ES8702949A1 - Procedimiento para la produccion de anticuerpos monoclonales a ciclosporinas. - Google Patents
Procedimiento para la produccion de anticuerpos monoclonales a ciclosporinas.Info
- Publication number
- ES8702949A1 ES8702949A1 ES547495A ES547495A ES8702949A1 ES 8702949 A1 ES8702949 A1 ES 8702949A1 ES 547495 A ES547495 A ES 547495A ES 547495 A ES547495 A ES 547495A ES 8702949 A1 ES8702949 A1 ES 8702949A1
- Authority
- ES
- Spain
- Prior art keywords
- cyclosporine
- cyclosporins
- monoclonal antibodies
- cyclosporings
- succinimidooxysuccinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Cephalosporin Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE ANTICUERPOS MONOCLONALES A CICLOSPORINAS. COMPRENDE LAS SIGUIENTES ETAPAS: A) CULTIVAR UNA LINEA DE CELULAS HIBRIDOMAS PRODUCTORAS DEL ANTICUERPO MONOCLONAL; Y B) RECUPERAR EL ANTICUERPO ASI OBTENIDO; DONDE ESTOS ANTICUERPOS SON CAPACES DE DISTINGUIR ENTRE UNA CICLOSPORINA PREDETERMINADA, TAL COMO CYCLOSPORINE, DIHIDRO-VAL2-CYCLOSPORINE O NVA2-CYCLOSPORINE, Y UN METABOLITO DE LA MISMA, TAL COMO AL MENOS UN METABOLITO DE LA MISMA EN EL HOMBRE, TAL COMO, EN EL CASO DE CYCLOSPORINE, EL METABOLITO CYCLOSPORINE 1, 8, 9, 10, 16, 17, 18 O 21, Y, EN PARTICULAR, 17. TIENE UTILIDAD EN KITS O SISTEMAS DE DIAGNOSTICO/ANALISIS, ASI COMO CON NUEVAS LINEAS DE CELULAS HIBRIDOMAS UTILIZADAS EN LA PRODUCCION DE DICHOS ANTICUERPOS MONOCLONALES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848425040A GB8425040D0 (en) | 1984-10-04 | 1984-10-04 | Organic compounds |
GB858515673A GB8515673D0 (en) | 1985-06-20 | 1985-06-20 | Organic compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8702949A1 true ES8702949A1 (es) | 1987-01-16 |
ES547495A0 ES547495A0 (es) | 1987-01-16 |
Family
ID=26288301
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES547495A Expired ES8702949A1 (es) | 1984-10-04 | 1985-10-02 | Procedimiento para la produccion de anticuerpos monoclonales a ciclosporinas. |
Country Status (15)
Country | Link |
---|---|
EP (4) | EP0314862A1 (es) |
JP (1) | JPH074269B2 (es) |
KR (1) | KR910002691B1 (es) |
AT (1) | ATE92501T1 (es) |
AU (4) | AU589917B2 (es) |
CA (1) | CA1309671C (es) |
CY (2) | CY1915A (es) |
DE (2) | DE3587342T2 (es) |
DK (1) | DK172037B1 (es) |
ES (1) | ES8702949A1 (es) |
FI (1) | FI93965C (es) |
HK (2) | HK78696A (es) |
NO (1) | NO173557C (es) |
NZ (1) | NZ213680A (es) |
WO (1) | WO1986002080A1 (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0283801A3 (en) * | 1987-03-27 | 1990-05-30 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
US5239057A (en) * | 1987-03-27 | 1993-08-24 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies |
US5427960A (en) * | 1987-03-27 | 1995-06-27 | Abbott Laboratories | Fluorescence polarization assay for cyclosporin A and metabolites and related immunogens and antibodies |
US5698448A (en) * | 1988-12-02 | 1997-12-16 | Soldin; Steven J. | Immunosuppressive drug binding proteins and use |
AU4958590A (en) * | 1988-12-05 | 1990-07-10 | Trustees Of Columbia University In The City Of New York, The | Novel derivatives of cyclosporine a, antibodies directed thereto and uses thereof |
GB8916901D0 (en) | 1989-07-24 | 1989-09-06 | Sandoz Ltd | Improvements in or relating to organic compounds |
CA2048302A1 (en) * | 1990-08-15 | 1992-02-16 | Victoria P. Meucci | Solubilization reagent for biological test samples |
