ATE92501T1 - Monoklonale antikoerper gegen zyklosporine. - Google Patents

Monoklonale antikoerper gegen zyklosporine.

Info

Publication number
ATE92501T1
ATE92501T1 AT85905210T AT85905210T ATE92501T1 AT E92501 T1 ATE92501 T1 AT E92501T1 AT 85905210 T AT85905210 T AT 85905210T AT 85905210 T AT85905210 T AT 85905210T AT E92501 T1 ATE92501 T1 AT E92501T1
Authority
AT
Austria
Prior art keywords
cyclosporins
monoclonal antibodies
cyclosporine
antibodies against
succinimidooxysuccinyl
Prior art date
Application number
AT85905210T
Other languages
English (en)
Inventor
Joachim Rosenthaler
Roland Wenger
Philipp E Ball
Max H Schreier
Valerie Quesniaux
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848425040A external-priority patent/GB8425040D0/en
Priority claimed from GB858515673A external-priority patent/GB8515673D0/en
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE92501T1 publication Critical patent/ATE92501T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
AT85905210T 1984-10-04 1985-09-27 Monoklonale antikoerper gegen zyklosporine. ATE92501T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB848425040A GB8425040D0 (en) 1984-10-04 1984-10-04 Organic compounds
GB858515673A GB8515673D0 (en) 1985-06-20 1985-06-20 Organic compounds
PCT/EP1985/000501 WO1986002080A1 (en) 1984-10-04 1985-09-27 Monoclonal antibodies to cyclosporings
EP85905210A EP0198026B1 (de) 1984-10-04 1985-09-27 Monoklonale antikörper gegen zyklosporine

Publications (1)

Publication Number Publication Date
ATE92501T1 true ATE92501T1 (de) 1993-08-15

Family

ID=26288301

Family Applications (1)

Application Number Title Priority Date Filing Date
AT85905210T ATE92501T1 (de) 1984-10-04 1985-09-27 Monoklonale antikoerper gegen zyklosporine.

Country Status (15)

