KR890001966A - 함염성 아릴 유도체 - Google Patents

함염성 아릴 유도체 Download PDF

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KR890001966A
KR890001966A KR1019880008745A KR880008745A KR890001966A KR 890001966 A KR890001966 A KR 890001966A KR 1019880008745 A KR1019880008745 A KR 1019880008745A KR 880008745 A KR880008745 A KR 880008745A KR 890001966 A KR890001966 A KR 890001966A
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compound
formula
methyl
phenyl
enyl
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KR1019880008745A
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안토니 살몬 존
폴 잭슨 윌리암
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엠. 피. 잭슨
더 웰컴 파운데이숀 리미티드
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Priority claimed from GB878716640A external-priority patent/GB8716640D0/en
Priority claimed from GB888802378A external-priority patent/GB8802378D0/en
Priority claimed from GB888806278A external-priority patent/GB8806278D0/en
Application filed by 엠. 피. 잭슨, 더 웰컴 파운데이숀 리미티드 filed Critical 엠. 피. 잭슨
Publication of KR890001966A publication Critical patent/KR890001966A/ko

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    • C07—ORGANIC CHEMISTRY
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    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
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    • A—HUMAN NECESSITIES
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    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/28—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the group; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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Abstract

내용 없음

Description

함염성 아릴 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 하기식(Ⅱ)의 화합물 또는 그의염.
    상기식에서 q는 1, k는 0그리고 p는 1 ; Ar은 페닐로서 C1-4(하나 또는 그 이상의 할로겐 원자로 치환됨)과 할로겐에서 독자적으로 선택된 하나 또는 그이상의 치환체에 의하여 치환될 수 있으며 L은 -O- ; Ar'은 1,3- 또는 1,4 -페닐렌 ; Y는 (E) -CH=CH- ; V는 수소 또는 C1-4; 알킬 ; W는 C1-4알킬 ; 그리고 Q는 하기식의 부로서
    상기식에서 m은 1, R1은 수소, 그리고 R2는 수소 또는 C1-4알킬.
  2. 제1항에 있어서, q=1, k=0, p=1, Ar은 메틸, 크리플루오로메틸, 브로모, 클로로와 플루오로 중에서 독자적으로 선택된 1또는 그 이상의 치환체에 의하여 치환된 페닐 : L은 -O-, Ar'은 1,3-페닐렌 ; Y는(E)-CH=CH- V는 수소, W는 메틸그리고 Q는 m=1, R1이 수소 그리고 R2가 메틸인 제1항의 부인식(Ⅱ)의 화합물 또는 그의염.
