KR900016194A - 퀴나졸린 유도체의 제조방법 - Google Patents

퀴나졸린 유도체의 제조방법 Download PDF

Info

Publication number
KR900016194A
KR900016194A KR1019900005608A KR900005608A KR900016194A KR 900016194 A KR900016194 A KR 900016194A KR 1019900005608 A KR1019900005608 A KR 1019900005608A KR 900005608 A KR900005608 A KR 900005608A KR 900016194 A KR900016194 A KR 900016194A
Authority
KR
South Korea
Prior art keywords
general formula
carried out
reaction
lower alkyl
following general
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019900005608A
Other languages
English (en)
Korean (ko)
Inventor
레이터 조세프
폰고 라스즐로
고르제니이 프리기에스
페케트 메르톤
크소르고 마르기트
스쭈헤르 일로나
Original Assignee
아띨라 만디, 메프톤 페케트
에기스 기오기스제르갸르
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU193189A external-priority patent/HU203342B/hu
Priority claimed from HU193089A external-priority patent/HU203333B/hu
Application filed by 아띨라 만디, 메프톤 페케트, 에기스 기오기스제르갸르 filed Critical 아띨라 만디, 메프톤 페케트
Publication of KR900016194A publication Critical patent/KR900016194A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019900005608A 1989-04-21 1990-04-20 퀴나졸린 유도체의 제조방법 Withdrawn KR900016194A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
HU1931/89 1989-04-21
HU193189A HU203342B (en) 1989-04-21 1989-04-21 Process for producing quinazoline deivatives
HU1930/8919 1989-04-21
HU193089A HU203333B (en) 1989-04-21 1989-04-21 Process for producing n-cyano-carboxamidine derivatives

Publications (1)

Publication Number Publication Date
KR900016194A true KR900016194A (ko) 1990-11-12

Family

ID=26317437

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900005608A Withdrawn KR900016194A (ko) 1989-04-21 1990-04-20 퀴나졸린 유도체의 제조방법

Country Status (16)

Country Link
JP (1) JPH02292282A (enrdf_load_stackoverflow)
KR (1) KR900016194A (enrdf_load_stackoverflow)
AT (1) AT398075B (enrdf_load_stackoverflow)
BG (1) BG91821A (enrdf_load_stackoverflow)
CA (2) CA2015066A1 (enrdf_load_stackoverflow)
CH (1) CH681300A5 (enrdf_load_stackoverflow)
DK (1) DK99090A (enrdf_load_stackoverflow)
ES (1) ES2019826A6 (enrdf_load_stackoverflow)
FI (1) FI902002A7 (enrdf_load_stackoverflow)
GB (1) GB2231571B (enrdf_load_stackoverflow)
GR (1) GR900100294A (enrdf_load_stackoverflow)
IT (1) IT1241128B (enrdf_load_stackoverflow)
PL (1) PL162976B1 (enrdf_load_stackoverflow)
RU (1) RU1838309C (enrdf_load_stackoverflow)
SE (1) SE9001402L (enrdf_load_stackoverflow)
YU (1) YU70890A (enrdf_load_stackoverflow)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2077252C (en) 1992-08-31 2001-04-10 Khashayar Karimian Methods of making ureas and guanidines, and intermediates therefor
ES2096518B1 (es) * 1994-03-28 1997-12-01 Grupo Farmaceutico Almirall S Nuevas anilinas.
WO2008015525A2 (en) * 2006-07-31 2008-02-07 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of alfuzosin hydrochloride
CN101687859A (zh) 2007-05-04 2010-03-31 阿克塔维什集团Ptc公司 阿呋唑嗪及其盐的制备工艺
NZ582950A (en) 2007-08-02 2011-06-30 Cipla Ltd Process for the preparation of alfuzosin hydrochloride

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4026894A (en) * 1975-10-14 1977-05-31 Abbott Laboratories Antihypertensive agents
US4044135A (en) * 1975-10-14 1977-08-23 Abbott Laboratories Antihypertensive agents
GB1591490A (en) * 1977-08-04 1981-06-24 Abbott Lab 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-tetrahydrofuroyl)piperazine hydrochloride dihydrate
US4138561A (en) * 1977-09-30 1979-02-06 Bristol-Myers Company Cyanocarboxamidines and quinazoline process
FI57751C (fi) * 1977-10-25 1980-10-10 Fermion Oy Foerfarande foer framstaellning av 6,7-dimetoxi- eller 6,7,8-trimetoxi-4-amino-2-(4-substituerade-piperazin-1-yl)-kinazoliner med blodtryckssaenkande verkan
FI56836C (fi) * 1977-10-25 1980-04-10 Fermion Oy 4-substituerade piperazin-1-(n-aryl-n'-cyano)-karboximidamider som aer mellanprodukter vid framstaellningen av farmakologiskt vaerdefulla 6,7-dimetoxi- eller 6,7,8-trimetoxi-4-amino-2-(4-substituerade-piperazin-1-yl)-kinazoliner
FR2421888A1 (fr) * 1978-02-06 1979-11-02 Synthelabo Amides d'alkylene-diamines et leur application en therapeutique
FI59800C (fi) * 1979-01-10 1981-10-12 Fermion Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(furo-2-yl)-piperazin-1-yl)-kinazolin
FI67699C (fi) * 1979-01-31 1985-05-10 Orion Yhtymae Oy Foerfarande foer framstaellning av 6,7-dimetoxi-4-amino-2-(4-(2-furoyl)-1-piperazinyl)kinazolinhydroklorid med blodtryckssaenkande verkan
EP0146642B1 (de) * 1983-11-22 1988-01-20 LUDWIG HEUMANN & CO GMBH Verfahren zur Herstellung von 4-Amino-6,7-dimethoxy-2-(4-(furo-2-yl)-piperazin-1-yl)-chinazolin und dessen physiologisch annehmbarer Salze

