KR890017241A - 신규의 1, 2-디티올-3-티온-s-옥사이드 화합물류를 함유한 약제 - Google Patents

신규의 1, 2-디티올-3-티온-s-옥사이드 화합물류를 함유한 약제 Download PDF

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Publication number
KR890017241A
KR890017241A KR1019890005296A KR890005296A KR890017241A KR 890017241 A KR890017241 A KR 890017241A KR 1019890005296 A KR1019890005296 A KR 1019890005296A KR 890005296 A KR890005296 A KR 890005296A KR 890017241 A KR890017241 A KR 890017241A
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South Korea
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dithiol
thione
carbon atoms
halogen
lower alkoxy
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KR1019890005296A
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KR970011289B1 (ko
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비아르 도미니끄
마리-오디르
단세뜨 파트릭
야세랑 다니엘
만쉬 다니엘
사시 아모르
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원본미기재
칼리-케미 파마 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/04—Five-membered rings having the hetero atoms in positions 1 and 2, e.g. lipoic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

신규의 1,2-디티올-3-티온-S-옥사이드 화합물류를 함유한 약제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 의약품으로서 사용가능한 일반구조식(Ⅰ)의 1,2∼디티올-3-티온-S-옥사이드 화합물.
    여기에서, R1은 수소, 1-2개의 탄소원자를 갖는 알킬, 저급알콕시, 하이드록시, 할로겐, 트리플루오로메틸 또는 니트로이고, R2는 수소, 할로겐 또는 저급알콕시이며, 또는 R1과 R2는 인접한 탄소원자와 연결되며 함께 1-2개의 탄소원자를 갖는 알킬렌디옥시를 형성한다.
  2. 제 1 항의 1,2-디티올-3-티온-S-옥사이드 화합물의 약리학적으로 유효한 량과 통상의 약제 보조제 및/또는 담체를 함유함을 특징으로 하는 약제.
  3. 간보호작응을 갖는 약제의 생산에 이용되는 제 1 항의 1,2-디티올-3-티온-S-옥사이드 화합물의 용도.
  4. 구조식(Ⅰa)의 1,2-디티올-3-티온-S-옥사이드 화합물.
    여기에서, Rl는 1-2개의 탄소원자를 갖는 알킬, 저급알콕시, 하이드록시, 할로겐, 트리플루오로메틸 또는 니트로이고, R2는 수소, 할로겐 또는 저급알콕시이며, 또는 R1'와 R2는 인접한 탄소원자와 연결되며, 함께 1-2개의 탄소원자를 갖는 알킬렌디옥시를 형성한다.
  5. 구조식(Ⅱa)의 1,2-디티올-3-티온 화합물을 산화시킴을 특징으로 하는 구조식(Ⅰa)의 1,2-디티올-3-티온-S-옥사이드 화합물을 제조하는 방법.
    여기에서, Rl'는 1-2개의 탄소원자를 갖는 알킬, 저급알콕시, 하이드록시, 할로겐, 트리플루오로메틸 또는 니트로이고, R2는 수소, 할로겐 또는 저급알콕시이며, 또는 Rl와 R2는 인접한 탄소원자와 연결되며, 함께 1-2개의 탄소원자를 갖는 알킬렌 디옥시를 형성한다.
  6. 제 1 항의 1,2-디티올-3-티온-S-옥사이드 화합물의 간보호작용에 유효한 량과 함께 통상의 약제보조제 및/또는 담체를 적당한 의약 형태로 한 간보호 작용을 갖는 의약의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890005296A 1988-05-27 1989-04-21 신규의 1,2-디티올-3-티온-s-옥사이드 화합물류를 함유한 약제 KR970011289B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE88401304.6 1988-05-27
EP88401304A EP0343303A1 (de) 1988-05-27 1988-05-27 Neue 1,2-Dithiol-3-thion-S-oxid-Verbindungen enthaltende Arzneimittel
EP88401304.6 1988-05-27

Publications (2)

Publication Number Publication Date
KR890017241A true KR890017241A (ko) 1989-12-15
KR970011289B1 KR970011289B1 (ko) 1997-07-09

Family

ID=8200390

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Application Number Title Priority Date Filing Date
KR1019890005296A KR970011289B1 (ko) 1988-05-27 1989-04-21 신규의 1,2-디티올-3-티온-s-옥사이드 화합물류를 함유한 약제

Country Status (22)

