CL2015003710A1 - Enlozador escindible por trombina con xten y usos del mismo - Google Patents
Enlozador escindible por trombina con xten y usos del mismoInfo
- Publication number
- CL2015003710A1 CL2015003710A1 CL2015003710A CL2015003710A CL2015003710A1 CL 2015003710 A1 CL2015003710 A1 CL 2015003710A1 CL 2015003710 A CL2015003710 A CL 2015003710A CL 2015003710 A CL2015003710 A CL 2015003710A CL 2015003710 A1 CL2015003710 A1 CL 2015003710A1
- Authority
- CL
- Chile
- Prior art keywords
- xten
- cleavable linker
- thrombin cleavable
- thrombin
- linker
- Prior art date
Links
- 108090000190 Thrombin Proteins 0.000 title 1
- 229960004072 thrombin Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361840872P | 2013-06-28 | 2013-06-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2015003710A1 true CL2015003710A1 (es) | 2016-08-26 |
Family
ID=52142742
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2015003710A CL2015003710A1 (es) | 2013-06-28 | 2015-12-23 | Enlozador escindible por trombina con xten y usos del mismo |
Country Status (17)
Country | Link |
---|---|
US (3) | US20160251408A1 (es) |
EP (2) | EP4368194A2 (es) |
JP (5) | JP2016523919A (es) |
KR (3) | KR20240023705A (es) |
CN (3) | CN113831415A (es) |
AU (3) | AU2014302100B2 (es) |
CA (1) | CA2913078A1 (es) |
CL (1) | CL2015003710A1 (es) |
EA (1) | EA201592022A1 (es) |
HK (1) | HK1223302A1 (es) |
IL (3) | IL297611A (es) |
MX (1) | MX2015016567A (es) |
NZ (1) | NZ713904A (es) |
PH (1) | PH12015502614A1 (es) |
SG (3) | SG11201509313PA (es) |
TW (3) | TW202313672A (es) |
WO (1) | WO2014210558A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8716448B2 (en) | 2009-02-03 | 2014-05-06 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
NZ626945A (en) | 2012-01-12 | 2016-10-28 | Biogen Ma Inc | Chimeric factor viii polypeptides and uses thereof |
KR20190094480A (ko) | 2012-02-15 | 2019-08-13 | 바이오버라티브 테라퓨틱스 인크. | 재조합 인자 viii 단백질 |
CN111548418A (zh) | 2012-02-15 | 2020-08-18 | 比奥贝拉蒂治疗公司 | 因子viii组合物及其制备和使用方法 |
EP3404105A1 (en) | 2012-07-06 | 2018-11-21 | Bioverativ Therapeutics Inc. | Cell line expressing single chain factor viii polypeptides and uses thereof |
PT2882450T (pt) | 2012-07-11 | 2020-02-19 | Bioverativ Therapeutics Inc | Complexo de fator viii com xten e a proteína fator de von willebrand, e utilizações do mesmo |
TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
SI3091997T1 (sl) * | 2014-01-10 | 2022-10-28 | Bioverativ Therapeutics Inc. | Himerni proteini faktorja VIII in njihova uporaba |
KR20170125942A (ko) * | 2015-03-06 | 2017-11-15 | 체에스엘 베링 리컴비넌트 퍼실리티 아게 | 폰 빌레브란트 인자의 반감기 개선용 화합물 |
JP6909203B2 (ja) | 2015-08-03 | 2021-07-28 | バイオベラティブ セラピューティクス インコーポレイテッド | 第ix因子融合タンパク質及びそれらの製造方法及び使用方法 |
JP6877469B2 (ja) * | 2016-06-24 | 2021-05-26 | モガム・インスティテュート・フォー・バイオメディカル・リサーチMogam Institute For Biomedical Research | Fviiiおよびvwf因子を含むキメラタンパク質、ならびにそれらの使用 |
KR20190085021A (ko) * | 2016-11-11 | 2019-07-17 | 체에스엘 베링 렝나우 아게 | 혈우병을 치료하기 위한 절단된 폰 빌레브란트 인자 폴리펩타이드 |
