KR20180026795A - 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질 - Google Patents

절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질 Download PDF

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KR20180026795A
KR20180026795A KR1020187005897A KR20187005897A KR20180026795A KR 20180026795 A KR20180026795 A KR 20180026795A KR 1020187005897 A KR1020187005897 A KR 1020187005897A KR 20187005897 A KR20187005897 A KR 20187005897A KR 20180026795 A KR20180026795 A KR 20180026795A
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Prior art keywords
actriib
polypeptide
glu
sequence
seq
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KR1020187005897A
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Korean (ko)
Inventor
자스비르 세라
라빈드라 쿠마르
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악셀레론 파마 인코포레이티드
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism

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  • Wood Science & Technology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
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  • Biophysics (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Microbiology (AREA)
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  • Heart & Thoracic Surgery (AREA)
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KR1020187005897A 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질 Ceased KR20180026795A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US26842009P 2009-06-12 2009-06-12
US61/268,420 2009-06-12
US28054309P 2009-11-03 2009-11-03
US61/280,543 2009-11-03
PCT/US2010/037787 WO2010151426A1 (en) 2009-06-12 2010-06-08 Truncated actriib-fc fusion proteins

Related Parent Applications (1)

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KR1020127000112A Division KR20120028358A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197021378A Division KR20190090049A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질

Publications (1)

Publication Number Publication Date
KR20180026795A true KR20180026795A (ko) 2018-03-13

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KR1020217036389A Ceased KR20210136174A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질
KR1020217008368A Ceased KR20210034684A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질
KR1020187005897A Ceased KR20180026795A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질
KR1020127000112A Ceased KR20120028358A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질
KR1020197021378A Ceased KR20190090049A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질

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KR1020217036389A Ceased KR20210136174A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질
KR1020217008368A Ceased KR20210034684A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질

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Application Number Title Priority Date Filing Date
KR1020127000112A Ceased KR20120028358A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질
KR1020197021378A Ceased KR20190090049A (ko) 2009-06-12 2010-06-08 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질

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US (6) US8293881B2 (enExample)
EP (3) EP2440577A4 (enExample)
JP (5) JP2012529294A (enExample)
KR (5) KR20210136174A (enExample)
CN (3) CN104805105A (enExample)
AU (5) AU2010263182B2 (enExample)
BR (2) BR122021017187B1 (enExample)
CA (1) CA2765108C (enExample)
CO (1) CO6491031A2 (enExample)
CY (1) CY1123580T1 (enExample)
ES (1) ES2836534T3 (enExample)
HK (2) HK1213013A1 (enExample)
IL (3) IL216861A (enExample)
MX (3) MX387164B (enExample)
WO (1) WO2010151426A1 (enExample)

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ES2426005T3 (es) 2004-07-23 2013-10-18 Acceleron Pharma Inc. Polipéptidos del receptor ACTRII, procedimientos y composiciones
US8128933B2 (en) 2005-11-23 2012-03-06 Acceleron Pharma, Inc. Method of promoting bone growth by an anti-activin B antibody
EP3811965A1 (en) 2005-11-23 2021-04-28 Acceleron Pharma, Inc. Activin-actriia antagonists in use for promoting bone growth
US8895016B2 (en) 2006-12-18 2014-11-25 Acceleron Pharma, Inc. Antagonists of activin-actriia and uses for increasing red blood cell levels
EP2599495A1 (en) 2007-02-01 2013-06-05 Acceleron Pharma, Inc. Activin-ActRIIa Antagonists and Uses for Treating or Preventing Breast Cancer
TW201940502A (zh) 2007-02-02 2019-10-16 美商艾瑟勒朗法瑪公司 衍生自ＡｃｔＲＩＩＢ的變體與其用途
KR20200054317A (ko) 2007-02-09 2020-05-19 악셀레론 파마 인코포레이티드 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도
CA2699936A1 (en) 2007-09-18 2009-03-26 Acceleron Pharma Inc. Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion
US20110104133A1 (en) * 2008-05-06 2011-05-05 Joslin Diabetes Center, Inc. Methods and compositions for inducing brown adipogenesis
CA2729096C (en) * 2008-06-26 2020-04-28 Acceleron Pharma Inc. Methods for dosing an actriib antagonist and monitoring of treated patients
US8216997B2 (en) 2008-08-14 2012-07-10 Acceleron Pharma, Inc. Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
HUE051137T2 (hu) 2008-08-14 2021-03-01 Acceleron Pharma Inc GDF-csapdák
WO2010083034A1 (en) 2009-01-13 2010-07-22 Acceleron Pharma Inc. Methods for increasing adiponectin
US8178488B2 (en) 2009-06-08 2012-05-15 Acceleron Pharma, Inc. Methods for increasing thermogenic adipocytes
EP2440577A4 (en) 2009-06-12 2013-01-23 Acceleron Pharma Inc SHORTEN ACTRIIB FC FUSION PROTEINS
MX340451B (es) * 2009-09-09 2016-07-08 Acceleron Pharma Inc Antagonistas de actriib y dosificacion y usos de los mismos.
EP3260130B1 (en) * 2009-11-03 2021-03-10 Acceleron Pharma Inc. Methods for treating fatty liver disease
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