PT87987A - Processo para a preparacao de derivados de arilo do acido hidroxamico ou efeito anti-inflamatorio e de composicoes farmaceuticas que os contem - Google Patents
Processo para a preparacao de derivados de arilo do acido hidroxamico ou efeito anti-inflamatorio e de composicoes farmaceuticas que os contemInfo
- Publication number
- PT87987A PT87987A PT87987A PT8798788A PT87987A PT 87987 A PT87987 A PT 87987A PT 87987 A PT87987 A PT 87987A PT 8798788 A PT8798788 A PT 8798788A PT 87987 A PT87987 A PT 87987A
- Authority
- PT
- Portugal
- Prior art keywords
- arylous
- derivatives
- preparing
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/32—Oximes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
- A01N37/28—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof containing the group; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878716640A GB8716640D0 (en) | 1987-07-15 | 1987-07-15 | Aryl derivatives |
| GB888802378A GB8802378D0 (en) | 1988-02-03 | 1988-02-03 | New aryl derivatives |
| GB888806278A GB8806278D0 (en) | 1988-03-16 | 1988-03-16 | New aryl derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT87987A true PT87987A (pt) | 1989-06-30 |
| PT87987B PT87987B (pt) | 1995-03-01 |
Family
ID=27263507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87987A PT87987B (pt) | 1987-07-15 | 1988-07-14 | Processo para a preparacao de derivados de arilo do acido hidroxamico ou efeito anti-inflamatorio e de composicoes farmaceuticas que os contem |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4988733A (pt) |
| EP (1) | EP0299761B1 (pt) |
| JP (1) | JPS6445344A (pt) |
| KR (1) | KR890001966A (pt) |
| AT (1) | ATE70530T1 (pt) |
| AU (1) | AU603468B2 (pt) |
| DE (1) | DE3866981D1 (pt) |
| DK (1) | DK392788A (pt) |
| ES (1) | ES2051854T3 (pt) |
| FI (1) | FI883355A7 (pt) |
| GR (1) | GR3003393T3 (pt) |
| HU (1) | HU203076B (pt) |
| IL (1) | IL87105A0 (pt) |
| MC (1) | MC1959A1 (pt) |
| NO (1) | NO883146L (pt) |
| NZ (1) | NZ225408A (pt) |
| PL (1) | PL154186B1 (pt) |
| PT (1) | PT87987B (pt) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0288553A (ja) * | 1988-07-14 | 1990-03-28 | Wellcome Found Ltd:The | 抗炎症性アリール誘導体 |
| ATE96427T1 (de) * | 1989-02-03 | 1993-11-15 | Wellcome Found | Entzuendungshemmende arylderivate. |
| JPH0819069B2 (ja) * | 1990-07-25 | 1996-02-28 | アボツト・ラボラトリーズ | リポキシゲナーゼ阻害活性を有するアセチレン誘導体 |
| US5476873A (en) * | 1990-07-25 | 1995-12-19 | Abbott Laboratories | Acetylene derivatives having lipoxygenase inhibitory activity |
| US5234933A (en) * | 1991-10-31 | 1993-08-10 | Board Of Governors Of Wayne State University And Vanderbilt University | Cyclic hydroxamic acids |
| US5169854A (en) * | 1992-02-26 | 1992-12-08 | Abbott Laboratories | N-substituted-furylalkenyl hydroxamic acid and N-hydroxyurea compounds having lipoxygenase inhibitory activity |
| US5187192A (en) * | 1992-03-13 | 1993-02-16 | Abbott Laboratories | Cyclobutyl derivatives having lipoxygenase inhibitory activity |
| PT687186E (pt) * | 1992-06-30 | 2000-05-31 | Us Health | Metodo para produzir materiais para barreiras de proteccao contra virus |
| GB9215921D0 (en) * | 1992-07-27 | 1992-09-09 | Wellcome Found | Anti-inflammatory compounds |
| AU5016793A (en) * | 1992-08-20 | 1994-03-15 | Cytomed, Inc | Dual functional anti-inflammatory and immunosuppressive agents |
| GB9308652D0 (en) * | 1993-04-27 | 1993-06-09 | Wellcome Found | Anti-inflammatory compounds |
| ATE301457T1 (de) * | 1995-06-12 | 2005-08-15 | Searle & Co | Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor |
| AR028075A1 (es) * | 2000-05-05 | 2003-04-23 | Smithkline Beecham Corp | Inhibidores de la peptido-desformilasa |
| AR029916A1 (es) * | 2000-05-05 | 2003-07-23 | Smithkline Beecham Corp | N-formil-n-hidroxi-ariloxi alquilaminas y metodos para tratar infecciones bacterianas |