Country Link
US (1) US5096920A (ko)
EP (2) EP0343303A1 (ko)
JP (1) JP2718429B2 (ko)
KR (1) KR970011289B1 (ko)
CN (2) CN1027893C (ko)
AR (1) AR247207A1 (ko)
AU (1) AU624141B2 (ko)
CA (1) CA1332609C (ko)
DD (1) DD283820A5 (ko)
DE (1) DE58905106D1 (ko)
DK (1) DK175286B1 (ko)
DZ (1) DZ1340A1 (ko)
ES (1) ES2058386T3 (ko)
FI (1) FI88503C (ko)
GR (1) GR3009107T3 (ko)
HU (1) HU203745B (ko)
IE (1) IE63291B1 (ko)
IL (1) IL90407A0 (ko)
NO (1) NO172579C (ko)
NZ (1) NZ229274A (ko)
PT (1) PT90521B (ko)
ZA (1) ZA893037B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100484526B1 (ko) * 2002-11-13 2005-04-20 씨제이 주식회사 티온 유도체, 그 제조방법 및 약제학적 조성물

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6437092B1 (en) * 1998-11-06 2002-08-20 Conjuchem, Inc. Conjugates of opioids and endogenous carriers
CN101463030B (zh) * 2009-01-09 2012-03-21 福建深纳生物工程有限公司 茴三硫的制备方法
CN103012394B (zh) * 2012-11-19 2015-03-25 苏州大学 一种罗丹宁衍生物及其制备方法
CN102993166B (zh) * 2012-12-13 2015-05-13 苏州大学 一种3h-1,2-二硫环戊烯-3-硫酮类化合物的制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE874447C (de) * 1944-08-22 1953-04-23 Bruno Dr Boettcher Verfahren zur Herstellung von 5-Thion-1, 2-dithiolen
US2556963A (en) * 1946-07-15 1951-06-12 Gaudin Olivier Benzenes containing sulfur in their allylic or propenylic side chains and process of preparing them
US2662899A (en) * 1950-07-29 1953-12-15 Stauffer Chemical Co Chlorinated cyclic organic trithiocarbonate and process for preparing same
US2688620A (en) * 1951-05-04 1954-09-07 Gaudin Olivier Trisulfureted heterocyclic compounds
US2816116A (en) * 1954-06-01 1957-12-10 Standard Oil Co 2-para-t-butyl phenyl trithione
US3225062A (en) * 1963-02-11 1965-12-21 American Cyanamid Co Process for 1,2-dithiole-3-thiones
US3214442A (en) * 1963-06-26 1965-10-26 American Cyanamid Co 4, 5-dicyano-1, 3-dithiole-2-thione oxide and its preparation
US3847943A (en) * 1972-09-08 1974-11-12 P Warner Preparing anethole trithione using sulfolane solvent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100484526B1 (ko) * 2002-11-13 2005-04-20 씨제이 주식회사 티온 유도체, 그 제조방법 및 약제학적 조성물

Also Published As

Publication number Publication date
GR3009107T3 (ko) 1993-12-30
DK175286B1 (da) 2004-08-09
AU624141B2 (en) 1992-06-04
HU203745B (en) 1991-09-30
DD283820A5 (de) 1990-10-24
JPH0219376A (ja) 1990-01-23
DK256689D0 (da) 1989-05-26
IE891777L (en) 1989-11-27
NO892147D0 (no) 1989-05-26
FI88503C (fi) 1993-05-25
PT90521B (pt) 1994-10-31
EP0343573B1 (de) 1993-08-04
CN1101348A (zh) 1995-04-12
NO892147L (no) 1989-11-28
DK256689A (da) 1989-11-28
EP0343303A1 (de) 1989-11-29
ZA893037B (en) 1989-12-27
DZ1340A1 (fr) 2004-09-13
CN1027893C (zh) 1995-03-15
KR970011289B1 (ko) 1997-07-09
CA1332609C (en) 1994-10-18
FI88503B (fi) 1993-02-15
HUT49870A (en) 1989-11-28
NO172579C (no) 1993-08-11
ES2058386T3 (es) 1994-11-01
FI892571A0 (fi) 1989-05-26
US5096920A (en) 1992-03-17
JP2718429B2 (ja) 1998-02-25
CN1047171C (zh) 1999-12-08
AU3521689A (en) 1989-11-30
EP0343573A1 (de) 1989-11-29
IL90407A0 (en) 1990-01-18
NO172579B (no) 1993-05-03
NZ229274A (en) 1990-10-26
PT90521A (pt) 1989-11-30
DE58905106D1 (de) 1993-09-09
AR247207A1 (es) 1994-11-30
FI892571A (fi) 1989-11-28
IE63291B1 (en) 1995-04-05
CN1039246A (zh) 1990-01-31

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