WO1995009872B1 - Dna encoding prostaglandin receptor ip - Google Patents
Dna encoding prostaglandin receptor ipInfo
- Publication number
- WO1995009872B1 WO1995009872B1 PCT/CA1994/000548 CA9400548W WO9509872B1 WO 1995009872 B1 WO1995009872 B1 WO 1995009872B1 CA 9400548 W CA9400548 W CA 9400548W WO 9509872 B1 WO9509872 B1 WO 9509872B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptor
- protein
- prostaglandin
- isolated
- prostaglandin receptor
- Prior art date
Links
- 108010050183 Prostaglandin Receptors Proteins 0.000 title claims abstract 9
- 102000015433 Prostaglandin Receptors Human genes 0.000 title claims abstract 9
- 229920003013 deoxyribonucleic acid Polymers 0.000 title claims abstract 6
- 108020003175 receptors Proteins 0.000 claims abstract 4
- 102000005962 receptors Human genes 0.000 claims abstract 4
- 230000000051 modifying Effects 0.000 claims abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 150000003180 prostaglandins Chemical class 0.000 claims 2
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 1
- 108091006303 Prostaglandin I receptors Proteins 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
Abstract
A novel prostaglandin receptor has been identified and DNA encoding the receptor has been isolated, purified, sequenced and expressed in host cells. This DNA encoding the novel prostaglandin receptor and host cells expressing the receptor are used to identify modulators of the prostaglandin receptor.
Claims
AMENDED CLAIMS
[received by the International Bureau on 4 April 1995 (04.04.95); original claims 1 and 9 amended; remaining claims unchanged (2 pages)]
1). An isolated and purified human prostaglandin IP receptor wherein said receptor specifically binds prostaglandin.
2). The isolated and purified prostaglandin receptor protein of Claim 1 wherein said protein is characterized by the amino acid sequence
MADSCR LTYVRGSVGPATSTLMFVAGWGNGLALGILSARRPARPSAFAV LVTGLAATDL GTSFLSPAVFVAYARNSSLLG ARGGPALCDAFAFAMTFF GLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCA PLLGLGQHQQYCPGS CFLRMR AQPGGAAFSLAYAGLVALLVAAIFLCNG SVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTWMAVCSLPL TIRCFTQAVAPDSSSEMGDLLAFRFYAFNPI DPWVFILFRKAVFQRLKLW VCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSA GEGQV EPLPPTQQSSGSAVGTSSKAEASVACSLC (SEQ.ID.NO.: 3).
3). An isolated and purified DNA molecule encoding a prostaglandin receptor protein wherein said protein is characterized by the amino acid sequence of Claim 2.
4). An isolated and purified DNA molecule encoding a prostaglandin receptor protein wherein said DNA molecule is characterized by the nucleotide sequence
5 GGCACAGACGCACGGGACAGGAGAGCCTGGGCAAGACTGGAGAGCCCAGAC CTGGGATGGCGGATTCGTGCAGGAACCTCACCTACGTGCGGGGCTCGGTGG GGCCGGCCACCAGCACCCTGATGTTCGTGGCCGGTGTGGTGGGCAACGGGC TGGCCCTGGGCATCCTGAGCGCACGGCGACCGGCGCGCCCCTCGGCCTTCG CGGTGCTGGTCACCGGACTGGCGGCCACCGACCTGCTGGGCACCAGCTTCC TGAGCCCGGCCGTGTTCGTGGCCTATGCGCGCAACAGCTCCCTGCTGGGCC o TGGCCCGAGGCGGCCCCGCCCTGTGCGATGCCTTCGCCTTCGCCATGACCT TCTTCGGCCTGGCGTCCATGCTCATCCTCTTTGCCATGGCCGTGGAGCGCT GCCTGGCGCTGAGCCACCCCTACCTCTACGCGCAGCTGGACGGGCCCCGCT GCGCCCGCCTGGCGCTGCCAGCCATCTACGCCTTCTGCGTCCTCTTCTGCG CGCTGCCCCTGCTGGGCCTGGGCCAACACCAGCAGTACTGCCCCGGCAGCT GGTGCTTCCTCCGCATGCGCTGGGCCCAGCCGGGCGGCGCCGCCTTCTCGC TGGCCTACGCCGGCCTGGTGGCCCTGCTGGTGGCTGCCATCTTCCTCTGCA
receptor is characterized by the amino acid sequence of Claim 2 in whole or in part; and (b) measuring the effect of a modulator on the prostaglandin receptor.
