ES2095907T3 - Un procedimiento de orto-litiacion para la sintesis de 1-(tetrazol-5-il)bencenos 2-sustituidos. - Google Patents

Un procedimiento de orto-litiacion para la sintesis de 1-(tetrazol-5-il)bencenos 2-sustituidos.

Info

Publication number
ES2095907T3
ES2095907T3 ES91303757T ES91303757T ES2095907T3 ES 2095907 T3 ES2095907 T3 ES 2095907T3 ES 91303757 T ES91303757 T ES 91303757T ES 91303757 T ES91303757 T ES 91303757T ES 2095907 T3 ES2095907 T3 ES 2095907T3
Authority
ES
Spain
Prior art keywords
benzene
synthesis
substituted
tetrazole
ortho
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91303757T
Other languages
English (en)
Inventor
Richard F Shuman
Anthony O King
Robert K Anderson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24061644&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2095907(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2095907T3 publication Critical patent/ES2095907T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)

Abstract

UN PROCESO UTILIZA EL GRUPO TETRAZOLO FUNCIONAL PARA DIRIGIR LA LITIACION A LA ORTO-POSICION DE UN FENILTETRAZOL Y GENERAR UNA ESPECIE DE ARILLITIO NUCLEOFITICO QUE LUEGO SE SOMETE A REACCION CON UN ELECTROFILO PARA GENERAR UN 1-(TETRAZOL-5-ILO) BENCENO 2-SUSTITUIDO. EL PROCESO ES UTIL PARA LA PRODUCCION DE INTERMEDIOS EN LA SINTESIS DE ANTAGONISTAS DE ANGIOTENSINA 11. ESTE NUEVO PROCESO ES UN CAMINO MAS EFECTIVO EN EL COSTE Y VERSATIL PARA LA PREPARACION A GRAN ESCALA DE ESTOS INTERMEDIARIOS CLAVE.
ES91303757T 1990-05-02 1991-04-25 Un procedimiento de orto-litiacion para la sintesis de 1-(tetrazol-5-il)bencenos 2-sustituidos. Expired - Lifetime ES2095907T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/517,889 US5039814A (en) 1990-05-02 1990-05-02 Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes

Publications (1)

Publication Number Publication Date
ES2095907T3 true ES2095907T3 (es) 1997-03-01

Family

ID=24061644

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91303757T Expired - Lifetime ES2095907T3 (es) 1990-05-02 1991-04-25 Un procedimiento de orto-litiacion para la sintesis de 1-(tetrazol-5-il)bencenos 2-sustituidos.

Country Status (15)

Country Link
US (1) US5039814A (es)
EP (1) EP0455423B1 (es)
JP (1) JPH0717619B2 (es)
AT (1) ATE146461T1 (es)
CA (1) CA2041620C (es)
CY (1) CY1998A (es)
DE (1) DE69123632T2 (es)
DK (1) DK0455423T3 (es)
ES (1) ES2095907T3 (es)
GR (1) GR3022107T3 (es)
HK (1) HK59497A (es)
IE (1) IE911455A1 (es)
LV (1) LV11893B (es)
PT (1) PT97528B (es)
RO (1) RO110339B1 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5256654A (en) * 1991-10-24 1993-10-26 American Home Products Corporation Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US5283242A (en) * 1991-10-24 1994-02-01 American Home Products Corporation Substituted benzimidazoles and quinazolines as antihypertensives
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists
US5252753A (en) * 1991-11-01 1993-10-12 Ortho Pharmaceutical Corporation Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof
ATE395341T1 (de) * 1991-11-18 2008-05-15 Du Pont 2-(2'-triphenylmethyl-2'h-tetrazol-5'- yl)phenylborsäure als zwischenprodukt zur synthese von a ii receptorenantagonisten
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
EP0550313A1 (fr) * 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
FR2688503B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle].
FR2696745B1 (fr) * 1992-10-12 1995-05-12 Synthelabo Procédé de préparation de dérivés de phényltétrazole.
FR2696746B1 (fr) * 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
CA2111662C (en) * 1992-12-17 2004-11-23 Hiroaki Yanagisawa Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease
US5567815A (en) * 1994-07-18 1996-10-22 Bridgestone Corporation Teritary amine containing antonic initiators used in preparing polymers and process for the preparation thereof
DE69507887T2 (de) * 1994-09-20 1999-06-17 Wakunaga Seiyaku K.K., Osaka Verfahren zur herstellung von n-biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
KR100354802B1 (ko) * 1994-10-20 2002-12-26 한국화학연구원 테트라졸유도체의제조방법
US5760220A (en) * 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
WO1996040684A1 (en) * 1995-06-07 1996-12-19 American Home Products Corporation Process for preparation of biphenyl derivatives
IT1292437B1 (it) 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
ES2264641B1 (es) * 2005-06-17 2008-03-01 Quimica Sintetica, S.A. Procedimiento para la obtencion de derivados de bencimidazol y sus intermedios.
WO2008058402A1 (en) 2006-11-17 2008-05-22 Queen's University At Kingston Compounds and methods for treating protein folding disorders
EP2252570B1 (en) 2007-12-17 2017-04-05 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin ®
EP2576492B1 (en) 2010-06-03 2017-09-20 United Therapeutics Corporation Treprostinil production
EP2681204B1 (en) 2011-03-02 2016-04-27 United Therapeutics Corporation Synthesis of intermediate for treprostinil production
EP3209415B1 (en) 2014-10-20 2020-02-19 United Therapeutics Corporation Synthesis of intermediates for producing prostacyclin derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3534113A (en) * 1968-02-08 1970-10-13 Lithium Corp Preparation of aryllithium compounds by metalation
CH530980A (de) * 1969-03-05 1972-11-30 Sandoz Ag Verfahren zur Herstellung von Imidazo(2,1-a)isoindolen
US4620025A (en) * 1984-08-01 1986-10-28 Merck & Co., Inc. Process for the preparation of biphenyl intermediates
US4870186A (en) * 1987-05-22 1989-09-26 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids

Also Published As

Publication number Publication date
JPH04225966A (ja) 1992-08-14
ATE146461T1 (de) 1997-01-15
US5039814A (en) 1991-08-13
PT97528A (pt) 1992-01-31
LV11893A (en) 1997-12-20
EP0455423A3 (en) 1992-12-09
LV11893B (en) 1998-03-20
DK0455423T3 (da) 1997-06-09
CA2041620A1 (en) 1991-11-03
GR3022107T3 (en) 1997-03-31
EP0455423A2 (en) 1991-11-06
JPH0717619B2 (ja) 1995-03-01
DE69123632T2 (de) 1997-05-15
HK59497A (en) 1997-05-16
DE69123632D1 (de) 1997-01-30
PT97528B (pt) 1998-08-31
IE911455A1 (en) 1991-11-06
EP0455423B1 (en) 1996-12-18
CA2041620C (en) 2003-03-11
CY1998A (en) 1997-12-05
RO110339B1 (ro) 1995-12-29

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