KR20160134687A - 항체의 생체내 반감기의 시험관내 예측방법 - Google Patents
항체의 생체내 반감기의 시험관내 예측방법 Download PDFInfo
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- KR20160134687A KR20160134687A KR1020167025760A KR20167025760A KR20160134687A KR 20160134687 A KR20160134687 A KR 20160134687A KR 1020167025760 A KR1020167025760 A KR 1020167025760A KR 20167025760 A KR20167025760 A KR 20167025760A KR 20160134687 A KR20160134687 A KR 20160134687A
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| PCT/EP2015/055482 WO2015140126A1 (en) | 2014-03-21 | 2015-03-17 | In vitro prediction of in vivo half-life of antibodies |
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| JP6580570B2 (ja) * | 2013-09-06 | 2019-09-25 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | 抗体安定性を向上させるための方法 |
| KR20160134687A (ko) | 2014-03-21 | 2016-11-23 | 에프. 호프만-라 로슈 아게 | 항체의 생체내 반감기의 시험관내 예측방법 |
| SI3215528T1 (sl) | 2014-11-06 | 2019-11-29 | Hoffmann La Roche | Variante regije Fc s spremenjeno vezavo FcRn in postopki uporabe |
| CN106957365B (zh) * | 2016-01-11 | 2021-03-16 | 上海交通大学 | 一种单克隆抗体FnAb8及其应用 |
| CN106957364B (zh) * | 2016-01-11 | 2021-03-16 | 上海交通大学 | 一种单克隆抗体FnAb12及其应用 |
| CN110573626B (zh) | 2017-04-28 | 2024-05-03 | 豪夫迈·罗氏有限公司 | 抗体选择方法 |
| US12172106B2 (en) | 2018-08-09 | 2024-12-24 | Regeneron Pharmaceuticals, Inc. | Methods for assessing binding affinity of an antibody variant to the neonatal Fc receptor |
| KR102716634B1 (ko) | 2018-10-01 | 2024-10-16 | 에프. 호프만-라 로슈 아게 | 항-fap 클론 212를 포함하는 이중특이적 항원 결합 분자 |
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| EP3870331B1 (en) | 2018-10-25 | 2025-07-23 | F. Hoffmann-La Roche AG | Modification of antibody fcrn binding |
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| AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
| WO2021204743A1 (en) * | 2020-04-08 | 2021-10-14 | F. Hoffmann-La Roche Ag | Large molecule unspecific clearance assay |
| JP7322857B2 (ja) * | 2020-11-02 | 2023-08-08 | 株式会社三洋物産 | 遊技機 |
| JP7322858B2 (ja) * | 2020-11-02 | 2023-08-08 | 株式会社三洋物産 | 遊技機 |
| CN113308476B (zh) * | 2021-05-12 | 2022-06-28 | 广东药康生物科技有限公司 | 一种FcRn基因人源化动物模型的构建方法 |
| EP4342984A4 (en) * | 2021-05-19 | 2025-04-23 | Chugai Seiyaku Kabushiki Kaisha | Method for predicting in vivo pharmacokinetics of molecule |
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| JP7032490B2 (ja) | 2022-03-08 |
| US12461109B2 (en) | 2025-11-04 |
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| BR112016023417A2 (pt) | 2019-04-16 |
| US20170227547A1 (en) | 2017-08-10 |
| MX2016011982A (es) | 2016-12-09 |
| JP2017517745A (ja) | 2017-06-29 |
| CN106103478A (zh) | 2016-11-09 |
| JP6744855B2 (ja) | 2020-08-19 |
| US20210190795A1 (en) | 2021-06-24 |
| MX377315B (es) | 2025-03-07 |
| RU2016137932A3 (enExample) | 2018-10-29 |
| RU2016137932A (ru) | 2018-04-23 |
| EP3119490A1 (en) | 2017-01-25 |
| RU2688349C2 (ru) | 2019-05-21 |
| CN106103478B (zh) | 2020-04-03 |
| JP2020183967A (ja) | 2020-11-12 |
| WO2015140126A1 (en) | 2015-09-24 |
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