ES2051854T3 - Procedimiento para preparar derivados del acido hidroxamico con propiedades anti-inflamatorias. - Google Patents

Procedimiento para preparar derivados del acido hidroxamico con propiedades anti-inflamatorias.

Info

Publication number
ES2051854T3
ES2051854T3 ES88306446T ES88306446T ES2051854T3 ES 2051854 T3 ES2051854 T3 ES 2051854T3 ES 88306446 T ES88306446 T ES 88306446T ES 88306446 T ES88306446 T ES 88306446T ES 2051854 T3 ES2051854 T3 ES 2051854T3
Authority
ES
Spain
Prior art keywords
procedure
acid derivatives
alkyl
hydroxamic acid
inflammatory properties
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88306446T
Other languages
English (en)
Inventor
John Anthony Salmon
William Paul Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB878716640A external-priority patent/GB8716640D0/en
Priority claimed from GB888802378A external-priority patent/GB8802378D0/en
Priority claimed from GB888806278A external-priority patent/GB8806278D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of ES2051854T3 publication Critical patent/ES2051854T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/32—Oximes
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A01N37/28—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the group; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Pest Control & Pesticides (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Dentistry (AREA)
  • Pain & Pain Management (AREA)
  • Plant Pathology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Agronomy & Crop Science (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA COMPUESTOS DE FORMULA (II), DONDE Q ES 1, K ES 0 Y P ES 1; AR ES FENILO, OPCIONALMENTE SUSTITUIDO POR UNO O MAS SUSTITUYENTES INDEPENDIENTEMENTE ELEGIDOS ENTRE ALQUILO C1-C4 (QUE PUEDE ESTAR SUSTITUIDO POR UNO O MAS ATOMOS DE HALOGENO) Y HALOGENO; L ES -O-; AR ES 1,3- O 1,4-FENILENO; Y ES (E)-CH=CH-; V ES HIDROGENO O ALQUILO C1-C4; W ES ALQUILO C1-C4; Y Q ES UN RADICAL DE FORMULA -(OR1)(CO)MR2, DONDE M ES 1; R1 ES HIDROGENO; Y R2 ES HIDROGENO O ALQUILO C1-C4; Y SUS SALES; PROCEDIMIENTO PARA LA PREPARACION DE ESTOS COMPUESTOS, FORMULACIONES FARMACEUTICAS QUE LOS CONTIENEN, Y USOS EN MEDICINA Y EN OTRAS APLICACIONES.
ES88306446T 1987-07-15 1988-07-14 Procedimiento para preparar derivados del acido hidroxamico con propiedades anti-inflamatorias. Expired - Lifetime ES2051854T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB878716640A GB8716640D0 (en) 1987-07-15 1987-07-15 Aryl derivatives
GB888802378A GB8802378D0 (en) 1988-02-03 1988-02-03 New aryl derivatives
GB888806278A GB8806278D0 (en) 1988-03-16 1988-03-16 New aryl derivatives

Publications (1)

Publication Number Publication Date
ES2051854T3 true ES2051854T3 (es) 1994-07-01

Family

ID=27263507

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88306446T Expired - Lifetime ES2051854T3 (es) 1987-07-15 1988-07-14 Procedimiento para preparar derivados del acido hidroxamico con propiedades anti-inflamatorias.

Country Status (18)

