KR830001188A - 신규 화합물 - Google Patents

신규 화합물 Download PDF

Info

Publication number
KR830001188A
KR830001188A KR1019790002483A KR790002483A KR830001188A KR 830001188 A KR830001188 A KR 830001188A KR 1019790002483 A KR1019790002483 A KR 1019790002483A KR 790002483 A KR790002483 A KR 790002483A KR 830001188 A KR830001188 A KR 830001188A
Authority
KR
South Korea
Prior art keywords
alkyl
substituted
formula
esters
lower alkyl
Prior art date
Application number
KR1019790002483A
Other languages
English (en)
Other versions
KR850000425B1 (ko
Inventor
떠블유. 그라함 도날드
에프. 로저스 에드워드
엠. 카한 프레드릭
Original Assignee
제임스 에프. 너우톤
맬크 앤드 캄파니 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26728044&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR830001188(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 제임스 에프. 너우톤, 맬크 앤드 캄파니 인코포레이티드 filed Critical 제임스 에프. 너우톤
Publication of KR830001188A publication Critical patent/KR830001188A/ko
Priority to KR8402461A priority Critical patent/KR850001600B1/ko
Application granted granted Critical
Publication of KR850000425B1 publication Critical patent/KR850000425B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Eye Examination Apparatus (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

신규 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 본문에 상술한 바와같이, 다음 일반식(3')의 2-케토산 또는 그의 저급 알킬 에스테르와 다음 일반식(4)의 아미드를 톨루엔 또는 메틸 이소발레레이트 같은 불활성 용매에서 아미드 대 케토산 또는 에스테르를 약 1-4:1부로 혼합한 다음 물을 공비 제거하면서 3-48시간 동안, 바람직 하기로는 5-24시간 동안 환류하에 가열 응축시키거나, 또는 다음 일반식(5)의 산클로라이드를 염기의 존재하에 다음 일반식(6)의 α-아미노산의 t-부틸 에스테르와 반응시킨 다음 나트륨 메톡사이드를 가하여 산화시켜 얻어진 중간 물질을 무수 염산으로 처리하는 것으로 구성된 다음 일반식(1)의 화합물의 제조방법.
    식중,
    R2및 R3는 각각 3-10 및 1-15개의 탄소원자를 갖는 탄화수소기이며, 이들 R2및 R3탄화수소기 중에서, 1-6개의 수소는 할로겐에 의하여 치환될 수 있으며, 또는 비-말단 메틸렌은 산소, 황, 또는 황의 산화형태에 의하여 치환될 수 있다. 또한 R3내의 말단 수소는 1-8개의 탄소원자를 갖는 알카노일산으로 아실화할 수 있거나, 또는 알킬 및 디알킬 카바메이트 유도체로 카바모일화 할 수 있는 하이드록실 또는 티올기에 의하여 치환될 수 있으며; 또 수소는 아실아미노, 우레이도, 아미디노, 구아니디노, 또는 알킬 또는 치환 알킬아미노가, 4질소기에서 유도될 수 있는 아미노기에 의하여 치환될 수 있으며; 이와는 달리 카르복실산기, 포스폰산기 또는 설폰산기와 같은 산기 또는 그의 에스테르나 아미드 및 시아노; 또는 말단 아미노산기 같은 그의 화합물에 의하여 치환될 수 있다.
    R1은 수소 또는 저급 알킬(C1-6), 또는 디알킬아미노 알킬, 또는 계약적으로 허용되는 양이온; 단 R2가 페닐 또는 C1-4의 직쇄 저급알킬이 아닌 경우 R3는 C1-4의 직쇄저급알킬이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR7902483A 1978-07-24 1979-07-24 Z-2-아실아미노-3-모노치환 프로테노에이트의 제조방법 KR850000425B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR8402461A KR850001600B1 (en) 1978-07-24 1984-05-04 Process for the preparation of z-alpha-acylamino-3-monosubstituted propenic acid and esters

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92721278A 1978-07-24 1978-07-24
US5023379A 1979-06-22 1979-06-22
US050,233 1979-06-22
US927,212 1979-07-16

Publications (2)

Publication Number Publication Date
KR830001188A true KR830001188A (ko) 1983-04-29
KR850000425B1 KR850000425B1 (ko) 1985-04-03

Family

ID=26728044

Family Applications (1)

Application Number Title Priority Date Filing Date
KR7902483A KR850000425B1 (ko) 1978-07-24 1979-07-24 Z-2-아실아미노-3-모노치환 프로테노에이트의 제조방법

Country Status (28)

