ES2067159T3 - Proceso para la preparacion de nitrilos. - Google Patents
Proceso para la preparacion de nitrilos.Info
- Publication number
- ES2067159T3 ES2067159T3 ES91307184T ES91307184T ES2067159T3 ES 2067159 T3 ES2067159 T3 ES 2067159T3 ES 91307184 T ES91307184 T ES 91307184T ES 91307184 T ES91307184 T ES 91307184T ES 2067159 T3 ES2067159 T3 ES 2067159T3
- Authority
- ES
- Spain
- Prior art keywords
- novel
- certain
- defined hereinafter
- formula
- biphenylcarbonitriles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Glass Compositions (AREA)
- Turning (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Air Bags (AREA)
- Electrotherapy Devices (AREA)
Abstract
LA INVENCION PROPORCIONA UN PROCESO NOVEDOSO PARA LA FABRICACION DE BIFENILCARBONITRILOS DE FORMULA III, COMO SE DESCRIBE MAS ADELANTE, LOS CUALES SON UTILES PARA LA PRODUCCION DE CIERTOS CONOCIDOS DERIVADOS DE IMIDAZOL Y CIERTOS NUEVOS DERIVADOS DE QUINOLINA QUE TIENEN UNA ACTIVIDAD INHIBIDORA ANGIOTENSINA II. EL PROCESO ENVUELVE UNA REACCION DE CATALISIS CON PALADIO O NICKEL DE UN COMPUESTO DE BORO DE FORMULA II CON UN NITRILO DE FORMULA III, EN DONDE LAS VARIABLES L ELEVADO 1, L (AL CUADRADO) , Q ELEVADO 1, Y Q (AL CUADRADO) TIENEN VARIOS SIGNIFICADOS DEFINIDOS MAS ADELANTE. ALGUNOS DE LOS BIFENILCARBONITRILOS SON NOVEDOSOS Y SON PROPORCIONADOS COMO UNA CARACTERISTICA MAS DE LA INVENCION. LA INVENCION TAMBIEN SE PROPORCIONA UN NUEVO PROCESO PARA LA PRODUCCION LOS CONOCIDOS Y NUEVOS INHIBIDORES DE ANGIOTENSINA II DE FORMULA VI Y VII COMO SE DEFINEN MAS ADELANTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB909017482A GB9017482D0 (en) | 1990-08-09 | 1990-08-09 | Manufacturing process |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2067159T3 true ES2067159T3 (es) | 1995-03-16 |
Family
ID=10680408
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES91307184T Expired - Lifetime ES2067159T3 (es) | 1990-08-09 | 1991-08-05 | Proceso para la preparacion de nitrilos. |
Country Status (23)
Country | Link |
---|---|
EP (1) | EP0470795B2 (es) |
JP (1) | JP3001298B2 (es) |
KR (1) | KR920004337A (es) |
CN (1) | CN1059516A (es) |
AT (1) | ATE117672T1 (es) |
AU (1) | AU646473B2 (es) |
CA (1) | CA2047369A1 (es) |
CS (1) | CS241391A3 (es) |
DE (1) | DE69106977T3 (es) |
ES (1) | ES2067159T3 (es) |
FI (1) | FI913640A (es) |
GB (2) | GB9017482D0 (es) |
HU (1) | HU207841B (es) |
IL (1) | IL98862A0 (es) |
NO (1) | NO174502B (es) |
NZ (1) | NZ239026A (es) |
PL (1) | PL291370A1 (es) |
PT (1) | PT98608A (es) |
RU (1) | RU2026285C1 (es) |
TW (1) | TW198710B (es) |
YU (1) | YU137891A (es) |
ZA (1) | ZA915566B (es) |
ZW (1) | ZW9591A1 (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU155290A (sh) * | 1989-08-11 | 1993-05-28 | Imperial Chemical Industries Plc. | Dusikove spojine |
DE4132632A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Substituierte imidazolyl-propensaeurederivate |
DE4132631A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Imidazolyl-propensaeurederivate |
DE4132633A1 (de) * | 1991-10-01 | 1993-04-08 | Bayer Ag | Cyclisch substituierte imidazolyl-propensaeurederivate |
