KR900016097A - 치료활성도를 가지는 시클로메틸렌-1,2-비카르복시산의 아미드, 이의 제조방법 및 이를 포함하는 제약학적 조성물 - Google Patents

치료활성도를 가지는 시클로메틸렌-1,2-비카르복시산의 아미드, 이의 제조방법 및 이를 포함하는 제약학적 조성물 Download PDF

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Publication number
KR900016097A
KR900016097A KR1019890004818A KR890004818A KR900016097A KR 900016097 A KR900016097 A KR 900016097A KR 1019890004818 A KR1019890004818 A KR 1019890004818A KR 890004818 A KR890004818 A KR 890004818A KR 900016097 A KR900016097 A KR 900016097A
Authority
KR
South Korea
Prior art keywords
carbonyl
oxoethyl
hydroxyamino
acid
cis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1019890004818A
Other languages
English (en)
Korean (ko)
Inventor
투르반티 루이기
세르바이 구이도
크리스쿠오리 마르코
Original Assignee
소크라테 구이도리
라보라토리 구이도티 쏘시에떼 퍼 아찌오니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 소크라테 구이도리, 라보라토리 구이도티 쏘시에떼 퍼 아찌오니 filed Critical 소크라테 구이도리
Publication of KR900016097A publication Critical patent/KR900016097A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/61—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polyamides (AREA)
  • Eyeglasses (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
KR1019890004818A 1988-04-12 1989-04-12 치료활성도를 가지는 시클로메틸렌-1,2-비카르복시산의 아미드, 이의 제조방법 및 이를 포함하는 제약학적 조성물 Ceased KR900016097A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT20172A/88 1988-04-02
IT8820172A IT1224627B (it) 1988-04-12 1988-04-12 Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono.

Publications (1)

Publication Number Publication Date
KR900016097A true KR900016097A (ko) 1990-11-12

Family

ID=11164400

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890004818A Ceased KR900016097A (ko) 1988-04-12 1989-04-12 치료활성도를 가지는 시클로메틸렌-1,2-비카르복시산의 아미드, 이의 제조방법 및 이를 포함하는 제약학적 조성물

Country Status (28)

Country Link
US (1) US5095137A (enExample)
EP (1) EP0337348B1 (enExample)
JP (1) JPH026452A (enExample)
KR (1) KR900016097A (enExample)
CN (1) CN1037344A (enExample)
AT (1) ATE101126T1 (enExample)
AU (1) AU611796B2 (enExample)
BG (1) BG60556B1 (enExample)
CA (1) CA1314903C (enExample)
DD (1) DD294014A5 (enExample)
DE (1) DE68912811T2 (enExample)
DK (1) DK173689A (enExample)
ES (1) ES2061759T3 (enExample)
FI (1) FI891712L (enExample)
HU (1) HU206194B (enExample)
IL (1) IL89895A0 (enExample)
IN (2) IN169836B (enExample)
IT (1) IT1224627B (enExample)
MX (1) MX15635A (enExample)
NO (1) NO177851C (enExample)
NZ (1) NZ228688A (enExample)
PL (1) PL159413B1 (enExample)
PT (1) PT90254B (enExample)
RO (1) RO104347B1 (enExample)
RU (2) RU2004538C1 (enExample)
UA (1) UA15920A (enExample)
YU (1) YU73889A (enExample)
ZA (1) ZA892674B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1252708B (it) * 1991-12-23 1995-06-26 Guidotti & C Spa Labor Sali stabili dell'acido (+)-(1r,2s)-2((n-(2-idrossilammino-2-ossoetil)-n-metilammino)carbonil)cicloesan-1-carbossilico,ad attivita' ace inibitrice, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
US5977160A (en) * 1992-04-10 1999-11-02 Brigham And Women's Hospital, Inc. Methods for reducing risk of repeat myocardial infarction and increasing survival in heart attack victims
IT1264860B1 (it) * 1993-06-21 1996-10-17 Guidotti & C Spa Labor Derivati di acidi cis- e trans-2(((2-(isdrossiammino)-2-ossoetil)- alchilammino)carbonil)cicloesancarbossilici
US5639746A (en) * 1994-12-29 1997-06-17 The Procter & Gamble Company Hydroxamic acid-containing inhibitors of matrix metalloproteases
US6028213A (en) 1998-04-16 2000-02-22 Eastman Chemical Company Optically active cis-1,3-cyclohexanedicarboxylic acid monoesters with high enantiomeric purity and process for their preparation
AU2007279092B2 (en) * 2006-07-24 2012-12-13 Ucb Pharma S.A. Substituted aniline derivatives
WO2008156816A2 (en) 2007-06-20 2008-12-24 Vitae Pharmaceuticals, Inc. Renin inhibitors
US20100168243A1 (en) * 2007-06-20 2010-07-01 Baldwin John J Renin Inhibitors
KR101861025B1 (ko) 2008-01-08 2018-05-24 랜티우스 메디컬 이메징, 인크. 영상화 제제로서의 ｎ-알콕시아미드 접합체
US8877157B2 (en) 2009-07-08 2014-11-04 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4077998A (en) * 1975-10-28 1978-03-07 Morton-Norwich Products, Inc. Phthaloyl amino acid hydroxamic acids
US4687841A (en) * 1985-10-18 1987-08-18 Monsanto Company Peptide hydroxamic acid derivatives

Also Published As

Publication number Publication date
MX15635A (es) 1993-12-01
NO891484D0 (no) 1989-04-11
PL278804A1 (en) 1990-01-08
DD294014A5 (de) 1991-09-19
ES2061759T3 (es) 1994-12-16
HUT50105A (en) 1989-12-28
ZA892674B (en) 1989-12-27
FI891712A7 (fi) 1989-10-13
CA1314903C (en) 1993-03-23
DK173689D0 (da) 1989-04-11
YU73889A (en) 1991-04-30
DE68912811T2 (de) 1994-06-16
DE68912811D1 (de) 1994-03-17
PT90254B (pt) 1994-07-29
IL89895A0 (en) 1989-12-15
CN1037344A (zh) 1989-11-22
PL159413B1 (pl) 1992-12-31
RU2004538C1 (ru) 1993-12-15
PT90254A (pt) 1989-11-10
JPH026452A (ja) 1990-01-10
FI891712A0 (fi) 1989-04-11
IN172059B (enExample) 1993-03-27
RO104347B1 (en) 1993-04-15
NO177851B (no) 1995-08-28
AU3265589A (en) 1989-10-19
IT8820172A0 (it) 1988-04-12
HU206194B (en) 1992-09-28
BG60556B1 (bg) 1995-08-28
DK173689A (da) 1989-10-13
NO177851C (no) 1995-12-06
US5095137A (en) 1992-03-10
EP0337348A2 (en) 1989-10-18
AU611796B2 (en) 1991-06-20
NZ228688A (en) 1992-03-26
IT1224627B (it) 1990-10-04
BG88028A (bg) 1993-12-24
FI891712L (fi) 1989-10-13
ATE101126T1 (de) 1994-02-15
EP0337348A3 (en) 1990-05-30
NO891484L (no) 1989-10-13
EP0337348B1 (en) 1994-02-02
RU1838294C (ru) 1993-08-30
IN169836B (enExample) 1991-12-28
UA15920A (uk) 1997-06-30

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PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19890412

PG1501 Laying open of application
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PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19940223

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19890412

Comment text: Patent Application

E902 Notification of reason for refusal
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Comment text: Notification of reason for refusal

Patent event date: 19970828

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 19971216

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 19970828

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I