Country Link
EP (1) EP0010573B1 (ko)
JP (1) JPS63295540A (ko)
KR (1) KR850000425B1 (ko)
AT (1) ATE5070T1 (ko)
AU (1) AU527772B2 (ko)
BG (1) BG60346B2 (ko)
CA (1) CA1161058A (ko)
CZ (1) CZ280564B6 (ko)
DE (1) DE2966328D1 (ko)
DK (1) DK157399C (ko)
EG (1) EG13961A (ko)
ES (2) ES482773A1 (ko)
FI (1) FI76069C (ko)
GR (1) GR70699B (ko)
HK (1) HK5085A (ko)
HU (1) HU182531B (ko)
IE (1) IE49182B1 (ko)
IL (1) IL57797A (ko)
MA (1) MA18534A1 (ko)
NZ (1) NZ190994A (ko)
PH (1) PH16708A (ko)
PL (2) PL131618B1 (ko)
PT (1) PT69954B (ko)
RO (2) RO83292B (ko)
SG (1) SG65484G (ko)
SU (1) SU1213983A3 (ko)
YU (2) YU43455B (ko)
ZW (1) ZW13379A1 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4880793A (en) * 1978-07-24 1989-11-14 Merck & Co., Inc. Combination of thienamycin-type antibiotics with dipeptidase inhibitors
EP0048025B1 (en) * 1980-09-17 1986-01-15 Merck & Co. Inc. Antibacterial composition of thienamycin type compound and a dipeptidase inhibitor
PT73640B (en) * 1980-09-17 1983-10-19 Merck & Co Inc Process for preparing chemical compounds selectively inhibit the metabolism of dipeptidase
JPS58170479A (ja) * 1982-03-30 1983-10-07 Sanraku Inc ジペプチダ−ゼ阻害剤
JPS58174345A (ja) * 1982-04-06 1983-10-13 Sumitomo Chem Co Ltd 光学活性２，２−ジメチルシクロプロパン−１−カルボン酸ハライドのラセミ化方法
US4798842A (en) * 1984-07-18 1989-01-17 Schering Corporation Inhibitors of slow reacting substance of anaphylaxis
DE3508564A1 (de) * 1985-03-11 1986-09-11 Degussa Ag, 6000 Frankfurt Verfahren zur herstellung von n-acyl-2, 3-dehydroaminocarbonsaeureestern
US4739113A (en) * 1986-05-30 1988-04-19 Merck & Co., Inc. Bis(cyclopropanecarboxamido)alkadienedioic acids as renal dipeptidase inhibitors
CA2052730A1 (en) 1990-10-11 1992-04-12 Frank P. Dininno 2-(substituted-dibenzofuranyl and dibenzothienyl) carbapenem antibacterial agents
EP0497353B1 (en) * 1991-02-01 2002-05-08 Suntory Limited Use of cilastatin, glutathione or N-acetyl-L-cysteine for the preparation of a medicament for the improvement of gastrointestinal absorption of penem or carbapenem antibiotics
CN103502411B (zh) 2011-04-28 2016-01-20 味之素株式会社 液体洗涤剂组合物
PL442220A1 (pl) 2022-09-07 2024-03-11 Politechnika Wrocławska Sposób i układ do wytwarzania nawozu mikroelementowego

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2449191A (en) * 1945-08-24 1948-09-14 Lilly Co Eli Phenacetylaminomethylcrotonic acid
US2569801A (en) * 1947-02-12 1951-10-02 American Cyanamid Co Preparation of azlactones of phenylacetamino acrylic acids
US2622074A (en) 1949-12-09 1952-12-16 Eastman Kodak Co Salts of alpha-acylamido and alpha-alkoxycarbonamido acrylic acids
BE664781A (ko) 1964-06-01
GB1260847A (en) 1968-12-06 1972-01-19 Nat Res Dev Esters of cyclopropane carboxylic acids
US3950357A (en) * 1974-11-25 1976-04-13 Merck & Co., Inc. Antibiotics
CS226166B2 (cs) 1975-11-21 1984-03-19 Merck & Co Inc Způsob přípravy derivátů thienamycinu
DK143713C (da) 1975-11-21 1982-03-08 Merck & Co Inc Fremgangsmaade til fremstilling af et antibiotisk stof n-acetyl-thienamycin og salte deraf
DK143712C (da) 1975-11-21 1982-03-22 Merck & Co Inc Fremgangsmaade til fremstilling af de antibiotiske stoffer 890a1 og 890a3
DK497476A (da) 1975-11-24 1977-05-25 Merck & Co Inc Fremgangsmade til fremstilling af et antibiotisk stof
US4070477A (en) 1975-12-08 1978-01-24 Ciba-Geigy Corporation 2-Penem compounds
NL7712091A (nl) 1976-11-17 1978-05-19 Merck & Co Inc Werkwijze ter bereiding van een nieuw antibiotisch middel.
DK487977A (da) 1976-11-17 1978-05-18 Merck & Co Inc Fremgangsmaade til fremstilling af et antiotisk stof
GB1593524A (en) 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
SE7800978L (sv) 1977-02-11 1978-08-12 Merck & Co Inc Antibiotikum
NL7800958A (nl) 1977-02-11 1978-08-15 Merck & Co Inc Antibioticum desacetyl-dihydro 890 a9, werkwijze ter bereiding daarvan en farmaceutisch preparaat dat dit antibioticum bevat.
JPS604719B2 (ja) 1977-03-31 1985-02-06 メルシャン株式会社 β‐ラクタマーゼ阻害活性を有する抗生物質ＰＳ―５の製造方法
US4162323A (en) 1977-04-18 1979-07-24 Merck & Co., Inc. Antibiotic N-acetyl-dehydro-thienamycin
BE867227A (fr) 1977-10-31 1978-11-20 Merck & Co Inc Preparation de l'acide 6-(alpha-hydroxyethyl)-7-oxo-1-azabicyclo (3,2,0) hept-2-ene-carboxylique et derives a activite antibiotique

