WO1995000551B1 - Prostaglandin receptor fp and dna encoding it - Google Patents

Prostaglandin receptor fp and dna encoding it

Info

Publication number
WO1995000551B1
WO1995000551B1 PCT/CA1994/000319 CA9400319W WO9500551B1 WO 1995000551 B1 WO1995000551 B1 WO 1995000551B1 CA 9400319 W CA9400319 W CA 9400319W WO 9500551 B1 WO9500551 B1 WO 9500551B1
Authority
WO
WIPO (PCT)
Prior art keywords
prostaglandin
receptor
isolated
purified
prostaglandin receptor
Prior art date
Application number
PCT/CA1994/000319
Other languages
French (fr)
Other versions
WO1995000551A1 (en
Filing date
Publication date
Priority claimed from US08/083,741 external-priority patent/US5869281A/en
Application filed filed Critical
Priority to JP50226995A priority Critical patent/JP3228751B2/en
Priority to CA002165954A priority patent/CA2165954C/en
Priority to DE69413039T priority patent/DE69413039T2/en
Priority to AU69918/94A priority patent/AU6991894A/en
Priority to EP94918699A priority patent/EP0705276B1/en
Publication of WO1995000551A1 publication Critical patent/WO1995000551A1/en
Publication of WO1995000551B1 publication Critical patent/WO1995000551B1/en

Links

Abstract

A novel prostaglandin receptor has been identified and DNA encoding the receptor has been isolated, purified, sequenced and expressed in host cells. This DNA encoding the novel prostaglandin receptor and host cells expressing the receptor are used to identify modulators of the prostaglandin receptor.

Claims

AMENDED CLAIMS[received by the International Bureau on 23 December 1994 (23.12.94); original claim 1 amended; remaining claims unchanged (1 page)]
1. An isolated and purified prostaglandin human FP receptor wherein said receptor specifically binds prostaglandin.
2. The isolated and purified prostaglandin receptor protein of Claim 1 wherein said protein is characterized by the amino acid sequence
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMK AYQRFRQKSKASFLLLASGLV1TDFFGHL1 GA1AVFVYASDKEW1RFDQSNV LCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGV CLFAVFLALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLAL GVSLLCNAITGITLLRVI FKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFL VTMAN1G__NGNHSLETCET1T.FALRMATWNQI DPWVY1-LLRKAVLK_NLYKL ASQCCGVHV1SLHIWELSSIKNSLKVAA1SESPVAEKSAST (SEQ.1D.NO.: 5).
3. An isolated and purified DNA molecule encoding a prostaglandin receptor protein wherein said proten is characterized by the amino acid sequence of Claim 2.
4. An isolated and purified DNA molecule encoding a prostaglandin receptor protein wherein said DNA molecule is characterized by the nucleotide sequence 5
GTGCGCGGAGGGGACGAGCGGCTGGACCACAGCCGGCGCCCGATCAGG
ATCTCCGCGCTGGGATCGGTGGAACTΓGAGGCAGCGGCGGCGCGGGGC
GCCATGGCACACCGAGCGGCTCCGTCTTCTGCTCCTCAGAGAGCCCGGCT
GGCGGCCTGGGATGACAAGATGTCTGGACTGCAATCCTGCACAGTTTTGA O GAGGGAG ATGACTTGAGTGGITGGCTTRTATCTCCACAACAATGTCCATG AACAATΓCCAAACAGCTAGTGTCTCCTGCAGCTGCGCTTCΠTCAAACACA ACCΓGCCAGAOΪGAAAAC∞GCITΓCCGTATΓΓTTΓTCAGTAATCΓΓCATG
ACAGTGGGAATCTTGTCAAACAGCCTTGCCATCGCCATTCTCATGAAGGC
ATATCAGAGATITAGACAGAAGTCCAAGGCATCGTΓTCTGCTΠTGGCCAG
CGGCCTGGTAATCACTGATTTCTTTGGCCATCTCATCAATGGAGCCATAGC
PCT/CA1994/000319 1993-06-25 1994-06-09 Prostaglandin receptor fp and dna encoding it WO1995000551A1 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP50226995A JP3228751B2 (en) 1993-06-25 1994-06-09 Prostaglandin receptor FP and DNA encoding the receptor
CA002165954A CA2165954C (en) 1993-06-25 1994-06-09 Prostaglandin receptor fp and dna encoding it
DE69413039T DE69413039T2 (en) 1993-06-25 1994-06-09 PROSTAGLANDIN RECEPTOR FP AND ENCODING DNA
AU69918/94A AU6991894A (en) 1993-06-25 1994-06-09 Prostaglandin receptor fp and dna encoding it
EP94918699A EP0705276B1 (en) 1993-06-25 1994-06-09 Prostaglandin receptor fp and dna encoding it