WO2019222682A1 (en) | 2018-05-18 | 2019-11-21 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia a |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6037452A (en) * | 1992-04-10 | 2000-03-14 | Alpha Therapeutic Corporation | Poly(alkylene oxide)-Factor VIII or Factor IX conjugate |
JP2003526625A (ja) * | 1999-07-23 | 2003-09-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 血小板の活性化の調節 |
WO2004076484A1 (en) * | 2003-02-27 | 2004-09-10 | National Research Council Of Canada | Peptide inhibitors of thrombin as potent anticoagulants |
GB0516091D0 (en) * | 2005-08-04 | 2005-09-14 | Haemostatix Ltd | Therapeutic agent |
US7846445B2 (en) * | 2005-09-27 | 2010-12-07 | Amunix Operating, Inc. | Methods for production of unstructured recombinant polymers and uses thereof |
LT2068907T (lt) * | 2006-10-04 | 2018-01-10 | Novo Nordisk A/S | Glicerolio sujungti pegilinti sacharidai ir glikopeptidai |
AU2008323768A1 (en) * | 2007-11-09 | 2009-05-14 | Baxter Healthcare S.A. | Modified recombinant Factor VIII and von Willebrand Factor and methods of use |
ES2654336T3 (es) * | 2008-06-24 | 2018-02-13 | Csl Behring Gmbh | Factor VIII, factor de von Willebrand o sus complejos con semivida in vivo prolongada |
EP2368124A4 (en) * | 2008-11-24 | 2012-09-19 | Bayer Healthcare Llc | METHOD FOR DETERMINING THE ACTIVITY OF A PEGYLATED BLOOD GENERATION FACTOR IN A SILICON-BASED ACTIVATED PART THROMBOPLASTINE TIME ASSAY |
CN102348715B (zh) * | 2009-02-03 | 2017-12-08 | 阿穆尼克斯运营公司 | 延伸重组多肽和包含该延伸重组多肽的组合物 |
US8716448B2 (en) * | 2009-02-03 | 2014-05-06 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
US20120142593A1 (en) * | 2009-03-24 | 2012-06-07 | Bayer Healthcare Llc | Factor VIII Variants and Methods of Use |
JP5544219B2 (ja) * | 2009-09-24 | 2014-07-09 | 富士フイルム株式会社 | 内視鏡システム |
US8759293B2 (en) * | 2009-11-13 | 2014-06-24 | Grifols Therapeutics Inc. | von Willebrand factor (vWF)-containing preparations, and methods, kits, and uses related thereto |
WO2011069164A2 (en) * | 2009-12-06 | 2011-06-09 | Biogen Idec Ma Inc. | Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof |
US20110312881A1 (en) * | 2009-12-21 | 2011-12-22 | Amunix, Inc. | Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases |
EP3508573A1 (en) * | 2010-07-09 | 2019-07-10 | Bioverativ Therapeutics Inc. | Systems for factor viii processing and methods thereof |
US20130017997A1 (en) * | 2010-08-19 | 2013-01-17 | Amunix Operating Inc. | Factor VIII Compositions and Methods of Making and Using Same |
NZ626945A (en) * | 2012-01-12 | 2016-10-28 | Biogen Ma Inc | Chimeric factor viii polypeptides and uses thereof |
CN111548418A (zh) * | 2012-02-15 | 2020-08-18 | 比奥贝拉蒂治疗公司 | 因子viii组合物及其制备和使用方法 |
US20150080309A1 (en) * | 2012-04-24 | 2015-03-19 | Nova Nordisk A/S | Compounds Suitable for Treatment of Haemophilia |
PT2882450T (pt) * | 2012-07-11 | 2020-02-19 | Bioverativ Therapeutics Inc | Complexo de fator viii com xten e a proteína fator de von willebrand, e utilizações do mesmo |