US5206374A (en) * | 1991-11-18 | 1993-04-27 | E. I. Du Pont De Nemours And Company | Process for preparing tetrazolylphenylboronic acid intermediates |
US5310928A (en) * | 1991-11-18 | 1994-05-10 | E. I. Du Pont De Nemours And Company | Process for preparing biphenyltetrazole compounds |
FR2688507B1 (fr) * | 1992-03-16 | 1994-05-06 | Synthelabo | Derives de l'acide tetrazolylbenzeneboronique, leur preparation et leur utilisation comme intermediaires de synthese. |
FR2689887B1 (fr) * | 1992-04-13 | 1995-06-23 | Sanofi Elf | Procede de preparation d'un derive de biphenyle. |
FR2696746B1 (fr) * | 1992-10-12 | 1994-11-18 | Synthelabo | Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse. |
DE4423061C1 (de) | 1994-07-01 | 1996-01-18 | Hoechst Ag | Verfahren zur Herstellung von Biphenylen mit Palladacyclen als Katalysatoren |
DE4426671A1 (de) * | 1994-07-28 | 1996-02-01 | Hoechst Ag | Verfahren zur Kreuzkupplung von aromatischen Borverbindungen mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten |
KR100354802B1 (ko) * | 1994-10-20 | 2002-12-26 | 한국화학연구원 | 테트라졸유도체의제조방법 |
JP2928982B2 (ja) | 1994-10-27 | 1999-08-03 | 住化ファインケム株式会社 | 4’−ブロモメチル−2−シアノビフェニルの製造法 |
DE19620023C2 (de) * | 1996-05-17 | 2001-03-08 | Celanese Chem Europe Gmbh | Verfahren zur Herstellung von Phosphinat- oder Phosphonatgruppen enthaltenden tertiären Phosphanen und neue Phosphinatgruppen enthaltende tertiäre Phosphane |
US6194599B1 (en) | 1997-04-08 | 2001-02-27 | Catalytica, Inc. | Process for preparing biaryl compounds |
US5922898A (en) * | 1997-04-08 | 1999-07-13 | Catalytica Pharmaceuticals, Inc. | Process for preparing biaryl compounds |
DE69903615T2 (de) | 1998-03-18 | 2003-06-26 | Ciba Sc Holding Ag | Kupplungsreaktionen mit palladiumkatalysatoren |
US6962999B2 (en) | 2001-07-25 | 2005-11-08 | Pharmacore, Inc. | Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles |
DE10211597A1 (de) * | 2002-03-15 | 2003-10-02 | Merck Patent Gmbh | Verfahren zur Herstellung von Ringverbindungen |
CA2482857A1 (en) | 2002-04-29 | 2003-11-13 | Teva Pharmaceutical Industries Ltd. | Processes for preparing losartan and losartan potassium |
ATE388136T1 (de) | 2002-06-12 | 2008-03-15 | Sumitomo Chemical Co | Verfahren zur herstellung von 4'-brommethyl-2- cyanobiphenyl |
US7105467B2 (en) | 2003-07-08 | 2006-09-12 | Pharmacore, Inc. | Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives |
US7105707B2 (en) | 2003-12-17 | 2006-09-12 | Pharmacore, Inc. | Process for preparing alkynyl-substituted aromatic and heterocyclic compounds |
JP2006151946A (ja) * | 2004-04-30 | 2006-06-15 | Konishi Kagaku Ind Co Ltd | ジアリール誘導体の製造方法 |
EA020466B1 (ru) | 2007-06-04 | 2014-11-28 | Синерджи Фармасьютикалз Инк. | Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
KR101751249B1 (ko) * | 2009-08-31 | 2017-06-27 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | 테트라아릴보레이트를 사용한 치환된 비페닐의 제조 방법 |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
CN113388007A (zh) | 2013-06-05 | 2021-09-14 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
JP5975081B2 (ja) * | 2013-09-30 | 2016-08-23 | ダイキン工業株式会社 | 含フッ素ビアリール化合物の製造方法 |
KR101512729B1 (ko) | 2014-01-17 | 2015-04-17 | 에프케이엔지니어링 주식회사 | 화장로 |
