NZ233704A - Dehydrocholecalciferol derivatives, pharmaceutical compositions thereof - Google Patents

Dehydrocholecalciferol derivatives, pharmaceutical compositions thereof

Info

Publication number
NZ233704A
NZ233704A NZ233704A NZ23370490A NZ233704A NZ 233704 A NZ233704 A NZ 233704A NZ 233704 A NZ233704 A NZ 233704A NZ 23370490 A NZ23370490 A NZ 23370490A NZ 233704 A NZ233704 A NZ 233704A
Authority
NZ
New Zealand
Prior art keywords
dehydrocholecalciferol
derivatives
pharmaceutical compositions
deuterium
new
Prior art date
Application number
NZ233704A
Inventor
Enrico Giuseppe Baggiolini
Bernard Michael Hennessy
Shian-Jan Shiuey
Gary Arthur Truitt
Milan Radoje Uskokovic
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NZ233704A publication Critical patent/NZ233704A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/008—Preparations for oily skin

Abstract

The use of dehydrocholecalciferal derivs. of formula (I) to make pharmaceuticals for treating diseases of the sebaceous glands is new. (Where R = H or OH; A = CC, (E)-CH=CH or CH2CH2; R'' = H or, where A = C=C, it can also be deuterium). (I) are new cpds. where R'' = deuterium.
NZ233704A 1989-05-18 1990-05-16 Dehydrocholecalciferol derivatives, pharmaceutical compositions thereof NZ233704A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35371689A 1989-05-18 1989-05-18

Publications (1)

Publication Number Publication Date
NZ233704A true NZ233704A (en) 1992-11-25

Family

ID=23390270

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ233704A NZ233704A (en) 1989-05-18 1990-05-16 Dehydrocholecalciferol derivatives, pharmaceutical compositions thereof

Country Status (10)

Country Link
EP (1) EP0398217B1 (en)
JP (1) JPH0686381B2 (en)
AT (1) ATE99942T1 (en)
AU (1) AU636609B2 (en)
CA (1) CA2016985C (en)
DE (1) DE69005897D1 (en)
DK (1) DK0398217T3 (en)
IE (1) IE64186B1 (en)
NZ (1) NZ233704A (en)
ZA (1) ZA903758B (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives
GB9004544D0 (en) * 1990-03-01 1990-04-25 Leo Pharm Prod Ltd Novel treatment ii
GB9017890D0 (en) * 1990-08-15 1990-09-26 Leo Pharm Prod Ltd Chemical compounds i
IL103224A (en) * 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
TW267161B (en) * 1992-11-20 1996-01-01 Hoffmann La Roche
US5428029A (en) * 1993-11-24 1995-06-27 Hoffmann-La Roche Inc. Vitamin D3 fluorinated analogs
AU708679B2 (en) * 1996-03-21 1999-08-12 F. Hoffmann-La Roche Ag 1,25-dihydroxy-16,22,23-trisdehydro-cholecalciferol derivatives
GB9625271D0 (en) * 1996-12-04 1997-01-22 Leo Pharm Prod Ltd Chemical compounds
DK0884308T3 (en) * 1997-05-02 2003-07-21 Duphar Int Res Process for Preparation of 16-Dehydro Vitamin D Compounds
JP4795023B2 (en) * 2004-02-03 2011-10-19 中外製薬株式会社 Method for synthesizing vitamin D compounds and synthetic intermediates thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4610978A (en) * 1983-03-22 1986-09-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compositions containing 1α-hydroxycholecalciferol for topical treatment of skin disorders and methods employing same
GB2183156B (en) * 1985-03-14 1989-06-21 Chugai Pharmaceutical Co Ltd Composition for treating skin disease
US4898855A (en) * 1987-09-14 1990-02-06 Hoffman-La Roche Inc. Deuterated analogs of 1,25-dihydroxycholecalciferol
US4804502A (en) * 1988-01-20 1989-02-14 Hoffmann-La Roche Inc. Vitamin D compounds
ZA8923B (en) * 1988-01-20 1989-09-27 Hoffmann La Roche 16-dehydro-vitamin d3-derivatives

Also Published As

Publication number Publication date
IE64186B1 (en) 1995-07-12
EP0398217B1 (en) 1994-01-12
ATE99942T1 (en) 1994-01-15
ZA903758B (en) 1992-01-29
CA2016985A1 (en) 1990-11-18
AU636609B2 (en) 1993-05-06
IE901780L (en) 1990-11-18
DK0398217T3 (en) 1994-02-14
EP0398217A1 (en) 1990-11-22
JPH0686381B2 (en) 1994-11-02
JPH0317019A (en) 1991-01-25
DE69005897D1 (en) 1994-02-24
CA2016985C (en) 2001-03-27
AU5516590A (en) 1990-11-22

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