ES2067159T3 - Proceso para la preparacion de nitrilos. - Google Patents

Proceso para la preparacion de nitrilos.

Info

Publication number
ES2067159T3
ES2067159T3 ES91307184T ES91307184T ES2067159T3 ES 2067159 T3 ES2067159 T3 ES 2067159T3 ES 91307184 T ES91307184 T ES 91307184T ES 91307184 T ES91307184 T ES 91307184T ES 2067159 T3 ES2067159 T3 ES 2067159T3
Authority
ES
Spain
Prior art keywords
formula
carbonitrils
biphenyl
square
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91307184T
Other languages
English (en)
Inventor
David Anthony Roberts
Simon Thomas Russell
John David Pittam
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10680408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2067159(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ES2067159T3 publication Critical patent/ES2067159T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Glass Compositions (AREA)
  • Turning (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Air Bags (AREA)
  • Electrotherapy Devices (AREA)

Abstract

LA INVENCION PROPORCIONA UN PROCESO NOVEDOSO PARA LA FABRICACION DE BIFENILCARBONITRILOS DE FORMULA III, COMO SE DESCRIBE MAS ADELANTE, LOS CUALES SON UTILES PARA LA PRODUCCION DE CIERTOS CONOCIDOS DERIVADOS DE IMIDAZOL Y CIERTOS NUEVOS DERIVADOS DE QUINOLINA QUE TIENEN UNA ACTIVIDAD INHIBIDORA ANGIOTENSINA II. EL PROCESO ENVUELVE UNA REACCION DE CATALISIS CON PALADIO O NICKEL DE UN COMPUESTO DE BORO DE FORMULA II CON UN NITRILO DE FORMULA III, EN DONDE LAS VARIABLES L ELEVADO 1, L (AL CUADRADO) , Q ELEVADO 1, Y Q (AL CUADRADO) TIENEN VARIOS SIGNIFICADOS DEFINIDOS MAS ADELANTE. ALGUNOS DE LOS BIFENILCARBONITRILOS SON NOVEDOSOS Y SON PROPORCIONADOS COMO UNA CARACTERISTICA MAS DE LA INVENCION. LA INVENCION TAMBIEN SE PROPORCIONA UN NUEVO PROCESO PARA LA PRODUCCION LOS CONOCIDOS Y NUEVOS INHIBIDORES DE ANGIOTENSINA II DE FORMULA VI Y VII COMO SE DEFINEN MAS ADELANTE.
ES91307184T 1990-08-09 1991-08-05 Proceso para la preparacion de nitrilos. Expired - Lifetime ES2067159T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909017482A GB9017482D0 (en) 1990-08-09 1990-08-09 Manufacturing process

Publications (1)

Publication Number Publication Date
ES2067159T3 true ES2067159T3 (es) 1995-03-16

Family

ID=10680408

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91307184T Expired - Lifetime ES2067159T3 (es) 1990-08-09 1991-08-05 Proceso para la preparacion de nitrilos.

Country Status (23)

