KR870700637A - 사이클로스포린에 대한 단일클론성 항체 - Google Patents

사이클로스포린에 대한 단일클론성 항체

Info

Publication number
KR870700637A
KR870700637A KR1019860700333A KR860700333A KR870700637A KR 870700637 A KR870700637 A KR 870700637A KR 1019860700333 A KR1019860700333 A KR 1019860700333A KR 860700333 A KR860700333 A KR 860700333A KR 870700637 A KR870700637 A KR 870700637A
Authority
KR
South Korea
Prior art keywords
cyclosporin
cyclosporine
amino acid
acid residue
antibody
Prior art date
Application number
KR1019860700333A
Other languages
English (en)
Other versions
KR910002691B1 (ko
Inventor
로젠탈러 요아킴
벤거 로란드
에. 발 필립
하. 쉬라이어 막스
께스니오 발레리
Original Assignee
에안크라메르, 한스루돌프하우스
산도즈 아크티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848425040A external-priority patent/GB8425040D0/en
Priority claimed from GB858515673A external-priority patent/GB8515673D0/en
Application filed by 에안크라메르, 한스루돌프하우스, 산도즈 아크티엔게젤샤프트 filed Critical 에안크라메르, 한스루돌프하우스
Publication of KR870700637A publication Critical patent/KR870700637A/ko
Application granted granted Critical
Publication of KR910002691B1 publication Critical patent/KR910002691B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

사이클로스포린에 대한 단일클론성 항체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 사이클로스포린 및 이것의 대사산물을 식별할 수 있는 단일클론 성항체.
  2. 제1항에 의단일클론성 항체를 생성하는 하이브리도마 셀라인.
  3. a) 활성화된 커플링기를 포함하는 α-아미노산 잔류기를 지니며; b) 8-위치에서 유리 또는 보호된 형태의 치환된 (D)α-아미노산 잔류기를 지니며; C) 아실아미노치환체가 유리카르복시기에 의해 이것의 아실부중에서 치환된 아실아미노 치환 (D)α-아미노산잔류기를 지닌 사이클로스포린.
  4. 활성화된 커플링기의 작용에 의해 사이클로스포린에 커플화된 담체를 포함하는, 즉, 제3항 a)의 사이클로스포린에 커플화된 담체를 포함하는 면역원성 접합체.
  5. 제1항의 단일클론성 항체제조에 사용되는 면역원성 접합체.
  6. 5-, 6-, 7- 또는 8-위치에서 α-아미노산 잔류기를 통해 사이클로스포린에 커플화된 담체를 포함하는 면역원성 접합체.
  7. 사이클로스포린에 반응하는 다클론성 항혈청을 포함하여 제6항의 면역원성접합체에 응답하기 위해 생성된 사이클로스포린에 반응성인 항체.
  8. 8-위치에서 잔류기가-(D)Lys인 사이클로스포린의 라벨화된 유로체.
  9. 키트 또는 분석요소로서 A) 제6항의 항체 또는 항혈청; 또는 B) 제10항의 사이클로스포린의 라벨화된 유도체를 포함하는 사이클로스포린 분석을 위한 면역분석키트 또는 면역분석 시스템.
  10. 상술된 신규의 제조공정, 제조방법, 생성물, 제조방식 및 기타특징 또는 이것의 조합.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860700333A 1984-10-04 1986-06-03 사이클로스포린류를 함유하는 면역원성 복합체의 제조방법 및 그것을 이용한 모노클론항체의 제조 방법 KR910002691B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB848425040A GB8425040D0 (en) 1984-10-04 1984-10-04 Organic compounds
GB8425040 1984-10-04
GB25040 1984-10-04
GB8515673 1985-06-20
GB858515673A GB8515673D0 (en) 1985-06-20 1985-06-20 Organic compounds
GB15673 1985-06-20
PCT/EP1985/000501 WO1986002080A1 (en) 1984-10-04 1985-09-27 Monoclonal antibodies to cyclosporings

Publications (2)

Publication Number Publication Date
KR870700637A true KR870700637A (ko) 1987-12-30
KR910002691B1 KR910002691B1 (ko) 1991-05-03

Family

ID=26288301

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860700333A KR910002691B1 (ko) 1984-10-04 1986-06-03 사이클로스포린류를 함유하는 면역원성 복합체의 제조방법 및 그것을 이용한 모노클론항체의 제조 방법

