WO1995000551B1 - Prostaglandin receptor fp and dna encoding it - Google Patents
Prostaglandin receptor fp and dna encoding itInfo
- Publication number
- WO1995000551B1 WO1995000551B1 PCT/CA1994/000319 CA9400319W WO9500551B1 WO 1995000551 B1 WO1995000551 B1 WO 1995000551B1 CA 9400319 W CA9400319 W CA 9400319W WO 9500551 B1 WO9500551 B1 WO 9500551B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- prostaglandin
- receptor
- isolated
- purified
- prostaglandin receptor
- Prior art date
Links
- 102000015433 Prostaglandin Receptors Human genes 0.000 title claims abstract 7
- 108010050183 Prostaglandin Receptors Proteins 0.000 title claims abstract 7
- 229920003013 deoxyribonucleic acid Polymers 0.000 title claims abstract 6
- 102000005962 receptors Human genes 0.000 claims abstract 3
- 108020003175 receptors Proteins 0.000 claims abstract 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 150000003180 prostaglandins Chemical class 0.000 claims 2
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 1
- 102000000471 Prostaglandin F receptors Human genes 0.000 claims 1
- 108050008995 Prostaglandin F receptors Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000000051 modifying Effects 0.000 abstract 1
Abstract
A novel prostaglandin receptor has been identified and DNA encoding the receptor has been isolated, purified, sequenced and expressed in host cells. This DNA encoding the novel prostaglandin receptor and host cells expressing the receptor are used to identify modulators of the prostaglandin receptor.
Claims
1. An isolated and purified prostaglandin human FP receptor wherein said receptor specifically binds prostaglandin.
2. The isolated and purified prostaglandin receptor protein of Claim 1 wherein said protein is characterized by the amino acid sequence
MSMNNSKQLVSPAAALLSNTTCQTENRLSVFFSVIFMTVGILSNSLAIAILMK AYQRFRQKSKASFLLLASGLV1TDFFGHL1 GA1AVFVYASDKEW1RFDQSNV LCSIFGICMVFSGLCPLLLGSVMAIERCIGVTKPIFHSTKITSKHVKMMLSGV CLFAVFLALLPILGHRDYKIQASRTWCFYNTEDIKDWEDRFYLLLFSFLGLLAL GVSLLCNAITGITLLRVI FKSQQHRQGRSHHLEMVIQLLAIMCVSCICWSPFL VTMAN1G__NGNHSLETCET1T.FALRMATWNQI DPWVY1-LLRKAVLK_NLYKL ASQCCGVHV1SLHIWELSSIKNSLKVAA1SESPVAEKSAST (SEQ.1D.NO.: 5).
3. An isolated and purified DNA molecule encoding a prostaglandin receptor protein wherein said proten is characterized by the amino acid sequence of Claim 2.
4. An isolated and purified DNA molecule encoding a prostaglandin receptor protein wherein said DNA molecule is characterized by the nucleotide sequence 5
GTGCGCGGAGGGGACGAGCGGCTGGACCACAGCCGGCGCCCGATCAGG
ATCTCCGCGCTGGGATCGGTGGAACTΓGAGGCAGCGGCGGCGCGGGGC
GCCATGGCACACCGAGCGGCTCCGTCTTCTGCTCCTCAGAGAGCCCGGCT
GGCGGCCTGGGATGACAAGATGTCTGGACTGCAATCCTGCACAGTTTTGA O GAGGGAG ATGACTTGAGTGGITGGCTTRTATCTCCACAACAATGTCCATG AACAATΓCCAAACAGCTAGTGTCTCCTGCAGCTGCGCTTCΠTCAAACACA ACCΓGCCAGAOΪGAAAAC∞GCITΓCCGTATΓΓTTΓTCAGTAATCΓΓCATG
ACAGTGGGAATCTTGTCAAACAGCCTTGCCATCGCCATTCTCATGAAGGC
ATATCAGAGATITAGACAGAAGTCCAAGGCATCGTΓTCTGCTΠTGGCCAG
CGGCCTGGTAATCACTGATTTCTTTGGCCATCTCATCAATGGAGCCATAGC
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP50226995A JP3228751B2 (en) | 1993-06-25 | 1994-06-09 | Prostaglandin receptor FP and DNA encoding the receptor |
CA002165954A CA2165954C (en) | 1993-06-25 | 1994-06-09 | Prostaglandin receptor fp and dna encoding it |
DE69413039T DE69413039T2 (en) | 1993-06-25 | 1994-06-09 | PROSTAGLANDIN RECEPTOR FP AND ENCODING DNA |
AU69918/94A AU6991894A (en) | 1993-06-25 | 1994-06-09 | Prostaglandin receptor fp and dna encoding it |
EP94918699A EP0705276B1 (en) | 1993-06-25 | 1994-06-09 | Prostaglandin receptor fp and dna encoding it |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US083,741 | 1993-06-25 | ||
US08/083,741 US5869281A (en) | 1993-06-25 | 1993-06-25 | DNA encoding prostaglandin receptor FP |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1995000551A1 WO1995000551A1 (en) | 1995-01-05 |
WO1995000551B1 true WO1995000551B1 (en) | 1995-02-02 |
Family
ID=22180389
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA1994/000319 WO1995000551A1 (en) | 1993-06-25 | 1994-06-09 | Prostaglandin receptor fp and dna encoding it |
Country Status (9)
Country | Link |
---|---|
US (3) | US5869281A (en) |
EP (1) | EP0705276B1 (en) |
JP (1) | JP3228751B2 (en) |
AT (1) | ATE170532T1 (en) |
AU (1) | AU6991894A (en) |
CA (1) | CA2165954C (en) |
DE (1) | DE69413039T2 (en) |
ES (1) | ES2120052T3 (en) |
