KR890001966A - 함염성 아릴 유도체 - Google Patents
함염성 아릴 유도체 Download PDFInfo
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- KR890001966A KR890001966A KR1019880008745A KR880008745A KR890001966A KR 890001966 A KR890001966 A KR 890001966A KR 1019880008745 A KR1019880008745 A KR 1019880008745A KR 880008745 A KR880008745 A KR 880008745A KR 890001966 A KR890001966 A KR 890001966A
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A01N37/28—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the group; Thio analogues thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (13)
- 하기식(Ⅱ)의 화합물 또는 그의염.상기식에서 q는 1, k는 0그리고 p는 1 ; Ar은 페닐로서 C1-4(하나 또는 그 이상의 할로겐 원자로 치환됨)과 할로겐에서 독자적으로 선택된 하나 또는 그이상의 치환체에 의하여 치환될 수 있으며 L은 -O- ; Ar'은 1,3- 또는 1,4 -페닐렌 ; Y는 (E) -CH=CH- ; V는 수소 또는 C1-4; 알킬 ; W는 C1-4알킬 ; 그리고 Q는 하기식의 부로서상기식에서 m은 1, R1은 수소, 그리고 R2는 수소 또는 C1-4알킬.
- 제1항에 있어서, q=1, k=0, p=1, Ar은 메틸, 크리플루오로메틸, 브로모, 클로로와 플루오로 중에서 독자적으로 선택된 1또는 그 이상의 치환체에 의하여 치환된 페닐 : L은 -O-, Ar'은 1,3-페닐렌 ; Y는(E)-CH=CH- V는 수소, W는 메틸그리고 Q는 m=1, R1이 수소 그리고 R2가 메틸인 제1항의 부인식(Ⅱ)의 화합물 또는 그의염.
- (+) 또는 (-)대장체 또는 이들의 임의비율의 혼합물 형태인 다음에서 선택된 식(Ⅱ)의 화합물 또는 그의염. (E) -N-[1-메틸 -3-(3페녹시페닐)프로프 -2-에닐]아세토히드록삼산, (E)-N-{1-메틸-3-[3-(4-메틸페녹시)페닐]프로프 -2-에닐}아세토히드록삼산, (E) -N-[1-메틸-3-[3-(4-t-부틸페녹시)페닐]프로프 -2-에닐}아세토히드록삼산, (E) -N-{1-메틸-3-[3-(4-클로로페녹시)페닐]프로프-2-에닐}아세토히드록삼산, (E) -N-{1-메틸-3-[3-(4-브로모페녹시)페닐]프로프-2-에닐}아세토히드록삼산, (E)-N-{1-메틸-3-[3-(3-트리플루오메틸페녹시)페닐]프로프 -2-에닐}아세토히드록삼산, (E)-N-{1-메틸-3-(3,5-디클로로페녹시)페닐]프로프 -2-에닐}아세토히드록삼산, (E)-N-{1-메틸-3-[3-(4-플루오로펜녹시)페닐]프로프-2-에닐}아세토히드록삼산, (E)-N-{1-메틸-3-[2,4-디플루오로페녹시)페닐]프로프-2-에닐}아세토히드록삼산.
- 제1항의 식(Ⅱ)의 화합물 또는 약학적으로 허용하가능한 그의염, 약학적으로 허용가능한 담체 및 하나 또는 그 이상의 약리학적 활성제로 구성된 약학적 제제.
- 제4항에 있어서, 식(Ⅱ)의 화합물이 제2항의 화합물 또는 그의 약학적으로 허용가능한 염인 제제.
- 제4항에 있어서, 식(Ⅱ)의 화합물이 제3항의 화합물 또는 약학적으로 허용가능한 그의 염인 제제.
- 제4항에 있어서, 제제가 폐동맥내 투어용 제제이며 식Ⅱ)의 화합물 또는 약학적으로 허용가능한 염이(+) 또는(-)거울상, 이성질체중의 하나 또는 임의의 비율로서의 혼합물로서 존재하는 (E)-N-{1-메틸-3-[3-(4-클로로페녹시)페닐]프로프-3-에닐}아세토히드록삼산 ; 또는 (E)-N-{1-메틸-3-[3-(4-플루오로페녹시)페닐]프로프-3-에닐}아세토히드록삼산인 제제.
- (a) 하기식(Ⅲ)의 화합물을 아실화제와 반응시키고 Z1이 보호기일 때 상기 보호기가 제거될수 있는 조건에 주입시키거나, 하나 또는 그 이상의 제제와 반응시키거나 (b) 하기식(Ⅳ)의 화합물을 하기식(Ⅴ)의 화합물과 반응시키거나 (c) 하기식(Ⅵ)의 화합물을 탄산칼슘과 같은 염기와 반응시키거나 (d) 하기식(Ⅶ)의 화합물을 부분환원시키는 것으로 구성된 하기식(Ⅱ)의 화합물 또는 그의 대응되는 염의 제조방법.R9N(OZ1)H (Ⅲ)R6NHOH (Ⅳ)R7-R8(Ⅴ)상기식에서 R9과 R7은 각각로서, Ar, L, Ar', q, x, k, y, p, v와 w는 제1항에서 정의된바와 같다. Z1은 수소 또는 알맞은 보호기 R2, R3은 제1항에서 정의된 바와같다. R6는 -(CO)mR2로서 m과 R2는 제1항에서 정의된 바와 같다. R8은 알맞은 이탈기.
- 포유류의 의약적치료와 예방에 사용하기 위한 제1항 내지 제3항중 어느 한항에서 청구된식(Ⅱ)의 화합물 또는 약학적으로 허용가능한 그의염.
- 절단되거나 뽑혀진 식물의 노쇄를 연장시키거나 식물성장을 조절하기 위한 제1항의 식(Ⅱ)의 화합물 또는 그의염.
- 항-경련제 또는 항-알레르기제의 제조에 제1항 내지 제3항중 어느 한항에서 청구된 식(Ⅱ)의 화합물 또는 약학적으로 허용가능한 그의염을 사용하는 방법.
- 제11항에 있어서, 제제가 항-천식제인 방법.
- 항-발열제, 지통제, 항-응집제 또는 함염제의 제조에 제1항 내지 제3항중 어느 한 항에서 청구된 식(Ⅱ)의 화합물 또는 약학적으로 허용가능한 그의 염을 사용하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8716640 | 1987-07-15 | ||
GB878716640A GB8716640D0 (en) | 1987-07-15 | 1987-07-15 | Aryl derivatives |
GB8802378 | 1988-02-03 | ||
GB888802378A GB8802378D0 (en) | 1988-02-03 | 1988-02-03 | New aryl derivatives |
GB888806278A GB8806278D0 (en) | 1988-03-16 | 1988-03-16 | New aryl derivatives |
GB8806278 | 1988-03-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR890001966A true KR890001966A (ko) | 1989-04-07 |
Family
ID=27263507
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019880008745A KR890001966A (ko) | 1987-07-15 | 1988-07-14 | 함염성 아릴 유도체 |
Country Status (18)
Country | Link |
---|---|
US (1) | US4988733A (ko) |
EP (1) | EP0299761B1 (ko) |
JP (1) | JPS6445344A (ko) |
KR (1) | KR890001966A (ko) |
AT (1) | ATE70530T1 (ko) |
AU (1) | AU603468B2 (ko) |
DE (1) | DE3866981D1 (ko) |
DK (1) | DK392788A (ko) |
ES (1) | ES2051854T3 (ko) |
FI (1) | FI883355A (ko) |
GR (1) | GR3003393T3 (ko) |
HU (1) | HU203076B (ko) |
IL (1) | IL87105A0 (ko) |
MC (1) | MC1959A1 (ko) |
NO (1) | NO883146L (ko) |
NZ (1) | NZ225408A (ko) |
PL (1) | PL154186B1 (ko) |
PT (1) | PT87987B (ko) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0288553A (ja) * | 1988-07-14 | 1990-03-28 | Wellcome Found Ltd:The | 抗炎症性アリール誘導体 |
ES2060015T3 (es) * | 1989-02-03 | 1994-11-16 | Wellcome Found | Derivados arilicos anti-inflamatorios. |
US5476873A (en) * | 1990-07-25 | 1995-12-19 | Abbott Laboratories | Acetylene derivatives having lipoxygenase inhibitory activity |
JPH0819069B2 (ja) * | 1990-07-25 | 1996-02-28 | アボツト・ラボラトリーズ | リポキシゲナーゼ阻害活性を有するアセチレン誘導体 |
US5234933A (en) * | 1991-10-31 | 1993-08-10 | Board Of Governors Of Wayne State University And Vanderbilt University | Cyclic hydroxamic acids |
US5169854A (en) * | 1992-02-26 | 1992-12-08 | Abbott Laboratories | N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity |
US5187192A (en) * | 1992-03-13 | 1993-02-16 | Abbott Laboratories | Cyclobutyl derivatives having lipoxygenase inhibitory activity |
ATE189123T1 (de) * | 1992-06-30 | 2000-02-15 | Us Health | Verfahren zur herstellung einer schutzsperre gegen virus |
GB9215921D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Anti-inflammatory compounds |
WO1994004537A2 (en) * | 1992-08-20 | 1994-03-03 | Cytomed, Inc. | Dual functional anti-inflammatory and immunosuppressive agents |
GB9308652D0 (en) * | 1993-04-27 | 1993-06-09 | Wellcome Found | Anti-inflammatory compounds |
EP0833622B8 (en) * | 1995-06-12 | 2005-10-12 | G.D. Searle & Co. | Compositions comprising a cyclooxygenase-2 inhibitor and a 5-lipoxygenase inhibitor |
AR029916A1 (es) * | 2000-05-05 | 2003-07-23 | Smithkline Beecham Corp | N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas |
AR028075A1 (es) * | 2000-05-05 | 2003-04-23 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
US20040034024A1 (en) * | 2001-05-04 | 2004-02-19 | Aubart Kelly M | Peptide deformylase inhibitors |
ATE445838T1 (de) | 2001-07-25 | 2009-10-15 | Raptor Pharmaceutical Inc | Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke |
EP2671508B1 (en) | 2005-04-28 | 2020-09-16 | Proteus Digital Health, Inc. | Pharma-informatics system |
CA2663377A1 (en) | 2006-09-18 | 2008-03-27 | Raptor Pharmaceutical Inc. | Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates |
GB0624187D0 (en) * | 2006-12-04 | 2007-01-10 | Jackson William P | HDAC inhibitors |
HUE059078T2 (hu) | 2009-02-20 | 2022-10-28 | Enhanx Biopharm Inc | Glutation-alapú hatóanyagszállító rendszer |
JP2012526144A (ja) | 2009-05-06 | 2012-10-25 | ラボラトリー スキン ケア インコーポレイテッド | 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法 |
US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0196184B1 (en) * | 1985-03-16 | 1992-09-16 | The Wellcome Foundation Limited | Aryl derivatives |
IE59397B1 (en) * | 1985-03-16 | 1994-02-23 | Wellcome Found | New aryl derivatives |
US4608390A (en) * | 1985-04-26 | 1986-08-26 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
GB8718212D0 (en) * | 1987-07-31 | 1987-09-09 | Angus Fire Armour Ltd | Lining tubular objects |
-
1988
- 1988-07-12 PL PL1988273728A patent/PL154186B1/pl unknown
- 1988-07-14 IL IL87105A patent/IL87105A0/xx unknown
- 1988-07-14 JP JP63176198A patent/JPS6445344A/ja active Pending
- 1988-07-14 NZ NZ225408A patent/NZ225408A/xx unknown
- 1988-07-14 AT AT88306446T patent/ATE70530T1/de not_active IP Right Cessation
- 1988-07-14 ES ES88306446T patent/ES2051854T3/es not_active Expired - Lifetime
- 1988-07-14 KR KR1019880008745A patent/KR890001966A/ko not_active Application Discontinuation
- 1988-07-14 DK DK392788A patent/DK392788A/da not_active Application Discontinuation
- 1988-07-14 MC MC881991A patent/MC1959A1/xx unknown
- 1988-07-14 FI FI883355A patent/FI883355A/fi not_active Application Discontinuation
- 1988-07-14 EP EP88306446A patent/EP0299761B1/en not_active Expired - Lifetime
- 1988-07-14 NO NO88883146A patent/NO883146L/no unknown
- 1988-07-14 HU HU883683A patent/HU203076B/hu unknown
- 1988-07-14 DE DE8888306446T patent/DE3866981D1/de not_active Expired - Fee Related
- 1988-07-14 AU AU19068/88A patent/AU603468B2/en not_active Ceased
- 1988-07-14 PT PT87987A patent/PT87987B/pt not_active IP Right Cessation
- 1988-07-14 US US07/219,096 patent/US4988733A/en not_active Expired - Fee Related
-
1991
- 1991-12-19 GR GR91401878T patent/GR3003393T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
PT87987B (pt) | 1995-03-01 |
JPS6445344A (en) | 1989-02-17 |
HU203076B (en) | 1991-05-28 |
PL273728A1 (en) | 1989-04-03 |
FI883355A (fi) | 1989-01-16 |
ES2051854T3 (es) | 1994-07-01 |
EP0299761A1 (en) | 1989-01-18 |
PL154186B1 (en) | 1991-07-31 |
PT87987A (pt) | 1989-06-30 |
US4988733A (en) | 1991-01-29 |
DK392788D0 (da) | 1988-07-14 |
GR3003393T3 (en) | 1993-02-17 |
DE3866981D1 (de) | 1992-01-30 |
IL87105A0 (en) | 1988-12-30 |
AU1906888A (en) | 1989-01-19 |
NO883146L (no) | 1989-01-16 |
ATE70530T1 (de) | 1992-01-15 |
MC1959A1 (fr) | 1989-06-30 |
FI883355A0 (fi) | 1988-07-14 |
NO883146D0 (no) | 1988-07-14 |
HUT48572A (en) | 1989-06-28 |
DK392788A (da) | 1989-01-16 |
NZ225408A (en) | 1991-09-25 |
AU603468B2 (en) | 1990-11-15 |
EP0299761B1 (en) | 1991-12-18 |
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