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US083,741 1993-06-25
US08/083,741 US5869281A (en) 1993-06-25 1993-06-25 DNA encoding prostaglandin receptor FP

Publications (2)

Publication Number Publication Date
WO1995000551A1 WO1995000551A1 (en) 1995-01-05
WO1995000551B1 true WO1995000551B1 (en) 1995-02-02

Family

ID=22180389

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA1994/000319 WO1995000551A1 (en) 1993-06-25 1994-06-09 Prostaglandin receptor fp and dna encoding it

Country Status (9)

Country Link
US (3) US5869281A (en)
EP (1) EP0705276B1 (en)
JP (1) JP3228751B2 (en)
AT (1) ATE170532T1 (en)
AU (1) AU6991894A (en)
CA (1) CA2165954C (en)
DE (1) DE69413039T2 (en)
ES (1) ES2120052T3 (en)
WO (1) WO1995000551A1 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9202892D0 (en) 1992-10-02 1992-10-02 Kabi Pharmacia Ab DNA ENCODING A PROSTAGLANDIN RECEPTOR, A HOST CELL TRANSFORMED THEREWITH AND AN EXPRESSION PRODUCT THEREOF
US6670134B1 (en) 1993-11-19 2003-12-30 Allergan, Inc. Human EP3 prostaglandin receptor
US6057433A (en) 1993-11-19 2000-05-02 Allergan Sales, Inc. Nucleic acid encoding human EP3 prostaglandin receptor
US7294331B2 (en) 1994-03-07 2007-11-13 Immunex Corporation Methods of using flt3-ligand in hematopoietic cell transplantation
JP3064015B2 (en) 1995-01-26 2000-07-12 メルク フロスト カナダ アンド カンパニー Prostaglandin receptor DP
US5955575A (en) * 1997-12-22 1999-09-21 Hopital Sainte-Justine Antagonists of G-protein-coupled receptor
US6984719B1 (en) 1998-09-17 2006-01-10 Hospital Sainte-Justine Peptide antagonists of prostaglandin F2α receptor
CA2342960C (en) 1998-09-17 2010-03-09 Hopital Sainte-Justine G protein-coupled receptor antagonists
AU9756898A (en) * 1998-11-12 2000-06-05 Gemini Genomics Ab Human prostaglandin receptors and methods of use thereof
JP4834224B2 (en) 1999-03-05 2011-12-14 デューク ユニバーシティ C16 unsaturated FP-selective prostaglandin analogs
US6894175B1 (en) * 1999-08-04 2005-05-17 The Procter & Gamble Company 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use
MXPA02005626A (en) 1999-12-06 2004-09-10 Pital Sainte Justine H Compositions for treating abnormalities in glomerular filtration, patent ductus arteriosus and osteoporosis.
US20020037914A1 (en) * 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020172693A1 (en) * 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020146439A1 (en) * 2000-03-31 2002-10-10 Delong Mitchell Anthony Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins
US20020013294A1 (en) * 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
EP1445613B1 (en) * 2001-05-21 2010-07-07 FUJIFILM Corporation Biochemical analysis unit and method for its production
US7521530B2 (en) 2002-06-11 2009-04-21 Universite De Montreal Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin F2α receptor
WO2004073590A2 (en) * 2003-02-24 2004-09-02 Bayer Healthcare Ag Diagnostics and therapeutics for deseases associated with g-protein coupled receptor prostaglandin f2-alpha (prostaglandin f2-alpha)
US7320871B2 (en) * 2003-07-14 2008-01-22 Allergan, Inc. Human prostaglandin FP receptor variants and methods of using same
US20050074847A1 (en) * 2003-10-07 2005-04-07 Yanbin Liang Human prostaglandin EP1 receptor variants and methods of using same
US20050084929A1 (en) * 2003-10-17 2005-04-21 Yanbin Liang Human prostaglandin EP4 receptor variants and methods of using same
US20050084931A1 (en) * 2003-10-20 2005-04-21 Yanbin Liang Human prostaglandin DP receptor variants and methods of using same
US8623918B2 (en) * 2008-10-29 2014-01-07 Novaer Holdings, Inc. Amino acid salts of prostaglandins
US8722739B2 (en) 2008-10-29 2014-05-13 Novaer Holdings, Inc. Amino acid salts of prostaglandins

