KR20200052369A - 올리고뉴클레오티드 제조 기술 - Google Patents

올리고뉴클레오티드 제조 기술 Download PDF

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KR20200052369A
KR20200052369A KR1020207010806A KR20207010806A KR20200052369A KR 20200052369 A KR20200052369 A KR 20200052369A KR 1020207010806 A KR1020207010806 A KR 1020207010806A KR 20207010806 A KR20207010806 A KR 20207010806A KR 20200052369 A KR20200052369 A KR 20200052369A
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oligonucleotides
capping
modification
independently
oligonucleotide
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Korean (ko)
Inventor
키이스 앤드류 보우만
찬드라 바르기스
데이비드 찰스 도넬 버틀러
파차무투 칸다사미
모하메드 로우숀 알람
마모루 시미즈
스테파니 미셸 스탠들리
빈센트 아두다
고팔 레디 봄미네니
스네흘라타 트리파시
일리아 코르보우크
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웨이브 라이프 사이언시스 리미티드
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Priority to KR1020257025660A priority Critical patent/KR20250123934A/ko
Publication of KR20200052369A publication Critical patent/KR20200052369A/ko
Ceased legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020207010806A 2017-09-18 2018-09-17 올리고뉴클레오티드 제조 기술 Ceased KR20200052369A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257025660A KR20250123934A (ko) 2017-09-18 2018-09-17 올리고뉴클레오티드 제조 기술

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762560169P 2017-09-18 2017-09-18
US62/560,169 2017-09-18
PCT/US2018/051398 WO2019055951A1 (en) 2017-09-18 2018-09-17 OLIGONUCLEOTIDE PREPARATION TECHNOLOGIES

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KR1020257025660A Division KR20250123934A (ko) 2017-09-18 2018-09-17 올리고뉴클레오티드 제조 기술

Publications (1)

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KR20200052369A true KR20200052369A (ko) 2020-05-14

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KR1020207010806A Ceased KR20200052369A (ko) 2017-09-18 2018-09-17 올리고뉴클레오티드 제조 기술
KR1020257025660A Pending KR20250123934A (ko) 2017-09-18 2018-09-17 올리고뉴클레오티드 제조 기술

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US (3) US11608355B2 (https=)
EP (1) EP3684755A4 (https=)
JP (2) JP7472018B2 (https=)
KR (2) KR20200052369A (https=)
CN (1) CN111108096A (https=)
AU (2) AU2018333065B2 (https=)
CA (1) CA3072110A1 (https=)
SG (1) SG11202000276YA (https=)
WO (1) WO2019055951A1 (https=)

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EP4422645A4 (en) 2021-10-27 2025-12-03 Wave Life Sciences Ltd OLIGONUCLEOTID COMPOSITIONS AND THEIR METHODS OF USE
EP4476202A1 (en) 2022-02-11 2024-12-18 Wave Life Sciences Ltd. Stereoselective technologies for chiral compounds
IL315089A (en) 2022-03-02 2024-10-01 Wave Life Sciences Ltd Oligonucleotide compositions and methods thereof for exon skipping
IL316178A (en) 2022-04-15 2024-12-01 Wave Life Sciences Ltd Oligonucleotide compositions and methods related thereto
CN119452084A (zh) 2022-05-12 2025-02-14 波涛生命科学有限公司 寡核苷酸组合物及其方法
JP2025526712A (ja) 2022-08-11 2025-08-15 ウェイブ ライフ サイエンシズ リミテッド オリゴヌクレオチド組成物及びその方法

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