KR850001600B1 - Process for the preparation of z-alpha-acylamino-3-monosubstituted propenic acid and esters - Google Patents

Process for the preparation of z-alpha-acylamino-3-monosubstituted propenic acid and esters

Info

Publication number
KR850001600B1
KR850001600B1 KR8402461A KR840002461A KR850001600B1 KR 850001600 B1 KR850001600 B1 KR 850001600B1 KR 8402461 A KR8402461 A KR 8402461A KR 840002461 A KR840002461 A KR 840002461A KR 850001600 B1 KR850001600 B1 KR 850001600B1
Authority
KR
South Korea
Prior art keywords
acylamino
esters
monosubstituted
alpha
preparation
Prior art date
Application number
KR8402461A
Other languages
Korean (ko)
Inventor
Donald W Graham
Edward F Rogers
Frederick M Kahan
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from KR7902483A external-priority patent/KR850000425B1/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Priority to KR8402461A priority Critical patent/KR850001600B1/en
Application granted granted Critical
Publication of KR850001600B1 publication Critical patent/KR850001600B1/en

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Z-2-acylamino-3-mono-substd. propenoic acid esters of formula (II) are prepd. by reacting bromo compds. of formula (I) with trimethylamine, guanidine, or mercaptan. In the formulas, R1 is H; R2 is C3-8 hydrocarbon; R3 is C1-10 hydrocarbon; and one or two H atoms of R2 or R3 can be substd. with halogen, the non-ending methylene being substd. with O, S, or oxidized S. (II) are useful as selective dipeptidase inhibitors through combination with thienamycin.
KR8402461A 1978-07-24 1984-05-04 Process for the preparation of z-alpha-acylamino-3-monosubstituted propenic acid and esters KR850001600B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR8402461A KR850001600B1 (en) 1978-07-24 1984-05-04 Process for the preparation of z-alpha-acylamino-3-monosubstituted propenic acid and esters

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US92721278A 1978-07-24 1978-07-24
US5023379A 1979-06-22 1979-06-22
KR7902483A KR850000425B1 (en) 1978-07-24 1979-07-24 Process for the preparation of z-2-acylamino-3-monosubstituted propenoates
KR8402461A KR850001600B1 (en) 1978-07-24 1984-05-04 Process for the preparation of z-alpha-acylamino-3-monosubstituted propenic acid and esters

Publications (1)

Publication Number Publication Date
KR850001600B1 true KR850001600B1 (en) 1985-10-24

Family

ID=26626573

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8402461A KR850001600B1 (en) 1978-07-24 1984-05-04 Process for the preparation of z-alpha-acylamino-3-monosubstituted propenic acid and esters

Country Status (1)

Country Link
KR (1) KR850001600B1 (en)

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