9). An antibody which specifically binds to a prostaglandin receptor protein wherein said protein is characterized by the amino acid sequence of Claim 2.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94928741A EP0722462B1 (en) | 1993-10-06 | 1994-10-03 | Dna encoding prostaglandin receptor ip |
| AT94928741T ATE236932T1 (en) | 1993-10-06 | 1994-10-03 | DNA CODING FOR PROSTAGLANDIN RECEPTOR IP |
| JP7510528A JP3029125B2 (en) | 1993-10-06 | 1994-10-03 | DNA encoding prostaglandin receptor IP |
| DE69432470T DE69432470T2 (en) | 1993-10-06 | 1994-10-03 | DNA CODING FOR PROSTAGLANDIN RECEPTOR IP |
| CA002173595A CA2173595C (en) | 1993-10-06 | 1994-10-03 | Dna encoding prostaglandin receptor ip |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/134,012 US5516652A (en) | 1993-10-06 | 1993-10-06 | DNA encoding prostaglandin receptor IP |
| US08/134,012 | 1993-10-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1995009872A1 WO1995009872A1 (en) | 1995-04-13 |
| WO1995009872B1 true WO1995009872B1 (en) | 1995-05-04 |
Family
ID=22461361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/CA1994/000548 WO1995009872A1 (en) | 1993-10-06 | 1994-10-03 | Dna encoding prostaglandin receptor ip |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5516652A (en) |
| EP (1) | EP0722462B1 (en) |
| JP (1) | JP3029125B2 (en) |
| AT (1) | ATE236932T1 (en) |
| CA (1) | CA2173595C (en) |
| DE (1) | DE69432470T2 (en) |
| ES (1) | ES2192561T3 (en) |
| WO (1) | WO1995009872A1 (en) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3692536B2 (en) * | 1994-02-10 | 2005-09-07 | 小野薬品工業株式会社 | Prostaglandin I2 receptor |
| US6395878B1 (en) * | 1994-05-05 | 2002-05-28 | Allergan Sales, Inc. | Nucleic acid encoding a human EP prostaglandin receptor |
| EP0812353A2 (en) | 1995-01-26 | 1997-12-17 | Merck Frosst Canada Inc. | Prostaglandin receptor dp |
| MXPA01008955A (en) | 1999-03-05 | 2002-04-24 | Procter & Gamble | C16. |
| US6894175B1 (en) * | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
| US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
| US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
| US20020146439A1 (en) * | 2000-03-31 | 2002-10-10 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins |
| US20020037914A1 (en) * | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
| US6673760B1 (en) * | 2000-06-29 | 2004-01-06 | Ecolab Inc. | Rinse agent composition and method for rinsing a substrate surface |
| WO2003062393A2 (en) * | 2002-01-22 | 2003-07-31 | Bristol-Myers Squibb Company | G protein-coupled receptor variants |
| DE10229872A1 (en) * | 2002-07-03 | 2004-01-29 | Curevac Gmbh | Immune stimulation through chemically modified RNA |
| WO2004071508A1 (en) * | 2003-02-14 | 2004-08-26 | Medical Research Council | Ip receptor antagonists for the treatment of pathological uterine conditions |
| DE102006035618A1 (en) * | 2006-07-31 | 2008-02-07 | Curevac Gmbh | New nucleic acid useful as immuno-stimulating adjuvant for manufacture of a composition for treatment of cancer diseases e.g. colon carcinomas and infectious diseases e.g. influenza and malaria |
| WO2008014979A2 (en) | 2006-07-31 | 2008-02-07 | Curevac Gmbh | NUCLEIC ACID OF FORMULA (I): GIXmGn, OR (II): CIXmCn, IN PARTICULAR AS AN IMMUNE-STIMULATING AGENT/ADJUVANT |
| WO2009030254A1 (en) | 2007-09-04 | 2009-03-12 | Curevac Gmbh | Complexes of rna and cationic peptides for transfection and for immunostimulation |
| EP3346005A1 (en) | 2008-01-31 | 2018-07-11 | CureVac AG | Nucleic acids of formula (i) (nuglxmgnnv)a and derivatives thereof as an immunostimulating agent/adjuvant |
| WO2010037408A1 (en) | 2008-09-30 | 2010-04-08 | Curevac Gmbh | Composition comprising a complexed (m)rna and a naked mrna for providing or enhancing an immunostimulatory response in a mammal and uses thereof |
| US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US8623918B2 (en) * | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
| US20110053829A1 (en) | 2009-09-03 | 2011-03-03 | Curevac Gmbh | Disulfide-linked polyethyleneglycol/peptide conjugates for the transfection of nucleic acids |
| WO2011159904A1 (en) * | 2010-06-17 | 2011-12-22 | The Trustees Of The University Of Pennsylvania | Methods for predicting cellular signaling responses to combinatorial stimuli |
| SG186989A1 (en) | 2010-07-14 | 2013-02-28 | Novartis Ag | Ip receptor agonist heterocyclic compounds |
| AU2011285200B2 (en) | 2010-07-30 | 2014-08-21 | CureVac SE | Complexation of nucleic acids with disulfide-crosslinked cationic components for transfection and immunostimulation |
| TW201335160A (en) | 2012-01-13 | 2013-09-01 | Novartis Ag | IP receptor agonist heterocyclic compounds |
| WO2013113326A1 (en) | 2012-01-31 | 2013-08-08 | Curevac Gmbh | Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen |
| JP2016507582A (en) | 2013-02-13 | 2016-03-10 | ノバルティス アーゲー | IP receptor agonist heterocyclic compound |
| CN105473158B (en) | 2013-08-21 | 2021-04-13 | 库瑞瓦格股份公司 | Respiratory Syncytial Virus (RSV) vaccine |
| WO2015149944A2 (en) | 2014-04-01 | 2015-10-08 | Curevac Gmbh | Polymeric carrier cargo complex for use as an immunostimulating agent or as an adjuvant |
-
1993
- 1993-10-06 US US08/134,012 patent/US5516652A/en not_active Expired - Lifetime
-
1994
- 1994-10-03 ES ES94928741T patent/ES2192561T3/en not_active Expired - Lifetime
- 1994-10-03 EP EP94928741A patent/EP0722462B1/en not_active Expired - Lifetime
- 1994-10-03 CA CA002173595A patent/CA2173595C/en not_active Expired - Lifetime
- 1994-10-03 WO PCT/CA1994/000548 patent/WO1995009872A1/en active IP Right Grant
- 1994-10-03 AT AT94928741T patent/ATE236932T1/en not_active IP Right Cessation
- 1994-10-03 DE DE69432470T patent/DE69432470T2/en not_active Expired - Lifetime
- 1994-10-03 JP JP7510528A patent/JP3029125B2/en not_active Expired - Lifetime
-
1995
- 1995-08-29 US US08/520,519 patent/US5728808A/en not_active Expired - Lifetime
-
1998
- 1998-03-16 US US09/039,798 patent/US6365360B1/en not_active Expired - Lifetime
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