KR20200137048A - Cdk 억제제 - Google Patents

Cdk 억제제 Download PDF

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Publication number
KR20200137048A
KR20200137048A KR1020207034378A KR20207034378A KR20200137048A KR 20200137048 A KR20200137048 A KR 20200137048A KR 1020207034378 A KR1020207034378 A KR 1020207034378A KR 20207034378 A KR20207034378 A KR 20207034378A KR 20200137048 A KR20200137048 A KR 20200137048A
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South Korea
Prior art keywords
compound
butyl
tert
methyl
chloro
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Korean (ko)
Inventor
프란시스 엑스. 타바레스
제이 씨. 스트럼
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쥐원 쎄라퓨틱스, 인크.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46024778&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20200137048(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 쥐원 쎄라퓨틱스, 인크. filed Critical 쥐원 쎄라퓨틱스, 인크.
Publication of KR20200137048A publication Critical patent/KR20200137048A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/20—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/499—Spiro-condensed pyrazines or piperazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
KR1020207034378A 2010-10-25 2011-10-25 Cdk 억제제 Ceased KR20200137048A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40649810P 2010-10-25 2010-10-25
US61/406,498 2010-10-25
PCT/US2011/057749 WO2012061156A1 (en) 2010-10-25 2011-10-25 Cdk inhibitors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197035200A Division KR102186969B1 (ko) 2010-10-25 2011-10-25 Cdk 억제제

Publications (1)

Publication Number Publication Date
KR20200137048A true KR20200137048A (ko) 2020-12-08

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ID=46024778

Family Applications (4)

Application Number Title Priority Date Filing Date
KR1020137013388A Active KR101929593B1 (ko) 2010-10-25 2011-10-25 Cdk 억제제
KR1020197035200A Active KR102186969B1 (ko) 2010-10-25 2011-10-25 Cdk 억제제
KR1020187035510A Active KR102051881B1 (ko) 2010-10-25 2011-10-25 Cdk 억제제
KR1020207034378A Ceased KR20200137048A (ko) 2010-10-25 2011-10-25 Cdk 억제제

Family Applications Before (3)

Application Number Title Priority Date Filing Date
KR1020137013388A Active KR101929593B1 (ko) 2010-10-25 2011-10-25 Cdk 억제제
KR1020197035200A Active KR102186969B1 (ko) 2010-10-25 2011-10-25 Cdk 억제제
KR1020187035510A Active KR102051881B1 (ko) 2010-10-25 2011-10-25 Cdk 억제제

Country Status (25)

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US (2) US8598197B2 (enExample)
EP (6) EP3567042B1 (enExample)
JP (4) JP5923509B2 (enExample)
KR (4) KR101929593B1 (enExample)
CN (5) CN106967074A (enExample)
AU (5) AU2011323739B2 (enExample)
BR (1) BR112013010018B1 (enExample)
CA (2) CA2961937C (enExample)
CY (1) CY1118004T1 (enExample)
DK (1) DK2632467T3 (enExample)
ES (1) ES2592515T3 (enExample)
HK (2) HK1197067A1 (enExample)
HR (1) HRP20161092T1 (enExample)
HU (1) HUE030714T2 (enExample)
IL (5) IL225940A0 (enExample)
LT (1) LT2632467T (enExample)
MX (4) MX379532B (enExample)
PL (1) PL2632467T3 (enExample)
PT (1) PT2632467T (enExample)
RS (1) RS55135B1 (enExample)
RU (1) RU2621674C2 (enExample)
SG (2) SG10201508715YA (enExample)
SI (1) SI2632467T1 (enExample)
SM (1) SMT201600311B (enExample)
WO (1) WO2012061156A1 (enExample)

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