DE69106977D1 - Verfahren zur Herstellung von Nitrilen. - Google Patents

Verfahren zur Herstellung von Nitrilen.

Info

Publication number
DE69106977D1
DE69106977D1 DE69106977T DE69106977T DE69106977D1 DE 69106977 D1 DE69106977 D1 DE 69106977D1 DE 69106977 T DE69106977 T DE 69106977T DE 69106977 T DE69106977 T DE 69106977T DE 69106977 D1 DE69106977 D1 DE 69106977D1
Authority
DE
Germany
Prior art keywords
novel
production
certain
defined hereinafter
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69106977T
Other languages
English (en)
Other versions
DE69106977T2 (de
DE69106977T3 (de
Inventor
David Anthony Roberts
Simon Thomas Russell
John David Pittam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avecia Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10680408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69106977(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of DE69106977D1 publication Critical patent/DE69106977D1/de
Publication of DE69106977T2 publication Critical patent/DE69106977T2/de
Application granted granted Critical
Publication of DE69106977T3 publication Critical patent/DE69106977T3/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
  • Turning (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Air Bags (AREA)
  • Electrotherapy Devices (AREA)
DE69106977T 1990-08-09 1991-08-05 Verfahren zur Herstellung von Nitrilen. Expired - Fee Related DE69106977T3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909017482A GB9017482D0 (en) 1990-08-09 1990-08-09 Manufacturing process

Publications (3)

Publication Number Publication Date
DE69106977D1 true DE69106977D1 (de) 1995-03-09
DE69106977T2 DE69106977T2 (de) 1995-05-24
DE69106977T3 DE69106977T3 (de) 2001-07-19

Family

ID=10680408

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69106977T Expired - Fee Related DE69106977T3 (de) 1990-08-09 1991-08-05 Verfahren zur Herstellung von Nitrilen.

Country Status (23)

Country Link
EP (1) EP0470795B2 (de)
JP (1) JP3001298B2 (de)
KR (1) KR920004337A (de)
CN (1) CN1059516A (de)
AT (1) ATE117672T1 (de)
AU (1) AU646473B2 (de)
CA (1) CA2047369A1 (de)
CS (1) CS241391A3 (de)
DE (1) DE69106977T3 (de)
ES (1) ES2067159T3 (de)
FI (1) FI913640A7 (de)
GB (2) GB9017482D0 (de)
HU (1) HU207841B (de)
IL (1) IL98862A0 (de)
NO (1) NO174502B (de)
NZ (1) NZ239026A (de)
PL (1) PL291370A1 (de)
PT (1) PT98608A (de)
RU (1) RU2026285C1 (de)
TW (1) TW198710B (de)
YU (1) YU137891A (de)
ZA (1) ZA915566B (de)
ZW (1) ZW9591A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69016125T2 (de) * 1989-08-11 1995-06-01 Zeneca Ltd Chinolin-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
FR2688507B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Derives de l'acide tetrazolylbenzeneboronique, leur preparation et leur utilisation comme intermediaires de synthese.
FR2689887B1 (fr) * 1992-04-13 1995-06-23 Sanofi Elf Procede de preparation d'un derive de biphenyle.
FR2696746B1 (fr) * 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
DE4423061C1 (de) * 1994-07-01 1996-01-18 Hoechst Ag Verfahren zur Herstellung von Biphenylen mit Palladacyclen als Katalysatoren
DE4426671A1 (de) * 1994-07-28 1996-02-01 Hoechst Ag Verfahren zur Kreuzkupplung von aromatischen Borverbindungen mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten
KR100354802B1 (ko) * 1994-10-20 2002-12-26 한국화학연구원 테트라졸유도체의제조방법
JP2928982B2 (ja) 1994-10-27 1999-08-03 住化ファインケム株式会社 ４’−ブロモメチル−２−シアノビフェニルの製造法
DE19620023C2 (de) * 1996-05-17 2001-03-08 Celanese Chem Europe Gmbh Verfahren zur Herstellung von Phosphinat- oder Phosphonatgruppen enthaltenden tertiären Phosphanen und neue Phosphinatgruppen enthaltende tertiäre Phosphane
US6194599B1 (en) 1997-04-08 2001-02-27 Catalytica, Inc. Process for preparing biaryl compounds
US5922898A (en) * 1997-04-08 1999-07-13 Catalytica Pharmaceuticals, Inc. Process for preparing biaryl compounds
CA2321791A1 (en) 1998-03-18 1999-09-23 Ciba Specialty Chemicals Holding Inc. Coupling reactions with palladium catalysts
US6962999B2 (en) 2001-07-25 2005-11-08 Pharmacore, Inc. Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
DE10211597A1 (de) 2002-03-15 2003-10-02 Merck Patent Gmbh Verfahren zur Herstellung von Ringverbindungen
DE60304175T2 (de) 2002-04-29 2007-03-15 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung von losartan und losartan-kaliumsalz
ES2299616T3 (es) 2002-06-12 2008-06-01 Sumitomo Chemical Company, Limited Procedimiento para producir 4'-bromometil-2-cianobifelino.
US7105467B2 (en) 2003-07-08 2006-09-12 Pharmacore, Inc. Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives
US7105707B2 (en) 2003-12-17 2006-09-12 Pharmacore, Inc. Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
JP2006151946A (ja) * 2004-04-30 2006-06-15 Konishi Kagaku Ind Co Ltd ジアリール誘導体の製造方法
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX2009013293A (es) 2007-06-04 2010-02-15 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos.
EP2810951B1 (de) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
CA2730603C (en) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
WO2011023324A1 (de) * 2009-08-31 2011-03-03 Bayer Cropscience Ag Tetraarylborat verfahren zur herstellung von substituierten biphenylen
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
EA201592263A1 (ru) 2013-06-05 2016-05-31 Синерджи Фармасьютикалз, Инк. Ультрачистые агонисты гуанилатциклазы c, способ их получения и использования
JP5975081B2 (ja) * 2013-09-30 2016-08-23 ダイキン工業株式会社 含フッ素ビアリール化合物の製造方法
DK4426434T3 (da) 2021-11-02 2025-11-10 Flare Therapeutics Inc Pparg inverse agonists and uses thereof
CN117623932A (zh) * 2023-11-30 2024-03-01 江苏康恒化工有限公司 中间体2，2’-二硝基联苯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
EP0395666B1 (de) * 1987-10-19 1994-05-04 The Secretary of State for Defence in Her Britannic Majesty's Government of the United Kingdom of Great Britain and Lateral cyano- und fluorosubstituierte terphenyle
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
DE69016125T2 (de) * 1989-08-11 1995-06-01 Zeneca Ltd Chinolin-Derivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel.