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9202892D0 (en) * 1992-10-02 1992-10-02 Kabi Pharmacia Ab DNA ENCODING A PROSTAGLANDIN RECEPTOR, A HOST CELL TRANSFORMED THEREWITH AND AN EXPRESSION PRODUCT THEREOF

Similar Documents

Publication Publication Date Title
WO1995000551B1 (en) Prostaglandin receptor fp and dna encoding it
WO1995009872B1 (en) Dna encoding prostaglandin receptor ip
WO1997036916B1 (en) dUTPASE, ITS ISOFORMS, AND DIAGNOSTIC AND OTHER USES
EP0962531A3 (en) Interferon-gamma production inducing isolated polypeptide fragment and an isolated DNA fragment encoding said polypeptide
EP2327775A3 (en) Therapy for alpha-galactosidase a deficiency
CA2083826A1 (en) Protein having cytokine type activity, recombinant dna coding for this protein, transformed cells and microorganisms
US5270176A (en) Method for the selective cleavage of fusion proteins with lysostaphin
WO2000002996A3 (en) Recombinant constructs and systems for secretion of proteins via type iii secretion systems
NZ296748A (en) Peripheral nervous system specific sodium channel proteins, DNA coding therefor, compositions and methods
CA2263889A1 (en) P-selectin ligand proteins
AU5020296A (en) C-C chemokine receptor 3: CKR-3 or EOS-l2
CA2165954A1 (en) Prostaglandin receptor fp and dna encoding it
CA2170515A1 (en) Nucleotide sequences for novel protein tyrosine phosphatases
EP1380648A3 (en) Recombinant DNAase B derived from streptococcus pyogenes
WO1995000552B1 (en) Prostaglandin receptor ep3 and dna encoding it
CA2230111A1 (en) Antisecretory factor peptides regulating pathological permeability changes
CA2329473A1 (en) Dna encoding prostaglandin receptor ep1
CA2032167A1 (en) Dna coding for protein binds to enhancer of.alpha.-fetoprotein gene
EP0195680A3 (en) The synthesis of protein with an identification peptide
MD20000034A (en) Grapevine leafroll virus proteins (type 2) and use thereof
CA2253006A1 (en) .beta.-carotene hydroxylase gene
ATE247164T1 (en) INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN
EP1022332A4 (en) Beta-fructofuranosidase and gene thereof
Ovchinnikov et al. The primary structure of a Leu, Ile and Val (LIV)-binding protein from Escherichia coli
WO1997049813A3 (en) Glucuronide repressors and uses thereof