Country Link
US (1) US4988733A (es)
EP (1) EP0299761B1 (es)
JP (1) JPS6445344A (es)
KR (1) KR890001966A (es)
AT (1) ATE70530T1 (es)
AU (1) AU603468B2 (es)
DE (1) DE3866981D1 (es)
DK (1) DK392788A (es)
ES (1) ES2051854T3 (es)
FI (1) FI883355A (es)
GR (1) GR3003393T3 (es)
HU (1) HU203076B (es)
IL (1) IL87105A0 (es)
MC (1) MC1959A1 (es)
NO (1) NO883146L (es)
NZ (1) NZ225408A (es)
PL (1) PL154186B1 (es)
PT (1) PT87987B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0288553A (ja) * 1988-07-14 1990-03-28 Wellcome Found Ltd:The 抗炎症性アリール誘導体
FI900536A0 (fi) * 1989-02-03 1990-02-02 Wellcome Found Anti-inflammatoriska arylkompositioner.
US5476873A (en) * 1990-07-25 1995-12-19 Abbott Laboratories Acetylene derivatives having lipoxygenase inhibitory activity
ATE144247T1 (de) * 1990-07-25 1996-11-15 Abbott Lab Acetylenderivate mit lipoxygenase inhibitorischer wirkung
US5234933A (en) * 1991-10-31 1993-08-10 Board Of Governors Of Wayne State University And Vanderbilt University Cyclic hydroxamic acids
US5169854A (en) * 1992-02-26 1992-12-08 Abbott Laboratories N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity
US5187192A (en) * 1992-03-13 1993-02-16 Abbott Laboratories Cyclobutyl derivatives having lipoxygenase inhibitory activity
AU683419B2 (en) * 1992-06-30 1997-11-13 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Method for producing viral protective barrier materials
GB9215921D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Anti-inflammatory compounds
EP0656004A1 (en) * 1992-08-20 1995-06-07 Cytomed, Inc. Dual functional anti-inflammatory and immunosuppressive agents
GB9308652D0 (en) * 1993-04-27 1993-06-09 Wellcome Found Anti-inflammatory compounds
JPH11507670A (ja) * 1995-06-12 1999-07-06 ジー．ディー．サール アンド カンパニー シクロオキシゲナーゼ−２インヒビターと５−リポキシゲナーゼインヒビターの組合せによる炎症と炎症関連疾患の治療
AR029916A1 (es) * 2000-05-05 2003-07-23 Smithkline Beecham Corp N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas
AR028075A1 (es) * 2000-05-05 2003-04-23 Smithkline Beecham Corp Inhibidores de la peptido-desformilasa
US20040034024A1 (en) * 2001-05-04 2004-02-19 Aubart Kelly M Peptide deformylase inhibitors
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
PT1889198E (pt) 2005-04-28 2015-03-06 Proteus Digital Health Inc Sistema fármaco-informático
GB0624187D0 (en) * 2006-12-04 2007-01-10 Jackson William P HDAC inhibitors
US8795627B2 (en) 2007-03-21 2014-08-05 Raptor Pharmaceuticals Inc. Treatment of liver disorders by administration of RAP conjugates
WO2010095940A2 (en) 2009-02-20 2010-08-26 To-Bbb Holding B.V. Glutathione-based drug delivery system
NZ596876A (en) 2009-05-06 2014-01-31 Lab Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE59397B1 (en) * 1985-03-16 1994-02-23 Wellcome Found New aryl derivatives
DK117986A (da) * 1985-03-16 1986-09-17 Wellcome Found Arylderivater, fremgangsmaader til deres fremstilling og deres anvendelse
US4608390A (en) * 1985-04-26 1986-08-26 Abbott Laboratories Lipoxygenase inhibiting compounds
GB8718212D0 (en) * 1987-07-31 1987-09-09 Angus Fire Armour Ltd Lining tubular objects

Also Published As

Publication number Publication date
EP0299761B1 (en) 1991-12-18
AU603468B2 (en) 1990-11-15
FI883355A (fi) 1989-01-16
DE3866981D1 (de) 1992-01-30
DK392788A (da) 1989-01-16
IL87105A0 (en) 1988-12-30
DK392788D0 (da) 1988-07-14
ATE70530T1 (de) 1992-01-15
KR890001966A (ko) 1989-04-07
PL273728A1 (en) 1989-04-03
NO883146L (no) 1989-01-16
FI883355A0 (fi) 1988-07-14
HU203076B (en) 1991-05-28
AU1906888A (en) 1989-01-19
PT87987A (pt) 1989-06-30
US4988733A (en) 1991-01-29
NO883146D0 (no) 1988-07-14
EP0299761A1 (en) 1989-01-18
HUT48572A (en) 1989-06-28
JPS6445344A (en) 1989-02-17
GR3003393T3 (en) 1993-02-17
NZ225408A (en) 1991-09-25
PL154186B1 (en) 1991-07-31
PT87987B (pt) 1995-03-01
MC1959A1 (fr) 1989-06-30

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