WO1995000552B1 - Prostaglandin receptor ep3 and dna encoding it - Google Patents

Prostaglandin receptor ep3 and dna encoding it

Info

Publication number
WO1995000552B1
WO1995000552B1 PCT/CA1994/000320 CA9400320W WO9500552B1 WO 1995000552 B1 WO1995000552 B1 WO 1995000552B1 CA 9400320 W CA9400320 W CA 9400320W WO 9500552 B1 WO9500552 B1 WO 9500552B1
Authority
WO
WIPO (PCT)
Prior art keywords
prostaglandin
receptor
dna encoding
seq
isolated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CA1994/000320
Other languages
French (fr)
Other versions
WO1995000552A1 (en
Filing date
Publication date
Application filed filed Critical
Priority to DE69414109T priority Critical patent/DE69414109T2/en
Priority to CA002165953A priority patent/CA2165953C/en
Priority to EP94918700A priority patent/EP0705277B1/en
Priority to DK94918700T priority patent/DK0705277T3/en
Priority to JP50227095A priority patent/JP3343258B2/en
Priority to AU69919/94A priority patent/AU6991994A/en
Publication of WO1995000552A1 publication Critical patent/WO1995000552A1/en
Publication of WO1995000552B1 publication Critical patent/WO1995000552B1/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Abstract

A novel prostaglandin receptor group of the EP3 subtype has been identified and DNA encoding the receptor has been isolated, purified, sequenced and expressed in host cells. DNA encoding the novel prostaglandin receptors and host cells expressing the receptors are used to identify modulators of the prostaglandin receptors.

Claims

AMENDEDCLAIMS [received by the International Bureau on 4 January 1995 (04.01.95); original claim 1 amended; remaining claims unchanged (1 page)]
1. An isolated and purified human prostaglandin EP3 receptor wherein said receptor specifically binds prostaglandin.
2. The isolated and purified prostaglandin receptor protein of Claim 1 wherein said protein is characterized by an amino acid sequence selected from the group consisting of:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNL TRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTWGLSSLFIASAMAVERALAIRAPHWY ASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTS SSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTΕKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQV
RYHTNNYASSSTSLPCQCSSTLMWSDHLER (SEQ.ID.No .: 10);
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLIVSRSYRRRES KRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQE
ANAVSSCSNDGQKGQPISLSNEIIQTEA (SEQ.ID.NO.: 11); and
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTG
FVGNALAMLLVSRSYRRRES KRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDP
SGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLA
FALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNL
ATIKLALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVE
HCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIEFWGN
(SEQ.ID.NO.: 12).
PCT/CA1994/000320 1993-06-25 1994-06-09 Prostaglandin receptor ep3 and dna encoding it Ceased WO1995000552A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE69414109T DE69414109T2 (en) 1993-06-25 1994-06-09 PROSTAGLANDIN RECEPTOR EP3 AND ENCODING DNA
CA002165953A CA2165953C (en) 1993-06-25 1994-06-09 Prostaglandin receptor ep3 and dna encoding it
EP94918700A EP0705277B1 (en) 1993-06-25 1994-06-09 Prostaglandin receptor ep3 and dna encoding it
DK94918700T DK0705277T3 (en) 1993-06-25 1994-06-09 Prostaglandin receptor EP3 and DNA encoding it
JP50227095A JP3343258B2 (en) 1993-06-25 1994-06-09 Prostaglandin receptor EP (3) and DNA encoding the receptor
AU69919/94A AU6991994A (en) 1993-06-25 1994-06-09 Prostaglandin receptor ep3 and dna encoding it

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8374693A 1993-06-25 1993-06-25
US083,746 1993-06-25

Publications (2)

Publication Number Publication Date
WO1995000552A1 WO1995000552A1 (en) 1995-01-05
WO1995000552B1 true WO1995000552B1 (en) 1995-02-02

Family

ID=22180426

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1994/000320 Ceased WO1995000552A1 (en) 1993-06-25 1994-06-09 Prostaglandin receptor ep3 and dna encoding it

Country Status (9)

Country Link
EP (1) EP0705277B1 (en)
JP (1) JP3343258B2 (en)
AT (1) ATE172471T1 (en)
AU (1) AU6991994A (en)
CA (1) CA2165953C (en)
DE (1) DE69414109T2 (en)
DK (1) DK0705277T3 (en)
ES (1) ES2122291T3 (en)
WO (1) WO1995000552A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
USRE43372E1 (en) 1999-03-05 2012-05-08 Duke University C16 unsaturated FP-selective prostaglandins analogs
US8906962B2 (en) 2000-03-31 2014-12-09 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US9346837B2 (en) 2000-03-31 2016-05-24 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6670134B1 (en) 1993-11-19 2003-12-30 Allergan, Inc. Human EP3 prostaglandin receptor
US6057433A (en) 1993-11-19 2000-05-02 Allergan Sales, Inc. Nucleic acid encoding human EP3 prostaglandin receptor
CA2211204C (en) 1995-01-26 2003-10-07 Merck Frosst Canada Inc. Prostaglandin receptor dp
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20030157599A1 (en) * 2002-01-30 2003-08-21 Decode Genetics Ehf Gene for peripheral arterial occlusive disease
WO2004074830A2 (en) * 2003-02-24 2004-09-02 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep3 iii (prostaglandin e2 ep3 iii)
WO2004075814A2 (en) * 2003-02-26 2004-09-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep3 i (prostaglandin e2 ep3 i)
WO2004075813A2 (en) * 2003-02-26 2004-09-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g-protein coupled receptor prostaglandin e2 ep3 ii (prostaglandin e2 ep3 ii)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3508865B2 (en) * 1992-02-24 2004-03-22 周 成宮 Prostaglandin E receptor protein, DNA encoding the same and method for producing the same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43372E1 (en) 1999-03-05 2012-05-08 Duke University C16 unsaturated FP-selective prostaglandins analogs
US6894175B1 (en) 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
US8906962B2 (en) 2000-03-31 2014-12-09 Duke University Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US9346837B2 (en) 2000-03-31 2016-05-24 Duke University Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives

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