KR890007736A - 11,28-디옥사-4-아자트리시클로[22.3.1.0^4·9]옥타코스-18-엔 유도체 및 이들을 함유한 약학적 조성물의 사용방법 - Google Patents

11,28-디옥사-4-아자트리시클로[22.3.1.0^4·9]옥타코스-18-엔 유도체 및 이들을 함유한 약학적 조성물의 사용방법 Download PDF

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KR890007736A
KR890007736A KR1019880014649A KR880014649A KR890007736A KR 890007736 A KR890007736 A KR 890007736A KR 1019880014649 A KR1019880014649 A KR 1019880014649A KR 880014649 A KR880014649 A KR 880014649A KR 890007736 A KR890007736 A KR 890007736A
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dermatitis
compound
formula
skin
psoriasis
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KR0133916B1 (ko
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그라스베거 맥시밀리안
고트프리드 메잉 게스너 조셉
스튜에즈 안톤
스튜에즈 피터
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예안크라메르·한스 루돌프 하우스
산도즈 리미티드
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Priority claimed from AT0295287A external-priority patent/AT400808B/de
Application filed by 예안크라메르·한스 루돌프 하우스, 산도즈 리미티드 filed Critical 예안크라메르·한스 루돌프 하우스
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

11,28-디옥사-4-아자트리시클로[22.3.1.O4.9]옥타코스-18-엔 유도체 및 이들을 함유한 약학적 조성물의 사용방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 염증 또는 과증식 피부질환, 그리고 면역학적으로 관계된 질병등의 피부발현, 예를들면, 건선, 과민성 피부염, 접촉 피부염 및 습진피부염, 지루성 피부염, 편평태선, 천포창, 수포성 천포창, 표피분열 수포증, 담마진, 혈관부종, 맥관염, 홍반, 피부호산구과다증, 낭창홍반 및 원형 탈모증을 국소 치료할시 유리 형태 또는 약학적 허용염형태로 하기 일반식(I)의 화합물을 사용하는 방법 : 상기식에서, R1은 임의의 보호 히드록시, R2는 수소 또는 임의의 보호 히드록시, R3는 메틸, 에틸, 프로필 또는 아릴, n는 1 또는 2이고, 직선 및 점선은 단일결합 또는 이중결합이다.
  2. 제1항에 있어서, 건선의 국소치료시 유리형태 또는 약학적 허용염형태로 제1항에서 정의된 일반식(I)의 화합물을 사용하는 방법.
  3. 제1항 또는 제2항에 있어서, R1및 R2가 히드록시, R3가 일릴, n이 2이고, 직선 및 점선이 단일결합인 유리형태 또는 약학적 허용 염형태의 일반식(I)의 화합물을 사용하는 방법.
  4. 제1항 또는 제2항에 있어서, 유리형태 또는 약학적 허용염 형태로 하기 일반식 (Ia)의 화합물을 사용하는 방법:
  5. 염증 또는 과증식 피부질환, 그리고 면역학적으로 관계된 질병등의 피부발현, 예를들면, 건선, 과민성피부염, 접촉피부염 및 습진 피부염, 지루성 피부염, 편평태선, 천포창, 수포성 천포창, 표피분열 수포증, 담마진, 혈관부종, 맥관염, 홍반, 피부 호산구 과다증, 낭창홍반 및 원형 탈모증을 국소 치료할시, 유리 형태 또는 약학적 허용염 형태로 제1항에서 정의된 일반식(I)의 화합물을 사용하는 약학적 조성물.
  6. 제5항에 있어서, 건선에 사용하는 조성물.
  7. 제5항 또는 제6항에 있어서, 활성물질의 농도 1-3%를 함유하는 조성물
  8. 제5항 또는 제6항에 있어서, 로션, 겔 또는 크리임인 조성물.
  9. 염증 또는 과증식 피부질환, 혹은, 면역학적으로 유발된 질병의 피부발현을 국소 치료하기 위한 약제의 제조시 제1항에서 정의된 일반식(I)의 화합물을 사용하는 방법.
  10. 제9항에 있어서, 건선, 과민성 피부염, 접촉 피부염 및 습진피부염, 지루성 피부염, 편평태선, 천포창, 수포성 천포창, 표피분열 수포증, 담마진, 혈관부종, 맥관염, 홍반, 피부호산구과다증, 낭창홍반 또는 원형 탈모증을 국소치료하기 위한 약제의 제조시 일반식(I)의 화합물을 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880014649A 1987-11-09 1988-11-08 11,28-디옥사-4-아자트리시클로[22.3.1.04,9]옥타코스-18-엔 유도체를 함유한 약학 조성물 KR0133916B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AT0295287A AT400808B (de) 1987-11-09 1987-11-09 Verwendung von tricyclischen verbindungen zur herstellung von topischen arzneimitteln
ATA2952/87 1987-11-09
DEP3742805.5 1987-12-17
DEP3742805,5 1987-12-17
DE3742805 1987-12-17

