AR029259A1 - Compuestos 1,1'(1,2 etendiilo) bis (benceno) sustituidos, un proceso para su preparacion composiciones farmaceuticas y el uso de dichos compuestos para preparar agentes intensificadores de la absorcion de glucosa - Google Patents
Compuestos 1,1'(1,2 etendiilo) bis (benceno) sustituidos, un proceso para su preparacion composiciones farmaceuticas y el uso de dichos compuestos para preparar agentes intensificadores de la absorcion de glucosaInfo
- Publication number
- AR029259A1 AR029259A1 ARP010102640A ARP010102640A AR029259A1 AR 029259 A1 AR029259 A1 AR 029259A1 AR P010102640 A ARP010102640 A AR P010102640A AR P010102640 A ARP010102640 A AR P010102640A AR 029259 A1 AR029259 A1 AR 029259A1
- Authority
- AR
- Argentina
- Prior art keywords
- lower alkyl
- substituted
- hydrogen
- nraara
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/56—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/64—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
- C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/57—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton
- C07C309/61—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing carboxyl groups bound to the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se refiere a un compuesto 1,1'-(1,2-etendiil)bis[benceno] sustituido de formula general (1), en donde Ra, Rl y R4 son, independientemente, hidrogeno, alquilo inferior, alquilo inferior sustituido, halo, hidroxilo, alquiloxi inferior optativamente sustituido, -C(O)ORal en la cual Ral es hidrogeno o alquilo inferior, -NRaaRa? o -C(O)NRaaRa?, en la cual Raa y Ra? son, independientemente, hidrogeno, alquilo inferior, alquilo inferior sustituido, arilo, arilo sustituido, arilalquilo (inferior), arilalquilo (inferior) sustituido, heteroarilalquilo (inferior), heteroarilalquilo (inferior) sustituido, heterociclilo, heterociclilo sustituido, heteroarilo o heteroarilo sustituido. R? es hidrogeno, alquilo inferior, alquilo inferior sustituido, halo, hidroxilo, alcoxi inferior, alquiloxi inferior sustituido, carboxilo, -NRaaRa?, -NRaaC(O)Ra? o -C(O)NRaaRa?, en la cual Raa y Ra? tienen los significados anteriores, o R? y Rl, junto con los átomos de carbono a los cuales están unidos, forman un anillo heterocíclico, R5 es hidrogeno, alquilo inferior, alquilo inferior sustituido, o arilo, R6 y R7 son, independientemente, hidrogeno, alquilo inferior o -C(O)ORal, en donde Ral tiene los significados anteriores; R8 y R9 son, independientemente, hidrogeno, alquilo inferior, alquilo inferior sustituido, halo, hidroxilo, alcoxi inferior, carboxilo, -NRaaRa?, -C(O)NRaaRa?, en la cual Raa y Ra? tienen los significados anteriores; R10 es hidrogeno, alquilo inferior, alquilo inferior sustituido, halo, hidroxi, alcoxi inferior, -C(O)ORal en donde Ral es hidrogeno o alquilo inferior, -SO3H o -C(O)NRaaRa?, en donde Raa y Ra? tienen los significados anteriores; o su sal farmacéuticamente aceptable; o un estereoisomero unico o mezcla de sus estereoisomeros, y procesos para su preparacion, composiciones farmacéuticas que comprenden dichos compuestos, el uso de los mismos para preparar medicamentos y/o agentes de tratamiento para intensificar la absorcion de glucosa dependiente de insulina. Más específicamente, se refiere a compuestos y composiciones farmacéuticas que activan la quinasa receptora de insulina, lo cual conduce a una sensibilidad aumentada a la insulina y a un aumento en la absorcion de glucosa, como así también procesos para la preparacion de los compuestos. También se refiere específicamente al uso de dichos compuestos para preparar medicamentos para tratar seres humanos con hiperglicemia, especialmente para el tratamiento de la diabetes Tipo II.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20859100P | 2000-06-02 | 2000-06-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR029259A1 true AR029259A1 (es) | 2003-06-18 |
