SG11201509313PA - Thrombin cleavable linker with xten and its uses thereof - Google Patents

Thrombin cleavable linker with xten and its uses thereof

Info

Publication number
SG11201509313PA
SG11201509313PA SG11201509313PA SG11201509313PA SG11201509313PA SG 11201509313P A SG11201509313P A SG 11201509313PA SG 11201509313P A SG11201509313P A SG 11201509313PA SG 11201509313P A SG11201509313P A SG 11201509313PA SG 11201509313P A SG11201509313P A SG 11201509313PA
Authority
SG
Singapore
Prior art keywords
xten
cleavable linker
thrombin cleavable
thrombin
linker
Prior art date
Application number
SG11201509313PA
Inventor
Ekta Seth Chhabra
John Kulman
Tongyao Liu
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of SG11201509313PA publication Critical patent/SG11201509313PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/90—Fusion polypeptide containing a motif for post-translational modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11201509313PA 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof SG11201509313PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361840872P 2013-06-28 2013-06-28
PCT/US2014/044731 WO2014210558A1 (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof

Publications (1)

Publication Number Publication Date
SG11201509313PA true SG11201509313PA (en) 2016-01-28

Family

ID=52142742

Family Applications (3)

Application Number Title Priority Date Filing Date
SG11201509313PA SG11201509313PA (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof
SG10201710616XA SG10201710616XA (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof
SG10201913738YA SG10201913738YA (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof

Family Applications After (2)

Application Number Title Priority Date Filing Date
SG10201710616XA SG10201710616XA (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof
SG10201913738YA SG10201913738YA (en) 2013-06-28 2014-06-27 Thrombin cleavable linker with xten and its uses thereof

Country Status (17)

Country Link
US (3) US20160251408A1 (en)
EP (2) EP4368194A2 (en)
JP (5) JP2016523919A (en)
KR (2) KR20230007555A (en)
CN (3) CN113831415A (en)
AU (3) AU2014302100B2 (en)
CA (1) CA2913078A1 (en)
CL (1) CL2015003710A1 (en)
EA (1) EA201592022A1 (en)
HK (1) HK1223302A1 (en)
IL (3) IL297611A (en)
MX (1) MX2015016567A (en)
NZ (1) NZ713904A (en)
PH (1) PH12015502614A1 (en)
SG (3) SG11201509313PA (en)
TW (2) TWI716340B (en)
WO (1) WO2014210558A1 (en)

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SG11202010767SA (en) 2018-05-18 2020-11-27 Bioverativ Therapeutics Inc Methods of treating hemophilia a

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Also Published As

Publication number Publication date
JP2019010124A (en) 2019-01-24
AU2023219840A1 (en) 2023-09-14
KR20240023705A (en) 2024-02-22
TWI770467B (en) 2022-07-11
TW202045535A (en) 2020-12-16
HK1223302A1 (en) 2017-07-28
EP3013358A1 (en) 2016-05-04
CA2913078A1 (en) 2014-12-31
AU2014302100A1 (en) 2015-11-26
EP3013358A4 (en) 2017-03-22
EA201592022A1 (en) 2016-05-31
US20240083975A1 (en) 2024-03-14
NZ713904A (en) 2022-02-25
WO2014210558A1 (en) 2014-12-31
IL242436B (en) 2019-05-30
IL266462A (en) 2019-06-30
SG10201710616XA (en) 2018-02-27
AU2014302100B2 (en) 2020-02-13
CN113831415A (en) 2021-12-24
AU2020203063B2 (en) 2023-05-25
CN113817069A (en) 2021-12-21
KR20160023654A (en) 2016-03-03
CN105392495A (en) 2016-03-09
BR112015031194A2 (en) 2017-09-19
JP2016523919A (en) 2016-08-12
TWI716340B (en) 2021-01-21
SG10201913738YA (en) 2020-03-30
PH12015502614A1 (en) 2016-02-29
MX2015016567A (en) 2016-03-31
JP7297837B2 (en) 2023-06-26
TW201514204A (en) 2015-04-16
AU2020203063A1 (en) 2020-05-28
JP2021072853A (en) 2021-05-13
JP2023107932A (en) 2023-08-03
TW202313672A (en) 2023-04-01
US20220106383A1 (en) 2022-04-07
IL266462B2 (en) 2023-04-01
JP2022000053A (en) 2022-01-04
IL266462B (en) 2022-12-01
US20160251408A1 (en) 2016-09-01
IL297611A (en) 2022-12-01
KR20230007555A (en) 2023-01-12
JP7005800B2 (en) 2022-02-10
CL2015003710A1 (en) 2016-08-26
EP4368194A2 (en) 2024-05-15

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