EP0473961B1 (en) * | 1990-08-15 | 1996-01-03 | Abbott Laboratories | Immunoassay reagents and method for determining cyclosporine |
ES2091301T3 (es) | 1990-11-20 | 1996-11-01 | Behringwerke Ag | Inmunoensayo de ciclosporina. |
USRE40596E1 (en) * | 1993-04-08 | 2008-12-02 | Novartis Ag | Rapamycin assay |
GB9307491D0 (en) | 1993-04-08 | 1993-06-02 | Sandoz Ltd | Organic compounds |
AU8918998A (en) | 1997-08-26 | 1999-03-16 | Wisconsin Alumni Research Foundation | Non-immunosuppressive cyclosporins and their use in the prevention and treatmentof hiv infection |
US6270957B1 (en) | 1997-08-26 | 2001-08-07 | Wisconsin Alumni Research Foundation | Non-Imuunosuppressive cyclosporins and their use in the prevention and treatment of HIV infection |
US5990274A (en) * | 1997-11-25 | 1999-11-23 | Dade Behring Inc. | Cyclosporine derivatives and uses thereof |
ATE312843T1 (de) | 1998-07-01 | 2005-12-15 | Debiopharm Sa | Neues cyclosporin mit verbesserter wirkung |
US6686454B1 (en) | 1998-10-09 | 2004-02-03 | Isotechnika, Inc. | Antibodies to specific regions of cyclosporine related compounds |
CN1319105A (zh) | 1998-10-09 | 2001-10-24 | 伊索技术公司 | 制备针对环孢菌素及其代谢物特异性区域的抗体的方法 |
WO2003033526A2 (en) | 2001-10-19 | 2003-04-24 | Isotechnika Inc. | Synthesis of cyclosporin analogs |
EP2174137B1 (en) | 2007-05-24 | 2011-11-30 | Abbott Laboratories | Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites |
TW200932240A (en) | 2007-10-25 | 2009-08-01 | Astellas Pharma Inc | Pharmaceutical composition containing lipophilic substance which inhibits IL-2 production |
WO2009141738A2 (en) * | 2008-05-23 | 2009-11-26 | The University Of British Columbia | Modified drugs for use in liposomal nanoparticles |
EP2391376A4 (en) | 2009-01-30 | 2012-08-01 | Enanta Pharm Inc | ANALOGUES OF CYCLOSPORIN FOR PREVENTING OR TREATING HEPATITIS C INFECTION |
US8481483B2 (en) | 2009-02-19 | 2013-07-09 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
US8367053B2 (en) | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
US8349312B2 (en) | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
US8685917B2 (en) | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
US8623814B2 (en) | 2010-02-23 | 2014-01-07 | Enanta Pharmaceuticals, Inc. | Antiviral agents |
US9428845B1 (en) | 2010-12-28 | 2016-08-30 | Warp Drive Bio, Inc. | Identifying new therapeutic agents |
WO2012145426A1 (en) | 2011-04-18 | 2012-10-26 | The Trustees Of Columbia University In The City Of New York | Methods to treat cancer using cyclosporine and cyclosporine derivatives |
WO2014085623A1 (en) | 2012-11-28 | 2014-06-05 | Enanta Pharmaceuticals, Inc. | Novel [n-me-4-hydroxyleucine]-9-cyclosporin analogues |
CN105579046A (zh) | 2013-08-26 | 2016-05-11 | 英安塔制药有限公司 | 用于预防或治疗丙型肝炎的环孢菌素类似物 |
US9669095B2 (en) | 2014-11-03 | 2017-06-06 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues for preventing or treating hepatitis C infection |
EP3247378B8 (en) | 2015-01-09 | 2023-08-23 | Revolution Medicines, Inc. | Macrocyclic compounds that participate in cooperative binding and medical uses thereof |
JP7411326B2 (ja) | 2015-10-01 | 2024-01-11 | ワープ ドライブ バイオ インコーポレイテッド | タンパク質-タンパク質インターフェースを分析するための方法および試薬 |
ES2921056T3 (es) | 2016-04-12 | 2022-08-17 | Warp Drive Bio Inc | Composiciones y métodos para la producción de compuestos |
CA3042231A1 (en) | 2016-10-28 | 2018-05-03 | Ginkgo Bioworks, Inc. | Compositions and methods for the production of compounds |