Also Published As

Publication number Publication date
FI792281A (fi) 1980-01-25
PL125506B1 (en) 1983-05-31
CA1161058A (en) 1984-01-24
HU182531B (en) 1984-02-28
DK157399C (da) 1990-05-21
JPS63295540A (ja) 1988-12-01
IL57797A (en) 1986-01-31
MA18534A1 (fr) 1980-04-01
AU527772B2 (en) 1983-03-24
CZ280564B6 (cs) 1996-02-14
YU10183A (en) 1983-04-30
EP0010573A1 (en) 1980-05-14
YU43144B (en) 1989-04-30
DK309879A (da) 1980-02-28
YU178879A (en) 1983-04-30
JPH0440338B2 (ko) 1992-07-02
RO83292A (ro) 1984-02-21
PL225939A1 (ko) 1981-10-02
DE2966328D1 (en) 1983-11-24
ZW13379A1 (en) 1981-05-06
ES8106132A1 (es) 1981-07-16
ATE5070T1 (de) 1983-11-15
NZ190994A (en) 1981-10-19
HK5085A (en) 1985-01-25
SU1213983A3 (ru) 1986-02-23
GR70699B (ko) 1982-12-30
PT69954A (en) 1979-08-01
RO78106A (ro) 1982-04-12
ES482773A1 (es) 1980-09-01
AU4893379A (en) 1980-01-31
FI76069B (fi) 1988-05-31
PH16708A (en) 1984-01-20
CZ513679A3 (en) 1995-09-13
ES492553A0 (es) 1981-07-16
PT69954B (pt) 1981-06-11
BG60346B2 (bg) 1994-09-30
YU43455B (en) 1989-08-31
IE791387L (en) 1980-01-24
PL131618B1 (en) 1984-12-31
IL57797A0 (en) 1979-11-30
FI76069C (fi) 1988-09-09
IE49182B1 (en) 1985-08-21
SG65484G (en) 1985-03-29
EG13961A (en) 1983-03-31
RO83292B (ro) 1984-02-28
EP0010573B1 (en) 1983-10-19
DK157399B (da) 1990-01-02
KR850000425B1 (ko) 1985-04-03
PL217327A1 (ko) 1980-12-01

Similar Documents

Publication Publication Date Title
KR830008999A (ko) N-치환된-아미도-아미노 산의 제조방법
KR830001188A (ko) 신규 화합물
EP0193148A3 (en) 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides
SE8302694L (sv) Immunomudulerande medel
KR890001966A (ko) 함염성 아릴 유도체
IE860411L (en) N, n - disubstituted aminoacidamides
IL89908A0 (en) 2-alkyl-3-benzoylbenzofurans and pharmaceutical compositions containing them
KR900007322A (ko) 살균 화합물, 이들의 제조방법 및 사용, 및 이들을 함유하는 조성물
JPS55145650A (en) Intermediate and its preparation
EP0587188A3 (en) Aryl and heterocyclic substituted propenamide derivatives
ES2039719T3 (es) Procedimiento para preparar un agente terapeutico para el tratamiento de la enfermedad de ulcera peptica.
GR3004834T3 (ko)
HK1032916A1 (en) N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents
ATE146481T1 (de) Epoxysuccinamidsäurederivat
KR900018082A (ko) 페닐알카노산의 에스테르
PH24369A (en) Novel 16,17-acetalsubstituted androstane-17b-carboxylic acid esters,pharmaceutical compositions containing said compounds and method of use thereof
GR76835B (ko)
DE3160821D1 (en) Alkyl and cycloalkyl substituted 2-(2-(2-hydroxy-3-tert.-butylamino-propoxy)-5-acylaminophenyl)-1,3,4-oxadiazoles, their preparation and pharmaceutical preparations containing them
KR890001438A (ko) 살진균성 활성 화합물의 배합물
KR880008984A (ko) 프로스타글란딘 유도체, 그의 제조방법 및 치료학적 용도
KR830007566A (ko) (티오노)(티올)포스포르(포스폰)산 에스테르 및 치환된 4-하이드록시 퀴놀린의 에스테르 아미드의 제조방법
MX9302970A (es) Analogos de acido l-glutamico y gaba para tratamiento anti-ataque.