ES2095907T3 - Un procedimiento de orto-litiacion para la sintesis de 1-(tetrazol-5-il)bencenos 2-sustituidos. - Google Patents
Un procedimiento de orto-litiacion para la sintesis de 1-(tetrazol-5-il)bencenos 2-sustituidos.Info
- Publication number
- ES2095907T3 ES2095907T3 ES91303757T ES91303757T ES2095907T3 ES 2095907 T3 ES2095907 T3 ES 2095907T3 ES 91303757 T ES91303757 T ES 91303757T ES 91303757 T ES91303757 T ES 91303757T ES 2095907 T3 ES2095907 T3 ES 2095907T3
- Authority
- ES
- Spain
- Prior art keywords
- benzene
- synthesis
- substituted
- tetrazole
- ortho
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Photoreceptors In Electrophotography (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Abstract
UN PROCESO UTILIZA EL GRUPO TETRAZOLO FUNCIONAL PARA DIRIGIR LA LITIACION A LA ORTO-POSICION DE UN FENILTETRAZOL Y GENERAR UNA ESPECIE DE ARILLITIO NUCLEOFITICO QUE LUEGO SE SOMETE A REACCION CON UN ELECTROFILO PARA GENERAR UN 1-(TETRAZOL-5-ILO) BENCENO 2-SUSTITUIDO. EL PROCESO ES UTIL PARA LA PRODUCCION DE INTERMEDIOS EN LA SINTESIS DE ANTAGONISTAS DE ANGIOTENSINA 11. ESTE NUEVO PROCESO ES UN CAMINO MAS EFECTIVO EN EL COSTE Y VERSATIL PARA LA PREPARACION A GRAN ESCALA DE ESTOS INTERMEDIARIOS CLAVE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/517,889 US5039814A (en) | 1990-05-02 | 1990-05-02 | Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2095907T3 true ES2095907T3 (es) | 1997-03-01 |
Family
ID=24061644
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91303757T Expired - Lifetime ES2095907T3 (es) | 1990-05-02 | 1991-04-25 | Un procedimiento de orto-litiacion para la sintesis de 1-(tetrazol-5-il)bencenos 2-sustituidos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US5039814A (es) |
EP (1) | EP0455423B1 (es) |
JP (1) | JPH0717619B2 (es) |
AT (1) | ATE146461T1 (es) |
CA (1) | CA2041620C (es) |
CY (1) | CY1998A (es) |
DE (1) | DE69123632T2 (es) |
DK (1) | DK0455423T3 (es) |
ES (1) | ES2095907T3 (es) |
GR (1) | GR3022107T3 (es) |
HK (1) | HK59497A (es) |
IE (1) | IE911455A1 (es) |
LV (1) | LV11893B (es) |
PT (1) | PT97528B (es) |
RO (1) | RO110339B1 (es) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
US5283242A (en) * | 1991-10-24 | 1994-02-01 | American Home Products Corporation | Substituted benzimidazoles and quinazolines as antihypertensives |
US5149699A (en) * | 1991-10-24 | 1992-09-22 | American Home Products Corporation | Substituted pyridopyrimidines useful as antgiotensin II antagonists |
US5256654A (en) * | 1991-10-24 | 1993-10-26 | American Home Products Corporation | Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists |
US5252753A (en) * | 1991-11-01 | 1993-10-12 | Ortho Pharmaceutical Corporation | Process for the preparation of certain substituted biphenyl tetrazoles and compounds thereof |
ES2203614T3 (es) * | 1991-11-18 | 2004-04-16 | E.I. Du Pont De Nemours And Company | Intermedios de acido tetrazolilfenilboronico para la sintesis de antagonistas de los receptores de aii. |
US5206374A (en) * | 1991-11-18 | 1993-04-27 | E. I. Du Pont De Nemours And Company | Process for preparing tetrazolylphenylboronic acid intermediates |
EP0550313A1 (fr) * | 1991-12-30 | 1993-07-07 | Synthelabo | Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse |
FR2688503B1 (fr) * | 1992-03-16 | 1994-05-06 | Synthelabo | Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle]. |
FR2696745B1 (fr) * | 1992-10-12 | 1995-05-12 | Synthelabo | Procédé de préparation de dérivés de phényltétrazole. |
FR2696746B1 (fr) * | 1992-10-12 | 1994-11-18 | Synthelabo | Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse. |
CA2111662C (en) * | 1992-12-17 | 2004-11-23 | Hiroaki Yanagisawa | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease |
US5567815A (en) * | 1994-07-18 | 1996-10-22 | Bridgestone Corporation | Teritary amine containing antonic initiators used in preparing polymers and process for the preparation thereof |
