SU938740A3 - Способ получени метанольного сольвата производного цефалоспорина - Google Patents

Способ получени метанольного сольвата производного цефалоспорина Download PDF

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Publication number
SU938740A3
SU938740A3 SU813233006A SU3233006A SU938740A3 SU 938740 A3 SU938740 A3 SU 938740A3 SU 813233006 A SU813233006 A SU 813233006A SU 3233006 A SU3233006 A SU 3233006A SU 938740 A3 SU938740 A3 SU 938740A3
Authority
SU
USSR - Soviet Union
Prior art keywords
methanol solvate
cephalosporin derivative
producing methanol
nitrobenzyl
hydroxy
Prior art date
Application number
SU813233006A
Other languages
English (en)
Inventor
Вэйн Фишер Джек
Original Assignee
Эли Лилли Энд Компани(Фирма)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани(Фирма) filed Critical Эли Лилли Энд Компани(Фирма)
Application granted granted Critical
Publication of SU938740A3 publication Critical patent/SU938740A3/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/32—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/59—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with hetero atoms directly attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/30—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino-radical acylated by an araliphatic carboxylic acid

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Description

(5«) СПОСОБ ПОЛУЧЕНИЯ МЕТАНОЛЬНОГО СОЛЬВАТА ПРОИЗВОДНОГО ЦЕФАЛОСПОРИНА
Изобретение относитс  к способу получени  нового метанольного соль VocH2-conH
который может найти применение в качестве полупродукта в синтезе антибиотиков цефалоспоринового р да.
Известен способ получени  сульфоксидов цефалоспоринов, содержащих в положении 3 гидроксильную группу, в частности -нитробензил-7-феноксиацетамидо-3-окси-3-цефем- -карбоксилат-1-оксида , озонолизом соответствующего 3 экзометиленцефамового соединени  р J.
Сульфоксид перевод т в соответствующее сульфидное соединение восстановлением ацетилбромидом в присутствии амилена 2.
вата производного цефахюспорина формулы
СНзОН
ОН
сооснг
+-Нитробензил-7-феноксиацетамидо-3-окси-3-цефем- -карбоксилат и его сульфоксид используют в качестве полупродуктов в синтезе антибиотиков цефалоспоринового р да.
Однако при синтезе этих соединений их выделение и очистка представл ют технологическую сложность.
Целью изобретени   вл етс  получение новых кристаллических форм полупродуктов в синтезе антибиотиков цефалоспоринового р да, облегчающих их выделение и очистку.
Эта цель достигаетс  способом получени  метанольного сольвата про

Claims (1)

  1. Формула изобретения
    Способ получения метанольного сольвата производного цефалоспорина формулы
SU813233006A 1979-02-01 1981-01-26 Способ получени метанольного сольвата производного цефалоспорина SU938740A3 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US846879A 1979-02-01 1979-02-01

Publications (1)

Publication Number Publication Date
SU938740A3 true SU938740A3 (ru) 1982-06-23

Family

ID=21731772

Family Applications (2)

Application Number Title Priority Date Filing Date
SU802877808A SU897109A3 (ru) 1979-02-01 1980-02-01 Способ получени сольватов цефалоспоринов
SU813233006A SU938740A3 (ru) 1979-02-01 1981-01-26 Способ получени метанольного сольвата производного цефалоспорина

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SU802877808A SU897109A3 (ru) 1979-02-01 1980-02-01 Способ получени сольватов цефалоспоринов

Country Status (32)