WO (1) | WO1995000551A1 (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9202892D0 (en) | 1992-10-02 | 1992-10-02 | Kabi Pharmacia Ab | DNA ENCODING A PROSTAGLANDIN RECEPTOR, A HOST CELL TRANSFORMED THEREWITH AND AN EXPRESSION PRODUCT THEREOF |
US6670134B1 (en) | 1993-11-19 | 2003-12-30 | Allergan, Inc. | Human EP3 prostaglandin receptor |
US6057433A (en) | 1993-11-19 | 2000-05-02 | Allergan Sales, Inc. | Nucleic acid encoding human EP3 prostaglandin receptor |
US7294331B2 (en) | 1994-03-07 | 2007-11-13 | Immunex Corporation | Methods of using flt3-ligand in hematopoietic cell transplantation |
JP3064015B2 (en) | 1995-01-26 | 2000-07-12 | メルク フロスト カナダ アンド カンパニー | Prostaglandin receptor DP |
US5955575A (en) * | 1997-12-22 | 1999-09-21 | Hopital Sainte-Justine | Antagonists of G-protein-coupled receptor |
US6984719B1 (en) | 1998-09-17 | 2006-01-10 | Hospital Sainte-Justine | Peptide antagonists of prostaglandin F2α receptor |
CA2342960C (en) | 1998-09-17 | 2010-03-09 | Hopital Sainte-Justine | G protein-coupled receptor antagonists |
AU9756898A (en) * | 1998-11-12 | 2000-06-05 | Gemini Genomics Ab | Human prostaglandin receptors and methods of use thereof |
JP4834224B2 (en) | 1999-03-05 | 2011-12-14 | デューク ユニバーシティ | C16 unsaturated FP-selective prostaglandin analogs |
US6894175B1 (en) * | 1999-08-04 | 2005-05-17 | The Procter & Gamble Company | 2-Decarboxy-2-phosphinico prostaglandin derivatives and methods for their preparation and use |
MXPA02005626A (en) | 1999-12-06 | 2004-09-10 | Pital Sainte Justine H | Compositions for treating abnormalities in glomerular filtration, patent ductus arteriosus and osteoporosis. |
US20020037914A1 (en) * | 2000-03-31 | 2002-03-28 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins |
US20020172693A1 (en) * | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
US20020146439A1 (en) * | 2000-03-31 | 2002-10-10 | Delong Mitchell Anthony | Compositions and methods for treating hair loss using oximyl and hydroxylamino prostaglandins |
US20020013294A1 (en) * | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
EP1445613B1 (en) * | 2001-05-21 | 2010-07-07 | FUJIFILM Corporation | Biochemical analysis unit and method for its production |
US7521530B2 (en) | 2002-06-11 | 2009-04-21 | Universite De Montreal | Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin F2α receptor |
WO2004073590A2 (en) * | 2003-02-24 | 2004-09-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for deseases associated with g-protein coupled receptor prostaglandin f2-alpha (prostaglandin f2-alpha) |
US7320871B2 (en) * | 2003-07-14 | 2008-01-22 | Allergan, Inc. | Human prostaglandin FP receptor variants and methods of using same |
US20050074847A1 (en) * | 2003-10-07 | 2005-04-07 | Yanbin Liang | Human prostaglandin EP1 receptor variants and methods of using same |
US20050084929A1 (en) * | 2003-10-17 | 2005-04-21 | Yanbin Liang | Human prostaglandin EP4 receptor variants and methods of using same |
US20050084931A1 (en) * | 2003-10-20 | 2005-04-21 | Yanbin Liang | Human prostaglandin DP receptor variants and methods of using same |
US8623918B2 (en) * | 2008-10-29 | 2014-01-07 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
US8722739B2 (en) | 2008-10-29 | 2014-05-13 | Novaer Holdings, Inc. | Amino acid salts of prostaglandins |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9202892D0 (en) * | 1992-10-02 | 1992-10-02 | Kabi Pharmacia Ab | DNA ENCODING A PROSTAGLANDIN RECEPTOR, A HOST CELL TRANSFORMED THEREWITH AND AN EXPRESSION PRODUCT THEREOF |
-
1993
- 1993-06-25 US US08/083,741 patent/US5869281A/en not_active Expired - Lifetime
-
1994
- 1994-06-09 WO PCT/CA1994/000319 patent/WO1995000551A1/en active IP Right Grant
- 1994-06-09 AT AT94918699T patent/ATE170532T1/en not_active IP Right Cessation
- 1994-06-09 AU AU69918/94A patent/AU6991894A/en not_active Abandoned
- 1994-06-09 ES ES94918699T patent/ES2120052T3/en not_active Expired - Lifetime
- 1994-06-09 DE DE69413039T patent/DE69413039T2/en not_active Expired - Lifetime
- 1994-06-09 EP EP94918699A patent/EP0705276B1/en not_active Expired - Lifetime
- 1994-06-09 JP JP50226995A patent/JP3228751B2/en not_active Expired - Fee Related
- 1994-06-09 CA CA002165954A patent/CA2165954C/en not_active Expired - Fee Related
-
1997
- 1997-11-21 US US08/976,074 patent/US5840847A/en not_active Expired - Lifetime
- 1997-11-21 US US08/976,166 patent/US6358694B1/en not_active Expired - Fee Related
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