KR20180083323A - N-설포닐화 피라졸로[3,4-b]피리딘-6-카복스아미드 및 사용 방법 - Google Patents

N-설포닐화 피라졸로[3,4-b]피리딘-6-카복스아미드 및 사용 방법 Download PDF

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Publication number
KR20180083323A
KR20180083323A KR1020187012937A KR20187012937A KR20180083323A KR 20180083323 A KR20180083323 A KR 20180083323A KR 1020187012937 A KR1020187012937 A KR 1020187012937A KR 20187012937 A KR20187012937 A KR 20187012937A KR 20180083323 A KR20180083323 A KR 20180083323A
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South Korea
Prior art keywords
pyrazolo
pyridine
carboxamide
cyclobutyl
methanesulfonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020187012937A
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English (en)
Korean (ko)
Inventor
랄리드 아카리
루크 요나단 앨비
하비에르 마리 보크
브라이언 에스. 브라운
피테르 이자벨 로저 클래스
말론 디. 코워트
레무스 엘사 드
니콜라스 데스로이
베랑제 뒤씨온
그레고리 에이. 페서
로맹 뤽 마리 고스미니
크리스토퍼 가에탕 우쎄망
? 카렐 얀센
지엔궈 지
필립 알. 킴
장-미셸 르프랑소와
오스카 맘몰리티
크리스텔 장 마리 마네
누리아 머레이오 머레이오
그레고리 존 로버트 뉴썸
아델린 마리 엘리스 팔리스
사친 브이. 파텔
마티유 라파엘 피조네로
아누루파 쉬레스타
엘리자베스 씨. 스위프트
데르 플라스 스티븐 에미엘 반
쉬에칭 왕
블리크 안 드
Original Assignee
애브비 에스.에이.알.엘.
갈라파고스 엔.브이.
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Application filed by 애브비 에스.에이.알.엘., 갈라파고스 엔.브이. filed Critical 애브비 에스.에이.알.엘.
Publication of KR20180083323A publication Critical patent/KR20180083323A/ko
Ceased legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020187012937A 2015-10-09 2016-10-07 N-설포닐화 피라졸로[3,4-b]피리딘-6-카복스아미드 및 사용 방법 Ceased KR20180083323A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562239647P 2015-10-09 2015-10-09
US62/239,647 2015-10-09
US201662309794P 2016-03-17 2016-03-17
US62/309,794 2016-03-17
PCT/IB2016/056029 WO2017060874A1 (en) 2015-10-09 2016-10-07 N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use

Publications (1)

Publication Number Publication Date
KR20180083323A true KR20180083323A (ko) 2018-07-20

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KR1020187012937A Ceased KR20180083323A (ko) 2015-10-09 2016-10-07 N-설포닐화 피라졸로[3,4-b]피리딘-6-카복스아미드 및 사용 방법

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US (4) US9890158B2 (https=)
EP (1) EP3359541B1 (https=)
JP (1) JP6779992B2 (https=)
KR (1) KR20180083323A (https=)
CN (1) CN108513574B (https=)
AU (1) AU2016333856C1 (https=)
BR (1) BR112018007161B1 (https=)
CA (1) CA3001096A1 (https=)
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DK (1) DK3359541T3 (https=)
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JP2025506382A (ja) 2022-02-03 2025-03-11 バーテックス ファーマシューティカルズ インコーポレイテッド 嚢胞性線維症の治療方法
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JP2025505643A (ja) 2022-02-08 2025-02-28 バーテックス ファーマシューティカルズ インコーポレイテッド 嚢胞性線維症膜コンダクタンス制御因子の調節因子
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