| US20040034024A1 (en) * | 2001-05-04 | 2004-02-19 | Aubart Kelly M | Peptide deformylase inhibitors |
| EP2147679B1 (en) | 2001-07-25 | 2014-06-25 | Raptor Pharmaceutical, Inc. | Compositions for blood-brain barrier transport |
| EP2392258B1 (en) | 2005-04-28 | 2014-10-08 | Proteus Digital Health, Inc. | Pharma-informatics system |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| GB0624187D0 (en) * | 2006-12-04 | 2007-01-10 | Jackson William P | HDAC inhibitors |
| PL3395372T3 (pl) | 2009-02-20 | 2022-07-25 | EnhanX Biopharm Inc. | Układ do dostarczania leków na bazie glutationu |
| CN102458374A (zh) | 2009-05-06 | 2012-05-16 | 实验室护肤股份有限公司 | 包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其使用方法 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU201300B (en) * | 1985-03-16 | 1990-10-28 | Wellcome Found | Process for production of derivatives of aryl and medical compositions containing them as active substance |
| IE59397B1 (en) * | 1985-03-16 | 1994-02-23 | Wellcome Found | New aryl derivatives |
| US4608390A (en) * | 1985-04-26 | 1986-08-26 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
| GB8718212D0 (en) * | 1987-07-31 | 1987-09-09 | Angus Fire Armour Ltd | Lining tubular objects |
-
1988
- 1988-07-12 PL PL1988273728A patent/PL154186B1/pl unknown
- 1988-07-14 HU HU883683A patent/HU203076B/hu unknown
- 1988-07-14 EP EP88306446A patent/EP0299761B1/en not_active Expired - Lifetime
- 1988-07-14 AU AU19068/88A patent/AU603468B2/en not_active Ceased
- 1988-07-14 ES ES88306446T patent/ES2051854T3/es not_active Expired - Lifetime
- 1988-07-14 IL IL87105A patent/IL87105A0/xx unknown
- 1988-07-14 DK DK392788A patent/DK392788A/da not_active Application Discontinuation
- 1988-07-14 NO NO88883146A patent/NO883146L/no unknown
- 1988-07-14 PT PT87987A patent/PT87987B/pt not_active IP Right Cessation
- 1988-07-14 DE DE8888306446T patent/DE3866981D1/de not_active Expired - Fee Related
- 1988-07-14 MC MC881991A patent/MC1959A1/fr unknown
- 1988-07-14 AT AT88306446T patent/ATE70530T1/de not_active IP Right Cessation
- 1988-07-14 JP JP63176198A patent/JPS6445344A/ja active Pending
- 1988-07-14 KR KR1019880008745A patent/KR890001966A/ko not_active Withdrawn
- 1988-07-14 FI FI883355A patent/FI883355A7/fi not_active Application Discontinuation
- 1988-07-14 NZ NZ225408A patent/NZ225408A/xx unknown
- 1988-07-14 US US07/219,096 patent/US4988733A/en not_active Expired - Fee Related
-
1991
- 1991-12-19 GR GR91401878T patent/GR3003393T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT48572A (en) | 1989-06-28 |
| FI883355A0 (fi) | 1988-07-14 |
| EP0299761A1 (en) | 1989-01-18 |
| GR3003393T3 (en) | 1993-02-17 |
| AU1906888A (en) | 1989-01-19 |
| AU603468B2 (en) | 1990-11-15 |
| PL154186B1 (en) | 1991-07-31 |
| NO883146L (no) | 1989-01-16 |
| FI883355A7 (fi) | 1989-01-16 |
| DK392788D0 (da) | 1988-07-14 |
| KR890001966A (ko) | 1989-04-07 |
| ATE70530T1 (de) | 1992-01-15 |
| MC1959A1 (fr) | 1989-06-30 |
| DK392788A (da) | 1989-01-16 |
| HU203076B (en) | 1991-05-28 |
| PL273728A1 (en) | 1989-04-03 |
| NZ225408A (en) | 1991-09-25 |
| JPS6445344A (en) | 1989-02-17 |
| IL87105A0 (en) | 1988-12-30 |
| EP0299761B1 (en) | 1991-12-18 |
| DE3866981D1 (de) | 1992-01-30 |
| NO883146D0 (no) | 1988-07-14 |
| ES2051854T3 (es) | 1994-07-01 |
| US4988733A (en) | 1991-01-29 |
| PT87987B (pt) | 1995-03-01 |
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| Publication | Publication Date | Title |
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| SE8603793D0 (sv) | Nya katekolderivat, forfarande for framstellning derav och farmaceutiska kompositioner innehallande dem | |
| TH6256A (th) | อนุพันธ์ แอริล สารต่อต้านการอักเสบ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG3A | Patent granted, date of granting |
Effective date: 19940817 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19960229 |