AP2015008838A0 - Ester derivatives of androgen receptor modulators and methods for their use - Google Patents

Ester derivatives of androgen receptor modulators and methods for their use

Info

Publication number
AP2015008838A0
AP2015008838A0 AP2015008838A AP2015008838A AP2015008838A0 AP 2015008838 A0 AP2015008838 A0 AP 2015008838A0 AP 2015008838 A AP2015008838 A AP 2015008838A AP 2015008838 A AP2015008838 A AP 2015008838A AP 2015008838 A0 AP2015008838 A0 AP 2015008838A0
Authority
AP
ARIPO
Prior art keywords
methods
androgen receptor
receptor modulators
ester derivatives
derivatives
Prior art date
Application number
AP2015008838A
Other languages
English (en)
Inventor
Marianne Dorothy Sadar
Javier Garcia Fernandez
Raymond John Andersen
Original Assignee
Univ British Columbia Industry Liaison Office
British Columbia Cancer Agency
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51864937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2015008838(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ British Columbia Industry Liaison Office, British Columbia Cancer Agency filed Critical Univ British Columbia Industry Liaison Office
Publication of AP2015008838A0 publication Critical patent/AP2015008838A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/16—Acetic acid esters of dihydroxylic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/18—Acetic acid esters of trihydroxylic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AP2015008838A 2013-05-10 2014-05-09 Ester derivatives of androgen receptor modulators and methods for their use AP2015008838A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361822186P 2013-05-10 2013-05-10
PCT/CA2014/000414 WO2014179867A1 (en) 2013-05-10 2014-05-09 Ester derivatives of androgen receptor modulators and methods for their use

Publications (1)

Publication Number Publication Date
AP2015008838A0 true AP2015008838A0 (en) 2015-11-30

Family

ID=51864937

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2015008838A AP2015008838A0 (en) 2013-05-10 2014-05-09 Ester derivatives of androgen receptor modulators and methods for their use

Country Status (17)

Country Link
US (2) US9173939B2 (enExample)
EP (1) EP2994451A4 (enExample)
JP (2) JP6100439B2 (enExample)
KR (2) KR20170060162A (enExample)
CN (1) CN105358522A (enExample)
AP (1) AP2015008838A0 (enExample)
AU (2) AU2014262333B2 (enExample)
BR (1) BR112015028174A2 (enExample)
CA (1) CA2911352A1 (enExample)
CL (1) CL2015003271A1 (enExample)
HK (1) HK1221712A1 (enExample)
IL (1) IL242345A (enExample)
MX (1) MX347705B (enExample)
PE (1) PE20160091A1 (enExample)
PH (2) PH12015502525A1 (enExample)
SG (2) SG10201607177XA (enExample)
WO (1) WO2014179867A1 (enExample)

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CA2786319C (en) 2010-01-06 2019-03-12 British Columbia Cancer Agency Branch Bisphenol derivatives and their use as androgen receptor activity modulators
US9365510B2 (en) 2012-04-16 2016-06-14 British Columbia Cancer Agency Branch Aziridine bisphenol ethers and related compounds and methods for their use
KR20170060162A (ko) 2013-05-10 2017-05-31 브리티쉬 콜롬비아 캔써 에이전시 브랜치 안드로겐 수용체 조절제의 에스터 유도체 및 그의 이용 방법
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US20170056336A1 (en) * 2015-09-02 2017-03-02 British Columbia Cancer Agency Branch Co-targeting androgen receptor splice variants and mtor signaling pathway for the treatment of castration-resistant prostate cancer
US20170298033A1 (en) 2016-04-15 2017-10-19 The University Of British Columbia Bisphenol derivatives and their use as androgen receptor activity modulators
WO2018045450A1 (en) * 2016-09-09 2018-03-15 British Columbia Cancer Agency Branch Bisphenol a compounds and methods for treating drug-resistant androgen receptor mediated cancers
US10933059B2 (en) * 2016-12-16 2021-03-02 Kangpu Biopharmaceuticals. Ltd. Combination, application thereof and treatment method
WO2018157232A1 (en) * 2017-02-28 2018-09-07 British Columbia Cancer Agency Branch Pharmaceutical compositions 'and combinations comprising inhibitors of the androgen receptor a1wd uses thereof
US11485713B2 (en) 2018-05-25 2022-11-01 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
CN118684633A (zh) 2018-10-18 2024-09-24 埃萨制药股份有限公司 雄激素受体调节剂及其使用方法
WO2020198712A1 (en) * 2019-03-28 2020-10-01 Essa Pharma, Inc. Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
JP2023522040A (ja) * 2020-04-17 2023-05-26 エッサ ファーマ，インコーポレイテッド Ｎ末端ドメインアンドロゲン受容体阻害剤の固体形態およびその使用
CN113666806A (zh) * 2020-05-15 2021-11-19 上海安谱实验科技股份有限公司 一种双酚f 2,3-二羟丙基(2-氯-1-丙基)乙醚的制备方法
WO2023046283A1 (en) 2021-09-22 2023-03-30 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Compounds and their use in a method for modulating ar (androgen receptor) transcriptional activity

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Also Published As

Publication number Publication date
WO2014179867A1 (en) 2014-11-13
AU2016228233A1 (en) 2016-10-06
CL2015003271A1 (es) 2016-04-22
PH12015502525A1 (en) 2016-03-28
JP2016518394A (ja) 2016-06-23
IL242345A (en) 2017-02-28
AU2014262333A1 (en) 2015-11-19
US20140335080A1 (en) 2014-11-13
HK1221712A1 (zh) 2017-06-09
US9173939B2 (en) 2015-11-03
JP6100439B2 (ja) 2017-03-22
PH12016501047A1 (en) 2018-06-25
JP2017125036A (ja) 2017-07-20
SG10201607177XA (en) 2016-10-28
SG11201509038UA (en) 2015-12-30
KR101739800B1 (ko) 2017-05-25
EP2994451A1 (en) 2016-03-16
BR112015028174A2 (pt) 2017-07-25
MX347705B (es) 2017-05-09
KR20160013072A (ko) 2016-02-03
CA2911352A1 (en) 2014-11-13
CN105358522A (zh) 2016-02-24
PE20160091A1 (es) 2016-03-03
AU2014262333B2 (en) 2016-06-16
KR20170060162A (ko) 2017-05-31
US20160068466A1 (en) 2016-03-10
EP2994451A4 (en) 2016-10-05
MX2015015509A (es) 2016-08-12

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