  3. (+) 또는 (-)대장체 또는 이들의 임의비율의 혼합물 형태인 다음에서 선택된 식(Ⅱ)의 화합물 또는 그의염. (E) -N-[1-메틸 -3-(3페녹시페닐)프로프 -2-에닐]아세토히드록삼산, (E)-N-{1-메틸-3-[3-(4-메틸페녹시)페닐]프로프 -2-에닐}아세토히드록삼산, (E) -N-[1-메틸-3-[3-(4-t-부틸페녹시)페닐]프로프 -2-에닐}아세토히드록삼산, (E) -N-{1-메틸-3-[3-(4-클로로페녹시)페닐]프로프-2-에닐}아세토히드록삼산, (E) -N-{1-메틸-3-[3-(4-브로모페녹시)페닐]프로프-2-에닐}아세토히드록삼산, (E)-N-{1-메틸-3-[3-(3-트리플루오메틸페녹시)페닐]프로프 -2-에닐}아세토히드록삼산, (E)-N-{1-메틸-3-(3,5-디클로로페녹시)페닐]프로프 -2-에닐}아세토히드록삼산, (E)-N-{1-메틸-3-[3-(4-플루오로펜녹시)페닐]프로프-2-에닐}아세토히드록삼산, (E)-N-{1-메틸-3-[2,4-디플루오로페녹시)페닐]프로프-2-에닐}아세토히드록삼산.
  4. 제1항의 식(Ⅱ)의 화합물 또는 약학적으로 허용하가능한 그의염, 약학적으로 허용가능한 담체 및 하나 또는 그 이상의 약리학적 활성제로 구성된 약학적 제제.
  5. 제4항에 있어서, 식(Ⅱ)의 화합물이 제2항의 화합물 또는 그의 약학적으로 허용가능한 염인 제제.
  6. 제4항에 있어서, 식(Ⅱ)의 화합물이 제3항의 화합물 또는 약학적으로 허용가능한 그의 염인 제제.
  7. 제4항에 있어서, 제제가 폐동맥내 투어용 제제이며 식Ⅱ)의 화합물 또는 약학적으로 허용가능한 염이(+) 또는(-)거울상, 이성질체중의 하나 또는 임의의 비율로서의 혼합물로서 존재하는 (E)-N-{1-메틸-3-[3-(4-클로로페녹시)페닐]프로프-3-에닐}아세토히드록삼산 ; 또는 (E)-N-{1-메틸-3-[3-(4-플루오로페녹시)페닐]프로프-3-에닐}아세토히드록삼산인 제제.
  8. (a) 하기식(Ⅲ)의 화합물을 아실화제와 반응시키고 Z1이 보호기일 때 상기 보호기가 제거될수 있는 조건에 주입시키거나, 하나 또는 그 이상의 제제와 반응시키거나 (b) 하기식(Ⅳ)의 화합물을 하기식(Ⅴ)의 화합물과 반응시키거나 (c) 하기식(Ⅵ)의 화합물을 탄산칼슘과 같은 염기와 반응시키거나 (d) 하기식(Ⅶ)의 화합물을 부분환원시키는 것으로 구성된 하기식(Ⅱ)의 화합물 또는 그의 대응되는 염의 제조방법.
    R9N(OZ1)H (Ⅲ)
    R6NHOH (Ⅳ)
    R7-R8(Ⅴ)
    상기식에서 R9과 R7은 각각로서, Ar, L, Ar', q, x, k, y, p, v와 w는 제1항에서 정의된바와 같다. Z1은 수소 또는 알맞은 보호기 R2, R3은 제1항에서 정의된 바와같다. R6는 -(CO)mR2로서 m과 R2는 제1항에서 정의된 바와 같다. R8은 알맞은 이탈기.
  9. 포유류의 의약적치료와 예방에 사용하기 위한 제1항 내지 제3항중 어느 한항에서 청구된식(Ⅱ)의 화합물 또는 약학적으로 허용가능한 그의염.
  10. 절단되거나 뽑혀진 식물의 노쇄를 연장시키거나 식물성장을 조절하기 위한 제1항의 식(Ⅱ)의 화합물 또는 그의염.
  11. 항-경련제 또는 항-알레르기제의 제조에 제1항 내지 제3항중 어느 한항에서 청구된 식(Ⅱ)의 화합물 또는 약학적으로 허용가능한 그의염을 사용하는 방법.
  12. 제11항에 있어서, 제제가 항-천식제인 방법.
  13. 항-발열제, 지통제, 항-응집제 또는 함염제의 제조에 제1항 내지 제3항중 어느 한 항에서 청구된 식(Ⅱ)의 화합물 또는 약학적으로 허용가능한 그의 염을 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880008745A 1987-07-15 1988-07-14 함염성 아릴 유도체 KR890001966A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB878716640A GB8716640D0 (en) 1987-07-15 1987-07-15 Aryl derivatives
GB8716640 1987-07-15
GB8802378 1988-02-03
GB888802378A GB8802378D0 (en) 1988-02-03 1988-02-03 New aryl derivatives
GB888806278A GB8806278D0 (en) 1988-03-16 1988-03-16 New aryl derivatives
GB8806278 1988-03-16

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KR890001966A true KR890001966A (ko) 1989-04-07

