KR830001951A - 결정성 3-하이드록시 세팔로스포린 용매 화합물 - Google Patents

결정성 3-하이드록시 세팔로스포린 용매 화합물 Download PDF

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Publication number
KR830001951A
KR830001951A KR1019800000402A KR800000402A KR830001951A KR 830001951 A KR830001951 A KR 830001951A KR 1019800000402 A KR1019800000402 A KR 1019800000402A KR 800000402 A KR800000402 A KR 800000402A KR 830001951 A KR830001951 A KR 830001951A
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KR
South Korea
Prior art keywords
solvent compound
cooh
hydroxy
crystalline
structural formula
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KR1019800000402A
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English (en)
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KR830001890B1 (ko
Inventor
웨인 피서 잭
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아더 알·웨일
일라이 릴리 앤드 캄파니
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Publication of KR830001951A publication Critical patent/KR830001951A/ko
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Publication of KR830001890B1 publication Critical patent/KR830001890B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/30—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino-radical acylated by an araliphatic carboxylic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용없음

Description

하이드록시 세팔로스포린 용매 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 구조식(Ⅰ)에서 n이 1 또는 0일 경우, 4′-니트로벤질 7-페녹서아세트아미도-3-하이드록시-3-세펨 카복실레이트 설파이드 또는 이의 설폭사이드를 아세트산 또는 프로피온산과 접촉시키고(임의로 물과 혼합가능하거나 혼합불가한 용매 존자하에) 아세트산 또는 프로피온산 용매 화합물을 결정화시키고, n이 0일 경우, 4′-니트로벤질 7-페녹시아세트아미노-3-하이드록시-3-세펨 카복실레이트 설파이드를 염화메틸렌에 용해시키고 염화메틸렌 용매 화합물을 결정화시킴을 특징으로 하여 다음 구조식(Ⅰ)의 세팔로스포린 용매 화합물을 제조하는 방법.
    상기 구조식에서,
    n은 0 또는 1이고,
    X는 n이 1일 경우 CH3COOH, CH3CH2COOH 또는 CH3OH이고 n이 0일경우 CH3COOH, CH3CH2COOH 또는 1/2 CH2Cl2이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800000402A 1979-02-01 1980-02-01 결정성 3하이드록시 세팔로스포린 용매화합물의 제조방법 KR830001890B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US846879A 1979-02-01 1979-02-01
US8468 1979-02-01
US008468 1995-12-11

Publications (2)

Publication Number Publication Date
KR830001951A true KR830001951A (ko) 1983-05-21
KR830001890B1 KR830001890B1 (ko) 1983-09-17

Family

ID=21731772

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019800000402A KR830001890B1 (ko) 1979-02-01 1980-02-01 결정성 3하이드록시 세팔로스포린 용매화합물의 제조방법

Country Status (32)

Country Link
EP (1) EP0014565B1 (ko)
JP (1) JPS55104288A (ko)
KR (1) KR830001890B1 (ko)
AR (1) AR228342A1 (ko)
AT (1) AT366052B (ko)
AU (1) AU532573B2 (ko)
BE (1) BE881423A (ko)
BG (1) BG32857A3 (ko)
CA (1) CA1142173A (ko)
CH (1) CH647525A5 (ko)
CS (1) CS214694B2 (ko)
DD (1) DD148953A5 (ko)
DE (1) DE3062095D1 (ko)
DK (1) DK159157C (ko)
ES (1) ES488229A0 (ko)
FI (1) FI68239C (ko)
FR (1) FR2447925A1 (ko)
GB (1) GB2041934B (ko)
GR (1) GR72785B (ko)
HU (2) HU182095B (ko)
IE (1) IE49374B1 (ko)
IL (1) IL59265A (ko)
IT (1) IT1130239B (ko)
LU (1) LU82118A1 (ko)
NZ (1) NZ192750A (ko)
PH (1) PH15152A (ko)
PL (1) PL122609B1 (ko)
PT (1) PT70742A (ko)
RO (2) RO83702B (ko)
SU (2) SU897109A3 (ko)
YU (1) YU22480A (ko)
ZA (1) ZA80523B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3128949A1 (de) * 1981-07-22 1983-02-10 Basf Ag, 6700 Ludwigshafen Lichtempfindliche aufzeichnungsmaterialien zur herstellung von abriebs- und kratzfesten tiefdruckformen sowie verfahren zur herstellung von tiefdruckformen mittels dieser aufzeichnungsmaterialien
JPS6011491A (ja) * 1983-03-04 1985-01-21 Shionogi & Co Ltd セフアロチンナトリウムの結晶性凍結乾燥粉末の製造法
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
US4044002A (en) * 1976-06-09 1977-08-23 Eli Lilly And Company Reduction process for cephalosporin sulfoxides

Also Published As

Publication number Publication date
FR2447925B1 (ko) 1984-02-03
GR72785B (ko) 1983-12-05
DK159157B (da) 1990-09-10
IE49374B1 (en) 1985-09-18
GB2041934B (en) 1983-03-23
AU532573B2 (en) 1983-10-06
PL122609B1 (en) 1982-08-31
HU181761B (en) 1983-11-28
SU938740A3 (ru) 1982-06-23
AR228342A1 (es) 1983-02-28
AT366052B (de) 1982-03-10
NZ192750A (en) 1982-05-25
BG32857A3 (en) 1982-10-15
IL59265A0 (en) 1980-05-30
HU182095B (en) 1983-12-28
DK159157C (da) 1991-02-11
BE881423A (fr) 1980-07-30
CS214694B2 (en) 1982-05-28
CA1142173A (en) 1983-03-01
ATA49980A (de) 1981-07-15
RO83702A (ro) 1984-03-15
ES8103098A1 (es) 1981-02-16
RO83702B (ro) 1984-03-30
FR2447925A1 (fr) 1980-08-29
EP0014565B1 (en) 1983-02-23
FI68239B (fi) 1985-04-30
FI800300A (fi) 1980-08-02
PT70742A (en) 1980-02-01
PH15152A (en) 1982-08-24
DK41180A (da) 1980-08-02
PL221748A1 (ko) 1980-12-15
YU22480A (en) 1983-02-28
IT1130239B (it) 1986-06-11
CH647525A5 (fr) 1985-01-31
IE800191L (en) 1980-08-01
RO79181A (ro) 1982-06-25
SU897109A3 (ru) 1982-01-07
ZA80523B (en) 1981-09-30
JPH0128035B2 (ko) 1989-05-31
FI68239C (fi) 1985-08-12
IT8019607A0 (it) 1980-01-31
GB2041934A (en) 1980-09-17
JPS55104288A (en) 1980-08-09
EP0014565A1 (en) 1980-08-20
LU82118A1 (fr) 1980-04-23
IL59265A (en) 1983-05-15
ES488229A0 (es) 1981-02-16
DD148953A5 (de) 1981-06-17
KR830001890B1 (ko) 1983-09-17
AU5502680A (en) 1980-08-07
DE3062095D1 (en) 1983-03-31

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