Also Published As

Publication number Publication date
YU70890A (en) 1992-05-28
BG91821A (bg) 1993-12-24
GR900100294A (el) 1991-09-27
SE9001402D0 (sv) 1990-04-20
ES2019826A6 (es) 1991-07-01
CA2028953A1 (en) 1990-10-22
DK99090D0 (da) 1990-04-20
RU1838309C (ru) 1993-08-30
GB9008941D0 (en) 1990-06-20
IT9020092A0 (it) 1990-04-20
IT1241128B (it) 1993-12-29
PL284860A1 (en) 1991-03-11
ATA93190A (de) 1994-01-15
FI902002A7 (fi) 1990-10-22
AT398075B (de) 1994-09-26
FI902002A0 (fi) 1990-04-20
PL162976B1 (pl) 1994-01-31
CH681300A5 (enrdf_load_stackoverflow) 1993-02-26
SE9001402L (sv) 1990-10-22
CA2015066A1 (en) 1990-10-21
DK99090A (da) 1990-10-22
JPH02292282A (ja) 1990-12-03
GB2231571A (en) 1990-11-21
IT9020092A1 (it) 1991-10-20
GB2231571B (en) 1992-09-16

Similar Documents

Publication Publication Date Title
KR890008188A (ko) 프로필렌의 결정형 공중합체
SE7907618L (sv) Sett att framstella nya pyridinderivat och anvendning derav som lekemedel
DE69405864D1 (de) Verfahren zur Herstellung von quaternären Diestern
ES8700856A1 (es) Un procedimiento para la preparacion de compuestos de 1, 4-dihidropiridina
KR890011904A (ko) 안드로스타-1,4, -디엔-3,17-디온의 6-메틸렌 유도체 합성방법
KR930019628A (ko) 피리딘디카르복실레이트 화합물의 제조방법
KR900016194A (ko) 퀴나졸린 유도체의 제조방법
KR870002069A (ko) 2-(3,5-디알킬-4-히드록시페닐) 인돌 유도체의 제조방법
US2810726A (en) Alpha-halo-alpha'-imino-substituted pyrrolines and piperideines and their acid saltsand method for their preparation
SU574156A3 (ru) Способ получени 6-аза-1,2-дигидро-3н1,4-бензодиазепинов или их солей
KR910015537A (ko) 신규 1-아릴술포닐-2-피페리디논 유도체, 이의 제조방법, 제조용 중간체, 의약품으로서의 용도 및 이 화합물을 함유하는 조성물
KR910002875A (ko) 디하이드로피리미도티아진 유도체
KR890002125A (ko) 4-아미노-6, 7-디메톡시 퀴나졸린 유도체의 제조방법.
KR910016673A (ko) 히드록시페닐프로피오네이트의 제조방법
US2855395A (en) Phthalides
AU560606B2 (en) Aziridinoderivaat van een tetramere cyclochloorfosfazeenverbinding werkwijze ter bereiding daarvan en een door substitutie van de chlooratomen van de
US3332994A (en) Alkoxycyanamides and their preparation
US3249605A (en) Lower-alkyl esters of 8-chloro-6-nitro-2-oxo-2h-1, 4-benzoxazine-3-lower-alkanoic acids
KR930019642A (ko) 치환된 페닐퀴나졸린 유도체
KR890002127A (ko) 퀴나졸린 유도체의 제조 방법
SU735593A1 (ru) Способ получени 2-оксо-з-арил-карбамоилтиозолидино-(3,2-а)-1,2-дигидропиридинов
EP0134245A4 (en) PROCESS FOR THE PREPARATION OF 3-CHLORO-1-FORMYL-4-PHENYL-PYRROLES.
KR890002126A (ko) 퀴나졸린 유도체의 제조방법
KR830009055A (ko) 치환된 페닐설포닐우레아 유도체 및 그의 중간물질의 제조방법
KR880002862A (ko) 트리아졸기를 갖는 테트라히드로푸란 화합물의 제조방법 및 이 화합물의 제조를 위한 신규 화합물

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19900420

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid