ES2039719T3 - Procedimiento para preparar un agente terapeutico para el tratamiento de la enfermedad de ulcera peptica. - Google Patents

Procedimiento para preparar un agente terapeutico para el tratamiento de la enfermedad de ulcera peptica.

Info

Publication number
ES2039719T3
ES2039719T3 ES198989102391T ES89102391T ES2039719T3 ES 2039719 T3 ES2039719 T3 ES 2039719T3 ES 198989102391 T ES198989102391 T ES 198989102391T ES 89102391 T ES89102391 T ES 89102391T ES 2039719 T3 ES2039719 T3 ES 2039719T3
Authority
ES
Spain
Prior art keywords
treatment
disease
peptica
ulcera
prepare
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198989102391T
Other languages
English (en)
Inventor
Erhard Dr. Wolf
Ulrich Dr. Gebert
Harald Dr. Furrer
Toshizo Tanaka
Masao Sakurai
Masayoshi Goto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis KK
Original Assignee
Hoechst Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Japan Ltd filed Critical Hoechst Japan Ltd
Application granted granted Critical
Publication of ES2039719T3 publication Critical patent/ES2039719T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

AGENTES TERAPEUTICOS PARA EL TRATAMIENTO DE ENFERMEDAD DE ULCERA PEPTICA, QUE CONTIENE COMO INGREDIENTE ACTIVO, AL MENOS UN COMPONENTE DE LA FORMULA GENERAL (I): EN DONDE R1 Y R3 SON LOS MISMOS O DIFERENTES Y SON CADA UNO (C1 C8) ALQUIL, (C3 - C6) ALQUINIL, FORMULA (II), FORMULA (III) O FORMULA (IV); R2 ES (C1 - C4) ALQUIL; R4 Y R5 SON EL MISMO O DIFERENTE Y SON CADA UNO HIDROGENO O (C1 - C2) ALQUIL; R6 ES (C1 - C2) ALQUIL; Y M, N Y P SON EL MISMO O DIFERENTE Y SON CADA UNO 1, 2, 3, 4, 5 O 6 CON LA CONDICION DE QUE UNO DE LOS GRUPOS R1 Y R3 SON FORMULA (V) O FORMULA (VI9 O QUE R3 REPRESENTA FORMULA (VII). ALGUNOS DE LOS COMPONENTES DE LA FORMULA (I) SON NUEVOS.
ES198989102391T 1988-02-19 1989-02-11 Procedimiento para preparar un agente terapeutico para el tratamiento de la enfermedad de ulcera peptica. Expired - Lifetime ES2039719T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63035484A JP2661666B2 (ja) 1988-02-19 1988-02-19 抗消化性潰瘍剤

Publications (1)

Publication Number Publication Date
ES2039719T3 true ES2039719T3 (es) 1993-10-01

Family

ID=12443024

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198989102391T Expired - Lifetime ES2039719T3 (es) 1988-02-19 1989-02-11 Procedimiento para preparar un agente terapeutico para el tratamiento de la enfermedad de ulcera peptica.

Country Status (17)

