KR850000964B1 - 에리트로마이신a의 옥심 유도체류의 제조방법 - Google Patents

에리트로마이신a의 옥심 유도체류의 제조방법 Download PDF

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Publication number
KR850000964B1
KR850000964B1 KR1019810000051A KR810000051A KR850000964B1 KR 850000964 B1 KR850000964 B1 KR 850000964B1 KR 1019810000051 A KR1019810000051 A KR 1019810000051A KR 810000051 A KR810000051 A KR 810000051A KR 850000964 B1 KR850000964 B1 KR 850000964B1
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KR
South Korea
Prior art keywords
group
erythromycin
substituted
carbon atoms
formula
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Expired
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KR1019810000051A
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English (en)
Korean (ko)
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KR830005258A (ko
Inventor
드 암브리레스 소랑제 고우인
앙드레 루트즈
Original Assignee
로우셀 우크라프
허버트 후리텔
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9237443&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR850000964(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 로우셀 우크라프, 허버트 후리텔 filed Critical 로우셀 우크라프
Publication of KR830005258A publication Critical patent/KR830005258A/ko
Priority to KR1019850002197A priority Critical patent/KR850001179B1/ko
Application granted granted Critical
Publication of KR850000964B1 publication Critical patent/KR850000964B1/ko
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1019810000051A 1980-01-11 1981-01-10 에리트로마이신a의 옥심 유도체류의 제조방법 Expired KR850000964B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019850002197A KR850001179B1 (ko) 1980-01-11 1985-03-30 에리트로마이신 a의 옥심 유도체류의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR80-00566 1980-01-11
FR8000566A FR2473525A1 (fr) 1980-01-11 1980-01-11 Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments

Publications (2)

Publication Number Publication Date
KR830005258A KR830005258A (ko) 1983-08-03
KR850000964B1 true KR850000964B1 (ko) 1985-07-02

Family

ID=9237443

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810000051A Expired KR850000964B1 (ko) 1980-01-11 1981-01-10 에리트로마이신a의 옥심 유도체류의 제조방법

Country Status (25)