Country Link
EP (1) EP0470795B2 (es)
JP (1) JP3001298B2 (es)
KR (1) KR920004337A (es)
CN (1) CN1059516A (es)
AT (1) ATE117672T1 (es)
AU (1) AU646473B2 (es)
CA (1) CA2047369A1 (es)
CS (1) CS241391A3 (es)
DE (1) DE69106977T3 (es)
ES (1) ES2067159T3 (es)
FI (1) FI913640A7 (es)
GB (2) GB9017482D0 (es)
HU (1) HU207841B (es)
IL (1) IL98862A0 (es)
NO (1) NO174502B (es)
NZ (1) NZ239026A (es)
PL (1) PL291370A1 (es)
PT (1) PT98608A (es)
RU (1) RU2026285C1 (es)
TW (1) TW198710B (es)
YU (1) YU137891A (es)
ZA (1) ZA915566B (es)
ZW (1) ZW9591A1 (es)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE902909A1 (en) * 1989-08-11 1991-02-27 Ici Plc Nitrogen compounds
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
DE4132633A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Cyclisch substituierte imidazolyl-propensaeurederivate
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
US5310928A (en) * 1991-11-18 1994-05-10 E. I. Du Pont De Nemours And Company Process for preparing biphenyltetrazole compounds
US5206374A (en) * 1991-11-18 1993-04-27 E. I. Du Pont De Nemours And Company Process for preparing tetrazolylphenylboronic acid intermediates
FR2688507B1 (fr) * 1992-03-16 1994-05-06 Synthelabo Derives de l'acide tetrazolylbenzeneboronique, leur preparation et leur utilisation comme intermediaires de synthese.
FR2689887B1 (fr) * 1992-04-13 1995-06-23 Sanofi Elf Procede de preparation d'un derive de biphenyle.
FR2696746B1 (fr) * 1992-10-12 1994-11-18 Synthelabo Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse.
DE4423061C1 (de) 1994-07-01 1996-01-18 Hoechst Ag Verfahren zur Herstellung von Biphenylen mit Palladacyclen als Katalysatoren
DE4426671A1 (de) * 1994-07-28 1996-02-01 Hoechst Ag Verfahren zur Kreuzkupplung von aromatischen Borverbindungen mit aromatischen Halogenverbindungen oder Perfluoralkylsulfonaten
KR100354802B1 (ko) * 1994-10-20 2002-12-26 한국화학연구원 테트라졸유도체의제조방법
JP2928982B2 (ja) 1994-10-27 1999-08-03 住化ファインケム株式会社 ４’−ブロモメチル−２−シアノビフェニルの製造法
DE19620023C2 (de) * 1996-05-17 2001-03-08 Celanese Chem Europe Gmbh Verfahren zur Herstellung von Phosphinat- oder Phosphonatgruppen enthaltenden tertiären Phosphanen und neue Phosphinatgruppen enthaltende tertiäre Phosphane
US5922898A (en) * 1997-04-08 1999-07-13 Catalytica Pharmaceuticals, Inc. Process for preparing biaryl compounds
US6194599B1 (en) 1997-04-08 2001-02-27 Catalytica, Inc. Process for preparing biaryl compounds
WO1999047474A1 (en) 1998-03-18 1999-09-23 Ciba Specialty Chemicals Holding Inc. Coupling reactions with palladium catalysts
US6962999B2 (en) 2001-07-25 2005-11-08 Pharmacore, Inc. Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
DE10211597A1 (de) 2002-03-15 2003-10-02 Merck Patent Gmbh Verfahren zur Herstellung von Ringverbindungen
ES2259412T3 (es) 2002-04-29 2006-10-01 Teva Pharmaceutical Industries Ltd. Procedimientos para la preparacion de losartan y losartan potasico.
KR100885148B1 (ko) 2002-06-12 2009-02-23 스미또모 가가꾸 가부시끼가이샤 4'-브로모메틸-2-시아노비페닐의 제조방법
US7105467B2 (en) 2003-07-08 2006-09-12 Pharmacore, Inc. Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives
US7105707B2 (en) 2003-12-17 2006-09-12 Pharmacore, Inc. Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
JP2006151946A (ja) * 2004-04-30 2006-06-15 Konishi Kagaku Ind Co Ltd ジアリール誘導体の製造方法
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
MX354786B (es) 2007-06-04 2018-03-21 Synergy Pharmaceuticals Inc Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos.
CA2726917C (en) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
JP5795583B2 (ja) * 2009-08-31 2015-10-14 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 置換ビフェニル類を調製するためのテトラアリールボレートプロセス
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
CN105764916B (zh) 2013-06-05 2021-05-18 博士医疗爱尔兰有限公司 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
JP5975081B2 (ja) * 2013-09-30 2016-08-23 ダイキン工業株式会社 含フッ素ビアリール化合物の製造方法
PT4426434T (pt) 2021-11-02 2025-11-24 Flare Therapeutics Inc Agonistas inversos de pparg e suas utilizações
CN117623932A (zh) * 2023-11-30 2024-03-01 江苏康恒化工有限公司 中间体2，2’-二硝基联苯的合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
WO1989003821A1 (en) * 1987-10-19 1989-05-05 The Secretary Of State For Defence In Her Britanni Laterally cyano- and fluoro-substituted terphenyls
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
IE902909A1 (en) * 1989-08-11 1991-02-27 Ici Plc Nitrogen compounds

Also Published As

Publication number Publication date
JPH04253949A (ja) 1992-09-09
NO913086D0 (no) 1991-08-08
DE69106977T3 (de) 2001-07-19
NO174502B (no) 1994-02-07
TW198710B (es) 1993-01-21
NO913086L (no) 1992-02-10
DE69106977D1 (de) 1995-03-09
CN1059516A (zh) 1992-03-18
FI913640A7 (fi) 1992-02-10
ZA915566B (en) 1992-04-29
JP3001298B2 (ja) 2000-01-24
HUT59662A (en) 1992-06-29
HU207841B (en) 1993-06-28
NO174502C (es) 1994-05-18
EP0470795A1 (en) 1992-02-12
KR920004337A (ko) 1992-03-27
NZ239026A (en) 1993-12-23
AU646473B2 (en) 1994-02-24
CA2047369A1 (en) 1992-02-10
EP0470795B2 (en) 2001-02-21
GB9017482D0 (en) 1990-09-26
ATE117672T1 (de) 1995-02-15
AU8043691A (en) 1992-02-13
PL291370A1 (en) 1992-11-16
FI913640A0 (fi) 1991-07-30
DE69106977T2 (de) 1995-05-24
HU912481D0 (en) 1991-12-30
YU137891A (sh) 1994-06-10
CS241391A3 (en) 1992-03-18
EP0470795B1 (en) 1995-01-25
GB9115244D0 (en) 1991-08-28
PT98608A (pt) 1992-06-30
ZW9591A1 (en) 1992-06-10
RU2026285C1 (ru) 1995-01-09
IL98862A0 (en) 1992-07-15

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