Also Published As

Publication number Publication date
ZA915566B (en) 1992-04-29
CS241391A3 (en) 1992-03-18
JPH04253949A (ja) 1992-09-09
PL291370A1 (en) 1992-11-16
FI913640A0 (fi) 1991-07-30
JP3001298B2 (ja) 2000-01-24
NO913086L (no) 1992-02-10
EP0470795B2 (de) 2001-02-21
AU8043691A (en) 1992-02-13
HUT59662A (en) 1992-06-29
FI913640A7 (fi) 1992-02-10
EP0470795A1 (de) 1992-02-12
YU137891A (sh) 1994-06-10
HU207841B (en) 1993-06-28
IL98862A0 (en) 1992-07-15
RU2026285C1 (ru) 1995-01-09
AU646473B2 (en) 1994-02-24
DE69106977T2 (de) 1995-05-24
NZ239026A (en) 1993-12-23
TW198710B (de) 1993-01-21
ES2067159T3 (es) 1995-03-16
NO174502B (no) 1994-02-07
ATE117672T1 (de) 1995-02-15
GB9115244D0 (en) 1991-08-28
HU912481D0 (en) 1991-12-30
CN1059516A (zh) 1992-03-18
KR920004337A (ko) 1992-03-27
PT98608A (pt) 1992-06-30
DE69106977T3 (de) 2001-07-19
ZW9591A1 (en) 1992-06-10
EP0470795B1 (de) 1995-01-25
NO913086D0 (no) 1991-08-08
CA2047369A1 (en) 1992-02-10
NO174502C (de) 1994-05-18
GB9017482D0 (en) 1990-09-26

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: AVECIA LTD., MANCHESTER, GB

8328 Change in the person/name/address of the agent

Free format text: HOFFMANN * EITLE, 81925 MUENCHEN

8339 Ceased/non-payment of the annual fee