Family
ID=22775164
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010102640A AR029259A1 (es) | 2000-06-02 | 2001-06-01 | Compuestos 1,1'(1,2 etendiilo) bis (benceno) sustituidos, un proceso para su preparacion composiciones farmaceuticas y el uso de dichos compuestos para preparar agentes intensificadores de la absorcion de glucosa |
Country Status (12)
Country | Link |
---|---|
US (1) | US6479548B2 (es) |
EP (1) | EP1289936B1 (es) |
JP (1) | JP2003535840A (es) |
AR (1) | AR029259A1 (es) |
AT (1) | ATE280148T1 (es) |
AU (2) | AU7508101A (es) |
CA (1) | CA2411340A1 (es) |
DE (1) | DE60106606T2 (es) |
DK (1) | DK1289936T3 (es) |
ES (1) | ES2231504T3 (es) |
TW (1) | TW579373B (es) |
WO (1) | WO2001094295A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE0102384D0 (sv) * | 2001-07-03 | 2001-07-03 | Pharmacia Ab | New compounds |
CN101649004B (zh) * | 2009-09-18 | 2012-08-22 | 中国海洋大学 | 具有抗ii型糖尿病活性的海洋寡糖化合物及制备方法 |
US11681100B2 (en) | 2016-09-30 | 2023-06-20 | 3Sae Technologies, Inc. | Multi-axis positioner |
CN117283539A (zh) | 2016-09-30 | 2023-12-26 | 3Sae技术有限公司 | 多轴相对定位台 |
EP3878837A1 (en) * | 2020-03-11 | 2021-09-15 | OM Pharma SA | 2,5- or 2,6-disubstituted hydroquinone derivatives with at least one carboxy, sulfo or amido group useful as medicaments |
CN114805102A (zh) * | 2022-05-27 | 2022-07-29 | 上海陶术生物科技有限公司 | 双酰胺衍生物中间体及双酰胺衍生物的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5681832A (en) * | 1995-02-17 | 1997-10-28 | The United States Of America As Represented By The Department Of Health And Human Services | Aroylaniline compounds, pharmaceutical compositions, and methods of using same to inhibit viral activity |
JPH09268169A (ja) | 1996-04-01 | 1997-10-14 | Otsuka Chem Co Ltd | サリチル酸アニリド誘導体、それを有効成分として含む植物病害防除剤 |
US5830918A (en) * | 1997-01-15 | 1998-11-03 | Terrapin Technologies, Inc. | Nonpeptide insulin receptor agonists |
FR2759368B1 (fr) | 1997-02-10 | 2001-06-01 | Galderma Rech Dermatologique | Composes biaromatiques, compositions les contenant et utilisations |
-
2001
- 2001-05-31 US US09/872,763 patent/US6479548B2/en not_active Expired - Fee Related
- 2001-06-01 AR ARP010102640A patent/AR029259A1/es unknown
- 2001-06-01 AU AU7508101A patent/AU7508101A/xx active Pending
- 2001-06-01 AU AU2001275081A patent/AU2001275081B2/en not_active Ceased
- 2001-06-01 ES ES01941753T patent/ES2231504T3/es not_active Expired - Lifetime
- 2001-06-01 TW TW090113322A patent/TW579373B/zh not_active IP Right Cessation
- 2001-06-01 EP EP01941753A patent/EP1289936B1/en not_active Expired - Lifetime
- 2001-06-01 DK DK01941753T patent/DK1289936T3/da active
- 2001-06-01 DE DE60106606T patent/DE60106606T2/de not_active Expired - Fee Related
- 2001-06-01 CA CA002411340A patent/CA2411340A1/en not_active Abandoned
- 2001-06-01 JP JP2002501812A patent/JP2003535840A/ja not_active Withdrawn
- 2001-06-01 WO PCT/US2001/017673 patent/WO2001094295A1/en active IP Right Grant
- 2001-06-01 AT AT01941753T patent/ATE280148T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK1289936T3 (da) | 2005-01-24 |
DE60106606T2 (de) | 2006-02-16 |
EP1289936A1 (en) | 2003-03-12 |
US6479548B2 (en) | 2002-11-12 |
CA2411340A1 (en) | 2001-12-13 |
ATE280148T1 (de) | 2004-11-15 |
ES2231504T3 (es) | 2005-05-16 |
AU7508101A (en) | 2001-12-17 |
AU2001275081B2 (en) | 2005-07-21 |
EP1289936B1 (en) | 2004-10-20 |
WO2001094295A1 (en) | 2001-12-13 |
JP2003535840A (ja) | 2003-12-02 |
US20020032218A1 (en) | 2002-03-14 |
TW579373B (en) | 2004-03-11 |
DE60106606D1 (de) | 2004-11-25 |
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