Country Link
EP (4) EP0198026B1 (de)
JP (1) JPH074269B2 (de)
KR (1) KR910002691B1 (de)
AT (1) ATE92501T1 (de)
AU (4) AU589917B2 (de)
CA (1) CA1309671C (de)
CY (2) CY1915A (de)
DE (2) DE3587342T2 (de)
DK (1) DK172037B1 (de)
ES (1) ES8702949A1 (de)
FI (1) FI93965C (de)
HK (2) HK78696A (de)
NO (1) NO173557C (de)
NZ (1) NZ213680A (de)
WO (1) WO1986002080A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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EP0283801A3 (de) * 1987-03-27 1990-05-30 Abbott Laboratories Fluoreszenz-Polarisations-Test für Cyclosporin A und Metaboliten und verwandte Immunogene und Antikörper
US5427960A (en) * 1987-03-27 1995-06-27 Abbott Laboratories Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies
US5239057A (en) * 1987-03-27 1993-08-24 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
US5698448A (en) * 1988-12-02 1997-12-16 Soldin; Steven J. Immunosuppressive drug binding proteins and use
JPH04502328A (ja) * 1988-12-05 1992-04-23 ザ・トラステイーズ・オブ・コロンビア・ユニヴアーシテイ・イン・ザ・シテイ・オブ・ニユー・ヨーク シクロスポリンａの新規誘導体、それに対する抗体及びその使用
GB8916901D0 (en) 1989-07-24 1989-09-06 Sandoz Ltd Improvements in or relating to organic compounds
ES2084069T3 (es) * 1990-08-15 1996-05-01 Abbott Lab Reactivos de inmunoensayo y metodo para la determinacion de ciclosporina.
CA2048302A1 (en) * 1990-08-15 1992-02-16 Victoria P. Meucci Solubilization reagent for biological test samples
ATE142344T1 (de) * 1990-11-20 1996-09-15 Behringwerke Ag Immunotest für cyclosporin
USRE40596E1 (en) * 1993-04-08 2008-12-02 Novartis Ag Rapamycin assay
GB9307491D0 (en) 1993-04-08 1993-06-02 Sandoz Ltd Organic compounds
US6270957B1 (en) 1997-08-26 2001-08-07 Wisconsin Alumni Research Foundation Non-Imuunosuppressive cyclosporins and their use in the prevention and treatment of HIV infection
AU9203898A (en) * 1997-08-26 1999-03-16 Wisconsin Alumni Research Foundation Cyclosporin a conjugates and uses therefor
US20030220234A1 (en) 1998-11-02 2003-11-27 Selvaraj Naicker Deuterated cyclosporine analogs and their use as immunodulating agents
US5990274A (en) * 1997-11-25 1999-11-23 Dade Behring Inc. Cyclosporine derivatives and uses thereof
USRE40987E1 (en) 1998-07-01 2009-11-17 Debiopharm S.A. Cyclosporin with improved activity profile
US6686454B1 (en) 1998-10-09 2004-02-03 Isotechnika, Inc. Antibodies to specific regions of cyclosporine related compounds
JP3595506B2 (ja) * 1998-10-09 2004-12-02 アイソテクニカ インコーポレイテッド シクロスポリンおよびシクロスポリン代謝産物の、特定領域に対する抗体の生産方法
RU2207870C2 (ru) * 2000-11-10 2003-07-10 Панацея Биотек Лимитед Фармацевтическая композиция, включающая циклоспорин в качестве активного ингредиента
ATE332917T1 (de) 2001-10-19 2006-08-15 Isotechnika Inc Synthese von cyclosporin-analogen
ATE535813T1 (de) 2007-05-24 2011-12-15 Abbott Lab Reduzierte kreuzreaktivität mit hydrophoben arzneistoffanalyt-stoffwechselprodukten zeigende immuntestverfahren
TW200932240A (en) 2007-10-25 2009-08-01 Astellas Pharma Inc Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production
KR101975843B1 (ko) * 2008-05-23 2019-05-09 더 유니버시티 오브 브리티쉬 콜롬비아 리포좀 나노입자에 사용하기 위한 변형된 약물
AU2010208071C1 (en) 2009-01-30 2013-06-20 Enanta Pharmaceuticals, Inc. Cyclosporin analogues for preventing or treating hepatitis C infection
US8481483B2 (en) 2009-02-19 2013-07-09 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8685917B2 (en) 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8623814B2 (en) 2010-02-23 2014-01-07 Enanta Pharmaceuticals, Inc. Antiviral agents
US9428845B1 (en) 2010-12-28 2016-08-30 Warp Drive Bio, Inc. Identifying new therapeutic agents
WO2012145426A1 (en) 2011-04-18 2012-10-26 The Trustees Of Columbia University In The City Of New York Methods to treat cancer using cyclosporine and cyclosporine derivatives
WO2014085623A1 (en) 2012-11-28 2014-06-05 Enanta Pharmaceuticals, Inc. Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues
SG11201601274QA (en) 2013-08-26 2016-03-30 Enanta Pharm Inc Cyclosporin analogues for preventing or treating hepatitis c
WO2016073480A1 (en) 2014-11-03 2016-05-12 Enanta Pharmaceuticals, Inc. Novel cyclosporin analogues for preventing or treating hepatitis c infection
US10533016B2 (en) 2015-01-09 2020-01-14 Revolution Medicines, Inc. Compounds that participate in cooperative binding and uses thereof
US9989535B2 (en) * 2015-10-01 2018-06-05 Warp Drive Bio, Inc. Methods and reagents for analyzing protein-protein interfaces
CN109641062A (zh) 2016-04-12 2019-04-16 华普卓威生物公司 用于产生化合物的组合物和方法
KR20190099396A (ko) 2016-10-28 2019-08-27 징코 바이오웍스, 인크. 화합물의 생산을 위한 조성물 및 방법
US11739074B2 (en) 2019-11-04 2023-08-29 Revolution Medicines, Inc. Ras inhibitors
CR20220241A (es) 2019-11-04 2022-08-03 Revolution Medicines Inc Inhibidores de ras
BR112022008535A2 (pt) 2019-11-04 2022-08-09 Revolution Medicines Inc Composto, composição farmacêutica, métodos para tratar câncer e um distúrbio relativo à proteína ras
US11690915B2 (en) 2020-09-15 2023-07-04 Revolution Medicines, Inc. Ras inhibitors
EP4334325A1 (de) 2021-05-05 2024-03-13 Revolution Medicines, Inc. Ras-hemmer zur behandlung von krebs
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB211526A (en) 1922-09-22 1924-02-22 John Fletcher Holliday Improvements in and relating to chain grate stokers
US4210581A (en) 1975-11-04 1980-07-01 Sandoz Ltd. Organic compounds
CH614931A5 (de) 1975-11-04 1979-12-28 Sandoz Ag
DE2819094A1 (de) 1977-05-10 1978-11-23 Sandoz Ag Cyclosporin-derivate, ihre verwendung und herstellung
EP0098456B1 (de) 1980-02-14 1989-05-24 Sandoz Ag Peptide die einen (1S,2R,3R)- oder (1R,2S,3S)-1-Nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder -hept-5-en-Rest enthalten brauchbar in totaler Synsthese von Cyclosporinen, und Verfahren zu ihrer Herstellung
IL62965A0 (en) 1980-07-17 1981-07-31 Scripps Miles Lab Inc Monoclonal antibodies to drugs and theri production
DE3260468D1 (en) * 1981-01-09 1984-09-06 Sandoz Ag Novel cyclosporins
CH667274A5 (de) 1984-03-23 1988-09-30 Sandoz Ag Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
GB8407618D0 (en) 1984-03-23 1984-05-02 Sandoz Ltd Organic compounds

