A., BRESSO, (MILANO), IT