SG10201607177XA - Ester derivatives of androgen receptor modulators and methods for their use - Google Patents

Ester derivatives of androgen receptor modulators and methods for their use

Info

Publication number
SG10201607177XA
SG10201607177XA SG10201607177XA SG10201607177XA SG10201607177XA SG 10201607177X A SG10201607177X A SG 10201607177XA SG 10201607177X A SG10201607177X A SG 10201607177XA SG 10201607177X A SG10201607177X A SG 10201607177XA SG 10201607177X A SG10201607177X A SG 10201607177XA
Authority
SG
Singapore
Prior art keywords
methods
androgen receptor
receptor modulators
ester derivatives
derivatives
Prior art date
Application number
SG10201607177XA
Inventor
Nasrin R Mawji
Jun Wang
Carmen Adriana Banuelos
Raymond John Andersen
Javier Garcia Fernandez
Marianne Dorothy Sadar
Original Assignee
British Columbia Cancer Agency
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51864937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201607177X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by British Columbia Cancer Agency, Univ British Columbia filed Critical British Columbia Cancer Agency
Publication of SG10201607177XA publication Critical patent/SG10201607177XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/16—Acetic acid esters of dihydroxylic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/18—Acetic acid esters of trihydroxylic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG10201607177XA 2013-05-10 2014-05-09 Ester derivatives of androgen receptor modulators and methods for their use SG10201607177XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361822186P 2013-05-10 2013-05-10

Publications (1)

Publication Number Publication Date
SG10201607177XA true SG10201607177XA (en) 2016-10-28

Family

ID=51864937

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201607177XA SG10201607177XA (en) 2013-05-10 2014-05-09 Ester derivatives of androgen receptor modulators and methods for their use
SG11201509038UA SG11201509038UA (en) 2013-05-10 2014-05-09 Ester derivatives of androgen receptor modulators and methods for their use

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201509038UA SG11201509038UA (en) 2013-05-10 2014-05-09 Ester derivatives of androgen receptor modulators and methods for their use

Country Status (17)

Country Link
US (2) US9173939B2 (en)
EP (1) EP2994451A4 (en)
JP (2) JP6100439B2 (en)
KR (2) KR20170060162A (en)
CN (1) CN105358522A (en)
AP (1) AP2015008838A0 (en)
AU (2) AU2014262333B2 (en)
BR (1) BR112015028174A2 (en)
CA (1) CA2911352A1 (en)
CL (1) CL2015003271A1 (en)
HK (1) HK1221712A1 (en)
IL (1) IL242345A (en)
MX (1) MX347705B (en)
PE (1) PE20160091A1 (en)
PH (2) PH12015502525A1 (en)
SG (2) SG10201607177XA (en)
WO (1) WO2014179867A1 (en)

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WO2011082487A1 (en) 2010-01-06 2011-07-14 British Columbia Cancer Agency Branch Bisphenol derivatives and their use as androgen receptor activity modulators
US9365510B2 (en) 2012-04-16 2016-06-14 British Columbia Cancer Agency Branch Aziridine bisphenol ethers and related compounds and methods for their use
US9173939B2 (en) * 2013-05-10 2015-11-03 The University Of British Columbia Ester derivatives of androgen receptor modulators and methods for their use
WO2015031984A1 (en) 2013-09-09 2015-03-12 British Columbia Cancer Agency Branch Halogenated compounds for cancer imaging and treatment and methods for their use
DK3245193T3 (en) 2015-01-13 2022-03-07 British Columbia Cancer Agency Branch HETEROCYCLIC COMPOUNDS FOR IMAGE SCANNING AND TREATMENT OF CANCER AND PROCEDURES FOR THE USE OF THESE
US10471023B2 (en) 2015-03-12 2019-11-12 British Columbia Cancer Agency Branch Bisphenol ether derivatives and methods for using the same
CA2929345A1 (en) * 2015-09-02 2017-03-02 British Columbia Cancer Agency Branch Co-targeting androgen receptor splice variants and mtor signaling pathway for the treatment of castration-resistant prostate cancer
US20170298033A1 (en) 2016-04-15 2017-10-19 The University Of British Columbia Bisphenol derivatives and their use as androgen receptor activity modulators
WO2018045450A1 (en) * 2016-09-09 2018-03-15 British Columbia Cancer Agency Branch Bisphenol a compounds and methods for treating drug-resistant androgen receptor mediated cancers
CN110049765B (en) 2016-12-16 2022-02-01 康朴生物医药技术（上海）有限公司 Combination, application and treatment method thereof
WO2018157232A1 (en) * 2017-02-28 2018-09-07 British Columbia Cancer Agency Branch Pharmaceutical compositions 'and combinations comprising inhibitors of the androgen receptor a1wd uses thereof
US11485713B2 (en) 2018-05-25 2022-11-01 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
AU2019362061A1 (en) * 2018-10-18 2021-05-06 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
WO2020198712A1 (en) * 2019-03-28 2020-10-01 Essa Pharma, Inc. Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
CA3174422A1 (en) 2020-04-17 2021-10-21 Essa Pharma, Inc. Solid forms of an n-terminal domain androgen receptor inhibitor and uses thereof
CN113666806A (en) * 2020-05-15 2021-11-19 上海安谱实验科技股份有限公司 Preparation method of bisphenol F2, 3-dihydroxypropyl (2-chloro-1-propyl) ethyl ether
WO2023046283A1 (en) 2021-09-22 2023-03-30 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Compounds and their use in a method for modulating ar (androgen receptor) transcriptional activity

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Also Published As

Publication number Publication date
US9173939B2 (en) 2015-11-03
MX2015015509A (en) 2016-08-12
JP2016518394A (en) 2016-06-23
HK1221712A1 (en) 2017-06-09
MX347705B (en) 2017-05-09
AP2015008838A0 (en) 2015-11-30
CA2911352A1 (en) 2014-11-13
JP6100439B2 (en) 2017-03-22
IL242345A (en) 2017-02-28
EP2994451A1 (en) 2016-03-16
US20140335080A1 (en) 2014-11-13
AU2016228233A1 (en) 2016-10-06
BR112015028174A2 (en) 2017-07-25
CL2015003271A1 (en) 2016-04-22
AU2014262333B2 (en) 2016-06-16
WO2014179867A1 (en) 2014-11-13
PE20160091A1 (en) 2016-03-03
KR20160013072A (en) 2016-02-03
PH12015502525A1 (en) 2016-03-28
US20160068466A1 (en) 2016-03-10
JP2017125036A (en) 2017-07-20
KR20170060162A (en) 2017-05-31
CN105358522A (en) 2016-02-24
EP2994451A4 (en) 2016-10-05
AU2014262333A1 (en) 2015-11-19
KR101739800B1 (en) 2017-05-25
SG11201509038UA (en) 2015-12-30
PH12016501047A1 (en) 2018-06-25

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