KR880001736B1 - 2,4-디아미노-5(치환된)피리미딘의 제조방법 - Google Patents

2,4-디아미노-5(치환된)피리미딘의 제조방법 Download PDF

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Publication number
KR880001736B1
KR880001736B1 KR1019810004348A KR810004348A KR880001736B1 KR 880001736 B1 KR880001736 B1 KR 880001736B1 KR 1019810004348 A KR1019810004348 A KR 1019810004348A KR 810004348 A KR810004348 A KR 810004348A KR 880001736 B1 KR880001736 B1 KR 880001736B1
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KR
South Korea
Prior art keywords
formula
compound
diamino
pyrimidine
amino
Prior art date
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Expired
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KR1019810004348A
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English (en)
Korean (ko)
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KR830007628A (ko
Inventor
메리 댈러그 수잔
마슬 스코네즈니 폴
Original Assignee
더 웰컴 화운데이숀 리미티드
미첼 피터 잭슨
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Publication of KR830007628A publication Critical patent/KR830007628A/ko
Application granted granted Critical
Publication of KR880001736B1 publication Critical patent/KR880001736B1/ko
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/64—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with oxygen atoms directly attached in position 8

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1019810004348A 1980-11-11 1981-11-10 2,4-디아미노-5(치환된)피리미딘의 제조방법 Expired KR880001736B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB36135 1980-11-11
GB8036135 1980-11-11

Publications (2)

Publication Number Publication Date
KR830007628A KR830007628A (ko) 1983-11-04
KR880001736B1 true KR880001736B1 (ko) 1988-09-10

Family

ID=10517217

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004348A Expired KR880001736B1 (ko) 1980-11-11 1981-11-10 2,4-디아미노-5(치환된)피리미딘의 제조방법

Country Status (35)

Country Link
US (4) US4438267A (enExample)
EP (1) EP0051879B1 (enExample)
JP (1) JPS57114581A (enExample)
KR (1) KR880001736B1 (enExample)
AR (1) AR245447A1 (enExample)
AU (1) AU549449B2 (enExample)
CA (1) CA1186310A (enExample)
CS (1) CS273153B2 (enExample)
CY (1) CY1419A (enExample)
DD (1) DD201896A5 (enExample)
DE (1) DE3173752D1 (enExample)
DK (1) DK172884B1 (enExample)
EG (1) EG16107A (enExample)
ES (5) ES506969A0 (enExample)
FI (1) FI76333C (enExample)
GB (1) GB2087881B (enExample)
GR (1) GR81317B (enExample)
HK (1) HK23388A (enExample)
HU (1) HU188762B (enExample)
IE (1) IE52128B1 (enExample)
IL (1) IL64256A (enExample)
IT (1) IT1210589B (enExample)
MC (1) MC1418A1 (enExample)
MY (1) MY8600678A (enExample)
NO (2) NO160137C (enExample)
NZ (1) NZ198932A (enExample)
PH (2) PH22654A (enExample)
PL (4) PL139523B1 (enExample)
PT (1) PT73960B (enExample)
RU (1) RU1819264C (enExample)
SG (1) SG62686G (enExample)
SU (4) SU1424732A3 (enExample)
YU (5) YU42444B (enExample)
ZA (1) ZA817780B (enExample)
ZM (1) ZM9481A1 (enExample)

Families Citing this family (36)