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KR890007736A true KR890007736A (ko) 1989-07-05
KR0133916B1 KR0133916B1 (ko) 1998-04-22

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US (1) US20050059694A1 (ko)
EP (2) EP0596541B1 (ko)
JP (1) JP2604834B2 (ko)
KR (1) KR0133916B1 (ko)
AU (1) AU619772B2 (ko)
CH (1) CH677448A5 (ko)
CY (1) CY1730A (ko)
DK (1) DK175235B1 (ko)
GB (1) GB2212061B (ko)
HK (1) HK8694A (ko)
NL (1) NL195077C (ko)
PH (1) PH26083A (ko)
SE (2) SE503236C2 (ko)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4894366A (en) 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
US5519049A (en) * 1989-06-06 1996-05-21 Fisons Plc Macrolides for the treatment of reversible obstructive airways diseases
IE64214B1 (en) * 1989-06-06 1995-07-26 Fujisawa Pharmaceutical Co Macrolides for the treatment of reversible obstructive airways diseases
EP0406791B1 (en) * 1989-07-05 1995-02-01 Fujisawa Pharmaceutical Co., Ltd. Aqueous liquid composition for external use
KR0159766B1 (ko) * 1989-10-16 1998-12-01 후지사와 토모키치로 양모제 조성물
US5215995A (en) * 1989-10-16 1993-06-01 Fujisawa Pharmaceutical Co., Ltd. Hair revitalizing agent
US5208228A (en) * 1989-11-13 1993-05-04 Merck & Co., Inc. Aminomacrolides and derivatives having immunosuppressive activity
GB8925797D0 (en) * 1989-11-15 1990-01-04 Fisons Plc Compositions
US5064835A (en) * 1990-03-01 1991-11-12 Merck & Co., Inc. Hydroxymacrolide derivatives having immunosuppressive activity
KR0177158B1 (ko) * 1990-03-01 1999-03-20 후지사와 도모기찌로 면역억제 활성을 갖는 트리사이클릭 화합물 함유 용액 제제
JPH05504956A (ja) * 1990-03-12 1993-07-29 藤沢薬品工業株式会社 トリシクロ化合物
EP0455427A1 (en) * 1990-04-30 1991-11-06 Merck & Co. Inc. Deoxymacrolide derivatives having immunosuppressive activity
US5342935A (en) * 1990-06-25 1994-08-30 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
US5190950A (en) * 1990-06-25 1993-03-02 Merck & Co., Inc. Antagonists of immunosuppressive macrolides
ES2099112T3 (es) * 1990-09-04 1997-05-16 Fujisawa Pharmaceutical Co Pomadas que contienen un compuesto triciclico.
GB2248184A (en) * 1990-09-28 1992-04-01 Fujisawa Pharmaceutical Co New use of macrolide compounds for active oxygen-mediated diseases
US5143918A (en) * 1990-10-11 1992-09-01 Merck & Co., Inc. Halomacrolides and derivatives having immunosuppressive activity
US5348966A (en) * 1990-10-24 1994-09-20 Fujisawa Pharmaceutical Co., Ltd. Method for treating pyoderma and Sezary's syndrome using FK 506 and related compounds
PH31204A (en) * 1990-11-02 1998-05-05 Fujisawa Pharmaceutical Co Pharmaceutical composition.
US5147877A (en) * 1991-04-18 1992-09-15 Merck & Co. Inc. Semi-synthetic immunosuppressive macrolides
US5250678A (en) 1991-05-13 1993-10-05 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5162334A (en) * 1991-05-13 1992-11-10 Merck & Co., Inc. Amino O-alkyl, O-alkenyl and O-alkynlmacrolides having immunosuppressive activity
US5565560A (en) * 1991-05-13 1996-10-15 Merck & Co., Inc. O-Aryl,O-alkyl,O-alkenyl and O-alkynylmacrolides having immunosuppressive activity
US5189042A (en) * 1991-08-22 1993-02-23 Merck & Co. Inc. Fluoromacrolides having immunosuppressive activity
US5208241A (en) * 1991-09-09 1993-05-04 Merck & Co., Inc. N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity
ZA926812B (en) 1991-09-09 1993-04-28 Merck & Co Inc O-heteroaryl,o-alkylheteroaryl,o-alkenylheteroaryl and o-alkynylheteroaryl macrolides having immunosupressive activity
US5286730A (en) * 1991-09-17 1994-02-15 American Home Products Corporation Method of treating immunoinflammatory disease
US5286731A (en) * 1991-09-17 1994-02-15 American Home Products Corporation Method of treating immunoinflammatory bowel disease
GB9218597D0 (en) * 1992-08-25 1992-10-14 Fisons Plc Novel method of treatment
MY110603A (en) * 1993-05-27 1998-08-29 Novartis Ag Tetrahydropyran derivatives
JPH06345646A (ja) * 1993-06-08 1994-12-20 Fujisawa Pharmaceut Co Ltd ローション剤
US5693648A (en) * 1994-09-30 1997-12-02 Merck & Co., Inc. O-aryl, O-alkyl, O-alkenyl and O-alkynyl-macrolides having immunosuppressive activity
KR100434682B1 (ko) 1994-10-26 2004-08-18 노바티스 아게 약학조성물
GB9826656D0 (en) 1998-12-03 1999-01-27 Novartis Ag Organic compounds
WO2004069247A1 (en) * 2003-02-06 2004-08-19 Cipla Ltd Topical immunotherapy and compositions for use therein
US7186518B2 (en) * 2003-11-21 2007-03-06 Dade Behring Inc. Method and composition useful for determining FK 506
WO2010041684A1 (ja) 2008-10-08 2010-04-15 高田製薬株式会社 タクロリムス外用剤
EP2308468A1 (en) * 2009-10-08 2011-04-13 Novaliq GmbH Novel pharmaceutical composition comprising a macrolide immunosuppressant drug
CN106074367A (zh) * 2016-07-20 2016-11-09 中山大学中山眼科中心 含fk506类化合物/fkbp蛋白二聚体的药物组合物及其制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139563A (en) * 1977-07-01 1979-02-13 Merrell Toraude Et Compagnie α-ACETYLENIC DERIVATIVES OF AMINES
DE2964567D1 (en) * 1978-12-21 1983-02-24 Lepetit Spa New 3h-naphtho(1,2-d)imidazoles, processes for preparing them, compounds for use as antiinflammatory and antimicrobial agents and compositions for that use containing them
US4411893A (en) * 1981-08-14 1983-10-25 Minnesota Mining And Manufacturing Company Topical medicament preparations
US4556654A (en) * 1983-06-28 1985-12-03 Warner-Lambert Company Antimicrobial substituted anthra[1,9-cd]pyrazol-6(2H)-ones
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
CA1272953A (en) * 1984-10-08 1990-08-21 Yuji Makino Pharmaceutical composition for external use containing active-type vitamin d.sub.3