Also Published As

Publication number Publication date
NO862177D0 (no) 1986-06-02
KR910002691B1 (ko) 1991-05-03
EP0314861A1 (de) 1989-05-10
ES8702949A1 (es) 1987-01-16
HK78696A (en) 1996-05-10
NO173557B (no) 1993-09-20
NO173557C (no) 1993-12-29
NO862177L (no) 1986-08-04
AU589917B2 (en) 1989-10-26
DK261386A (da) 1986-06-03
CY1927A (en) 1997-05-16
FI862370A0 (fi) 1986-06-03
HK124696A (en) 1996-07-19
AU4967185A (en) 1986-04-17
JPH074269B2 (ja) 1995-01-25
DK172037B1 (da) 1997-09-22
EP0198026A1 (de) 1986-10-22
FI862370A7 (fi) 1986-06-03
DE3587505T2 (de) 1994-01-05
FI93965B (fi) 1995-03-15
DE3587505D1 (de) 1993-09-09
AU3914389A (en) 1989-11-16
AU3914189A (en) 1989-11-16
AU3914289A (en) 1989-10-26
CY1915A (en) 1985-09-27
KR870700637A (ko) 1987-12-30
CA1309671C (en) 1992-11-03
FI93965C (fi) 1995-06-26
JPS62500383A (ja) 1987-02-19
ES547495A0 (es) 1987-01-16
DE3587342D1 (en) 1993-06-17
EP0198026B1 (de) 1993-08-04
EP0290762A1 (de) 1988-11-17
EP0314862A1 (de) 1989-05-10
DK261386D0 (da) 1986-06-03
WO1986002080A1 (en) 1986-04-10
DE3587342T2 (de) 1993-12-02
NZ213680A (en) 1990-05-28
EP0290762B1 (de) 1993-05-12

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEFA Change of the company name
EELA Cancelled due to lapse of time