JP6744855B2 - 抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測 - Google Patents

抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測 Download PDF

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Publication number
JP6744855B2
JP6744855B2 JP2017500408A JP2017500408A JP6744855B2 JP 6744855 B2 JP6744855 B2 JP 6744855B2 JP 2017500408 A JP2017500408 A JP 2017500408A JP 2017500408 A JP2017500408 A JP 2017500408A JP 6744855 B2 JP6744855 B2 JP 6744855B2
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antibody
fcrn
retention time
region
life
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JP2017517745A5 (enExample
JP2017517745A (ja
Inventor
エムリッヒ，トーマス
ケッテンベルガー，フーベルト
シュロットハウアー，ティルマン
ショック，アンゲラ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B01D15/168—Fluid composition conditioning, e.g. gradient pH gradient or chromatofocusing, i.e. separation according to the isoelectric point pI
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
JP2017500408A 2014-03-21 2015-03-17 抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測 Active JP6744855B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP14161103.8 2014-03-21
EP14161103 2014-03-21
EP14165987.0 2014-04-25
EP14165987 2014-04-25
PCT/EP2015/055482 WO2015140126A1 (en) 2014-03-21 2015-03-17 In vitro prediction of in vivo half-life of antibodies

Related Child Applications (1)

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JP2020129979A Division JP7032490B2 (ja) 2014-03-21 2020-07-31 抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測

Publications (3)

Publication Number Publication Date
JP2017517745A JP2017517745A (ja) 2017-06-29
JP2017517745A5 JP2017517745A5 (enExample) 2018-04-12
JP6744855B2 true JP6744855B2 (ja) 2020-08-19

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JP2017500408A Active JP6744855B2 (ja) 2014-03-21 2015-03-17 抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測
JP2020129979A Active JP7032490B2 (ja) 2014-03-21 2020-07-31 抗体のｉｎ ｖｉｖｏでの半減期のｉｎ ｖｉｔｒｏでの予測

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Country Status (10)

Country Link
US (2) US20170227547A1 (enExample)
EP (1) EP3119490B1 (enExample)
JP (2) JP6744855B2 (enExample)
KR (1) KR20160134687A (enExample)
CN (1) CN106103478B (enExample)
BR (1) BR112016023417A2 (enExample)
CA (1) CA2938722A1 (enExample)
MX (1) MX377315B (enExample)
RU (1) RU2688349C2 (enExample)
WO (1) WO2015140126A1 (enExample)

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SI2814587T1 (en) 2012-02-15 2018-08-31 F. Hoffmann-La Roche Ag Affinity chromatography based on the Fc receptor
JP6580570B2 (ja) * 2013-09-06 2019-09-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 抗体安定性を向上させるための方法
KR20160134687A (ko) 2014-03-21 2016-11-23 에프. 호프만-라 로슈 아게 항체의 생체내 반감기의 시험관내 예측방법
SI3215528T1 (sl) 2014-11-06 2019-11-29 Hoffmann La Roche Variante regije Fc s spremenjeno vezavo FcRn in postopki uporabe
CN106957365B (zh) * 2016-01-11 2021-03-16 上海交通大学 一种单克隆抗体FnAb8及其应用
CN106957364B (zh) * 2016-01-11 2021-03-16 上海交通大学 一种单克隆抗体FnAb12及其应用
CN110573626B (zh) 2017-04-28 2024-05-03 豪夫迈·罗氏有限公司 抗体选择方法
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WO2020070035A1 (en) 2018-10-01 2020-04-09 F. Hoffmann-La Roche Ag Bispecific antigen binding molecules with trivalent binding to cd40
EP3870331B1 (en) 2018-10-25 2025-07-23 F. Hoffmann-La Roche AG Modification of antibody fcrn binding
EP3892632A4 (en) 2018-12-05 2022-08-17 Bica Therapeutics Inc. MODIFIED PRODUCT OF FC DOMAIN OF ANTIBODIES
WO2020141117A1 (en) 2018-12-30 2020-07-09 F. Hoffmann-La Roche Ag Ph-gradient spr-based binding assay
AR121706A1 (es) 2020-04-01 2022-06-29 Hoffmann La Roche Moléculas de unión a antígeno biespecíficas dirigidas a ox40 y fap
WO2021204743A1 (en) * 2020-04-08 2021-10-14 F. Hoffmann-La Roche Ag Large molecule unspecific clearance assay
JP7322857B2 (ja) * 2020-11-02 2023-08-08 株式会社三洋物産 遊技機
JP7322858B2 (ja) * 2020-11-02 2023-08-08 株式会社三洋物産 遊技機
CN113308476B (zh) * 2021-05-12 2022-06-28 广东药康生物科技有限公司 一种FcRn基因人源化动物模型的构建方法
EP4342984A4 (en) * 2021-05-19 2025-04-23 Chugai Seiyaku Kabushiki Kaisha Method for predicting in vivo pharmacokinetics of molecule
WO2025090910A2 (en) * 2023-10-25 2025-05-01 Multiverse Pharma Inc. Antigen binding molecules targeting il-12 and il-23
WO2025224705A1 (en) * 2024-04-26 2025-10-30 Waters Technologies Corporation Direct affinity to size-exclusion chromatography methods and systems thereof

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US12461109B2 (en) 2025-11-04
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BR112016023417A2 (pt) 2019-04-16
US20170227547A1 (en) 2017-08-10
MX2016011982A (es) 2016-12-09
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US20210190795A1 (en) 2021-06-24
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