MX347705B - Derivados de ester moduladores del receptor de androgeno y metodos para su uso. - Google Patents

Derivados de ester moduladores del receptor de androgeno y metodos para su uso.

Info

Publication number
MX347705B
MX347705B MX2015015509A MX2015015509A MX347705B MX 347705 B MX347705 B MX 347705B MX 2015015509 A MX2015015509 A MX 2015015509A MX 2015015509 A MX2015015509 A MX 2015015509A MX 347705 B MX347705 B MX 347705B
Authority
MX
Mexico
Prior art keywords
methods
androgen receptor
receptor modulators
ester derivatives
compounds
Prior art date
Application number
MX2015015509A
Other languages
English (en)
Other versions
MX2015015509A (es
Inventor
Wang Jun
R Mawji Nasrin
Adriana Banuelos Carmen
John ANDERSEN Raymond
garcia fernandez Javier
Dorothy Sadar Marianne
Original Assignee
British Columbia Cancer Agency Branch
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51864937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX347705(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by British Columbia Cancer Agency Branch filed Critical British Columbia Cancer Agency Branch
Publication of MX2015015509A publication Critical patent/MX2015015509A/es
Publication of MX347705B publication Critical patent/MX347705B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/16—Acetic acid esters of dihydroxylic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/18—Acetic acid esters of trihydroxylic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

(ver Fórmula). Se proporcionan compuestos que tienen una estructura de Estructura I o una sal farmacéuticamente aceptable, tautámero o estereoisómero del mismo, en donde R1, R2, R3, R4, R5, J1, J2, X, Z, n1 y n2 son como se definen en este documento, y en donde al menos uno de R1, R2 o R3 es un éster de alquilo, alquenilo, arilo o aralquilo. Usos de tales compuestos para el tratamiento de varias indicaciones, incluyendo el cáncer de próstata, así como métodos de tratamiento que involucran tales compuestos también se proporcionan.
MX2015015509A 2013-05-10 2014-05-09 Derivados de ester moduladores del receptor de androgeno y metodos para su uso. MX347705B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361822186P 2013-05-10 2013-05-10
PCT/CA2014/000414 WO2014179867A1 (en) 2013-05-10 2014-05-09 Ester derivatives of androgen receptor modulators and methods for their use

Publications (2)

Publication Number Publication Date
MX2015015509A MX2015015509A (es) 2016-08-12
MX347705B true MX347705B (es) 2017-05-09

Family

ID=51864937

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015509A MX347705B (es) 2013-05-10 2014-05-09 Derivados de ester moduladores del receptor de androgeno y metodos para su uso.

Country Status (17)

Country Link
US (2) US9173939B2 (es)
EP (1) EP2994451A4 (es)
JP (2) JP6100439B2 (es)
KR (2) KR20170060162A (es)
CN (1) CN105358522A (es)
AP (1) AP2015008838A0 (es)
AU (2) AU2014262333B2 (es)
BR (1) BR112015028174A2 (es)
CA (1) CA2911352A1 (es)
CL (1) CL2015003271A1 (es)
HK (1) HK1221712A1 (es)
IL (1) IL242345A (es)
MX (1) MX347705B (es)
PE (1) PE20160091A1 (es)
PH (2) PH12015502525A1 (es)
SG (2) SG11201509038UA (es)
WO (1) WO2014179867A1 (es)

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MX347705B (es) 2013-05-10 2017-05-09 British Columbia Cancer Agency Branch Derivados de ester moduladores del receptor de androgeno y metodos para su uso.
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US10471023B2 (en) 2015-03-12 2019-11-12 British Columbia Cancer Agency Branch Bisphenol ether derivatives and methods for using the same
CA2929345A1 (en) * 2015-09-02 2017-03-02 British Columbia Cancer Agency Branch Co-targeting androgen receptor splice variants and mtor signaling pathway for the treatment of castration-resistant prostate cancer
US20170298033A1 (en) * 2016-04-15 2017-10-19 The University Of British Columbia Bisphenol derivatives and their use as androgen receptor activity modulators
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US20200123117A1 (en) * 2018-10-18 2020-04-23 Essa Pharma, Inc. Androgen receptor modulators and methods for their use
US12109179B2 (en) 2019-03-28 2024-10-08 Essa Pharma Inc. Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
CN115916170A (zh) * 2020-04-17 2023-04-04 埃萨制药股份有限公司 固体形式的n-末端结构域雄激素受体抑制剂及其用途
CN113666806A (zh) * 2020-05-15 2021-11-19 上海安谱实验科技股份有限公司 一种双酚f 2,3-二羟丙基(2-氯-1-丙基)乙醚的制备方法
WO2023046283A1 (en) 2021-09-22 2023-03-30 Fundació Institut De Recerca Biomèdica (Irb Barcelona) Compounds and their use in a method for modulating ar (androgen receptor) transcriptional activity

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Also Published As

Publication number Publication date
WO2014179867A1 (en) 2014-11-13
SG10201607177XA (en) 2016-10-28
JP2016518394A (ja) 2016-06-23
IL242345A (en) 2017-02-28
KR20170060162A (ko) 2017-05-31
KR101739800B1 (ko) 2017-05-25
PH12015502525A1 (en) 2016-03-28
SG11201509038UA (en) 2015-12-30
CA2911352A1 (en) 2014-11-13
CN105358522A (zh) 2016-02-24
AU2014262333A1 (en) 2015-11-19
EP2994451A4 (en) 2016-10-05
KR20160013072A (ko) 2016-02-03
PH12016501047A1 (en) 2018-06-25
MX2015015509A (es) 2016-08-12
PE20160091A1 (es) 2016-03-03
US20160068466A1 (en) 2016-03-10
JP2017125036A (ja) 2017-07-20
BR112015028174A2 (pt) 2017-07-25
AU2016228233A1 (en) 2016-10-06
HK1221712A1 (zh) 2017-06-09
AP2015008838A0 (en) 2015-11-30
US9173939B2 (en) 2015-11-03
EP2994451A1 (en) 2016-03-16
CL2015003271A1 (es) 2016-04-22
JP6100439B2 (ja) 2017-03-22
AU2014262333B2 (en) 2016-06-16
US20140335080A1 (en) 2014-11-13

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