RU2688349C2 - In vitro прогнозирование времени полужизни антител in vivo - Google Patents
In vitro прогнозирование времени полужизни антител in vivo Download PDFInfo
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
- B01D15/168—Fluid composition conditioning, e.g. gradient pH gradient or chromatofocusing, i.e. separation according to the isoelectric point pI
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
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- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
Applications Claiming Priority (5)
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| EP14161103.8 | 2014-03-21 | ||
| EP14161103 | 2014-03-21 | ||
| EP14165987.0 | 2014-04-25 | ||
| EP14165987 | 2014-04-25 | ||
| PCT/EP2015/055482 WO2015140126A1 (en) | 2014-03-21 | 2015-03-17 | In vitro prediction of in vivo half-life of antibodies |
Publications (3)
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| RU2016137932A RU2016137932A (ru) | 2018-04-23 |
| RU2016137932A3 RU2016137932A3 (enExample) | 2018-10-29 |
| RU2688349C2 true RU2688349C2 (ru) | 2019-05-21 |
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| RU2016137932A RU2688349C2 (ru) | 2014-03-21 | 2015-03-17 | In vitro прогнозирование времени полужизни антител in vivo |
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| MX (1) | MX377315B (enExample) |
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| SI2814587T1 (en) | 2012-02-15 | 2018-08-31 | F. Hoffmann-La Roche Ag | Affinity chromatography based on the Fc receptor |
| JP6580570B2 (ja) * | 2013-09-06 | 2019-09-25 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 抗体安定性を向上させるための方法 |
| KR20160134687A (ko) | 2014-03-21 | 2016-11-23 | 에프. 호프만-라 로슈 아게 | 항체의 생체내 반감기의 시험관내 예측방법 |
| SI3215528T1 (sl) | 2014-11-06 | 2019-11-29 | Hoffmann La Roche | Variante regije Fc s spremenjeno vezavo FcRn in postopki uporabe |
| CN106957365B (zh) * | 2016-01-11 | 2021-03-16 | 上海交通大学 | 一种单克隆抗体FnAb8及其应用 |
| CN106957364B (zh) * | 2016-01-11 | 2021-03-16 | 上海交通大学 | 一种单克隆抗体FnAb12及其应用 |
| CN110573626B (zh) | 2017-04-28 | 2024-05-03 | 豪夫迈·罗氏有限公司 | 抗体选择方法 |
| US12172106B2 (en) | 2018-08-09 | 2024-12-24 | Regeneron Pharmaceuticals, Inc. | Methods for assessing binding affinity of an antibody variant to the neonatal Fc receptor |
| KR102716634B1 (ko) | 2018-10-01 | 2024-10-16 | 에프. 호프만-라 로슈 아게 | 항-fap 클론 212를 포함하는 이중특이적 항원 결합 분자 |
| WO2020070035A1 (en) | 2018-10-01 | 2020-04-09 | F. Hoffmann-La Roche Ag | Bispecific antigen binding molecules with trivalent binding to cd40 |
| EP3870331B1 (en) | 2018-10-25 | 2025-07-23 | F. Hoffmann-La Roche AG | Modification of antibody fcrn binding |
| EP3892632A4 (en) | 2018-12-05 | 2022-08-17 | Bica Therapeutics Inc. | MODIFIED PRODUCT OF FC DOMAIN OF ANTIBODIES |
| WO2020141117A1 (en) | 2018-12-30 | 2020-07-09 | F. Hoffmann-La Roche Ag | Ph-gradient spr-based binding assay |
| AR121706A1 (es) | 2020-04-01 | 2022-06-29 | Hoffmann La Roche | Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap |
| WO2021204743A1 (en) * | 2020-04-08 | 2021-10-14 | F. Hoffmann-La Roche Ag | Large molecule unspecific clearance assay |
| JP7322857B2 (ja) * | 2020-11-02 | 2023-08-08 | 株式会社三洋物産 | 遊技機 |
| JP7322858B2 (ja) * | 2020-11-02 | 2023-08-08 | 株式会社三洋物産 | 遊技機 |
| CN113308476B (zh) * | 2021-05-12 | 2022-06-28 | 广东药康生物科技有限公司 | 一种FcRn基因人源化动物模型的构建方法 |
| EP4342984A4 (en) * | 2021-05-19 | 2025-04-23 | Chugai Seiyaku Kabushiki Kaisha | Method for predicting in vivo pharmacokinetics of molecule |
| WO2025090910A2 (en) * | 2023-10-25 | 2025-05-01 | Multiverse Pharma Inc. | Antigen binding molecules targeting il-12 and il-23 |
| WO2025224705A1 (en) * | 2024-04-26 | 2025-10-30 | Waters Technologies Corporation | Direct affinity to size-exclusion chromatography methods and systems thereof |
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- 2015-03-17 EP EP15710178.3A patent/EP3119490B1/en active Active
- 2015-03-17 BR BR112016023417-0A patent/BR112016023417A2/pt not_active Application Discontinuation
- 2015-03-17 JP JP2017500408A patent/JP6744855B2/ja active Active
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- 2015-03-17 CN CN201580015172.9A patent/CN106103478B/zh active Active
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2020
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2021
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| EP3119490B1 (en) | 2021-09-08 |
| JP7032490B2 (ja) | 2022-03-08 |
| US12461109B2 (en) | 2025-11-04 |
| CA2938722A1 (en) | 2015-09-24 |
| BR112016023417A2 (pt) | 2019-04-16 |
| US20170227547A1 (en) | 2017-08-10 |
| MX2016011982A (es) | 2016-12-09 |
| JP2017517745A (ja) | 2017-06-29 |
| CN106103478A (zh) | 2016-11-09 |
| JP6744855B2 (ja) | 2020-08-19 |
| KR20160134687A (ko) | 2016-11-23 |
| US20210190795A1 (en) | 2021-06-24 |
| MX377315B (es) | 2025-03-07 |
| RU2016137932A3 (enExample) | 2018-10-29 |
| RU2016137932A (ru) | 2018-04-23 |
| EP3119490A1 (en) | 2017-01-25 |
| CN106103478B (zh) | 2020-04-03 |
| JP2020183967A (ja) | 2020-11-12 |
| WO2015140126A1 (en) | 2015-09-24 |
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