Country Link
US (1) US4349545A (enExample)
EP (1) EP0033255B1 (enExample)
JP (1) JPS56100799A (enExample)
KR (1) KR850000964B1 (enExample)
AU (1) AU537247B2 (enExample)
BG (1) BG61369B2 (enExample)
CA (1) CA1162535A (enExample)
CY (1) CY1319A (enExample)
DE (1) DE3165720D1 (enExample)
DK (1) DK157878C (enExample)
ES (1) ES498395A0 (enExample)
FI (1) FI69473C (enExample)
FR (1) FR2473525A1 (enExample)
GR (1) GR73103B (enExample)
GT (1) GT198500080A (enExample)
HK (1) HK586A (enExample)
HU (1) HU187760B (enExample)
IE (1) IE50680B1 (enExample)
IL (1) IL61808A (enExample)
LU (1) LU88283I2 (enExample)
MY (1) MY8500984A (enExample)
NL (1) NL930097I2 (enExample)
OA (1) OA06719A (enExample)
PT (1) PT72331B (enExample)
ZA (1) ZA808108B (enExample)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2534588B2 (fr) * 1982-10-15 1985-09-20 Roussel Uclaf Nouvelles oximes derivees de l'erythromycine, leur procede de preparation et leur application comme medicaments
US4526889A (en) * 1982-11-15 1985-07-02 Pfizer Inc. Epimeric azahomoerythromycin A derivative, intermediates and method of use
DK149776C (da) * 1984-01-06 1987-04-21 Orion Yhtymae Oy Antibiotisk virksom erytromycinforbindelse og praeparat indeholdende forbindelsen
JPS60214796A (ja) * 1984-04-06 1985-10-28 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシン類の製法
JPS61103890A (ja) * 1984-10-26 1986-05-22 Taisho Pharmaceut Co Ltd ６−０−メチルエリスロマイシンａ誘導体
HUT42502A (en) 1985-03-12 1987-07-28 Beecham Group Plc Process for preparing new erythromycine derivatives
JPS61229895A (ja) * 1985-04-03 1986-10-14 Nippon Zeon Co Ltd 保護化デス−ｎ−メチルエリスロマイシン誘導体
US4740502A (en) * 1986-06-20 1988-04-26 Abbott Laboratories Semisynthetic erythromycin antibiotics
DE3782994T2 (de) 1986-09-18 1993-04-08 Taisho Pharma Co Ltd Erythromycin-a-derivate und verfahren zu ihrer herstellung.
JP2751385B2 (ja) * 1988-05-19 1998-05-18 大正製薬株式会社 エリスロマイシンａオキシム及びその塩の製造方法
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
US5302705A (en) * 1989-10-07 1994-04-12 Taisho Pharmaceutical Co., Ltd. 6-O-methylerythromycin a oxime derivatives
US5912331A (en) * 1991-03-15 1999-06-15 Merck & Co., Inc. Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A
CA2062932A1 (en) 1991-03-15 1992-09-16 Robert R. Wilkening 9-deoxo-9(z)-hydroxyiminoerythromycin a and o-derivatives thereof
US5985844A (en) * 1992-03-26 1999-11-16 Merck & Co., Inc. Homoerythromycin A derivatives modified at the 4"-and 8A-positions
US5189159A (en) * 1992-04-02 1993-02-23 Merck & Co., Inc. 8a-AZA-8a-homoerythromycin cyclic iminoethers
ES2036472B1 (es) * 1991-10-01 1994-03-01 Prodesfarma Sa Procedimiento de obtencion de eritromicina 9-(0-((2-metoxietoxi)metil)oxima) (roxitromicina).
US5210235A (en) * 1992-08-26 1993-05-11 Merck & Co., Inc. Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics
US5332807A (en) * 1993-04-14 1994-07-26 Merck & Co., Inc. Process of producing 8A- and 9A-azalide antibiotics
KR970702725A (ko) * 1994-04-26 1997-06-10 노부히로 나리따 비소세포 폐암 치료용 의약 조성물(Medicinal Composition as a Remedy for Nonsmall Cell Lung Cancer)
IT1276901B1 (it) * 1994-12-13 1997-11-03 Zambon Spa Derivati dell'eritromicina a 9-0-ossina dotati di attivita' antibiotica
US5872229A (en) 1995-11-21 1999-02-16 Abbott Laboratories Process for 6-O-alkylation of erythromycin derivatives
FR2760017B1 (fr) * 1997-02-27 1999-04-30 Hoechst Marion Roussel Inc Nouveaux derives de l'erytromycine, leur procede de preparation et leur application comme medicaments
US5929219A (en) 1997-09-10 1999-07-27 Abbott Laboratories 9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
PT102202B (pt) * 1998-09-10 2001-04-30 Hovione Sociedade Quimica S A Processo para a purificacao de roxitromicina
IN190782B (enExample) * 1998-09-30 2003-08-23 Max India Ltd
DE69813244T2 (de) * 1998-11-24 2004-03-04 Jubilant Organosys Ltd. Verfahren zur Herstellung von Roxithromycin und Derivate davon
AU783055B2 (en) 1999-12-16 2005-09-22 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin polymorphs and novel polymorph IV
RU2002118308A (ru) 2000-01-11 2004-02-20 Тева Фамэситикл Индастрис Лтд. (Il) Способы получения полиморфных модификаций кларитромицина
US6617436B2 (en) 2000-02-29 2003-09-09 Teva Pharmaceutical Industries Ltd. Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same
HRP20020885B1 (en) 2002-11-11 2007-05-31 GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A
HRP20020991A2 (en) 2002-12-12 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. N"-Substituted 9a-N-(N'-carbamoyl-Gamma-aminopropyl), 9a-N-(N'? -thiocarbamoyl-Gamma-aminopropyl), 9a-N-(N'-((Beta-cyanoethyl)-N'-carbamoyl-Gamma? -aminopropyl) and 9a-N-(N'-(Beta-cyanoethyl)-N'-thiocarbamoyl-Gamma? -aminopropyl) derivatives of 9-de
AU2003271408B2 (en) * 2002-12-31 2008-07-17 Alembic Limited A process for the purification of roxithromycin
RU2222333C1 (ru) * 2003-03-06 2004-01-27 Открытое акционерное общество "Химико-фармацевтический комбинат "Акрихин" Фармацевтическая композиция с антибактериальной активностью и способ ее получения
EP2056844A4 (en) 2006-08-24 2010-11-24 Wockhardt Research Center NEW MACROLIDS AND KETOLIDS WITH ANTIMICROBIAL EFFECT
US20090005326A1 (en) * 2007-06-26 2009-01-01 Idexx Laboratories, Inc. Single dose roxithromycin
KR101657751B1 (ko) 2010-12-09 2016-09-19 욱크하르트 리미티드 케토라이드 화합물
US9206214B2 (en) 2011-03-01 2015-12-08 Wockhardt Ltd. Process for preparation of ketolide intermediates
CN103619863B (zh) 2011-03-22 2016-03-16 沃克哈特有限公司 酮内酯化合物的制备方法
CN102219816A (zh) * 2011-05-12 2011-10-19 浙江国邦药业有限公司 一种罗红霉素的纯化方法
PL222631B1 (pl) 2012-11-14 2016-08-31 Gdański Univ Medyczny Kompozycja farmaceutyczna zawierająca roksytromycynę, sposób jej wytwarzania oraz zastosowanie medyczne tej kompozycji i produkt leczniczy zawierający kompozycję
CN104163840A (zh) * 2013-08-30 2014-11-26 郑州后羿制药有限公司 一种罗红霉素的精制方法
FR3049861A1 (fr) 2016-04-07 2017-10-13 Univ Claude Bernard Lyon Nouvelles compositions antivirales pour le traitement de la grippe

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU31319B (en) * 1967-08-03 1973-04-30 Pliva Pharm & Chem Works Postupak za dobijanje acil derivata eritromicin oksima
US3869444A (en) * 1972-10-10 1975-03-04 Abbott Lab Esters of erythromycin oxime
ES434842A1 (es) * 1975-02-19 1976-12-01 Andreu Sa Dr Procedimiento para la preparacion de esteres de la oxima deeritromicina.
DE2515076A1 (de) * 1975-04-07 1976-10-28 Thomae Gmbh Dr K Neue erythromycinderivate, deren salze und verfahren zu ihrer herstellung
DK139522C (da) * 1975-04-07 1979-08-20 Thomae Gmbh Dr K Analogifremgangsmaade til fremstilling af 9-iminoalkylamino-erythromyciner eller syreadditionssalte deraf
DE2515077A1 (de) * 1975-04-07 1976-10-28 Thomae Gmbh Dr K Neue 9-alkylidenamino-erythromycine, ihre salze und verfahren zu ihrer herstellung
DE2750288A1 (de) * 1977-11-10 1979-05-17 Thomae Gmbh Dr K Neue 9-(omega-heteroarylamino- alkylamino)-erythromycine, ihre salze, verfahren zu ihrer herstellung und diese enthaltende arzneimittel

Also Published As

Publication number Publication date
IL61808A (en) 1986-12-31
BG61369B2 (bg) 1997-06-30
FI69473C (fi) 1986-02-10
US4349545A (en) 1982-09-14
JPS56100799A (en) 1981-08-12
PT72331B (fr) 1982-07-23
EP0033255B1 (fr) 1984-08-29
IL61808A0 (en) 1981-01-30
FR2473525B1 (enExample) 1983-04-15
HU187760B (en) 1986-02-28
NL930097I2 (nl) 1995-04-03
FR2473525A1 (fr) 1981-07-17
GR73103B (enExample) 1984-02-02
NL930097I1 (nl) 1993-10-01
EP0033255A1 (fr) 1981-08-05
FI69473B (fi) 1985-10-31
FI810042L (fi) 1981-07-12
CY1319A (en) 1986-03-28
JPS6237639B2 (enExample) 1987-08-13
GT198500080A (es) 1987-03-06
IE810046L (en) 1981-07-11
HK586A (en) 1986-01-10
LU88283I2 (fr) 1994-09-09
KR830005258A (ko) 1983-08-03
ES8200702A1 (es) 1981-11-01
DE3165720D1 (en) 1984-10-04
DK157878C (da) 1990-07-30
ES498395A0 (es) 1981-11-01
CA1162535A (fr) 1984-02-21
MY8500984A (en) 1985-12-31
PT72331A (fr) 1981-02-01
IE50680B1 (en) 1986-06-11
AU537247B2 (en) 1984-06-14
DK157878B (da) 1990-02-26
ZA808108B (en) 1982-01-27
OA06719A (fr) 1982-06-30
AU6613181A (en) 1981-07-16
DK7881A (da) 1981-07-12

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