WO1996009301A1 (fr) * | 1994-09-20 | 1996-03-28 | Wakunaga Seiyaku Kabushiki Kaisha | Procede de production d'un derive de n-biphenylmethylthiadiazoline ou un sel de celui-ci et son intermediaire de production |
KR100354802B1 (ko) * | 1994-10-20 | 2002-12-26 | 한국화학연구원 | 테트라졸유도체의제조방법 |
JPH11507625A (ja) * | 1995-06-07 | 1999-07-06 | アメリカン・ホーム・プロダクツ・コーポレイション | ビフェニル誘導体の製造方法 |
US5760220A (en) * | 1995-06-07 | 1998-06-02 | American Home Products Corporation | Process for preparation of biphenyl derivatives |
IT1292437B1 (it) * | 1997-06-30 | 1999-02-08 | Zambon Spa | Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti |
ES2264641B1 (es) * | 2005-06-17 | 2008-03-01 | Quimica Sintetica, S.A. | Procedimiento para la obtencion de derivados de bencimidazol y sus intermedios. |
WO2008058402A1 (en) | 2006-11-17 | 2008-05-22 | Queen's University At Kingston | Compounds and methods for treating protein folding disorders |
EP2252570B1 (en) | 2007-12-17 | 2017-04-05 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin ® |
CN103261142B (zh) | 2010-06-03 | 2014-12-10 | 联合治疗公司 | 曲前列环素的制备 |
JP5580491B2 (ja) | 2011-03-02 | 2014-08-27 | ユナイテッド セラピューティクス コーポレイション | トレプロスチニル製造のための中間体の合成 |
EP3209415B1 (en) | 2014-10-20 | 2020-02-19 | United Therapeutics Corporation | Synthesis of intermediates for producing prostacyclin derivatives |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3534113A (en) * | 1968-02-08 | 1970-10-13 | Lithium Corp | Preparation of aryllithium compounds by metalation |
CH530980A (de) * | 1969-03-05 | 1972-11-30 | Sandoz Ag | Verfahren zur Herstellung von Imidazo(2,1-a)isoindolen |
US4620025A (en) * | 1984-08-01 | 1986-10-28 | Merck & Co., Inc. | Process for the preparation of biphenyl intermediates |
US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
US4870186A (en) * | 1987-05-22 | 1989-09-26 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
-
1990
- 1990-05-02 US US07/517,889 patent/US5039814A/en not_active Expired - Lifetime
-
1991
- 1991-04-25 DK DK91303757.8T patent/DK0455423T3/da active
- 1991-04-25 EP EP91303757A patent/EP0455423B1/en not_active Expired - Lifetime
- 1991-04-25 AT AT91303757T patent/ATE146461T1/de not_active IP Right Cessation
- 1991-04-25 DE DE69123632T patent/DE69123632T2/de not_active Expired - Lifetime
- 1991-04-25 ES ES91303757T patent/ES2095907T3/es not_active Expired - Lifetime
- 1991-04-30 PT PT97528A patent/PT97528B/pt not_active IP Right Cessation
- 1991-04-30 IE IE145591A patent/IE911455A1/en unknown
- 1991-05-01 CA CA002041620A patent/CA2041620C/en not_active Expired - Lifetime
- 1991-05-02 JP JP3100245A patent/JPH0717619B2/ja not_active Expired - Lifetime
-
1992
- 1992-10-27 RO RO92-01355A patent/RO110339B1/ro unknown
-
1996
- 1996-12-19 GR GR960403182T patent/GR3022107T3/el unknown
-
1997
- 1997-05-08 HK HK59497A patent/HK59497A/xx not_active IP Right Cessation
- 1997-09-05 LV LVP-97-162A patent/LV11893B/en unknown
- 1997-12-05 CY CY199897A patent/CY1998A/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CY1998A (en) | 1997-12-05 |
EP0455423A3 (en) | 1992-12-09 |
DE69123632D1 (de) | 1997-01-30 |
PT97528A (pt) | 1992-01-31 |
LV11893A (en) | 1997-12-20 |
JPH0717619B2 (ja) | 1995-03-01 |
HK59497A (en) | 1997-05-16 |
DE69123632T2 (de) | 1997-05-15 |
DK0455423T3 (da) | 1997-06-09 |
PT97528B (pt) | 1998-08-31 |
RO110339B1 (ro) | 1995-12-29 |
ATE146461T1 (de) | 1997-01-15 |
EP0455423A2 (en) | 1991-11-06 |
CA2041620C (en) | 2003-03-11 |
EP0455423B1 (en) | 1996-12-18 |
US5039814A (en) | 1991-08-13 |
CA2041620A1 (en) | 1991-11-03 |
JPH04225966A (ja) | 1992-08-14 |
LV11893B (en) | 1998-03-20 |
IE911455A1 (en) | 1991-11-06 |
GR3022107T3 (en) | 1997-03-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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