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HK8694A (en) 1994-02-04
GB2212061B (en) 1991-08-28
SE9402558D0 (sv) 1994-07-22
GB2212061A (en) 1989-07-19
US20050059694A1 (en) 2005-03-17
SE519137C2 (sv) 2003-01-21
EP0315978A3 (en) 1990-06-13
SE8804036D0 (sv) 1988-11-08
JP2604834B2 (ja) 1997-04-30
CY1730A (en) 1994-05-06
EP0315978B1 (en) 1994-10-26
CH677448A5 (ko) 1991-05-31
EP0315978A2 (en) 1989-05-17
DK175235B1 (da) 2004-07-19
DK620388D0 (da) 1988-11-07
AU619772B2 (en) 1992-02-06
NL195077C (nl) 2003-07-23
PH26083A (en) 1992-02-06
SE8804036L (sv) 1989-05-10
NL8802734A (nl) 1989-06-01
SE503236C2 (sv) 1996-04-22
AU2490288A (en) 1989-05-11
GB8826066D0 (en) 1988-12-14
DK620388A (da) 1989-05-10
EP0596541A1 (en) 1994-05-11
KR0133916B1 (ko) 1998-04-22
EP0596541B1 (en) 2000-03-15
JPH01157913A (ja) 1989-06-21

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