EP2796145B1 (en) * | 2013-04-22 | 2017-11-01 | CSL Ltd. | A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge |
US20160229903A1 (en) * | 2013-06-28 | 2016-08-11 | Biogen Ma Inc. | Thrombin cleavable linker |
SI3091997T1 (sl) * | 2014-01-10 | 2022-10-28 | Bioverativ Therapeutics Inc. | Himerni proteini faktorja VIII in njihova uporaba |
-
2014
- 2014-06-27 IL IL297611A patent/IL297611A/en unknown
- 2014-06-27 SG SG11201509313PA patent/SG11201509313PA/en unknown
- 2014-06-27 CA CA2913078A patent/CA2913078A1/en active Pending
- 2014-06-27 CN CN202110797628.9A patent/CN113831415A/zh active Pending
- 2014-06-27 KR KR1020247004922A patent/KR20240023705A/ko not_active Application Discontinuation
- 2014-06-27 KR KR1020227045978A patent/KR20230007555A/ko not_active Application Discontinuation
- 2014-06-27 NZ NZ713904A patent/NZ713904A/en unknown
- 2014-06-27 US US14/894,108 patent/US20160251408A1/en not_active Abandoned
- 2014-06-27 CN CN202110796045.4A patent/CN113817069A/zh active Pending
- 2014-06-27 SG SG10201710616XA patent/SG10201710616XA/en unknown
- 2014-06-27 AU AU2014302100A patent/AU2014302100B2/en not_active Withdrawn - After Issue
- 2014-06-27 EP EP24150415.8A patent/EP4368194A2/en active Pending
- 2014-06-27 CN CN201480029781.5A patent/CN105392495A/zh active Pending
- 2014-06-27 WO PCT/US2014/044731 patent/WO2014210558A1/en active Application Filing
- 2014-06-27 MX MX2015016567A patent/MX2015016567A/es unknown
- 2014-06-27 KR KR1020157033268A patent/KR20160023654A/ko active IP Right Grant
- 2014-06-27 EA EA201592022A patent/EA201592022A1/ru unknown
- 2014-06-27 SG SG10201913738YA patent/SG10201913738YA/en unknown
- 2014-06-27 EP EP14817900.5A patent/EP3013358A4/en active Pending
- 2014-06-27 JP JP2016524268A patent/JP2016523919A/ja active Pending
- 2014-06-30 TW TW111122793A patent/TW202313672A/zh unknown
- 2014-06-30 TW TW103122511A patent/TWI716340B/zh active
- 2014-06-30 TW TW109104938A patent/TWI770467B/zh active
-
2015
- 2015-11-04 IL IL242436A patent/IL242436B/en active IP Right Grant
- 2015-11-24 PH PH12015502614A patent/PH12015502614A1/en unknown
- 2015-12-23 CL CL2015003710A patent/CL2015003710A1/es unknown
-
2016
- 2016-10-11 HK HK16111718.0A patent/HK1223302A1/zh unknown
-
2018
- 2018-10-17 JP JP2018195860A patent/JP2019010124A/ja active Pending
-
2019
- 2019-05-05 IL IL266462A patent/IL266462B2/en unknown
-
2020
- 2020-05-08 AU AU2020203063A patent/AU2020203063B2/en active Active
-
2021
- 2021-02-08 JP JP2021018123A patent/JP7005800B2/ja active Active
- 2021-09-20 US US17/479,705 patent/US20220106383A1/en not_active Abandoned
- 2021-10-05 JP JP2021163956A patent/JP7297837B2/ja active Active
-
2023
- 2023-06-14 JP JP2023097660A patent/JP2023107932A/ja active Pending
- 2023-07-25 US US18/358,601 patent/US20240083975A1/en active Pending
- 2023-08-22 AU AU2023219840A patent/AU2023219840A1/en active Pending
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