Country Status (15)

Country Link
EP (4) EP0314861A1 (ko)
JP (1) JPH074269B2 (ko)
KR (1) KR910002691B1 (ko)
AT (1) ATE92501T1 (ko)
AU (4) AU589917B2 (ko)
CA (1) CA1309671C (ko)
CY (2) CY1915A (ko)
DE (2) DE3587342T2 (ko)
DK (1) DK172037B1 (ko)
ES (1) ES8702949A1 (ko)
FI (1) FI93965C (ko)
HK (2) HK78696A (ko)
NO (1) NO173557C (ko)
NZ (1) NZ213680A (ko)
WO (1) WO1986002080A1 (ko)

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GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
EP0473961B1 (en) * 1990-08-15 1996-01-03 Abbott Laboratories Immunoassay reagents and method for determining cyclosporine
CA2048302A1 (en) * 1990-08-15 1992-02-16 Victoria P. Meucci Solubilization reagent for biological test samples
ES2091301T3 (es) 1990-11-20 1996-11-01 Behringwerke Ag Inmunoensayo de ciclosporina.
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GB9307491D0 (en) 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
US6270957B1 (en) 1997-08-26 2001-08-07 Wisconsin Alumni Research Foundation Non-Imuunosuppressive cyclosporins and their use in the prevention and treatment of HIV infection
WO1999010373A1 (en) * 1997-08-26 1999-03-04 Wisconsin Alumni Research Foundation Non-immunosuppressive cyclosporins and their use in the prevention and treatment of hiv infection
US5990274A (en) * 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
USRE40987E1 (en) 1998-07-01 2009-11-17 Debiopharm S.A. Cyclosporin with improved activity profile
US6686454B1 (en) 1998-10-09 2004-02-03 Isotechnika, Inc. Antibodies to specific regions of cyclosporine related compounds
JP3595506B2 (ja) * 1998-10-09 2004-12-02 アイソテクニカ インコーポレイテッド シクロスポリンおよびシクロスポリン代謝産物の、特定領域に対する抗体の生産方法
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WO2012145426A1 (en) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Methods to treat cancer using cyclosporine and cyclosporine derivatives
US8906853B2 (en) 2012-11-28 2014-12-09 Enanta Pharmaceuticals, Inc. [N-Me-4-hydroxyleucine]-9-cyclosporin analogues for treatment and prevention of hepatitis C infection
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Also Published As

Publication number Publication date
FI862370A0 (fi) 1986-06-03
EP0198026B1 (en) 1993-08-04
JPS62500383A (ja) 1987-02-19
FI93965C (fi) 1995-06-26
CA1309671C (en) 1992-11-03
DE3587505D1 (de) 1993-09-09
NO173557C (no) 1993-12-29
FI93965B (fi) 1995-03-15
EP0290762B1 (en) 1993-05-12
NO862177D0 (no) 1986-06-02
JPH074269B2 (ja) 1995-01-25
DE3587342T2 (de) 1993-12-02
FI862370A (fi) 1986-06-03
EP0290762A1 (en) 1988-11-17
AU589917B2 (en) 1989-10-26
HK78696A (en) 1996-05-10
AU4967185A (en) 1986-04-17
DE3587505T2 (de) 1994-01-05
EP0314862A1 (en) 1989-05-10
KR910002691B1 (ko) 1991-05-03
AU3914189A (en) 1989-11-16
DK261386D0 (da) 1986-06-03
ATE92501T1 (de) 1993-08-15
WO1986002080A1 (en) 1986-04-10
HK124696A (en) 1996-07-19
EP0198026A1 (en) 1986-10-22
DK261386A (da) 1986-06-03
ES8702949A1 (es) 1987-01-16
NO173557B (no) 1993-09-20
DE3587342D1 (en) 1993-06-17
NO862177L (no) 1986-08-04
NZ213680A (en) 1990-05-28
CY1927A (en) 1997-05-16
EP0314861A1 (en) 1989-05-10
AU3914289A (en) 1989-10-26
CY1915A (en) 1985-09-27
ES547495A0 (es) 1987-01-16
DK172037B1 (da) 1997-09-22
AU3914389A (en) 1989-11-16

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