BR112015028174A2 - composto, composição farmacêutica, uso de uma composição farmacêutica, e, métodos para modulação de atividade de receptores de andrógeno e para aumentar a biodisponibilidade de um modulador de receptor de andrógeno - Google Patents

composto, composição farmacêutica, uso de uma composição farmacêutica, e, métodos para modulação de atividade de receptores de andrógeno e para aumentar a biodisponibilidade de um modulador de receptor de andrógeno

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Publication number
BR112015028174A2
BR112015028174A2 BR112015028174A BR112015028174A BR112015028174A2 BR 112015028174 A2 BR112015028174 A2 BR 112015028174A2 BR 112015028174 A BR112015028174 A BR 112015028174A BR 112015028174 A BR112015028174 A BR 112015028174A BR 112015028174 A2 BR112015028174 A2 BR 112015028174A2
Authority
BR
Brazil
Prior art keywords
pharmaceutical composition
androgen receptor
methods
compound
bioavailability
Prior art date
Application number
BR112015028174A
Other languages
English (en)
Inventor
Adriana Banuelos Carmen
Wang Jun
garcia fernandez Javier
Dorothy Sadar Marianne
R Mawji Nasrin
John ANDERSEN Raymond
Original Assignee
British Columbia Cancer Agency Branch
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51864937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015028174(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by British Columbia Cancer Agency Branch, Univ British Columbia filed Critical British Columbia Cancer Agency Branch
Publication of BR112015028174A2 publication Critical patent/BR112015028174A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/63—Halogen-containing esters of saturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/16—Acetic acid esters of dihydroxylic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/18—Acetic acid esters of trihydroxylic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1 / 1 resumo “composto, composiã‡ãƒo farmacãšutica, uso de uma composiã‡ãƒo farmacãšutica, e, mã‰todos para modulaã‡ãƒo de atividade de receptores de andrã“geno e para aumentar a biodisponibilidade de um modulador de receptor de andrã“geno” compostos tendo uma estrutura de estrutura i: i ou um sal farmaceuticamente aceitã¡vel, tautã´mero ou 1 2 3 4 5 1 2 1 2 estereoisã´mero do mesmo, em que r , r , r , r , r , j , j , x, z, n e n sã£o 1 2 3 definidas neste documento e em que pelo menos um dentre r , r ou r ã© um ã©ster alquil, alceno, aril ou aralquil, sã£o fornecidos. usos de tais compostos para tratamento de vã¡rias indicaã§ãµes, incluindo cã¢ncer de prã³stata, bem como mã©todos de tratamento envolvendo tais compostos tambã©m sã£o providos.
BR112015028174A 2013-05-10 2014-05-09 composto, composição farmacêutica, uso de uma composição farmacêutica, e, métodos para modulação de atividade de receptores de andrógeno e para aumentar a biodisponibilidade de um modulador de receptor de andrógeno BR112015028174A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361822186P 2013-05-10 2013-05-10
PCT/CA2014/000414 WO2014179867A1 (en) 2013-05-10 2014-05-09 Ester derivatives of androgen receptor modulators and methods for their use

Publications (1)

Publication Number Publication Date
BR112015028174A2 true BR112015028174A2 (pt) 2017-07-25

Family

ID=51864937

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015028174A BR112015028174A2 (pt) 2013-05-10 2014-05-09 composto, composição farmacêutica, uso de uma composição farmacêutica, e, métodos para modulação de atividade de receptores de andrógeno e para aumentar a biodisponibilidade de um modulador de receptor de andrógeno

Country Status (17)

Country Link
US (2) US9173939B2 (pt)
EP (1) EP2994451A4 (pt)
JP (2) JP6100439B2 (pt)
KR (2) KR101739800B1 (pt)
CN (1) CN105358522A (pt)
AP (1) AP2015008838A0 (pt)
AU (2) AU2014262333B2 (pt)
BR (1) BR112015028174A2 (pt)
CA (1) CA2911352A1 (pt)
CL (1) CL2015003271A1 (pt)
HK (1) HK1221712A1 (pt)
IL (1) IL242345A (pt)
MX (1) MX347705B (pt)
PE (1) PE20160091A1 (pt)
PH (2) PH12015502525A1 (pt)
SG (2) SG10201607177XA (pt)
WO (1) WO2014179867A1 (pt)

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WO2020198712A1 (en) * 2019-03-28 2020-10-01 Essa Pharma, Inc. Pharmaceutical compositions and combinations comprising inhibitors of the androgen receptor and uses thereof
JP2023522040A (ja) 2020-04-17 2023-05-26 エッサ ファーマ，インコーポレイテッド Ｎ末端ドメインアンドロゲン受容体阻害剤の固体形態およびその使用
CN113666806A (zh) * 2020-05-15 2021-11-19 上海安谱实验科技股份有限公司 一种双酚f 2,3-二羟丙基(2-氯-1-丙基)乙醚的制备方法
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Also Published As

Publication number Publication date
US20140335080A1 (en) 2014-11-13
KR20160013072A (ko) 2016-02-03
AU2014262333B2 (en) 2016-06-16
AU2014262333A1 (en) 2015-11-19
KR20170060162A (ko) 2017-05-31
CA2911352A1 (en) 2014-11-13
AU2016228233A1 (en) 2016-10-06
MX2015015509A (es) 2016-08-12
PE20160091A1 (es) 2016-03-03
JP2016518394A (ja) 2016-06-23
EP2994451A1 (en) 2016-03-16
JP2017125036A (ja) 2017-07-20
PH12015502525A1 (en) 2016-03-28
CL2015003271A1 (es) 2016-04-22
US20160068466A1 (en) 2016-03-10
PH12016501047A1 (en) 2018-06-25
SG10201607177XA (en) 2016-10-28
SG11201509038UA (en) 2015-12-30
IL242345A (en) 2017-02-28
CN105358522A (zh) 2016-02-24
HK1221712A1 (zh) 2017-06-09
KR101739800B1 (ko) 2017-05-25
AP2015008838A0 (en) 2015-11-30
US9173939B2 (en) 2015-11-03
MX347705B (es) 2017-05-09
EP2994451A4 (en) 2016-10-05
WO2014179867A1 (en) 2014-11-13
JP6100439B2 (ja) 2017-03-22

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