Country Link
EP (1) EP0014565B1 (ru)
JP (1) JPS55104288A (ru)
KR (1) KR830001890B1 (ru)
AR (1) AR228342A1 (ru)
AT (1) AT366052B (ru)
AU (1) AU532573B2 (ru)
BE (1) BE881423A (ru)
BG (1) BG32857A3 (ru)
CA (1) CA1142173A (ru)
CH (1) CH647525A5 (ru)
CS (1) CS214694B2 (ru)
DD (1) DD148953A5 (ru)
DE (1) DE3062095D1 (ru)
DK (1) DK159157C (ru)
ES (1) ES8103098A1 (ru)
FI (1) FI68239C (ru)
FR (1) FR2447925A1 (ru)
GB (1) GB2041934B (ru)
GR (1) GR72785B (ru)
HU (2) HU182095B (ru)
IE (1) IE49374B1 (ru)
IL (1) IL59265A (ru)
IT (1) IT1130239B (ru)
LU (1) LU82118A1 (ru)
NZ (1) NZ192750A (ru)
PH (1) PH15152A (ru)
PL (1) PL122609B1 (ru)
PT (1) PT70742A (ru)
RO (2) RO83702B (ru)
SU (2) SU897109A3 (ru)
YU (1) YU22480A (ru)
ZA (1) ZA80523B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3128949A1 (de) * 1981-07-22 1983-02-10 Basf Ag, 6700 Ludwigshafen Lichtempfindliche aufzeichnungsmaterialien zur herstellung von abriebs- und kratzfesten tiefdruckformen sowie verfahren zur herstellung von tiefdruckformen mittels dieser aufzeichnungsmaterialien
JPS6011491A (ja) * 1983-03-04 1985-01-21 Shionogi & Co Ltd セフアロチンナトリウムの結晶性凍結乾燥粉末の製造法
US4782144A (en) * 1987-09-14 1988-11-01 Eli Lilly And Company 1-carba(dethia)-3-hydroxy-3-cephem ester crystalline and crystalline solvate thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3985747A (en) * 1974-05-24 1976-10-12 Bristol-Myers Company Crystalline sesquihydrate of 7-[D-α-amino-α-(p-hydroxyphenyl)acetamido]-3-(1,2,3-triazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid
US4044002A (en) * 1976-06-09 1977-08-23 Eli Lilly And Company Reduction process for cephalosporin sulfoxides

Also Published As

Publication number Publication date
GB2041934B (en) 1983-03-23
KR830001890B1 (ko) 1983-09-17
PT70742A (en) 1980-02-01
SU897109A3 (ru) 1982-01-07
AU532573B2 (en) 1983-10-06
GR72785B (ru) 1983-12-05
RO83702A (ro) 1984-03-15
DK159157B (da) 1990-09-10
BG32857A3 (en) 1982-10-15
PH15152A (en) 1982-08-24
CH647525A5 (fr) 1985-01-31
FI68239C (fi) 1985-08-12
HU181761B (en) 1983-11-28
ES488229A0 (es) 1981-02-16
FR2447925A1 (fr) 1980-08-29
JPS55104288A (en) 1980-08-09
EP0014565B1 (en) 1983-02-23
IE49374B1 (en) 1985-09-18
FR2447925B1 (ru) 1984-02-03
IL59265A0 (en) 1980-05-30
IL59265A (en) 1983-05-15
RO83702B (ro) 1984-03-30
JPH0128035B2 (ru) 1989-05-31
LU82118A1 (fr) 1980-04-23
AT366052B (de) 1982-03-10
AU5502680A (en) 1980-08-07
NZ192750A (en) 1982-05-25
CS214694B2 (en) 1982-05-28
EP0014565A1 (en) 1980-08-20
RO79181A (ro) 1982-06-25
IT8019607A0 (it) 1980-01-31
PL122609B1 (en) 1982-08-31
HU182095B (en) 1983-12-28
DE3062095D1 (en) 1983-03-31
BE881423A (fr) 1980-07-30
DK41180A (da) 1980-08-02
PL221748A1 (ru) 1980-12-15
KR830001951A (ko) 1983-05-21
AR228342A1 (es) 1983-02-28
GB2041934A (en) 1980-09-17
FI68239B (fi) 1985-04-30
ZA80523B (en) 1981-09-30
IT1130239B (it) 1986-06-11
IE800191L (en) 1980-08-01
ATA49980A (de) 1981-07-15
FI800300A (fi) 1980-08-02
YU22480A (en) 1983-02-28
ES8103098A1 (es) 1981-02-16
DK159157C (da) 1991-02-11
CA1142173A (en) 1983-03-01
DD148953A5 (de) 1981-06-17

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