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US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
US4590271A (en) * 1982-05-01 1986-05-20 Burroughs Wellcome Co. 2,4-diamino-5-(substituted)pyrimidines, useful as antimicrobials
DK190983A (da) * 1982-05-01 1983-11-02 Wellcome Found 2,4-diamino-5-(substituerede)pyrimidiner, fremgangsmaade til deres fremstilling og mellemprodukter derfor
ZA833067B (en) * 1982-05-01 1984-12-24 Wellcome Found Antibacterial compounds
US4587341A (en) * 1982-05-07 1986-05-06 Burroughs Wellcome Co. 2,4-diamino-5-(1,2,3,4-tetrahydro-(substituted or unsubstituted)-6-quinolylmethyl)pyrimidines, useful as antimicrobials
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
GB8603964D0 (en) * 1986-02-18 1986-03-26 Cooper Animal Health Ltd Compositions
GB8603962D0 (en) * 1986-02-18 1986-03-26 Wellcome Found Chemical compositions
LU86703A1 (fr) * 1986-12-08 1988-07-14 Oreal Composition cosmetique photostable contenant un filtre uv-a et un filtre uv-b,son utilisation pour la protection de la peau contre les rayons uv et procede de stabilisation du filtre uv-a par le filtre uv-b
FI895821A7 (fi) * 1988-12-07 1990-06-08 The Wellcome Foundation Ltd Farmaseuttisesti aktivisia CNS-yhdisteitä
GB8903978D0 (en) * 1989-02-22 1989-04-05 Coopers Animal Health Chemical compositions
GB9000241D0 (en) * 1990-01-05 1990-03-07 Coopers Animal Health Pharmaceutical use
RU95113597A (ru) * 1992-12-02 1997-06-10 ФМК Корпорейшн (US) Инсектицидная композиция, способы борьбы с насекомыми
NO940245D0 (no) * 1993-01-28 1994-01-24 Takeda Chemical Industries Ltd Quinolin eller quinazolinderivater, deres fremstilling og anvendelse
US5707996A (en) * 1995-11-06 1998-01-13 Macleod Pharmaceuticals, Inc. Pharmaceutical solution and methods for preparation thereof
ATE212629T1 (de) * 1995-12-04 2002-02-15 Arpida Ag Diaminopyrimidine, diese enthaltende pharmazeutische zusammensetzungen und ihre verwendung als antibakterielle mittel
RU2141322C1 (ru) * 1997-08-12 1999-11-20 Голощапов Николай Михайлович Иммуномодулятор с антимикобактериальной активностью "изофон", способ его получения и применения
GB0016877D0 (en) * 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
WO2002010156A1 (en) * 2000-07-29 2002-02-07 Arpida Ag Benzofuran derivatives and their use as antibacterial agents
US7741335B2 (en) * 2001-06-29 2010-06-22 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory diseases
JP2005500041A (ja) * 2001-06-29 2005-01-06 アブ サイエンス 強力で選択的かつ非毒性のｃ−ｋｉｔ阻害剤
US7678805B2 (en) 2001-06-29 2010-03-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (IBD)
JP2004537536A (ja) * 2001-06-29 2004-12-16 アブ サイエンス アレルギー疾患を治療するためのチロシンキナーゼ阻害剤の使用方法
DE60227701D1 (de) * 2001-09-20 2008-08-28 Ab Science Die verwendung von c-kithemmern zur förderung des haarwuchses
US20040242601A1 (en) * 2001-09-20 2004-12-02 Alain Moussy Use of potent, selective and non toxic c-kit inhibitors for treating interstitial cystitis
EP1450775B1 (en) * 2001-09-20 2008-03-12 AB Science C-kit inhibitors for treating bacterial infections
NZ545197A (en) 2003-07-11 2009-06-26 Arpida Ag Benzofuran derivatives and their use in the treatment of microbial infections
RO122912B8 (ro) * 2005-02-18 2010-09-30 Arpida Ag Procedeu de preparare a unui derivat de 2h-cromen
BRPI0615613A2 (pt) * 2005-09-01 2009-05-19 Hoffmann La Roche diaminopirimidinas como moduladores de p2x3 e p3x2/3
US20100029689A1 (en) * 2008-07-02 2010-02-04 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
WO2010142027A1 (en) * 2009-06-12 2010-12-16 Socpra - Sciences Et Genie S. E. C. Guanine riboswitch binding compounds and their use as antibiotics
CN102649786B (zh) * 2011-02-28 2014-08-27 郑州福源动物药业有限公司 一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法
CN103755684B (zh) * 2014-02-10 2015-09-09 青岛蔚蓝生物股份有限公司 一种巴喹普林的制备方法
CN113924293B (zh) * 2019-06-06 2024-07-09 北京泰德制药股份有限公司 P2x3和/或p2x2/3受体拮抗剂、包含其的药物组合物及其用途
CN110818694B (zh) * 2019-11-18 2023-04-21 上海医药工业研究院有限公司 艾拉普林中间体及其应用
EP4320104A4 (en) * 2021-04-09 2025-06-04 The Trustees of The University of Pennsylvania CONTROL OF PROTEIN EXPRESSION WITH TMP-PROTAC COMPOUNDS