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US (1) US4988733A (ko)
EP (1) EP0299761B1 (ko)
JP (1) JPS6445344A (ko)
KR (1) KR890001966A (ko)
AT (1) ATE70530T1 (ko)
AU (1) AU603468B2 (ko)
DE (1) DE3866981D1 (ko)
DK (1) DK392788A (ko)
ES (1) ES2051854T3 (ko)
FI (1) FI883355A (ko)
GR (1) GR3003393T3 (ko)
HU (1) HU203076B (ko)
IL (1) IL87105A0 (ko)
MC (1) MC1959A1 (ko)
NO (1) NO883146L (ko)
NZ (1) NZ225408A (ko)
PL (1) PL154186B1 (ko)
PT (1) PT87987B (ko)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0288553A (ja) * 1988-07-14 1990-03-28 Wellcome Found Ltd:The 抗炎症性アリール誘導体
HU208523B (en) * 1989-02-03 1993-11-29 Wellcome Found Process for producing antiphlogistic aryl-compounds and pharmaceutical compositions containing them
CA2087836A1 (en) * 1990-07-25 1992-01-26 Dee W. Brooks Acetylene derivatives having lipoxygenase inhibitory activity
US5476873A (en) * 1990-07-25 1995-12-19 Abbott Laboratories Acetylene derivatives having lipoxygenase inhibitory activity
US5234933A (en) * 1991-10-31 1993-08-10 Board Of Governors Of Wayne State University And Vanderbilt University Cyclic hydroxamic acids
US5169854A (en) * 1992-02-26 1992-12-08 Abbott Laboratories N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity
US5187192A (en) * 1992-03-13 1993-02-16 Abbott Laboratories Cyclobutyl derivatives having lipoxygenase inhibitory activity
WO1994000166A1 (en) * 1992-06-30 1994-01-06 Government Of The United States As Represented By Secretary Department Of Health And Human Services Method for producing viral protective barrier materials
GB9215921D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Anti-inflammatory compounds
WO1994004537A2 (en) * 1992-08-20 1994-03-03 Cytomed, Inc. Dual functional anti-inflammatory and immunosuppressive agents
GB9308652D0 (en) * 1993-04-27 1993-06-09 Wellcome Found Anti-inflammatory compounds
DE69635048T2 (de) * 1995-06-12 2006-02-16 G.D. Searle & Co. Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
AR028075A1 (es) * 2000-05-05 2003-04-23 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
AR029916A1 (es) * 2000-05-05 2003-07-23 Smithkline Beecham Corp N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas
US20040034024A1 (en) * 2001-05-04 2004-02-19 Aubart Kelly M Peptide deformylase inhibitors
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
WO2008036682A2 (en) 2006-09-18 2008-03-27 Raptor Pharmaceutical Inc. Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
GB0624187D0 (en) * 2006-12-04 2007-01-10 Jackson William P HDAC inhibitors
ES2728225T3 (es) 2009-02-20 2019-10-23 2 Bbb Medicines B V Sistema de administración de fármacos a base de glutatión
US8445002B2 (en) 2009-05-06 2013-05-21 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59397B1 (en) * 1985-03-16 1994-02-23 Wellcome Found New aryl derivatives
EP0196184B1 (en) * 1985-03-16 1992-09-16 The Wellcome Foundation Limited Aryl derivatives
US4608390A (en) * 1985-04-26 1986-08-26 Abbott Laboratories Lipoxygenase inhibiting compounds
GB8718212D0 (en) * 1987-07-31 1987-09-09 Angus Fire Armour Ltd Lining tubular objects

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FI883355A (fi) 1989-01-16
EP0299761B1 (en) 1991-12-18
FI883355A0 (fi) 1988-07-14
HU203076B (en) 1991-05-28
NZ225408A (en) 1991-09-25
JPS6445344A (en) 1989-02-17
EP0299761A1 (en) 1989-01-18
HUT48572A (en) 1989-06-28
PT87987B (pt) 1995-03-01
NO883146L (no) 1989-01-16
AU1906888A (en) 1989-01-19
MC1959A1 (fr) 1989-06-30
ES2051854T3 (es) 1994-07-01
PL273728A1 (en) 1989-04-03
ATE70530T1 (de) 1992-01-15
PT87987A (pt) 1989-06-30
IL87105A0 (en) 1988-12-30
AU603468B2 (en) 1990-11-15
PL154186B1 (en) 1991-07-31
DE3866981D1 (de) 1992-01-30
NO883146D0 (no) 1988-07-14
DK392788A (da) 1989-01-16
DK392788D0 (da) 1988-07-14
US4988733A (en) 1991-01-29
GR3003393T3 (en) 1993-02-17

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