Country Link
US (1) US5082845A (es)
EP (1) EP0330031B1 (es)
JP (1) JP2661666B2 (es)
KR (1) KR0133075B1 (es)
AT (1) ATE70182T1 (es)
AU (1) AU605669B2 (es)
DE (1) DE68900516D1 (es)
DK (1) DK74189A (es)
ES (1) ES2039719T3 (es)
GR (1) GR3003952T3 (es)
HU (1) HU204702B (es)
IE (1) IE61147B1 (es)
IL (1) IL89324A0 (es)
NZ (1) NZ228020A (es)
PH (1) PH27149A (es)
PT (1) PT89757B (es)
ZA (1) ZA891241B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2661666B2 (ja) * 1988-02-19 1997-10-08 ヘキスト薬品工業株式会社 抗消化性潰瘍剤
DD298051A5 (de) * 1989-08-16 1992-02-06 ��@���������@�������k�� Verfahren zur herstellung eines therapeutischen agens zur behandlung von verdauungskrankheiten
IT1240843B (it) * 1990-05-24 1993-12-17 Malesci Istituto Farmacobiologico Derivati xantinici 1-7 sostituiti ad attivita' antiasmatica, loro sali fisiologicamente accettabili, loro composizioni farmaceutiche e procedimento per la loro preparazione.
JP2549480B2 (ja) * 1991-12-10 1996-10-30 ヘキストジャパン株式会社 排尿障害改善剤
EP0570831A2 (de) * 1992-05-20 1993-11-24 Hoechst Aktiengesellschaft Verwendung von Xanthinderivaten zur Behandlung von Nervenschädigungen nach Unterbrechung der Blutzirkulation
US5354756A (en) * 1993-01-12 1994-10-11 Cell Therapeutics, Inc. Olefin-substituted long chain xanthine compounds
US5620676A (en) * 1994-03-08 1997-04-15 The United States Of America As Represented By The Department Of Health And Human Services Biologically active ATP analogs
US20090239886A1 (en) 2008-02-29 2009-09-24 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
US20110053961A1 (en) 2009-02-27 2011-03-03 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH608236A5 (es) * 1974-01-22 1978-12-29 Wuelfing J A Fa
DE2432702C2 (de) * 1974-07-08 1983-01-20 Hoechst Ag, 6000 Frankfurt Verfahren zur Herstellung von Hydroxyalkylxanthinen
US4207321A (en) * 1977-04-02 1980-06-10 Hoechst Aktiengesellschaft Pharmaceutical compositions containing xanthines
EP0157098A1 (en) * 1980-06-21 1985-10-09 Beecham Wuelfing GmbH & Co KG Xanthine derivatives, pharmaceuticals compositions containing them and a process for their preparation
DE3138397A1 (de) * 1981-09-26 1983-04-07 Hoechst Ag, 6230 Frankfurt "arzneimittel, darin enthaltene vicinale dihydroxyalkylxanthine und herstellungsverfahren fuer diese xanthinverbindungen"
US4636507A (en) * 1984-04-30 1987-01-13 Hoechst-Roussel Pharmaceuticals Inc. Host defense mechanism enhancement
GB8418430D0 (en) * 1984-07-19 1984-08-22 Beecham Wuelfing Gmbh & Co Kg Treatment
DE3508097A1 (de) * 1984-07-21 1986-02-06 Hoechst Ag, 6230 Frankfurt Kombinationspraeparat aus xanthinderivaten und o-acetylsalicylsaeure bzw. deren pharmakologisch vertraeglichen salzen und dessen verwendung
DE3525801A1 (de) * 1985-07-19 1987-01-22 Hoechst Ag Tertiaere hydroxyalkylxanthine, verfahren zu ihrer herstellung, die sie enthaltenden arzneimittel und ihre verwendung
US4772607A (en) * 1986-05-20 1988-09-20 Warner-Lambert Company Dialkenyl derivatives of xanthine, pharmaceutical compositions and methods of use therefor
JPS63225317A (ja) * 1986-10-06 1988-09-20 Hoechst Japan Kk 抗消化性潰瘍剤
JP2661666B2 (ja) * 1988-02-19 1997-10-08 ヘキスト薬品工業株式会社 抗消化性潰瘍剤

Also Published As

Publication number Publication date
IE61147B1 (en) 1994-10-05
IE890514L (en) 1989-08-19
ATE70182T1 (de) 1991-12-15
PT89757A (pt) 1989-10-04
US5082845A (en) 1992-01-21
IL89324A0 (en) 1989-09-10
PH27149A (en) 1993-04-02
KR890012652A (ko) 1989-09-18
ZA891241B (en) 1989-10-25
NZ228020A (en) 1991-07-26
DE68900516D1 (de) 1992-01-23
DK74189D0 (da) 1989-02-17
HUT49283A (en) 1989-09-28
EP0330031B1 (en) 1991-12-11
PT89757B (pt) 1994-03-31
JP2661666B2 (ja) 1997-10-08
AU605669B2 (en) 1991-01-17
JPH01211524A (ja) 1989-08-24
KR0133075B1 (ko) 1998-04-17
GR3003952T3 (es) 1993-03-16
DK74189A (da) 1989-08-20
AU2853889A (en) 1989-08-24
HU204702B (en) 1992-02-28
EP0330031A1 (en) 1989-08-30

Similar Documents

Publication Publication Date Title
EP0369627A3 (en) Pyrimidinedione derivative compounds, method of producing the same and antiarrythmic agents containing the same
ES2174989T3 (es) Pirido(3,2-e)pirazinonas con antiasmatica y procedimiento para su preparacion.
ES2039719T3 (es) Procedimiento para preparar un agente terapeutico para el tratamiento de la enfermedad de ulcera peptica.
ATE110721T1 (de) 2-alkyl-3-benzoylbenzofurane und diese enthaltende pharmazeutische zusammensetzungen.
ES2059348T3 (es) Composicion farmaceutica para el tratamiento de cataratas.
ES2035915T3 (es) Agentes antiarritmicos n-fenetil-aminoalquil-benzamida.
ES2032797T3 (es) Agente terapeutico para el tratamiento de la enfermedad ulcera peptica.
ZA906446B (en) Therapeutic agents for the treatment of peptic ulcer disease
IL90942A0 (en) Topical pharmaceutical compositions containing retinoids
MX166479B (es) Composicion farmaceutica que contiene carbinolimidazoles
TH12150EX (th) อนุพันธ์ซีลอกเซนชนิดใหม่วิธีการผลิตและสารที่รวมถึงอนุพันธ์ซีลอกเซนนี้
KR890002222A (ko) 치매 치료제

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 330031

Country of ref document: ES