LV11472A - Kristalisks mononatrija 4-amino-1-hidroksibutilidin-1,1-difosfata trihidrats - Google Patents

Kristalisks mononatrija 4-amino-1-hidroksibutilidin-1,1-difosfata trihidrats

Info

Publication number
LV11472A
LV11472A LV960028A LV960028A LV11472A LV 11472 A LV11472 A LV 11472A LV 960028 A LV960028 A LV 960028A LV 960028 A LV960028 A LV 960028A LV 11472 A LV11472 A LV 11472A
Authority
LV
Latvia
Prior art keywords
amino
hydroxybutylidine
crystalline monosodium
acid
diphosphate trihydrate
Prior art date
Application number
LV960028A
Other languages
English (en)
Other versions
LV11472B (en
Inventor
Gerald R Kieczykowski
David G Melillo
Ronald B Jobson
Gerald S Brenner
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23431886&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LV11472(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of LV11472A publication Critical patent/LV11472A/lv
Publication of LV11472B publication Critical patent/LV11472B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Seasonings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
LVP-96-28A 1989-06-09 1996-02-02 Crystalline 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid monosodium trihydrate, process therefor and compositions and use thereof LV11472B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/363,820 US4922007A (en) 1989-06-09 1989-06-09 Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof

Publications (2)

Publication Number Publication Date
LV11472A true LV11472A (lv) 1996-08-20
LV11472B LV11472B (en) 1996-12-20

Family

ID=23431886

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-96-28A LV11472B (en) 1989-06-09 1996-02-02 Crystalline 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid monosodium trihydrate, process therefor and compositions and use thereof

Country Status (23)

Country Link
US (1) US4922007A (lv)
EP (1) EP0402152B1 (lv)
JP (2) JPH0662651B2 (lv)
KR (1) KR0137455B1 (lv)
AT (1) ATE129713T1 (lv)
AU (1) AU625704C (lv)
CA (1) CA2018477C (lv)
CH (1) CH0402152H1 (lv)
CY (1) CY1894A (lv)
DE (1) DE69023280T2 (lv)
DK (1) DK0402152T3 (lv)
ES (1) ES2080116T3 (lv)
FI (1) FI93219C (lv)
GR (1) GR3018379T3 (lv)
HK (1) HK69596A (lv)
HU (1) HU211908A9 (lv)
IE (1) IE69564B1 (lv)
IL (1) IL94612A (lv)
LV (1) LV11472B (lv)
NO (2) NO177997C (lv)
NZ (1) NZ233972A (lv)
PT (1) PT94306B (lv)
ZA (1) ZA904446B (lv)

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DE2745083C2 (de) * 1977-10-07 1985-05-02 Henkel KGaA, 4000 Düsseldorf Hydroxydiphosphonsäuren und Verfahren zu deren Herstellung
DE2943498C2 (de) * 1979-10-27 1983-01-27 Henkel KGaA, 4000 Düsseldorf Verfahren zur Herstellung von 3-Amino-1-hydroxypropan-1,1-diphosphonsäure
DE3016289A1 (de) * 1980-04-28 1981-10-29 Henkel KGaA, 4000 Düsseldorf Verfahren zur herstellung von omega -amino-1-hydroxyalkyliden-1,1-bis-phosphonsaeuren
US4304734A (en) * 1980-10-16 1981-12-08 Vysoka Skola Chemicko-Technologicka 6-Amino-1-hydroxyhexylidene diphosphonic acid, salts and a process for production thereof
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) * 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
IT1196315B (it) * 1984-10-29 1988-11-16 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici

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NO178228C (no) 1996-02-14
HU211908A9 (en) 1996-01-29
CY1894A (en) 1990-06-08
CA2018477A1 (en) 1990-12-09
DE69023280D1 (de) 1995-12-07
JPH0662651B2 (ja) 1994-08-17
CA2018477C (en) 1995-08-01
ZA904446B (en) 1992-06-24
NO902559L (no) 1990-12-10
IE69564B1 (en) 1996-10-02
LV11472B (en) 1996-12-20
PT94306B (pt) 1997-05-28
IL94612A (en) 1995-03-30
NZ233972A (en) 1992-05-26
IL94612A0 (en) 1991-04-15
KR0137455B1 (ko) 1998-05-01
KR910000768A (ko) 1991-01-30
NO902559D0 (no) 1990-06-08
ATE129713T1 (de) 1995-11-15
JPH03101684A (ja) 1991-04-26
PT94306A (pt) 1991-02-08
NO941726D0 (no) 1994-05-09
US4922007A (en) 1990-05-01
FI902845A0 (fi) 1990-06-07
EP0402152B1 (en) 1995-11-02
CH0402152H1 (fr) 2006-02-28
FI93219B (fi) 1994-11-30
IE902073L (en) 1990-12-09
NO177997B (no) 1995-09-25
HK69596A (en) 1996-04-26
NO177997C (no) 1996-01-03
GR3018379T3 (en) 1996-03-31
ES2080116T3 (es) 1996-02-01
EP0402152A3 (en) 1991-07-03
FI93219C (fi) 1995-03-10
NO941726L (no) 1990-12-10
AU625704C (en) 2001-07-26
JPH0748391A (ja) 1995-02-21
AU5701990A (en) 1990-12-13
DK0402152T3 (da) 1995-12-04
DE69023280T2 (de) 1996-06-20
EP0402152A2 (en) 1990-12-12
AU625704B2 (en) 1992-07-16
NO178228B (no) 1995-11-06

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