AU2020379731A1 (en) | 2019-11-04 | 2022-05-05 | Revolution Medicines, Inc. | Ras inhibitors |
EP4055028A1 (en) | 2019-11-04 | 2022-09-14 | Revolution Medicines, Inc. | Ras inhibitors |
MX2022005359A (es) | 2019-11-04 | 2022-06-02 | Revolution Medicines Inc | Inhibidores de ras. |
KR20230067635A (ko) | 2020-09-15 | 2023-05-16 | 레볼루션 메디슨즈, 인크. | 암의 치료에서 ras 억제제로서 인돌 유도체 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB211526A (en) | 1922-09-22 | 1924-02-22 | John Fletcher Holliday | Improvements in and relating to chain grate stokers |
US4210581A (en) | 1975-11-04 | 1980-07-01 | Sandoz Ltd. | Organic compounds |
CH614931A5 (es) | 1975-11-04 | 1979-12-28 | Sandoz Ag | |
DE2819094A1 (de) | 1977-05-10 | 1978-11-23 | Sandoz Ag | Cyclosporin-derivate, ihre verwendung und herstellung |
EP0098457B1 (en) | 1980-02-14 | 1987-08-05 | Sandoz Ag | (1s,2r,3r)- and (1r,2s,3s)-nitrilo-1-carbonyl-3-methyl-2-oxy-heptanes and -hept-5-enes useful in the total synthesis of cyclosporins and processes for their production |
IL62965A0 (en) | 1980-07-17 | 1981-07-31 | Scripps Miles Lab Inc | Monoclonal antibodies to drugs and theri production |
EP0056782B1 (en) | 1981-01-09 | 1984-08-01 | Sandoz Ag | Novel cyclosporins |
GB8407618D0 (en) | 1984-03-23 | 1984-05-02 | Sandoz Ltd | Organic compounds |
CH667274A5 (de) | 1984-03-23 | 1988-09-30 | Sandoz Ag | Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen. |
-
1985
- 1985-09-27 AT AT85905210T patent/ATE92501T1/de not_active IP Right Cessation
- 1985-09-27 JP JP60504679A patent/JPH074269B2/ja not_active Expired - Lifetime
- 1985-09-27 EP EP88104792A patent/EP0314862A1/en not_active Withdrawn
- 1985-09-27 AU AU49671/85A patent/AU589917B2/en not_active Expired
- 1985-09-27 DE DE88104793T patent/DE3587342T2/de not_active Expired - Lifetime
- 1985-09-27 CY CY191585A patent/CY1915A/xx unknown
- 1985-09-27 WO PCT/EP1985/000501 patent/WO1986002080A1/en active IP Right Grant
- 1985-09-27 DE DE85905210T patent/DE3587505T2/de not_active Expired - Lifetime
- 1985-09-27 EP EP85905210A patent/EP0198026B1/en not_active Expired - Lifetime
- 1985-09-27 EP EP88104791A patent/EP0314861A1/en not_active Ceased
- 1985-09-27 EP EP88104793A patent/EP0290762B1/en not_active Expired - Lifetime
- 1985-10-02 NZ NZ213680A patent/NZ213680A/xx unknown
- 1985-10-02 CA CA000492047A patent/CA1309671C/en not_active Expired - Lifetime
- 1985-10-02 ES ES547495A patent/ES8702949A1/es not_active Expired
-
1986
- 1986-06-02 NO NO862177A patent/NO173557C/no not_active IP Right Cessation
- 1986-06-03 FI FI862370A patent/FI93965C/fi not_active IP Right Cessation
- 1986-06-03 KR KR1019860700333A patent/KR910002691B1/ko not_active IP Right Cessation
- 1986-06-03 DK DK261386A patent/DK172037B1/da not_active IP Right Cessation
-
1989
- 1989-07-31 AU AU39141/89A patent/AU3914189A/en not_active Abandoned
- 1989-07-31 AU AU39142/89A patent/AU3914289A/en not_active Abandoned
- 1989-07-31 AU AU39143/89A patent/AU3914389A/en not_active Abandoned
-
1996
- 1996-05-02 HK HK78696A patent/HK78696A/xx not_active IP Right Cessation
- 1996-07-11 HK HK124696A patent/HK124696A/xx not_active IP Right Cessation
-
1997
- 1997-05-16 CY CY192797A patent/CY1927A/xx unknown
Also Published As
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC1A | Transfer granted | ||
FD1A | Patent lapsed |
Effective date: 20061120 |