CN111108096A - 寡核苷酸制备技术 - Google Patents

寡核苷酸制备技术 Download PDF

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Publication number
CN111108096A
CN111108096A CN201880057920.3A CN201880057920A CN111108096A CN 111108096 A CN111108096 A CN 111108096A CN 201880057920 A CN201880057920 A CN 201880057920A CN 111108096 A CN111108096 A CN 111108096A
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China
Prior art keywords
oligonucleotides
modification
independently
capping
oligonucleotide
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Pending
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CN201880057920.3A
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English (en)
Chinese (zh)
Inventor
基思·安德鲁·鲍曼
钱德拉·瓦尔格赛
大卫·查尔斯·唐奈·巴特勒
帕查穆图·坎德萨米
穆罕默德·罗肖恩·阿拉姆
清水护
斯蒂芬妮·米歇尔·斯坦德利
文森特·阿杜达
戈帕尔·雷迪·博米涅尼
斯奈拉塔·特里帕蒂
伊利亚·科尔伯克
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Wave Life Sciences Pte Ltd
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Wave Life Sciences Pte Ltd
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Publication of CN111108096A publication Critical patent/CN111108096A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN201880057920.3A 2017-09-18 2018-09-17 寡核苷酸制备技术 Pending CN111108096A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762560169P 2017-09-18 2017-09-18
US62/560,169 2017-09-18
PCT/US2018/051398 WO2019055951A1 (en) 2017-09-18 2018-09-17 OLIGONUCLEOTIDE PREPARATION TECHNOLOGIES

Publications (1)

Publication Number Publication Date
CN111108096A true CN111108096A (zh) 2020-05-05

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CN201880057920.3A Pending CN111108096A (zh) 2017-09-18 2018-09-17 寡核苷酸制备技术

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US (3) US11608355B2 (https=)
EP (1) EP3684755A4 (https=)
JP (2) JP7472018B2 (https=)
KR (2) KR20250123934A (https=)
CN (1) CN111108096A (https=)
AU (2) AU2018333065B2 (https=)
CA (1) CA3072110A1 (https=)
SG (1) SG11202000276YA (https=)
WO (1) WO2019055951A1 (https=)

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