KR20230007555A - Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도 - Google Patents

Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도 Download PDF

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KR20230007555A
KR20230007555A KR1020227045978A KR20227045978A KR20230007555A KR 20230007555 A KR20230007555 A KR 20230007555A KR 1020227045978 A KR1020227045978 A KR 1020227045978A KR 20227045978 A KR20227045978 A KR 20227045978A KR 20230007555 A KR20230007555 A KR 20230007555A
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vwf
fviii
ser
leu
gly
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Korean (ko)
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엑타 세스 차브라
존 쿨맨
통야오 리우
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바이오버라티브 테라퓨틱스 인크.
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Application filed by 바이오버라티브 테라퓨틱스 인크. filed Critical 바이오버라티브 테라퓨틱스 인크.
Priority to KR1020247004922A priority Critical patent/KR102714760B1/ko
Publication of KR20230007555A publication Critical patent/KR20230007555A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
KR1020227045978A 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도 Ceased KR20230007555A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247004922A KR102714760B1 (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361840872P 2013-06-28 2013-06-28
US61/840,872 2013-06-28
PCT/US2014/044731 WO2014210558A1 (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof
KR1020157033268A KR102666819B1 (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도

Related Parent Applications (1)

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KR1020157033268A Division KR102666819B1 (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도

Related Child Applications (1)

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KR1020247004922A Division KR102714760B1 (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도

Publications (1)

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KR20230007555A true KR20230007555A (ko) 2023-01-12

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ID=52142742

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020227045978A Ceased KR20230007555A (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도
KR1020247032926A Active KR102865153B1 (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도
KR1020157033268A Active KR102666819B1 (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도
KR1020247004922A Active KR102714760B1 (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도

Family Applications After (3)

Application Number Title Priority Date Filing Date
KR1020247032926A Active KR102865153B1 (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도
KR1020157033268A Active KR102666819B1 (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도
KR1020247004922A Active KR102714760B1 (ko) 2013-06-28 2014-06-27 Xten을 지닌 트롬빈 절단가능한 링커 및 이의 용도

Country Status (17)

Country Link
US (3) US20160251408A1 (https=)
EP (2) EP4368194A3 (https=)
JP (6) JP2016523919A (https=)
KR (4) KR20230007555A (https=)
CN (3) CN113817069A (https=)
AU (3) AU2014302100B2 (https=)
CA (1) CA2913078A1 (https=)
CL (1) CL2015003710A1 (https=)
EA (1) EA201592022A1 (https=)
HK (1) HK1223302A1 (https=)
IL (3) IL297611B2 (https=)
MX (1) MX2015016567A (https=)
NZ (1) NZ713904A (https=)
PH (1) PH12015502614A1 (https=)
SG (3) SG10201710616XA (https=)
TW (3) TWI716340B (https=)
WO (1) WO2014210558A1 (https=)

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