KR20160134687A - 항체의 생체내 반감기의 시험관내 예측방법 - Google Patents

항체의 생체내 반감기의 시험관내 예측방법 Download PDF

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Publication number
KR20160134687A
KR20160134687A KR1020167025760A KR20167025760A KR20160134687A KR 20160134687 A KR20160134687 A KR 20160134687A KR 1020167025760 A KR1020167025760 A KR 1020167025760A KR 20167025760 A KR20167025760 A KR 20167025760A KR 20160134687 A KR20160134687 A KR 20160134687A
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antibody
fcrn
residence time
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val
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Korean (ko)
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토마스 엠리치
후버트 케텐버거
틸만 슐로타우어
안젤라 쇼흐
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에프. 호프만-라 로슈 아게
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Publication of KR20160134687A publication Critical patent/KR20160134687A/ko
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B01D15/168—Fluid composition conditioning, e.g. gradient pH gradient or chromatofocusing, i.e. separation according to the isoelectric point pI
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
KR1020167025760A 2014-03-21 2015-03-17 항체의 생체내 반감기의 시험관내 예측방법 Ceased KR20160134687A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14161103 2014-03-21
EP14161103.8 2014-03-21
EP14165987 2014-04-25
EP14165987.0 2014-04-25
PCT/EP2015/055482 WO2015140126A1 (en) 2014-03-21 2015-03-17 In vitro prediction of in vivo half-life of antibodies

Publications (1)

Publication Number Publication Date
KR20160134687A true KR20160134687A (ko) 2016-11-23

Family

ID=52684232

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167025760A Ceased KR20160134687A (ko) 2014-03-21 2015-03-17 항체의 생체내 반감기의 시험관내 예측방법

Country Status (10)

Country Link
US (2) US20170227547A1 (enExample)
EP (1) EP3119490B1 (enExample)
JP (2) JP6744855B2 (enExample)
KR (1) KR20160134687A (enExample)
CN (1) CN106103478B (enExample)
BR (1) BR112016023417A2 (enExample)
CA (1) CA2938722A1 (enExample)
MX (1) MX377315B (enExample)
RU (1) RU2688349C2 (enExample)
WO (1) WO2015140126A1 (enExample)

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RU2711719C2 (ru) * 2013-09-06 2020-01-21 Ф. Хоффманн-Ля Рош Аг Способ улучшения стабильности антител
RU2688349C2 (ru) 2014-03-21 2019-05-21 Ф. Хоффманн-Ля Рош Аг In vitro прогнозирование времени полужизни антител in vivo
PT3215528T (pt) 2014-11-06 2019-10-11 Hoffmann La Roche Variantes da região fc com ligação modificada ao fcrn e métodos de utilização
CN106957365B (zh) * 2016-01-11 2021-03-16 上海交通大学 一种单克隆抗体FnAb8及其应用
CN106957364B (zh) * 2016-01-11 2021-03-16 上海交通大学 一种单克隆抗体FnAb12及其应用
CN110573626B (zh) * 2017-04-28 2024-05-03 豪夫迈·罗氏有限公司 抗体选择方法
US12172106B2 (en) 2018-08-09 2024-12-24 Regeneron Pharmaceuticals, Inc. Methods for assessing binding affinity of an antibody variant to the neonatal Fc receptor
CN112654641A (zh) 2018-10-01 2021-04-13 豪夫迈·罗氏有限公司 具有与cd40的三价结合的双特异性抗原结合分子
US11242396B2 (en) 2018-10-01 2022-02-08 Hoffmann-La Roche Inc. Bispecific antigen binding molecules comprising anti-FAP clone 212
CN112955240B (zh) * 2018-10-25 2022-09-16 豪夫迈·罗氏有限公司 抗体FcRn结合的修饰
WO2020116560A1 (ja) * 2018-12-05 2020-06-11 株式会社バイカ・セラピュティクス 抗体のＦｃ領域改変体
WO2020141117A1 (en) 2018-12-30 2020-07-09 F. Hoffmann-La Roche Ag Ph-gradient spr-based binding assay
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
CN121577898A (zh) * 2020-04-08 2026-02-27 豪夫迈·罗氏有限公司 大分子非特异性清除测定
JP7322857B2 (ja) * 2020-11-02 2023-08-08 株式会社三洋物産 遊技機
JP7322858B2 (ja) * 2020-11-02 2023-08-08 株式会社三洋物産 遊技機
CN116888473A (zh) * 2021-02-18 2023-10-13 豪夫迈·罗氏有限公司 用于解析复杂、多步骤抗体相互作用的方法
CN113308476B (zh) * 2021-05-12 2022-06-28 广东药康生物科技有限公司 一种FcRn基因人源化动物模型的构建方法
EP4342984A4 (en) * 2021-05-19 2025-04-23 Chugai Seiyaku Kabushiki Kaisha Method for predicting in vivo pharmacokinetics of molecule
WO2025090910A2 (en) * 2023-10-25 2025-05-01 Multiverse Pharma Inc. Antigen binding molecules targeting il-12 and il-23
WO2025224705A1 (en) * 2024-04-26 2025-10-30 Waters Technologies Corporation Direct affinity to size-exclusion chromatography methods and systems thereof

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