KR850003538A - 피리미도이소퀴놀린 유도체의 제조방법 - Google Patents

피리미도이소퀴놀린 유도체의 제조방법 Download PDF

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Publication number
KR850003538A
KR850003538A KR1019840007323A KR840007323A KR850003538A KR 850003538 A KR850003538 A KR 850003538A KR 1019840007323 A KR1019840007323 A KR 1019840007323A KR 840007323 A KR840007323 A KR 840007323A KR 850003538 A KR850003538 A KR 850003538A
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KR
South Korea
Prior art keywords
compound
formula
salt
carboxy
derivative
Prior art date
Application number
KR1019840007323A
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English (en)
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KR920008168B1 (ko
Inventor
이꾸오(외 2) 우에다
Original Assignee
후지사와 도모기찌로
후지사와 야꾸힝 고교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB838331228A external-priority patent/GB8331228D0/en
Priority claimed from GB848405776A external-priority patent/GB8405776D0/en
Priority claimed from GB848425791A external-priority patent/GB8425791D0/en
Application filed by 후지사와 도모기찌로, 후지사와 야꾸힝 고교 가부시끼가이샤 filed Critical 후지사와 도모기찌로
Publication of KR850003538A publication Critical patent/KR850003538A/ko
Priority to KR1019910016712A priority Critical patent/KR920001673B1/ko
Application granted granted Critical
Publication of KR920008168B1 publication Critical patent/KR920008168B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/08—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with a hetero atom directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

피리미도이소퀴놀린 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 구조식(Ⅱ)화합물 또는 그 염을 구조식(Ⅲ) 화합물과 반응시켜서 구조식(Ⅰa)의 화합물을 제조하거나; 구조식(Ⅰb)의 화합물 또는 그 염을 환원시켜서 구조식(Ⅰc)의 화합물 또는 그 염을 제조하거나; 구조식(Ⅰc)의 화합물 또는 그 아미노기 에서의 반응성 유도체 또는 그 염을 아실화제로 아실화시켜서 구조식(Ⅰd)의 화합물 또는 그 염을 제조하거나; 구조식(Ⅰa)의 화합물 또는 그 염으로부터 카복시 보호기를 제거하여 구조식(Ⅰe)의 화합물 또는 그 염을 제조하거나; 구조식(Ⅰe)의 화합물; 그 카복시기에서의 반응성 유도체 또는 그 염을 아마이드화제와 반응시켜서 구조식(Ⅰf)의 화합물, 또는 그 염을 제조하거나; 또는 구조식(Ⅰc)의 화합물, 그 카복시기에서의 반응성 유도체 또는 그 염을 에스테르화제와 반응시켜서 구조식(Ⅰg)의 화합물 또는 그 염을 제조함을 특징으로 하는 구조식(Ⅰ)화합물을 제조하는 방법.
    상기식에서, R1은 수소, 할로겐 또는 저급알킬, R2는 아미노, 니트로 또는 아실아미노,는 아실아미노, R3는 카복시 또는 보호된 카복시,및는 각각 보호된 카복시,는 아마이드화 카복시,는 에스테르화 카복시이며, R4는 알콕시이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840007323A 1983-11-23 1984-11-22 피리미도이소퀴놀린 유도체의 제조방법 KR920008168B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019910016712A KR920001673B1 (ko) 1983-11-23 1991-09-25 피리미도이소퀴놀린 유도체의 제조방법

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8331228 1983-11-23
GB838331228A GB8331228D0 (en) 1983-11-23 1983-11-23 Pyrimidoisoquinoline derivatives
GB848405776A GB8405776D0 (en) 1984-03-06 1984-03-06 Pyrimidoisoquinoline derivatives
GB8405776 1984-03-06
GB848425791A GB8425791D0 (en) 1984-10-12 1984-10-12 Pyrimidoisoquinoline derivatives
GB8425791 1984-10-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019910016712A Division KR920001673B1 (ko) 1983-11-23 1991-09-25 피리미도이소퀴놀린 유도체의 제조방법

Publications (2)

Publication Number Publication Date
KR850003538A true KR850003538A (ko) 1985-06-20
KR920008168B1 KR920008168B1 (ko) 1992-09-24

