KR20170060162A - 안드로겐 수용체 조절제의 에스터 유도체 및 그의 이용 방법 - Google Patents

안드로겐 수용체 조절제의 에스터 유도체 및 그의 이용 방법 Download PDF

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Publication number
KR20170060162A
KR20170060162A KR1020177013536A KR20177013536A KR20170060162A KR 20170060162 A KR20170060162 A KR 20170060162A KR 1020177013536 A KR1020177013536 A KR 1020177013536A KR 20177013536 A KR20177013536 A KR 20177013536A KR 20170060162 A KR20170060162 A KR 20170060162A
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South Korea
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compound
pharmaceutically acceptable
alkyl
stereoisomer
tautomer
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KR1020177013536A
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Korean (ko)
Inventor
나스린 알. 마우지
준 왕
카르멘 아드리아나 바누에로스
레이먼드 존 안데르센
하비에르 가르시아 페르난데스
마리안 도로시 사다르
Original Assignee
브리티쉬 콜롬비아 캔써 에이전시 브랜치
더 유니버시티 오브 브리티쉬 콜롬비아
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51864937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20170060162(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 브리티쉬 콜롬비아 캔써 에이전시 브랜치, 더 유니버시티 오브 브리티쉬 콜롬비아 filed Critical 브리티쉬 콜롬비아 캔써 에이전시 브랜치
Publication of KR20170060162A publication Critical patent/KR20170060162A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/16—Acetic acid esters of dihydroxylic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/18—Acetic acid esters of trihydroxylic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020177013536A 2013-05-10 2014-05-09 안드로겐 수용체 조절제의 에스터 유도체 및 그의 이용 방법 Withdrawn KR20170060162A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361822186P 2013-05-10 2013-05-10
US61/822,186 2013-05-10
PCT/CA2014/000414 WO2014179867A1 (en) 2013-05-10 2014-05-09 Ester derivatives of androgen receptor modulators and methods for their use

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020157035129A Division KR101739800B1 (ko) 2013-05-10 2014-05-09 안드로겐 수용체 조절제의 에스터 유도체 및 그의 이용 방법

Publications (1)

Publication Number Publication Date
KR20170060162A true KR20170060162A (ko) 2017-05-31

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ID=51864937

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KR1020177013536A Withdrawn KR20170060162A (ko) 2013-05-10 2014-05-09 안드로겐 수용체 조절제의 에스터 유도체 및 그의 이용 방법
KR1020157035129A Expired - Fee Related KR101739800B1 (ko) 2013-05-10 2014-05-09 안드로겐 수용체 조절제의 에스터 유도체 및 그의 이용 방법

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Country Status (17)

Country Link
US (2) US9173939B2 (enExample)
EP (1) EP2994451A4 (enExample)
JP (2) JP6100439B2 (enExample)
KR (2) KR20170060162A (enExample)
CN (1) CN105358522A (enExample)
AP (1) AP2015008838A0 (enExample)
AU (2) AU2014262333B2 (enExample)
BR (1) BR112015028174A2 (enExample)
CA (1) CA2911352A1 (enExample)
CL (1) CL2015003271A1 (enExample)
HK (1) HK1221712A1 (enExample)
IL (1) IL242345A (enExample)
MX (1) MX347705B (enExample)
PE (1) PE20160091A1 (enExample)
PH (2) PH12015502525A1 (enExample)
SG (2) SG11201509038UA (enExample)
WO (1) WO2014179867A1 (enExample)

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US10471023B2 (en) 2015-03-12 2019-11-12 British Columbia Cancer Agency Branch Bisphenol ether derivatives and methods for using the same
CA2929345A1 (en) * 2015-09-02 2017-03-02 British Columbia Cancer Agency Branch Co-targeting androgen receptor splice variants and mtor signaling pathway for the treatment of castration-resistant prostate cancer
US20170298033A1 (en) * 2016-04-15 2017-10-19 The University Of British Columbia Bisphenol derivatives and their use as androgen receptor activity modulators
WO2018045450A1 (en) * 2016-09-09 2018-03-15 British Columbia Cancer Agency Branch Bisphenol a compounds and methods for treating drug-resistant androgen receptor mediated cancers
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WO2018157232A1 (en) * 2017-02-28 2018-09-07 British Columbia Cancer Agency Branch Pharmaceutical compositions 'and combinations comprising inhibitors of the androgen receptor a1wd uses thereof
US11485713B2 (en) 2018-05-25 2022-11-01 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
US20200123117A1 (en) * 2018-10-18 2020-04-23 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
US12109179B2 (en) 2019-03-28 2024-10-08 Essa Pharma Inc. Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
CN115916170A (zh) * 2020-04-17 2023-04-04 埃萨制药股份有限公司 固体形式的n-末端结构域雄激素受体抑制剂及其用途
CN113666806A (zh) * 2020-05-15 2021-11-19 上海安谱实验科技股份有限公司 一种双酚f 2,3-二羟丙基(2-氯-1-丙基)乙醚的制备方法
WO2023046283A1 (en) 2021-09-22 2023-03-30 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Compounds and their use in a method for modulating ar (androgen receptor) transcriptional activity

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Also Published As

Publication number Publication date
WO2014179867A1 (en) 2014-11-13
SG10201607177XA (en) 2016-10-28
JP2016518394A (ja) 2016-06-23
IL242345A (en) 2017-02-28
KR101739800B1 (ko) 2017-05-25
PH12015502525A1 (en) 2016-03-28
SG11201509038UA (en) 2015-12-30
CA2911352A1 (en) 2014-11-13
CN105358522A (zh) 2016-02-24
AU2014262333A1 (en) 2015-11-19
EP2994451A4 (en) 2016-10-05
KR20160013072A (ko) 2016-02-03
PH12016501047A1 (en) 2018-06-25
MX2015015509A (es) 2016-08-12
PE20160091A1 (es) 2016-03-03
US20160068466A1 (en) 2016-03-10
JP2017125036A (ja) 2017-07-20
BR112015028174A2 (pt) 2017-07-25
AU2016228233A1 (en) 2016-10-06
HK1221712A1 (zh) 2017-06-09
AP2015008838A0 (en) 2015-11-30
MX347705B (es) 2017-05-09
US9173939B2 (en) 2015-11-03
EP2994451A1 (en) 2016-03-16
CL2015003271A1 (es) 2016-04-22
JP6100439B2 (ja) 2017-03-22
AU2014262333B2 (en) 2016-06-16
US20140335080A1 (en) 2014-11-13

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Patent event code: PA01041R01D

Patent event date: 20170518

Application number text: 1020157035129

Filing date: 20151210

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