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3049544A (en) * 1962-08-14 Method for the preparation of
DE1303727B (de) 1959-09-03 1976-02-05 Ausscheidung aus: 14 45 176 The Wellcome Foundation Ltd., London Alpha-Arylidensubstituierte Propioni-Irile
US3956327A (en) * 1969-03-06 1976-05-11 Burroughs Wellcome Co. Method of preparing 2,4-diamino-5-benzyl pyrimidines
BE792096A (fr) * 1971-12-01 1973-05-30 Hoffmann La Roche Nouvelles benzylpyrimidines
GB1468374A (en) 1974-03-06 1977-03-23 Wellcome Found Process for preparing a pyrimidine derivative
US4039543A (en) 1974-12-24 1977-08-02 Hoffmann-La Roche Inc. Benzylpyrimidines
GB1582245A (en) * 1976-06-09 1981-01-07 Wellcome Found Benzyl cyanoacetal derivatives and their conversion to pyrimidine derivatives
DE2730467A1 (de) * 1977-07-06 1979-01-18 Basf Ag Benzylpyrimidine, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
US4258045A (en) * 1979-11-30 1981-03-24 Merck & Co., Inc. Inhibitor of dihydrofolate reductase
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use

Also Published As

Publication number Publication date
ES8405380A1 (es) 1984-06-01
FI76333C (fi) 1988-10-10
ES8307759A1 (es) 1983-07-01
EG16107A (en) 1987-10-30
JPH0474351B2 (enExample) 1992-11-26
NZ198932A (en) 1985-05-31
YU144288A (en) 1990-04-30
IT1210589B (it) 1989-09-14
IT8149676A0 (it) 1981-11-10
JPS57114581A (en) 1982-07-16
NO160137C (no) 1989-03-15
ES521204A0 (es) 1984-06-01
ES8405379A1 (es) 1984-06-01
PL239280A1 (en) 1983-08-01
US4438267A (en) 1984-03-20
PL239279A1 (en) 1983-08-01
US4761475A (en) 1988-08-02
SU1318148A3 (ru) 1987-06-15
RU1819264C (ru) 1993-05-30
DE3173752D1 (en) 1986-03-20
NO160137B (no) 1988-12-05
PH22654A (en) 1988-10-28
NO813804L (no) 1982-05-12
AU549449B2 (en) 1986-01-30
HK23388A (en) 1988-04-08
ES8405378A1 (es) 1984-06-01
GB2087881B (en) 1985-05-15
PL239278A1 (en) 1983-08-01
YU198283A (en) 1984-04-30
FI813546L (fi) 1982-05-12
DD201896A5 (de) 1983-08-17
ES521202A0 (es) 1984-06-01
CS825781A2 (en) 1990-07-12
ES8405377A1 (es) 1984-06-01
SU1306473A3 (ru) 1987-04-23
GB2087881A (en) 1982-06-03
NO1994029I1 (no) 1994-12-29
YU42444B (en) 1988-08-31
PT73960B (en) 1983-11-23
DK496681A (da) 1982-05-12
MY8600678A (en) 1986-12-31
SU1535379A3 (ru) 1990-01-07
MC1418A1 (fr) 1982-10-18
US4603136A (en) 1986-07-29
CS273153B2 (en) 1991-03-12
YU198183A (en) 1984-04-30
US4587342A (en) 1986-05-06
ZA817780B (en) 1983-06-29
EP0051879B1 (en) 1986-02-05
YU266381A (en) 1984-04-30
CY1419A (en) 1988-04-22
IE52128B1 (en) 1987-06-24
EP0051879A2 (en) 1982-05-19
IL64256A (en) 1988-01-31
AR245447A1 (es) 1994-01-31
KR830007628A (ko) 1983-11-04
AU7733481A (en) 1982-05-20
CA1186310A (en) 1985-04-30
GR81317B (enExample) 1984-12-11
FI76333B (fi) 1988-06-30
DK172884B1 (da) 1999-09-06
IE812631L (en) 1982-05-11
YU46697B (sh) 1994-04-05
ZM9481A1 (en) 1983-11-21
YU198383A (en) 1984-04-30
YU43551B (en) 1989-08-31
PH25053A (en) 1991-01-28
ES506969A0 (es) 1983-07-01
SU1424732A3 (ru) 1988-09-15
EP0051879A3 (en) 1982-08-04
PL139427B1 (en) 1987-01-31
PL139827B1 (en) 1987-02-28
PT73960A (en) 1981-12-01
ES521203A0 (es) 1984-06-01
PL139828B1 (en) 1987-02-28
HU188762B (en) 1986-05-28
SG62686G (en) 1987-03-27
ES521201A0 (es) 1984-06-01
IL64256A0 (en) 1982-02-28
PL139523B1 (en) 1987-01-31
PL233754A1 (en) 1983-08-01

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