Family

ID=27262222

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019840007323A KR920008168B1 (ko) 1983-11-23 1984-11-22 피리미도이소퀴놀린 유도체의 제조방법
KR1019910016712A KR920001673B1 (ko) 1983-11-23 1991-09-25 피리미도이소퀴놀린 유도체의 제조방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019910016712A KR920001673B1 (ko) 1983-11-23 1991-09-25 피리미도이소퀴놀린 유도체의 제조방법

Country Status (17)

Country Link
US (1) US4673676A (ko)
EP (1) EP0143001B1 (ko)
KR (2) KR920008168B1 (ko)
AR (1) AR243889A1 (ko)
AT (1) ATE62484T1 (ko)
AU (1) AU582554B2 (ko)
CA (1) CA1232605A (ko)
DE (1) DE3484420D1 (ko)
DK (1) DK165789C (ko)
ES (2) ES8602786A1 (ko)
FI (1) FI77034C (ko)
GR (1) GR81006B (ko)
HU (1) HU202528B (ko)
IL (1) IL73586A (ko)
NO (1) NO162019C (ko)
PH (1) PH22068A (ko)
SU (1) SU1512482A3 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO162019C (no) * 1983-11-23 1989-10-25 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US4661592A (en) * 1984-06-27 1987-04-28 G. D. Searle & Co. 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives
KR101709141B1 (ko) 2008-01-25 2017-02-22 브이티브이 테라퓨틱스 엘엘씨 ＴＮＦ-α 합성의 조절자 및 ＰＤＥ4 억제제로서 3고리 화합물

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3876788A (en) * 1970-08-27 1975-04-08 Burroughs Wellcome Co Heterocyclic compounds in the treatment of inflammatory of arthritic conditions
US4017625A (en) * 1975-08-01 1977-04-12 Pfizer Inc. Anti-allergic N-(5-tetrazolyl)-1-oxo-1H-6-alkoxypyrimido-[1,2-a]quinoline-2-carboxamides and intermediates therefor
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom
US4127720A (en) * 1977-09-21 1978-11-28 Bristol-Myers Company Pyrimido[2,1-a]isoquinoline derivatives having antiallergy activity
IE51802B1 (en) * 1979-12-03 1987-04-01 Fujisawa Pharmaceutical Co Quinazoline derivatives,processes for their preparation and pharmaceutical compositions containing them
JPS59172490A (ja) * 1983-03-18 1984-09-29 Fujisawa Pharmaceut Co Ltd ピリミドイソキノリン誘導体およびその塩類、それらの製造法ならびにそれらを有効成分とする抗アレルギ−剤
JPS59172472A (ja) * 1983-03-18 1984-09-29 Fujisawa Pharmaceut Co Ltd イソキノリン誘導体およびその塩類、それらの製造法ならびにそれらを有効成分とする抗アレルギ−剤
NO162019C (no) * 1983-11-23 1989-10-25 Fujisawa Pharmaceutical Co Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrimidoiskinolinderivater.
US4661592A (en) * 1984-06-27 1987-04-28 G. D. Searle & Co. 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives

Also Published As

Publication number Publication date
HUT35674A (en) 1985-07-29
DK536184A (da) 1985-05-24
AU3540584A (en) 1985-05-30
AR243889A1 (es) 1993-09-30
PH22068A (en) 1988-05-20
ES537928A0 (es) 1985-12-01
NO844466L (no) 1985-05-24
ATE62484T1 (de) 1991-04-15
CA1232605A (en) 1988-02-09
GR81006B (en) 1985-01-03
IL73586A0 (en) 1985-02-28
DE3484420D1 (en) 1991-05-16
ES8602786A1 (es) 1985-12-01
FI77034C (fi) 1989-01-10
DK536184D0 (da) 1984-11-09
IL73586A (en) 1988-12-30
NO162019B (no) 1989-07-17
ES8604220A1 (es) 1986-01-16
EP0143001A2 (en) 1985-05-29
DK165789C (da) 1993-06-14
KR920008168B1 (ko) 1992-09-24
FI77034B (fi) 1988-09-30
EP0143001B1 (en) 1991-04-10
FI844406A0 (fi) 1984-11-09
EP0143001A3 (en) 1986-03-19
KR920001673B1 (ko) 1992-02-22
AU582554B2 (en) 1989-04-06
NO162019C (no) 1989-10-25
ES546222A0 (es) 1986-01-16
SU1512482A3 (ru) 1989-09-30
HU202528B (en) 1991-03-28
US4673676A (en) 1987-06-16
DK165789B (da) 1993-01-18
FI844406L (fi) 1985-05-24

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