TW202334089A (zh) | 2021-11-02 | 2023-09-01 | 美商夫雷爾醫療公司 | Pparg反向激動劑及其用途 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
JP2633338B2 (ja) * | 1987-10-19 | 1997-07-23 | イギリス国 | 側方がシアノ―置換されているテルフェニル |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
YU155290A (sh) * | 1989-08-11 | 1993-05-28 | Imperial Chemical Industries Plc. | Dusikove spojine |
-
1990
- 1990-08-09 GB GB909017482A patent/GB9017482D0/en active Pending
-
1991
- 1991-07-15 ZW ZW95/91A patent/ZW9591A1/xx unknown
- 1991-07-16 IL IL98862A patent/IL98862A0/xx unknown
- 1991-07-16 AU AU80436/91A patent/AU646473B2/en not_active Ceased
- 1991-07-16 ZA ZA915566A patent/ZA915566B/xx unknown
- 1991-07-16 GB GB919115244A patent/GB9115244D0/en active Pending
- 1991-07-18 CA CA002047369A patent/CA2047369A1/en not_active Abandoned
- 1991-07-18 NZ NZ239026A patent/NZ239026A/en unknown
- 1991-07-24 HU HU912481A patent/HU207841B/hu not_active IP Right Cessation
- 1991-07-29 CN CN91105206A patent/CN1059516A/zh active Pending
- 1991-07-30 FI FI913640A patent/FI913640A/fi unknown
- 1991-08-02 CS CS912413A patent/CS241391A3/cs unknown
- 1991-08-05 DE DE69106977T patent/DE69106977T3/de not_active Expired - Fee Related
- 1991-08-05 EP EP91307184A patent/EP0470795B2/en not_active Expired - Lifetime
- 1991-08-05 ES ES91307184T patent/ES2067159T3/es not_active Expired - Lifetime
- 1991-08-05 AT AT91307184T patent/ATE117672T1/de active
- 1991-08-08 NO NO913086A patent/NO174502B/no unknown
- 1991-08-08 RU SU915001352A patent/RU2026285C1/ru active
- 1991-08-08 KR KR1019910013873A patent/KR920004337A/ko not_active Application Discontinuation
- 1991-08-08 JP JP3199442A patent/JP3001298B2/ja not_active Expired - Fee Related
- 1991-08-08 PT PT98608A patent/PT98608A/pt not_active Application Discontinuation
- 1991-08-08 PL PL29137091A patent/PL291370A1/xx unknown
- 1991-08-09 YU YU137891A patent/YU137891A/sh unknown
- 1991-08-12 TW TW080106352A patent/TW198710B/zh active
Also Published As
Publication number | Publication date |
---|---|
FI913640A (fi) | 1992-02-10 |
CS241391A3 (en) | 1992-03-18 |
DE69106977T3 (de) | 2001-07-19 |
HU912481D0 (en) | 1991-12-30 |
GB9115244D0 (en) | 1991-08-28 |
JP3001298B2 (ja) | 2000-01-24 |
JPH04253949A (ja) | 1992-09-09 |
NO913086L (no) | 1992-02-10 |
IL98862A0 (en) | 1992-07-15 |
ZA915566B (en) | 1992-04-29 |
EP0470795B1 (en) | 1995-01-25 |
FI913640A0 (fi) | 1991-07-30 |
PL291370A1 (en) | 1992-11-16 |
ATE117672T1 (de) | 1995-02-15 |
HU207841B (en) | 1993-06-28 |
EP0470795B2 (en) | 2001-02-21 |
ZW9591A1 (en) | 1992-06-10 |
PT98608A (pt) | 1992-06-30 |
AU8043691A (en) | 1992-02-13 |
YU137891A (sh) | 1994-06-10 |
CA2047369A1 (en) | 1992-02-10 |
RU2026285C1 (ru) | 1995-01-09 |
AU646473B2 (en) | 1994-02-24 |
CN1059516A (zh) | 1992-03-18 |
NO913086D0 (no) | 1991-08-08 |
NZ239026A (en) | 1993-12-23 |
DE69106977D1 (de) | 1995-03-09 |
EP0470795A1 (en) | 1992-02-12 |
DE69106977T2 (de) | 1995-05-24 |
KR920004337A (ko) | 1992-03-27 |
NO174502C (es) | 1994-05-18 |
TW198710B (es) | 1993-01-21 |
NO174502B (no) | 1994-02-07 |
GB9017482D0 (en) | 1990-09-26 |
HUT59662A (en) | 1992-06-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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